{"id":"https://openalex.org/W2182237765","doi":null,"title":"Mathematical Models of Some Signaling Pathways Regulating Cell Survival and Death","display_name":"Mathematical Models of Some Signaling Pathways Regulating Cell Survival and Death","publication_year":2008,"publication_date":"2008-10-23","ids":{"openalex":"https://openalex.org/W2182237765","mag":"2182237765"},"language":"en","primary_location":{"id":"pmh:oai:vtechworks.lib.vt.edu:10919/29443","doi":null,"is_oa":true,"landing_page_url":"http://scholar.lib.vt.edu/theses/available/etd-11032008-114621/","pdf_url":"http://hdl.handle.net/10919/29443","source":{"id":"https://openalex.org/S4306400248","display_name":"VTechWorks (Virginia Tech)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I859038795","host_organization_name":"Virginia Tech","host_organization_lineage":["https://openalex.org/I859038795"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10919/29443","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003112405","display_name":"Tongli Zhang","orcid":"https://orcid.org/0000-0003-1773-6279","observed_orcids":["https://orcid.org/0000-0003-1773-6279"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tongli Zhang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1773-6279","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028908910","display_name":"John J. Tyson","orcid":"https://orcid.org/0000-0001-7560-6013","observed_orcids":["https://orcid.org/0000-0001-7560-6013"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John J. Tyson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7560-6013","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035808792","display_name":"Paul Brazhnik","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul Brazhnik","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100455242","display_name":"Liwu Li","orcid":"https://orcid.org/0000-0001-8870-5299","observed_orcids":["https://orcid.org/0000-0001-8870-5299"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Liwu Li","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8870-5299","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058635802","display_name":"Pedro Mendes","orcid":"https://orcid.org/0000-0001-6507-9168","observed_orcids":["https://orcid.org/0000-0001-6507-9168","https://orcid.org/0009-0004-1924-0407"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pedro Mendes","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6507-9168","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031291395","display_name":"Carla V. Finkielstein","orcid":"https://orcid.org/0000-0002-8417-4643","observed_orcids":["https://orcid.org/0000-0002-8417-4643"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carla V. Finkielstein","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8417-4643","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5103705026","display_name":"John A. Burns","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John A. Burns","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.009499999694526196,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/signaling-pathways","display_name":"signaling pathways","score":0.8190000057220459},{"id":"https://openalex.org/keywords/cell-survival","display_name":"cell survival","score":0.699999988079071},{"id":"https://openalex.org/keywords/programmed-cell-death","display_name":"programmed cell death","score":0.9269999861717224},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7760000228881836},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9179999828338623},{"id":"https://openalex.org/keywords/cell-fate-determination","display_name":"cell fate determination","score":0.8690000176429749},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.8679999709129333},{"id":"https://openalex.org/keywords/feedback-loops","display_name":"feedback loops","score":0.44699999690055847},{"id":"https://openalex.org/keywords/nonlinear-dynamics","display_name":"nonlinear dynamics","score":0.6909999847412109},{"id":"https://openalex.org/keywords/mathematical-modeling-of-gene-regulation","display_name":"mathematical modeling of gene regulation","score":0.640999972820282},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.5950000286102295},{"id":"https://openalex.org/keywords/growth-regulation","display_name":"growth