{"id":"https://openalex.org/W2182235855","doi":"https://doi.org/10.1016/s0022-2275(20)33888-8","title":"Regulation of endothelial nitric oxide synthase gene expression by oxidized linoleic acid","display_name":"Regulation of endothelial nitric oxide synthase gene expression by oxidized linoleic acid","publication_year":1998,"publication_date":"1998-02-01","ids":{"openalex":"https://openalex.org/W2182235855","doi":"https://doi.org/10.1016/s0022-2275(20)33888-8","mag":"2182235855","pmid":"https://pubmed.ncbi.nlm.nih.gov/9507987"},"language":"en","primary_location":{"id":"doi:10.1016/s0022-2275(20)33888-8","doi":"https://doi.org/10.1016/s0022-2275(20)33888-8","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0022-2275(20)33888-8","pdf_url":"http://www.jlr.org/article/S0022227520338888/pdf","source":{"id":"https://openalex.org/S11400418","display_name":"Journal of Lipid Research","issn_l":"0022-2275","issn":["0022-2275","1539-7262"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lipid Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jlr.org/article/S0022227520338888/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030390724","display_name":"Santhini Ramasamy","orcid":"https://orcid.org/0000-0001-5863-416X","observed_orcids":["https://orcid.org/0000-0001-5863-416X"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Santhini Ramasamy","raw_affiliation_strings":["Division of Cardiology, Department of Medicine, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Department of Medicine, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113514023","display_name":"Sampath Parthasarathy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sampath Parthasarathy","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011627807","display_name":"David Glenn Harrison","orcid":"https://orcid.org/0000-0001-9363-6451","observed_orcids":["https://orcid.org/0000-0001-9363-6451"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David G. Harrison","raw_affiliation_strings":["Division of Cardiology, Department of Medicine, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Department of Medicine, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322","institution_ids":["https://openalex.org/I150468666"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5030390724"],"corresponding_institution_ids":["https://openalex.org/I150468666"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":6.1455,"has_fulltext":true,"cited_by_count":92,"citation_normalized_percentile":{"value":0.97495627,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"39","issue":"2","first_page":"268","last_page":"276"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endothelial-nitric-oxide-synthase","display_name":"endothelial nitric oxide synthase","score":0.996999979019165},{"id":"https://openalex.org/keywords/oxidized-ldl","display_name":"oxidized LDL","score":0.8889999985694885},{"id":"https://openalex.org/keywords/hypercholesterolemia","display_name":"hypercholesterolemia","score":0.9660000205039978},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.6349999904632568},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.7839999794960022},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.8629999756813049},{"id":"https://openalex.org/keywords/post-transcriptional-regulation","display_name":"post-transcriptional regulation","score":0.9279999732971191},{"id":"https://openalex.org/keywords/mrna-stability","display_name":"mRNA stability","score":0.878000020980835},{"id":"https://openalex.org/keywords/lysophosphatidylcholine","display_name":"lysophosphatidylcholine","score":0.9070000052452087},{"id":"https://openalex.org/keywords/oxidative-damage","display_name":"oxidative damage","score":0.5860000252723694},{"id":"https://openalex.org/keywords/endothelium-dependent-relaxation","display_name":"endothelium-dependent relaxation","score":0.6349999904632568}],"concepts":[{"id":"https://openalex.org/C2778326061","wikidata":"https://www.wikidata.org/wiki/Q1761022","display_name":"Enos","level":4,"score":0.9788755178451538},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.5952575206756592},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.5254582166671753},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.4825815260410309},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.47108566761016846},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4621816873550415},{"id":"https://openalex.org/C2908688039","wikidata":"https://www.wikidata.org/wiki/Q408853","display_name":"Nitric Oxide Synthase Type III","level":5,"score":0.4374561905860901},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4187507629394531},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4183427393436432},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4114346206188202},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3894381523132324},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.38005000352859497},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13059043884277344}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004355","descriptor_name":"Drug Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008041","descriptor_name":"Linoleic Acids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008041","descriptor_name":"Linoleic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008054","descriptor_name":"Lipid Peroxides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015971","descriptor_name":"Gene Expression Regulation, Enzymologic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/s0022-2275(20)33888-8","doi":"https://doi.org/10.1016/s0022-2275(20)33888-8","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0022-2275(20)33888-8","pdf_url":"http://www.jlr.org/article/S0022227520338888/pdf","source":{"id":"https://openalex.org/S11400418","display_name":"Journal of Lipid Research","issn_l":"0022-2275","issn":["0022-2275","1539-7262"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lipid