{"id":"https://openalex.org/W2182232282","doi":"https://doi.org/10.1152/ajpheart.1998.275.1.h23","title":"Cellular mechanisms of heparinase III protection in rat traumatic shock","display_name":"Cellular mechanisms of heparinase III protection in rat traumatic shock","publication_year":1998,"publication_date":"1998-07-01","ids":{"openalex":"https://openalex.org/W2182232282","doi":"https://doi.org/10.1152/ajpheart.1998.275.1.h23","mag":"2182232282","pmid":"https://pubmed.ncbi.nlm.nih.gov/9688892"},"language":"en","primary_location":{"id":"doi:10.1152/ajpheart.1998.275.1.h23","doi":"https://doi.org/10.1152/ajpheart.1998.275.1.h23","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpheart.1998.275.1.h23","pdf_url":null,"source":{"id":"https://openalex.org/S87338489","display_name":"American Journal of Physiology-Heart and Circulatory Physiology","issn_l":"0363-6135","issn":["0363-6135","1522-1539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Heart and Circulatory Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025746476","display_name":"Reid Hayward","orcid":"https://orcid.org/0000-0002-6324-5190","observed_orcids":["https://orcid.org/0000-0002-6324-5190"]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Reid Hayward","raw_affiliation_strings":["Department of Physiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089912252","display_name":"Rosario G. Scalia","orcid":"https://orcid.org/0000-0002-1829-943X","observed_orcids":["https://orcid.org/0000-0002-1829-943X"]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rosario Scalia","raw_affiliation_strings":["Department of Physiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Bruce Hopper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bruce Hopper","raw_affiliation_strings":["Department of Physiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111799375","display_name":"James Z. Appel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Z. Appel","raw_affiliation_strings":["Department of Physiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110287816","display_name":"Allan M. Lefer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allan M. Lefer","raw_affiliation_strings":["Department of Physiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107","institution_ids":["https://openalex.org/I149251103"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I149251103"],"apc_list":null,"apc_paid":null,"fwci":0.295,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.62543601,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"275","issue":"1","first_page":"H23","last_page":"H30"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11116","display_name":"Trauma, Hemostasis, Coagulopathy, Resuscitation","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11116","display_name":"Trauma, Hemostasis, Coagulopathy, Resuscitation","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heparinase-iii","display_name":"heparinase III","score":0.9829999804496765},{"id":"https://openalex.org/keywords/traumatic-shock","display_name":"traumatic shock","score":0.9909999966621399},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.7289999723434448},{"id":"https://openalex.org/keywords/leukocyte-endothelial-interaction","display_name":"leukocyte-endothelium interaction","score":0.7979999780654907},{"id":"https://openalex.org/keywords/p-selectin","display_name":"P-selectin","score":0.9929999709129333},{"id":"https://openalex.org/keywords/myeloperoxidase","display_name":"myeloperoxidase","score":0.8769999742507935},{"id":"https://openalex.org/keywords/leukocyte-rolling-and-adhesion","display_name":"leukocyte rolling and adhesion","score":0.8130000233650208},{"id":"https://openalex.org/keywords/mesenteric-microvasculature","display_name":"mesenteric microvasculature","score":0.8809999823570251},{"id":"https://openalex.org/keywords/vasorelaxation","display_name":"vasorelaxation","score":0.8679999709129333},{"id":"https://openalex.org/keywords/hypotension","display_name":"hypotension","score":0.8100000023841858},{"id":"https://openalex.org/keywords/survival-time","display_name":"survival time","score":0.35600000619888306}],"concepts":[{"id":"https://openalex.org/C2859252","wikidata":"https://www.wikidata.org/wiki/Q1543928","display_name":"Intravital microscopy","level":3,"score":0.6688361167907715},{"id":"https://openalex.org/C203565725","wikidata":"https://www.wikidata.org/wiki/Q420012","display_name":"Myeloperoxidase","level":3,"score":0.6466469764709473},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.551510751247406},{"id":"https://openalex.org/C2781300812","wikidata":"https://www.wikidata.org/wiki/Q178061","display_name":"Shock (circulatory)","level":2,"score":0.5055065155029297},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48395565152168274},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.4805793762207031},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.47634008526802063},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.4650854468345642},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43935877084732056},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4317903220653534},{"id":"https://openalex.org/C12722491","wikidata":"https://www.wikidata.org/wiki/Q1632335","display_name":"Microcirculation","level":2,"score":0.38159510493278503},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.34658709168434143},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.2709198594093323},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.12445291876792908},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11218234896659851}],"mesh":[{"descriptor_ui":"D000768","descriptor_name":"Anesthesia, General","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007022","descriptor_name":"Hypotension","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007022","descriptor_name":"Hypotension","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D007022","descriptor_name