{"id":"https://openalex.org/W2182239800","doi":null,"title":"Changes in Neural Stem Cells in Neonatal Rats with Hypoxic-ischaemic Encephalopathy","display_name":"Changes in Neural Stem Cells in Neonatal Rats with Hypoxic-ischaemic Encephalopathy","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2182239800","mag":"2182239800"},"language":"en","primary_location":{"id":"mag:2182239800","doi":null,"is_oa":false,"landing_page_url":"http://www.hkjpaed.org/pdf/2012;17;31-37.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103690009","display_name":"Feng Zc","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Feng Zc","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045351628","display_name":"J Liu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5101837450","display_name":"Rong Ju","orcid":"https://orcid.org/0000-0003-3401-4243","observed_orcids":["https://orcid.org/0000-0003-3401-4243","https://orcid.org/0000-0002-0148-9974"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rong Ju","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3401-4243","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.02410000003874302,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neural-stem-cells","display_name":"neural stem cells","score":0.9929999709129333},{"id":"https://openalex.org/keywords/hypoxic-ischemic-encephalopathy","display_name":"hypoxic-ischemic encephalopathy","score":0.9639999866485596},{"id":"https://openalex.org/keywords/neonatal-brain-injury","display_name":"neonatal brain injury","score":0.9070000052452087},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.7269999980926514},{"id":"https://openalex.org/keywords/treatment-window","display_name":"therapeutic time window","score":0.6690000295639038},{"id":"https://openalex.org/keywords/nestin","display_name":"nestin","score":0.7039999961853027},{"id":"https://openalex.org/keywords/postnatal-brain-development","display_name":"postnatal brain development","score":0.6959999799728394},{"id":"https://openalex.org/keywords/sprague-dawley-rats","display_name":"Sprague-Dawley rats","score":0.7760000228881836}],"concepts":[{"id":"https://openalex.org/C136834591","wikidata":"https://www.wikidata.org/wiki/Q2944097","display_name":"Neural stem cell","level":3,"score":0.67803555727005},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.6335809826850891},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6267989873886108},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.6067048907279968},{"id":"https://openalex.org/C2777738006","wikidata":"https://www.wikidata.org/wiki/Q14906812","display_name":"Nestin","level":4,"score":0.5935704112052917},{"id":"https://openalex.org/C2778621155","wikidata":"https://www.wikidata.org/wiki/Q576349","display_name":"Encephalopathy","level":2,"score":0.5491759777069092},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4711952209472656},{"id":"https://openalex.org/C2781458332","wikidata":"https://www.wikidata.org/wiki/Q720026","display_name":"Brain damage","level":2,"score":0.45933687686920166},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.42904385924339294},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.36488455533981323},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.36474108695983887},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.3601098954677582},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3232451379299164},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26206520199775696},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.14962926506996155},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2182239800","doi":null,"is_oa":false,"landing_page_url":"http://www.hkjpaed.org/pdf/2012;17;31-37.