{"id":"https://openalex.org/W2182236093","doi":null,"title":"AN OVERVIEW ON SICKLE CELL DISEASE PROFILE","display_name":"AN OVERVIEW ON SICKLE CELL DISEASE PROFILE","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2182236093","mag":"2182236093"},"language":"en","primary_location":{"id":"mag:2182236093","doi":null,"is_oa":false,"landing_page_url":"http://www.ajpcr.com/Vol6Suppl1/1594.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Manpreet Kaur","orcid":"https://orcid.org/0000-0002-3177-6093","observed_orcids":["https://orcid.org/0000-0002-3177-6093"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Manpreet Kaur","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3177-6093","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112089798","display_name":"C. B. S. Dangi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dangi Cbs","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5073104368","display_name":"Monika Singh","orcid":"https://orcid.org/0009-0009-1827-4740","observed_orcids":["https://orcid.org/0009-0009-1827-4740"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Monika Singh","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0009-1827-4740","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.89,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.84169162,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sickle-cell-disease","display_name":"sickle cell disease","score":1.0},{"id":"https://openalex.org/keywords/hemoglobinopathies","display_name":"hemoglobinopathies","score":0.8230000138282776},{"id":"https://openalex.org/keywords/hemoglobin-s","display_name":"hemoglobin S","score":0.9049999713897705},{"id":"https://openalex.org/keywords/beta-globin-gene-mutations","display_name":"beta-globin gene mutations","score":0.6970000267028809},{"id":"https://openalex.org/keywords/vasoocclusion","display_name":"vasoocclusion","score":0.9369999766349792},{"id":"https://openalex.org/keywords/hemolysis","display_name":"hemolysis","score":0.9649999737739563},{"id":"https://openalex.org/keywords/chronic-anemia","display_name":"chronic anemia","score":0.8209999799728394},{"id":"https://openalex.org/keywords/vaso-occlusive-crisis","display_name":"vaso-occlusive crisis","score":0.6679999828338623},{"id":"https://openalex.org/keywords/acute-chest-syndrome","display_name":"acute chest syndrome","score":0.9850000143051147},{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.9599999785423279},{"id":"https://openalex.org/keywords/bacterial-infection","display_name":"bacterial infection","score":0.7720000147819519},{"id":"https://openalex.org/keywords/prenatal-screening","display_name":"prenatal screening","score":0.9319999814033508},{"id":"https://openalex.org/keywords/penicillin-prophylaxis","display_name":"penicillin prophylaxis","score":0.9269999861717224},{"id":"https://openalex.org/keywords/hydroxyurea","display_name":"hydroxyurea","score":0.9020000100135803},{"id":"https://openalex.org/keywords/blood-transfusion","display_name":"blood transfusion","score":0.968999981880188},{"id":"https://openalex.org/keywords/bone-marrow-transplantation","display_name":"bone marrow transplantation","score":0.9980000257492065},{"id":"https://openalex.org/keywords/genetic-counseling","display_name":"genetic counseling","score":0.9430000185966492}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7973366975784302},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6564838886260986},{"id":"https://openalex.org/C80227256","wikidata":"https://www.wikidata.org/wiki/Q1124169","display_name":"Genetic counseling","level":2,"score":0.5924105644226074},{"id":"https://openalex.org/C2910801743","wikidata":"https://www.wikidata.org/wiki/Q471706","display_name":"Haemolysis","level":2,"score":0.5642649531364441},{"id":"https://openalex.org/C2780976302","wikidata":"https://www.wikidata.org/wiki/Q4677915","display_name":"Acute chest