":"Hypotension","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D007082","descriptor_name":"Ileum","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008833","descriptor_name":"Microcirculation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008833","descriptor_name":"Microcirculation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009195","descriptor_name":"Peroxidase","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D010424","descriptor_name":"Pentobarbital","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011133","descriptor_name":"Polysaccharide-Lyases","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011133","descriptor_name":"Polysaccharide-Lyases","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D012774","descriptor_name":"Shock, Traumatic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D012774","descriptor_name":"Shock, Traumatic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012774","descriptor_name":"Shock, Traumatic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D013152","descriptor_name":"Splanchnic Circulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014699","descriptor_name":"Venules","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014699","descriptor_name":"Venules","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014699","descriptor_name":"Venules","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019007","descriptor_name":"P-Selectin","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D019331","descriptor_name":"NG-Nitroarginine Methyl Ester","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpheart.1998.275.1.h23","doi":"https://doi.org/10.1152/ajpheart.1998.275.1.h23","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpheart.1998.275.1.h23","pdf_url":null,"source":{"id":"https://openalex.org/S87338489","display_name":"American Journal of Physiology-Heart and Circulatory Physiology","issn_l":"0363-6135","issn":["0363-6135","1522-1539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Heart and Circulatory Physiology","raw_type":"journal-article"},{"id":"pmid:9688892","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9688892","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7147433128","display_name":"ENDOTHELIAL INJURY IN TRAUMA AND ISCHEMIA--REPERFUSION","funder_award_id":"R01GM045434","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W41311728","https://openalex.org/W1480533478","https://openalex.org/W1502480849","https://openalex.org/W1507242932","https://openalex.org/W1511533680","https://openalex.org/W1528569576","https://openalex.org/W1536042050","https://openalex.org/W1544915536","https://openalex.org/W1558391881","https://openalex.org/W1574987094","https://openalex.org/W1965754431","https://openalex.org/W1972730346","https://openalex.org/W1977869187","https://openalex.org/W1980842222","https://openalex.org/W1988456139","https://openalex.org/W2015314915","https://openalex.org/W2015781874","https://openalex.org/W2020358486","https://openalex.org/W2032494769","https://openalex.org/W2037332138","https://openalex.org/W2050922265","https://openalex.org/W2059829735","https://openalex.org/W2062887651","https://openalex.org/W2067488129","https://openalex.org/W2075260321","https://openalex.org/W2103013259","https://openalex.org/W2108550131","https://openalex.org/W2110402304","https://openalex.org/W2116638383","https://openalex.org/W2135402792","https://openalex.org/W2282081083","https://openalex.org/W2417991481","https://openalex.org/W4246991801"],"related_works":["https://openalex.org/W2069484435","https://openalex.org/W7058301816","https://openalex.org/W2032990578","https://openalex.org/W2056442237","https://openalex.org/W2783628421","https://openalex.org/W2370778514","https://openalex.org/W2133699464","https://openalex.org/W1475445580","https://openalex.org/W2049515886","https://openalex.org/W2404912641"],"abstract_inverted_index":{"Pentobarbital-anesthetized":[0],"rats":[1],"subjected":[2],"to":[3,14,49,68,127],"traumatic":[4],"shock":[5,8],"developed":[6],"a":[7,17,41,181],"state":[9],"characterized":[10],"by":[11,40,175],"marked":[12],"hypotension":[13],"65-70":[15],"mmHg,":[16],"survival":[18,66],"time":[19,67],"of":[20,94,101,134,166],"88":[21],"+/-":[22,70],"13":[23],"min,":[24],"significant":[25,42],"increases":[26],"in":[27,47,120,125,159,173],"ileal":[28,78],"myeloperoxidase":[29,79],"activity":[30,80],"(P":[31,43,73,81,89,111,153],"<":[32,44,74,82,90,112,154],"0.01),":[33,83],"and":[34,84,118],"severe":[35],"endothelial":[36,87],"dysfunction":[37],"as":[38],"evidenced":[39],"0.01)":[45,113],"decrease":[46],"vasorelaxation":[48],"endothelium-dependent":[50],"dilators.":[51],"Treatment":[52],"with":[53],"heparinase":[54,102,142,167],"III":[55,103,143,168],"(45":[56],"microg":[57,105,147],".":[58,60,106,108,148,150],"kg-1":[59,107,149],"min-1)":[61,109],"10":[62],"min":[63,72],"posttrauma":[64],"prolonged":[65],"223":[69],"19":[71],"0.001),":[75],"significantly":[76,85,110,152],"attenuated":[77,114,156],"preserved":[86],"function":[88],"0.05).":[91],"Intravital":[92],"microscopy":[93],"the":[95,121,157],"rat":[96,122],"mesentery":[97],"showed":[98,140],"that":[99,141],"infusion":[100,144],"(45-67":[104],"both":[115],"leukocyte":[116],"rolling":[117],"adherence":[119],"mesenteric":[123,138],"microvasculature":[124],"response":[126],"NG-nitro-L-arginine":[128],"methyl":[129],"ester":[130],"stimulation.":[131],"Immunohistochemical":[132],"localization":[133],"surface-expressed":[135],"P-selectin":[136,161],"on":[137],"venules":[139],"at":[145,171],"45-67":[146],"min-1":[151],"0.05)":[155],"increase":[158],"surface":[160],"expression.":[162],"The":[163],"beneficial":[164],"effects":[165],"are":[169],"mediated":[170],"least":[172],"part":[174],"attenuating":[176],"leukocyte-endothelial":[177],"cell":[178],"interactions":[179],"via":[180],"P-selectin-dependent":[182],"mechanism.":[183]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}