regulation","score":0.3310000002384186}],"concepts":[{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4736018180847168},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.42254769802093506},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4139939248561859},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4050157070159912},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4043903052806854},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.22531458735466003},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17182278633117676}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:vtechworks.lib.vt.edu:10919/29443","doi":null,"is_oa":true,"landing_page_url":"http://scholar.lib.vt.edu/theses/available/etd-11032008-114621/","pdf_url":"http://hdl.handle.net/10919/29443","source":{"id":"https://openalex.org/S4306400248","display_name":"VTechWorks (Virginia Tech)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I859038795","host_organization_name":"Virginia Tech","host_organization_lineage":["https://openalex.org/I859038795"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},{"id":"mag:2182237765","doi":null,"is_oa":false,"landing_page_url":"https://theses.lib.vt.edu/theses/available/etd-11032008-114621/unrestricted/tonglidisnov19.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:vtechworks.lib.vt.edu:10919/29443","doi":null,"is_oa":true,"landing_page_url":"http://scholar.lib.vt.edu/theses/available/etd-11032008-114621/","pdf_url":"http://hdl.handle.net/10919/29443","source":{"id":"https://openalex.org/S4306400248","display_name":"VTechWorks (Virginia Tech)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I859038795","host_organization_name":"Virginia Tech","host_organization_lineage":["https://openalex.org/I859038795"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4000000059604645,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2182237765.pdf","grobid_xml":"https://content.openalex.org/works/W2182237765.grobid-xml"},"referenced_works_count":120,"referenced_works":["https://openalex.org/W172276776","https://openalex.org/W1509012393","https://openalex.org/W1511058669","https://openalex.org/W1520563041","https://openalex.org/W1535444616","https://openalex.org/W1574698301","https://openalex.org/W1591281137","https://openalex.org/W1596321532","https://openalex.org/W1604468403","https://openalex.org/W1641228030","https://openalex.org/W1650797637","https://openalex.org/W1654008137","https://openalex.org/W1659382355","https://openalex.org/W1694093395","https://openalex.org/W1876456565","https://openalex.org/W1938231136","https://openalex.org/W1963501271","https://openalex.org/W1964037688","https://openalex.org/W1964742508","https://openalex.org/W1968006317","https://openalex.org/W1971459774","https://openalex.org/W1976842123","https://openalex.org/W1976873804","https://openalex.org/W1979634817","https://openalex.org/W1982528660","https://openalex.org/W1982545718","https://openalex.org/W1989903496","https://openalex.org/W1990039929","https://openalex.org/W1992282800","https://openalex.org/W1992989336","https://openalex.org/W1996861281","https://openalex.org/W1999248906","https://openalex.org/W2005909927","https://openalex.org/W2007269038","https://openalex.org/W2007875429","https://openalex.org/W2008257691","https://openalex.org/W2008841394","https://openalex.org/W2008887283","https://openalex.org/W2009183786","https://openalex.org/W2009214172","https://openalex.org/W2009348177","https://openalex.org/W2009845042","https://openalex.org/W2012114168","https://openalex.org/W2014999693","https://openalex.org/W2020661522","https://openalex.org/W2021051229","https://openalex.org/W2024105041","https://openalex.org/W2025476423","https://openalex.org/W2027533135","https://openalex.org/W2028886214","https://openalex.org/W2029030701","https://openalex.org/W2030239546","https://openalex.org/W2031495220","https://openalex.org/W2033853356","https://openalex.org/W2034269086","https://openalex.org/W2038305733","https://openalex.org/W2041603328","https://openalex.org/W2042990867","https://openalex.org/W2049225749","https://openalex.org/W2050259175","https://openalex.org/W2051258629","https://openalex.org/W2057428268","https://openalex.org/W2061019845","https://openalex.org/W2061552846","https://openalex.org/W2063107060","https://openalex.org/W2064434771","https://openalex.org/W2065