syndrome","level":4,"score":0.4971330463886261},{"id":"https://openalex.org/C2780345856","wikidata":"https://www.wikidata.org/wiki/Q156590","display_name":"Priapism","level":2,"score":0.48353099822998047},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.46549686789512634},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.45122307538986206},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4201762080192566},{"id":"https://openalex.org/C2778620579","wikidata":"https://www.wikidata.org/wiki/Q185034","display_name":"Sickle cell anemia","level":3,"score":0.3219871520996094},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30682146549224854},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.25081297755241394},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2507830262184143},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2182236093","doi":null,"is_oa":false,"landing_page_url":"http://www.ajpcr.com/Vol6Suppl1/1594.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":115,"referenced_works":["https://openalex.org/W14959226","https://openalex.org/W24461196","https://openalex.org/W25054622","https://openalex.org/W41502270","https://openalex.org/W117828388","https://openalex.org/W128213231","https://openalex.org/W145680385","https://openalex.org/W185680520","https://openalex.org/W1481849334","https://openalex.org/W1593776078","https://openalex.org/W1597151660","https://openalex.org/W1602899744","https://openalex.org/W1608551040","https://openalex.org/W1919238100","https://openalex.org/W1933201213","https://openalex.org/W1959608898","https://openalex.org/W1973861544","https://openalex.org/W1975642553","https://openalex.org/W1976763101","https://openalex.org/W1977508606","https://openalex.org/W1978325610","https://openalex.org/W1981208216","https://openalex.org/W1988814676","https://openalex.org/W1989426645","https://openalex.org/W1992897598","https://openalex.org/W1993327317","https://openalex.org/W2002666303","https://openalex.org/W2003271897","https://openalex.org/W2011184261","https://openalex.org/W2017507006","https://openalex.org/W2019449116","https://openalex.org/W2019578579","https://openalex.org/W2019673916","https://openalex.org/W2027526975","https://openalex.org/W2027546426","https://openalex.org/W2027593618","https://openalex.org/W2031039743","https://openalex.org/W2033975683","https://openalex.org/W2035494124","https://openalex.org/W2044770745","https://openalex.org/W2044789512","https://openalex.org/W2048400258","https://openalex.org/W2048686385","https://openalex.org/W2049129790","https://openalex.org/W2050249572","https://openalex.org/W2050711676","https://openalex.org/W2053229854","https://openalex.org/W2054055531","https://openalex.org/W2056584805","https://openalex.org/W2063080769","https://openalex.org/W2071159249","https://openalex.org/W2071460171","https://openalex.org/W2072702503","https://openalex.org/W2077174747","https://openalex.org/W2077328361","https://openalex.org/W2081948879","https://openalex.org/W2082635065","https://openalex.org/W2084295229","https://openalex.org/W2086443283","https://openalex.org/W2086766106","https://openalex.org/W2087078196","https://openalex.org/W2087450601","https://openalex.org/W2089819802","https://openalex.org/W2092193282","https://openalex.org/W2093712211","https://openalex.org/W2094278084","https://openalex.org/W2094698820","https://openalex.org/W2096505183","https://openalex.org/W2097744068","https://openalex.org/W2111653865","https://openalex.org/W2113422674","https://openalex.org/W2116051995","https://openalex.org/W2120488597","https://openalex.org/W2121292999","https://openalex.org/W2121538856","https://openalex.org/W2123449311","https://openalex.org/W2142833399","https://openalex.org/W2142864885","https://openalex.org/W2144398905","https://openalex.org/W2144772386","https://openalex.org/W2146190354","https://openalex.org/W2147182596","https://openalex.org/W2148547093","https://openalex.org/W2148763283","https://openalex.org/W2149019059","https://openalex.org/W2150519485","https://openalex.org/W2154766878","