Research","raw_type":"journal-article"},{"id":"pmid:9507987","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9507987","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of lipid research","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:743baa1bef7c4f45add855ef5436b357","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/743baa1bef7c4f45add855ef5436b357","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Lipid Research, Vol 39, Iss 2, Pp 268-276 (1998)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/s0022-2275(20)33888-8","doi":"https://doi.org/10.1016/s0022-2275(20)33888-8","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0022-2275(20)33888-8","pdf_url":"http://www.jlr.org/article/S0022227520338888/pdf","source":{"id":"https://openalex.org/S11400418","display_name":"Journal of Lipid Research","issn_l":"0022-2275","issn":["0022-2275","1539-7262"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lipid Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G252741084","display_name":null,"funder_award_id":"HL 39000 6","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5181204812","display_name":"INITIATING EVENTS IN VASCULAR LESION FORMATION","funder_award_id":"P01HL048667","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2182235855.pdf","grobid_xml":"https://content.openalex.org/works/W2182235855.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W16458099","https://openalex.org/W119779276","https://openalex.org/W290636344","https://openalex.org/W1483473649","https://openalex.org/W1530430636","https://openalex.org/W1548697318","https://openalex.org/W1857052429","https://openalex.org/W1964469583","https://openalex.org/W1967230525","https://openalex.org/W1978099891","https://openalex.org/W1983273892","https://openalex.org/W1986745677","https://openalex.org/W2000048889","https://openalex.org/W2000700725","https://openalex.org/W2002018178","https://openalex.org/W2004046639","https://openalex.org/W2024187381","https://openalex.org/W2038522823","https://openalex.org/W2042277367","https://openalex.org/W2043677838","https://openalex.org/W2048505284","https://openalex.org/W2049267063","https://openalex.org/W2050825707","https://openalex.org/W2051048068","https://openalex.org/W2055855948","https://openalex.org/W2057232608","https://openalex.org/W2064330801","https://openalex.org/W2082092019","https://openalex.org/W2091732701","https://openalex.org/W2128539657","https://openalex.org/W2131993725","https://openalex.org/W2134785329","https://openalex.org/W2134812217","https://openalex.org/W2135633069","https://openalex.org/W2145570729","https://openalex.org/W2155921604","https://openalex.org/W2163275136","https://openalex.org/W2167120310","https://openalex.org/W2183454150","https://openalex.org/W2189280733","https://openalex.org/W2615351713","https://openalex.org/W2748101318","https://openalex.org/W6737859797"],"related_works":["https://openalex.org/W2051048068","https://openalex.org/W2885873470","https://openalex.org/W2156030365","https://openalex.org/W2090535996","https://openalex.org/W2347675874","https://openalex.org/W2135837520","https://openalex.org/W2060434705","https://openalex.org/W2358730263","https://openalex.org/W7096593858","https://openalex.org/W2096363956"],"abstract_inverted_index":{"Hypercholesterolemia":[0],"is":[1,15,70,216],"associated":[2],"with":[3,110,144],"impairments":[4],"in":[5,17,97,116,147,242],"endothelium-dependent":[6],"vascular":[7],"relaxations.":[8],"Paradoxically,":[9],"endothelial":[10,39,100,108,228],"production":[11],"of":[12,20,55,67,77,82,90,95,107,170,172,196,213,240,245],"nitrogen":[13],"oxides":[14],"increased":[16,134,156,200],"early":[18,243],"stages":[19,244],"hypercholesterolemia.":[21,246],"Prior":[22],"work":[23],"has":[24,32,46],"shown":[25],"that":[26,130,167,193,227],"oxidized":[27,56,68,75],"low":[28],"density":[29],"lipoprotein":[30],"(LDL)":[31],"both":[33,219],"stimulatory":[34],"and":[35,45,140,160,221],"inhibitory":[36],"effects":[37],"on":[38,48,92],"nitric":[40],"oxide":[41],"synthase":[42],"expression":[43,94,215,239],"(eNOS)":[44],"focused":[47],"lysophosphatidyl":[49],"choline":[50],"(LPC)":[51],"as":[52,120],"a":[53,113],"component":[54,66],"LDL":[57,69],"which":[58],"may":[59,230],"modulate":[60],"this":[61,83],"effect.":[62],"Another":[63],"biologically":[64],"active":[65],"13-hydroperoxyoctadecadienoic":[71],"acid":[72],"(13-HPODE),":[73],"an":[74],"form":[76],"linoleic":[78],"acid.":[79],"The":[80,125],"purpose":[81],"study":[84],"was":[85,175,199],"to":[86,185,204,232],"determine":[87],"the":[88,93,145,168,194],"effect":[89],"HPODE":[91,111,131,153,181,208],"eNOS":[96,117,135,148,157,173,197,214,241],"bovine":[98],"aortic":[99],"cells":[101,109,229],"(BAECs).":[102],"Twenty":[103],"four":[104],"hour":[105],"treatment":[106,132,154,182],"caused":[112],"dose-dependent":[114],"increase":[115,146],"mRNA":[118,136,149,198],"levels":[119,137],"assessed":[121],"by":[122,207,218,237],"Northern":[123],"analysis.":[124],"time":[126],"response":[127],"studies":[128,165,191],"show":[129],"significantly":[133,155,176],"at":[138],"12":[139,205],"24":[141],"h.":[142],"Concomitant":[143],"levels,":[150],"20":[151],"microM":[152],"protein":[158],"content":[159],"enzyme":[161],"activity.":[162],"Nuclear":[163],"run-on":[164],"indicated":[166],"rate":[169],"transcription":[171],"gene":[174],"elevated":[177],"4":[178],"h":[179,203,206],"after":[180],"when":[183],"compared":[184],"control":[186],"cultures.":[187],"Also,":[188],"actinomycin":[189],"D":[190],"demonstrated":[192],"half-life":[195],"from":[201],"6":[202],"treatment.":[209],"Thus,":[210],"HPODE-induced":[211],"up-regulation":[212],"mediated":[217],"transcriptional":[220],"posttranscriptional":[222],"mechanisms.":[223],"These":[224],"observations":[225],"suggest":[226],"attempt":[231],"compensate":[233],"for":[234],"oxidative":[235],"injury":[236],"increasing":[238]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}