372463","https://openalex.org/W2065886319","https://openalex.org/W2068705865","https://openalex.org/W2070005695","https://openalex.org/W2072636863","https://openalex.org/W2073028327","https://openalex.org/W2074097004","https://openalex.org/W2074501845","https://openalex.org/W2077206871","https://openalex.org/W2077326330","https://openalex.org/W2082185914","https://openalex.org/W2082979850","https://openalex.org/W2085418817","https://openalex.org/W2087450028","https://openalex.org/W2087764283","https://openalex.org/W2088762003","https://openalex.org/W2089442061","https://openalex.org/W2091818021","https://openalex.org/W2093730092","https://openalex.org/W2094494461","https://openalex.org/W2097465618","https://openalex.org/W2097531829","https://openalex.org/W2097651998","https://openalex.org/W2098975407","https://openalex.org/W2099791142","https://openalex.org/W2105896701","https://openalex.org/W2113999599","https://openalex.org/W2116755440","https://openalex.org/W2116875795","https://openalex.org/W2120531171","https://openalex.org/W2125937596","https://openalex.org/W2131532199","https://openalex.org/W2133554538","https://openalex.org/W2136269288","https://openalex.org/W2137066151","https://openalex.org/W2141997480","https://openalex.org/W2144702196","https://openalex.org/W2145006562","https://openalex.org/W2146977885","https://openalex.org/W2150114634","https://openalex.org/W2152585118","https://openalex.org/W2152750766","https://openalex.org/W2152826290","https://openalex.org/W2159583680","https://openalex.org/W2166668167","https://openalex.org/W2168639189","https://openalex.org/W2169205569","https://openalex.org/W2313997600","https://openalex.org/W2317926428","https://openalex.org/W2326293895","https://openalex.org/W2334988436","https://openalex.org/W2418796884","https://openalex.org/W2530014580","https://openalex.org/W4300790656"],"related_works":["https://openalex.org/W2170103858","https://openalex.org/W2023168478","https://openalex.org/W2095433609","https://openalex.org/W2158611221","https://openalex.org/W4303699844","https://openalex.org/W2103971077","https://openalex.org/W93977340","https://openalex.org/W2106362845","https://openalex.org/W4303634039","https://openalex.org/W2196747299"],"abstract_inverted_index":{"In":[0,15],"a":[1],"multi-cellular":[2],"organism,":[3],"cells":[4,20],"constantly":[5],"receive":[6],"signals":[7],"on":[8],"their":[9],"internal":[10],"condition":[11],"and":[12,99,111,131,151],"surrounding":[13],"environment.":[14],"response":[16],"to":[17,64,82,157],"various":[18],"signals,":[19],"proliferate,":[21],"move":[22],"around":[23],"or":[24],"even":[25],"undergo":[26],"suicide.":[27],"The":[28,115],"signal-response":[29],"is":[30,39,50,80],"controlled":[31],"by":[32,87,129],"complex":[33],"molecular":[34,45,73,94,143],"machinery,":[35],"understanding":[36,49],"of":[37,43,108,121,134],"which":[38],"an":[40],"important":[41],"goal":[42],"basic":[44],"biological":[46],"research.":[47],"Such":[48],"also":[51],"valuable":[52],"for":[53,146],"clinical":[54],"application,":[55],"since":[56],"lethal":[57],"diseases":[58],"like":[59],"cancer":[60],"show":[61],"maladaptive":[62],"responses":[63],"growth-regulating":[65],"signals.":[66],"Because":[67],"the":[68,72,93,101,106,118,125,132,135,147,159,163],"multiple":[69],"feedbacks":[70],"in":[71,162],"regulatory":[74],"machinery":[75],"obscure":[76],"cause-effect":[77],"relations,":[78],"it":[79],"hard":[81],"understand":[83],"these":[84],"control":[85,137],"systems":[86],"intuition":[88],"alone.":[89],"Here":[90],"we":[91],"translate":[92],"interactions":[95,144],"into":[96],"differential":[97],"equations":[98],"recapture":[100],"cellular":[102],"physiological":[103,119,149],"properties":[104],"with":[105],"help":[107],"numerical":[109],"simulations":[110],"non-linear":[112],"dynamical":[113],"tools.":[114],"models":[116,140],"address":[117],"features":[120],"programmed":[122],"cell":[123,126],"death,":[124],"fate":[127],"decision":[128],"p53":[130],"dynamics":[133],"NF-?B":[136],"system.":[138],"These":[139],"identify":[141],"key":[142],"responsible":[145],"observed":[148],"properties,":[150],"they":[152],"generate":[153],"experimentally":[154],"testable":[155],"predictions":[156],"validate":[158],"assumptions":[160],"made":[161],"models.":[164]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}
