{"id":"https://openalex.org/W2182201616","doi":"https://doi.org/10.1038/bjc.2015.407","title":"Increased sensitivity to platinum drugs of cancer cells with acquired resistance to trabectedin","display_name":"Increased sensitivity to platinum drugs of cancer cells with acquired resistance to trabectedin","publication_year":2015,"publication_date":"2015-12-01","ids":{"openalex":"https://openalex.org/W2182201616","doi":"https://doi.org/10.1038/bjc.2015.407","mag":"2182201616","pmid":"https://pubmed.ncbi.nlm.nih.gov/26633559","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4701998"},"language":"en","primary_location":{"id":"doi:10.1038/bjc.2015.407","doi":"https://doi.org/10.1038/bjc.2015.407","is_oa":true,"landing_page_url":"https://doi.org/10.1038/bjc.2015.407","pdf_url":"https://www.nature.com/articles/bjc2015407.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.nature.com/articles/bjc2015407.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004629379","display_name":"Benedetta Colmegna","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19630809","display_name":"Mario Negri Institute for Pharmacological Research","ror":"https://ror.org/05aspc753","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I19630809","https://openalex.org/I4210110338","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"B Colmegna","raw_affiliation_strings":["Department of Oncology, IRCCS - Istituto di Ricerche Farmacologiche Mario Negri, via La Masa 19, Milan 20156, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, IRCCS - Istituto di Ricerche Farmacologiche Mario Negri, via La Masa 19, Milan 20156, Italy","institution_ids":["https://openalex.org/I19630809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067193071","display_name":"Sarah Uboldi","orcid":"https://orcid.org/0000-0002-6430-0323","observed_orcids":["https://orcid.org/0000-0002-6430-0323"]},"institutions":[{"id":"https://openalex.org/I19630809","display_name":"Mario Negri Institute for Pharmacological Research","ror":"https://ror.org/05aspc753","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I19630809","https://openalex.org/I4210110338","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"S Uboldi","raw_affiliation_strings":["Department of Oncology, IRCCS - Istituto di Ricerche Farmacologiche Mario Negri, via La Masa 19, Milan 20156, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, IRCCS - Istituto di Ricerche Farmacologiche Mario Negri, via La Masa 19, Milan 20156, Italy","institution_ids":["https://openalex.org/I19630809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079394240","display_name":"Roberta Frapolli","orcid":"https://orcid.org/0000-0003-2907-273X","observed_orcids":["https://orcid.org/0000-0003-2907-273X"]},"institutions":[{"id":"https://openalex.org/I19630809","display_name":"Mario Negri Institute for Pharmacological Research","ror":"https://ror.org/05aspc753","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I19630809","https://openalex.org/I4210110338","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"R Frapolli","raw_affiliation_strings":["Department of Oncology, IRCCS - Istituto di Ricerche Farmacologiche Mario Negri, via La Masa 19, Milan 20156, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, IRCCS - Istituto di Ricerche Farmacologiche Mario Negri, via La Masa 19, Milan 20156, Italy","institution_ids":["https://openalex.org/I19630809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025764276","display_name":"Simonetta Andrea Licandro","orcid":"https://orcid.org/0000-0001-7597-7084","observed_orcids":["https://orcid.org/0000-0001-7597-7084"]},"institutions":[{"id":"https://openalex.org/I19630809","display_name":"Mario Negri Institute for Pharmacological Research","ror":"https://ror.org/05aspc753","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I19630809","https://openalex.org/I4210110338","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"S A Licandro","raw_affiliation_strings":["Department of Oncology, IRCCS - Istituto di Ricerche Farmacologiche Mario Negri, via La Masa 19, Milan 20156, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, IRCCS - Istituto di Ricerche Farmacologiche Mario Negri, via La Masa 19, Milan 20156, Italy","institution_ids":["https://openalex.org/I19630809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073594327","display_name":"Nicol\u00f2 