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9789000153541565,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W6711125","https://openalex.org/W1975596483","https://openalex.org/W2004927868","https://openalex.org/W2009703235","https://openalex.org/W2014547350","https://openalex.org/W2022491750","https://openalex.org/W2033994927","https://openalex.org/W2039552347","https://openalex.org/W2066215889","https://openalex.org/W2069465086","https://openalex.org/W2094958540","https://openalex.org/W2101601043","https://openalex.org/W2101873759","https://openalex.org/W2115933592","https://openalex.org/W2117381245","https://openalex.org/W2135669794","https://openalex.org/W2141373720","https://openalex.org/W2144475971","https://openalex.org/W2153229538","https://openalex.org/W2164127547","https://openalex.org/W2171942570"],"related_works":["https://openalex.org/W2183704855","https://openalex.org/W2347806548","https://openalex.org/W2372468627","https://openalex.org/W2412334933","https://openalex.org/W2519431631","https://openalex.org/W7056819359","https://openalex.org/W2273385080","https://openalex.org/W2003489088","https://openalex.org/W2364180589","https://openalex.org/W3031046992"],"abstract_inverted_index":{"Background:":[0],"Human":[1],"neural":[2],"stem":[3],"cells":[4,130],"(hNSC)":[5],"transplantation":[6,43,253],"has":[7,20],"been":[8],"used":[9],"for":[10,41,69,119,244,254],"the":[11,26,32,38,56,74,195,202,236,246,255],"treatment":[12,248,256],"of":[13,124,128,192,213,235,251,257],"neurological":[14],"injury":[15],"and":[16,19,31,63,95,114,141,162,181,199],"neurodegenerative":[17],"disease":[18],"produced":[21],"some":[22,226],"desired":[23],"effects,":[24],"but":[25,228],"beneficial":[27],"effects":[28,34],"are":[29],"limited":[30],"long-term":[33],"remain":[35],"unknown":[36],"because":[37],"best":[39,247],"time":[40,105,183,249],"NSC":[42,59,167,186,214,223,252],"after":[44,60,208],"hypoxic-ischaemia":[45],"(HI)":[46],"is":[47],"unclear.":[48],"Objectives:":[49],"This":[50],"study":[51],"was":[52,166],"designed":[53],"to":[54,64,73,201,225,231],"investigate":[55],"changes":[57],"in":[58,143,169,194],"cerebral":[61],"HI-damage,":[62],"provide":[65,241],"a":[66,89,92,96,121,134,211],"theoretical":[67],"reference":[68,242],"NSC'":[70],"therapeutic":[71],"benefits":[72],"HI-damaged":[75],"brain.":[76],"Methods:":[77],"210":[78],"seven-day-old":[79],"Sprague-Dawley":[80],"(SD)":[81],"rats":[82],"were":[83,101,117,131,187],"randomly":[84],"assigned":[85],"into":[86,103],"three":[87],"groups:":[88,107],"HI":[90,163],"group,":[91,198],"hypoxic":[93,160],"group":[94],"normal":[97,158,196],"control":[98,197],"group.":[99],"They":[100],"subdivided":[102],"7":[104],"point":[106],"3-hour,":[108,174],"6-hour,":[109],"1-day,":[110],"3-day,":[111],"7-day,":[112],"14-day":[113],"21-day.":[115],"Cells":[116],"stained":[118],"Nestin,":[120],"representative":[122],"protein":[123],"NSC.":[125],"The":[126,152,239],"counts":[127],"immunoreactive":[129],"made":[132],"under":[133],"light":[135],"microscope,":[136],"photographed":[137],"at":[138,173,189,205],"400X":[139],"magnification":[140],"counted":[142],"ten":[144],"random":[145],"different":[146],"visual":[147],"fields":[148],"per":[149],"section.":[150],"Results:":[151],"results":[153,240],"showed":[154],"that:":[155],"(1)":[156],"In":[157],"controls,":[159],"groups":[161],"groups,":[164],"there":[165],"organisation":[168],"SD":[170],"rat":[171],"brains":[172],"6-hour":[175],"or":[176],"1-,":[177],"3-,":[178],"7-,":[179],"14-":[180],"21-day":[182],"points.":[184],"(2)":[185],"reduced":[188,200],"2":[190],"weeks":[191,207],"life":[193],"lowest":[203],"number":[204],"3":[206],"birth,":[209],"presenting":[210],"trend":[212],"gradually":[215],"reducing":[216],"with":[217,233],"age.":[218],"(3)":[219],"Hypoxia":[220],"can":[221],"improve":[222],"proliferation":[224,229],"degree,":[227],"begins":[230],"decrease":[232],"development":[234],"HI.":[237],"Conclusions:":[238],"value":[243],"selecting":[245],"window":[250],"neonatal":[258],"hypoxic-ischaemic":[259],"brain":[260],"damage.":[261]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}