https://openalex.org/W2169952241","https://openalex.org/W2175212754","https://openalex.org/W2175335096","https://openalex.org/W2224339414","https://openalex.org/W2313541759","https://openalex.org/W2315173715","https://openalex.org/W2317398680","https://openalex.org/W2322074970","https://openalex.org/W2324143840","https://openalex.org/W2326476344","https://openalex.org/W2330393631","https://openalex.org/W2332642667","https://openalex.org/W2334263927","https://openalex.org/W2344869195","https://openalex.org/W2398232357","https://openalex.org/W2398530991","https://openalex.org/W2404705955","https://openalex.org/W2412227310","https://openalex.org/W2416342265","https://openalex.org/W2437356308","https://openalex.org/W2605494478","https://openalex.org/W2887375283","https://openalex.org/W3093093377","https://openalex.org/W3113247834","https://openalex.org/W3143545514","https://openalex.org/W3144957394","https://openalex.org/W4241694836","https://openalex.org/W4294571412"],"related_works":["https://openalex.org/W2331167489","https://openalex.org/W4283837991","https://openalex.org/W2742335692","https://openalex.org/W4303832607","https://openalex.org/W1948637240","https://openalex.org/W7155356009","https://openalex.org/W2945978819","https://openalex.org/W2114000939","https://openalex.org/W7218250243","https://openalex.org/W4390006924"],"abstract_inverted_index":{"Sickle":[0],"cell":[1,87,165],"disease":[2,17,59,88],"(SCD)":[3],"is":[4,37,77,171],"a":[5],"very":[6],"devastating":[7],"condition":[8],"caused":[9],"by":[10],"an":[11],"autosomal":[12],"recessive":[13],"inherited":[14],"haemoglobinopathy.":[15],"This":[16,34,58],"affects":[18],"millions":[19],"of":[20,41,53,56,74,85,134,186,195],"peoples":[21],"globally":[22],"which":[23],"results":[24],"in":[25],"serious":[26],"complications":[27,168],"due":[28,38,90],"to":[29,39,91,103],"vasoocclusive":[30],"phenomenon":[31],"and":[32,80,101,119,126,128,151,169,190],"haemolysis.":[33],"genetic":[35],"abnormality":[36],"substitution":[40],"amino":[42],"acid":[43,48],"valine":[44],"for":[45,143,160],"the":[46,50,193],"glutamic":[47],"at":[49],"sixth":[51],"position":[52],"beta":[54],"chain":[55],"haemoglobin.":[57],"was":[60],"described":[61],"about":[62,163],"one":[63],"hundred":[64],"year":[65],"ago.":[66],"The":[67],"haemoglobin":[68],"S":[69],"(hbS)":[70],"produced":[71],"as":[72],"result":[73],"this":[75],"defect":[76],"poorly":[78],"soluble":[79],"polymerized":[81],"when":[82],"deoxygenated.":[83],"Symptoms":[84],"sickle":[86,164],"are":[89,146],"chronic":[92],"anaemia,":[93],"pain":[94],"full":[95],"crises,":[96],"acute":[97],"chest":[98],"syndrome,":[99],"stroke":[100],"susceptibility":[102],"bacterial":[104],"infection.":[105],"In":[106],"recent":[107],"years":[108],"measures":[109],"like":[110],"prenatal":[111],"screening,":[112],"better":[113],"medical":[114,158],"care,":[115],"parent":[116],"education,":[117],"immunization":[118],"penicillin":[120],"prophylaxis":[121],"have":[122,129],"successfully":[123],"reduced":[124],"morbidity":[125],"mortality":[127],"increased":[130],"tremendously":[131],"life":[132],"expectancy":[133],"affected":[135,197],"individuals.":[136],"Three":[137],"principal":[138],"current":[139],"therapeutics":[140],"modalities":[141],"available":[142],"childhood":[144],"SCD":[145],"blood":[147],"transfusion,":[148],"Hydroxy":[149],"urea":[150],"bone":[152],"marrow":[153],"transplantation.":[154],"Genetic":[155],"counseling,":[156],"continued":[157],"education":[159],"health":[161,174],"professionals":[162],"disease,":[166],"its":[167],"management":[170],"necessary.":[172],"World":[173],"organization":[175],"has":[176],"actively":[177],"promoted":[178],"several":[179],"national":[180],"screening":[181],"programms":[182],"with":[183],"dual":[184],"goals":[185],"informing":[187],"reproductive":[188],"choice":[189],"thereby":[191],"reducing":[192],"number":[194],"severely":[196],"children.":[198]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}