Panini","orcid":"https://orcid.org/0000-0002-8121-1197","observed_orcids":["https://orcid.org/0000-0002-8121-1197"]},"institutions":[{"id":"https://openalex.org/I19630809","display_name":"Mario Negri Institute for Pharmacological Research","ror":"https://ror.org/05aspc753","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I19630809","https://openalex.org/I4210110338","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"N Panini","raw_affiliation_strings":["Department of Oncology, IRCCS - Istituto di Ricerche Farmacologiche Mario Negri, via La Masa 19, Milan 20156, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, IRCCS - Istituto di Ricerche Farmacologiche Mario Negri, via La Masa 19, Milan 20156, Italy","institution_ids":["https://openalex.org/I19630809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067025614","display_name":"Carlos Mar\u00eda Galmarini","orcid":"https://orcid.org/0000-0001-5494-6617","observed_orcids":["https://orcid.org/0000-0001-5494-6617","https://orcid.org/0000-0003-3361-217X"]},"institutions":[{"id":"https://openalex.org/I4210116403","display_name":"PharmaMar (Spain)","ror":"https://ror.org/02h694m69","country_code":"ES","type":"company","lineage":["https://openalex.org/I4210116403"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"C M Galmarini","raw_affiliation_strings":["Department of Research and Development (R&D), PharmaMar S.A., Colmenar Viejo, Madrid 28770, Spain","Department of Research and Development (R&D), PharmaMar S.A., Colmenar Viejo, 28770, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Research and Development (R&D), PharmaMar S.A., Colmenar Viejo, Madrid 28770, Spain","institution_ids":["https://openalex.org/I4210116403"]},{"raw_affiliation_string":"Department of Research and Development (R&D), PharmaMar S.A., Colmenar Viejo, 28770, Madrid, Spain","institution_ids":["https://openalex.org/I4210116403"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111626795","display_name":"Nadia Badri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116403","display_name":"PharmaMar (Spain)","ror":"https://ror.org/02h694m69","country_code":"ES","type":"company","lineage":["https://openalex.org/I4210116403"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Nadia Badri","raw_affiliation_strings":["Department of Research and Development (R&D), PharmaMar S.A., Colmenar Viejo, Madrid 28770, Spain","Department of Research and Development (R&D), PharmaMar S.A., Colmenar Viejo, 28770, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Research and Development (R&D), PharmaMar S.A., Colmenar Viejo, Madrid 28770, Spain","institution_ids":["https://openalex.org/I4210116403"]},{"raw_affiliation_string":"Department of Research and Development (R&D), PharmaMar S.A., Colmenar Viejo, 28770, Madrid, Spain","institution_ids":["https://openalex.org/I4210116403"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040495838","display_name":"Victoria J. Spanswick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"V J Spanswick","raw_affiliation_strings":["Cancer Research UK Drug-DNA Interactions Research Group, UCL Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6BT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research UK Drug-DNA Interactions Research Group, UCL Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6BT, UK","institution_ids":["https://openalex.org/I2801316944","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070047090","display_name":"John P. Bingham","orcid":"https://orcid.org/0000-0002-2442-5076","observed_orcids":["https://orcid.org/0000-0002-2442-5076"]},"institutions":[{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J P Bingham","raw_affiliation_strings":["Cancer Research UK Drug-DNA Interactions Research Group, UCL Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6BT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research UK Drug-DNA Interactions Research Group, UCL Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6BT, UK","institution_ids":["https://openalex.org/I2801316944","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021172317","display_name":"Konstantinos Kiakos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Konstantinos Kiakos","raw_affiliation_strings":["Cancer Research UK Drug-DNA Interactions Research Group, UCL Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6BT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research UK Drug-DNA Interactions Research Group, UCL Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6BT, UK","institution_ids":["https://openalex.org/I2801316944","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009671002","display_name":"Eugenio Erba","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19630809","display_name":"Mario Negri Institute for Pharmacological Research","ror":"https://ror.org/05aspc753","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I19630809","https://openalex.org/I4210110338","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"E Erba","raw_affiliation_strings":["Department of Oncology, IRCCS - Istituto di Ricerche Farmacologiche Mario Negri, via La Masa 19, Milan 20156, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, IRCCS - Istituto di Ricerche Farmacologiche Mario Negri, via La Masa 19, Milan 20156, Italy","institution_ids":["https://openalex.org/I19630809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055669649","display_name":"John Anthony Hartley","orcid":"https://orcid.org/0000-0003-3737-9897","observed_orcids":["https://orcid.org/0000-0003-3737-9897"]},"institutions":[{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J A Hartley","raw_affiliation_strings":["Cancer Research UK Drug-DNA Interactions Research Group, UCL Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6BT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research UK Drug-DNA Interactions Research Group, UCL Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6BT, UK","institution_ids":["https://openalex.org/I2801316944","https://openalex.org/I45129253"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055703421","display_name":"Maurizio D\u2019Incalci","orcid":"https://orcid.org/0000-0001-8784-1360","observed_orcids":["https://orcid.org/0000-0001-8784-1360"]},"institutions":[{"id":"https://openalex.org/I19630809","display_name":"Mario Negri Institute for Pharmacological Research","ror":"https://ror.org/05aspc753","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I19630809","https://openalex.org/I4210110338","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"M D'Incalci","raw_affiliation_strings":["Department of Oncology, IRCCS - Istituto di Ricerche Farmacologiche Mario Negri, via La Masa 19, Milan 20156, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, IRCCS - Istituto di Ricerche Farmacologiche Mario Negri, via La Masa 19, Milan 20156, Italy","institution_ids":["https://openalex.org/I19630809"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5055703421"],"corresponding_institution_ids":["https://openalex.org/I19630809"],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":{"value":5190,"currency":"USD","value_usd":5190},"fwci":2.8819,"has_fulltext":true,"cited_by_count":46,"citation_normalized_percentile":{"value":0.92878602,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":99},"biblio":{"volume":"113","issue":"12","first_page":"1687","last_page":"1693"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.5356000065803528,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.5356000065803528,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.3515999913215637,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.009999999776482582,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trabectedin","display_name":"trabectedin","score":0.9319999814033508},{"id":"https://openalex.org/keywords/acquired-drug-resistance","display_name":"acquired drug resistance","score":0.9829999804496765},{"id":"https://openalex.org/keywords/platinum-based-drugs","display_name":"platinum drugs","score":0.6949999928474426},{"id":"https://openalex.org/keywords/collateral-sensitivity","display_name":"collateral sensitivity","score":0.8650000095367432},{"id":"https://openalex.org/keywords/nucleotide-excision-repair","display_name":"nucleotide excision repair","score":0.9829999804496765},{"id":"https://openalex.org/keywords/xpg","display_name":"XPG","score":0.6759999990463257},{"id":"https://openalex.org/keywords/xpc","display_name":"XPC","score":0.5799999833106995},{"id":"https://openalex.org/keywords/ercc2","display_name":"XPD","score":0.6549999713897705},{"id":"https://openalex.org/keywords/myxoid-liposarcoma","display_name":"myxoid liposarcoma","score":0.8899999856948853},{"id":"https://openalex.org/keywords/ovarian-carcinoma","display_name":"ovarian carcinoma","score":0.9850000143051147},{"id":"https://openalex.org/keywords/interstrand-crosslinks","display_name":"interstrand cross-links","score":0.8519999980926514},{"id":"https://openalex.org/keywords/g2-m-cell-cycle-arrest","display_name":"G2/M cell cycle arrest","score":0.9089999794960022},{"id":"https://openalex.org/keywords/uv-hypersensitivity","display_name":"UV hypersensitivity","score":0.6930000185966492},{"id":"https://openalex.org/keywords/xenografts","display_name":"xenografts","score":0.8069999814033508}],"concepts":[{"id":"https://openalex.org/C2780752271","wikidata":"https://www.wikidata.org/wiki/Q2637746","display_name":"Trabectedin","level":4,"score":0.9848875999450684},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6372232437133789},{"id":"https://openalex.org/C2779309665","wikidata":"https://www.wikidata.org/wiki/Q17917256","display_name":"ERCC1","level":5,"score":0.6103824973106384},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5945115089416504},{"id":"https://openalex.org/C104451858","wikidata":"https://www.wikidata.org/wiki/Q2714458","display_name":"Nucleotide excision repair","level":4,"score":0.5659875869750977},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4697941541671753},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43376150727272034},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.3763379454612732},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35450881719589233},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.15285953879356384},{"id":"https://openalex.org/C2778256501","wikidata":"https://www.wikidata.org/wiki/Q223911","display_name":"Sarcoma","level":2,"score":0.1397671103477478},{"id":"https://openalex.org/C2778629024","wikidata":"https://www.wikidata.org/wiki/Q720020","display_name":"Soft tissue sarcoma","level":3,"score":0.1342090666294098},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12082192301750183},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1106908917427063},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09831038117408752}],"mesh":[{"descriptor_ui":"D000077606","descriptor_name":"Trabectedin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004149","descriptor_name":"Dioxoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009944","descriptor_name":"Organoplatinum Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044005","descriptor_name":"Tetrahydroisoquinolines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1038/bjc.2015.407","doi":"https://doi.org/10.1038/bjc.2015.407","is_oa":true,"landing_page_url":"https://doi.org/10.1038/bjc.2015.407","pdf_url":"https://www.nature.com/articles/bjc2015407.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4098096","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4701998","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:26633559","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26633559","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of cancer","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4701998","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4701998/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Cancer","raw_type":"Text"},{"id":"pmh:oai:boa.unimib.it:10281/280742","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10281/280742","pdf_url":null,"source":{"id":"https://openalex.org/S4306401259","display_name":"BOA (University of Milano-Bicocca)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I66752286","host_organization_name":"University of Milano-Bicocca","host_organization_lineage":["https://openalex.org/I66752286"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1483622","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1483622/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BRITISH JOURNAL OF CANCER , 113 (12) pp. 1687-1693. (2015)","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1038/bjc.2015.407","doi":"https://doi.org/10.1038/bjc.2015.407","is_oa":true,"landing_page_url":"https://doi.org/10.1038/bjc.2015.407","pdf_url":"https://www.nature.com/articles/bjc2015407.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2180761677","display_name":null,"funder_award_id":"A16569","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G6573473627","display_name":null,"funder_award_id":"C2259","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G6860612535","display_name":null,"funder_award_id":"C2259/A16569","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G7215985847","display_name":null,"funder_award_id":"16569","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"}],"funders":[{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320323054","display_name":"Associazione Italiana per la Ricerca sul Cancro","ror":"https://ror.org/02g2x7380"},{"id":"https://openalex.org/F4320324143","display_name":"Fondazione Italiana per la Ricerca sul Cancro","ror":"https://ror.org/02g2x7380"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2182201616.pdf","grobid_xml":"https://content.openalex.org/works/W2182201616.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1494474122","https://openalex.org/W1513901790","https://openalex.org/W1577378579","https://openalex.org/W1987646951","https://openalex.org/W2006470256","https://openalex.org/W2011411415","https://openalex.org/W2018169190","https://openalex.org/W2025615771","https://openalex.org/W2039214489","https://openalex.org/W2054558227","https://openalex.org/W2058578736","https://openalex.org/W2061795391","https://openalex.org/W2065600610","https://openalex.org/W2068942574","https://openalex.org/W2069168033","https://openalex.org/W2071664483","https://openalex.org/W2099134833","https://openalex.org/W2103455702","https://openalex.org/W2106503128","https://openalex.org/W2107277218","https://openalex.org/W2108403591","https://openalex.org/W2110891275","https://openalex.org/W2114360920","https://openalex.org/W2115785123","https://openalex.org/W2124227044","https://openalex.org/W2138266786","https://openalex.org/W2139210450","https://openalex.org/W2146054274","https://openalex.org/W2148085582","https://openalex.org/W2153737617","https://openalex.org/W2159212221","https://openalex.org/W2165293053","https://openalex.org/W2166027044","https://openalex.org/W2169704652","https://openalex.org/W2171302499","https://openalex.org/W2339300075","https://openalex.org/W2403530027","https://openalex.org/W4243574300"],"related_works":["https://openalex.org/W2003907468","https://openalex.org/W2022959188","https://openalex.org/W2118303160","https://openalex.org/W2577622689","https://openalex.org/W2065545570","https://openalex.org/W2734601486","https://openalex.org/W7095607376","https://openalex.org/W2763975305","https://openalex.org/W2025615771","https://openalex.org/W2971801617"],"abstract_inverted_index":{"BACKGROUND:":[0],"In":[1,60,142],"order":[2],"to":[3,10,41,78,88,91,139,165,180,198],"investigate":[4],"the":[5,102,125,170,184],"mechanisms":[6],"of":[7,127,156,172,189],"acquired":[8,196],"resistance":[9,164,197],"trabectedin,":[11],"trabectedin-resistant":[12,120],"human":[13],"myxoid":[14],"liposarcoma":[15],"(402-91/T)":[16],"and":[17,25,29,55,67,72,94,109,113,134],"ovarian":[18],"carcinoma":[19],"(A2780/T)":[20],"cell":[21,34,50],"lines":[22,35],"were":[23,36,63,75,86],"derived":[24],"characterised":[26],"in":[27,30,101,111,115,119,148,192],"vitro":[28],"vivo.":[31],"METHODS:":[32],"Resistant":[33,84],"obtained":[37],"by":[38,46,132],"repeated":[39],"exposures":[40],"trabectedin.":[42,199],"Characterisation":[43],"was":[44,122,150],"performed":[45,64],"evaluating":[47],"drug":[48],"sensitivity,":[49,146],"cycle":[51],"perturbations,":[52],"DNA":[53,56,157],"damage":[54],"repair":[57,105],"protein":[58],"expression.":[59],"vivo":[61],"experiments":[62],"on":[65],"A2780":[66],"A2780/T":[68,73],"xenografts.":[69],"RESULTS:":[70],"402-91/T":[71,112],"cells":[74,85,121],"six-fold":[76],"resistant":[77],"trabectedin":[79,133,166],"compared":[80],"with":[81,124,135,152,169,175],"parental":[82],"cells.":[83],"found":[87],"be":[89],"hypersensitive":[90],"UV":[92],"light":[93],"did":[95],"not":[96],"express":[97],"specific":[98],"proteins":[99],"involved":[100],"nucleotide":[103],"excision":[104],"(NER)":[106],"pathway:":[107],"XPF":[108],"ERCC1":[110],"XPG":[114],"A2780/T.":[116],"NER":[117,173],"deficiency":[118],"associated":[123,151,168],"absence":[126],"a":[128,176],"G2/M":[129],"arrest":[130],"induced":[131],"enhanced":[136],"sensitivity":[137,179],"(two-fold)":[138],"platinum":[140,181],"drugs.":[141],"A2780/T,":[143],"this":[144],"collateral":[145],"confirmed":[147],"vivo,":[149],"an":[153],"increased":[154,178],"formation":[155],"interstrand":[158],"crosslinks.":[159],"CONCLUSIONS:":[160],"Our":[161],"finding":[162],"that":[163],"is":[167],"loss":[171],"function,":[174],"consequent":[177],"drugs,":[182],"provides":[183],"rational":[185],"for":[186],"sequential":[187],"use":[188],"these":[190],"drugs":[191],"patients":[193],"who":[194],"have":[195]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":5}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}