{"id":"https://openalex.org/W2182195867","doi":null,"title":"In vitro anticancer activity of cyanidin-3-O-beta-glucopyranoside: effects on transformed and non-transformed T lymphocytes.","display_name":"In vitro anticancer activity of cyanidin-3-O-beta-glucopyranoside: effects on transformed and non-transformed T lymphocytes.","publication_year":2005,"publication_date":"2005-07-01","ids":{"openalex":"https://openalex.org/W2182195867","mag":"2182195867","pmid":"https://pubmed.ncbi.nlm.nih.gov/16080535"},"language":"en","primary_location":{"id":"pmid:16080535","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16080535","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074119826","display_name":"Carmela Fimognari","orcid":"https://orcid.org/0000-0002-2461-8214","observed_orcids":["https://orcid.org/0000-0002-2461-8214"]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Carmela Fimognari","raw_affiliation_strings":["Department of Pharmacology, University of Bologna, via Irnerio 48 - 40126 Bologna, Italy. carmela.fimognari@unibo.it","Department of Pharmacology, University of Bologna, via Irnerio 48, 40126 Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Bologna, via Irnerio 48 - 40126 Bologna, Italy. carmela.fimognari@unibo.it","institution_ids":["https://openalex.org/I9360294"]},{"raw_affiliation_string":"Department of Pharmacology, University of Bologna, via Irnerio 48, 40126 Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036394830","display_name":"Fausto Berti","orcid":"https://orcid.org/0000-0002-7684-1792","observed_orcids":["https://orcid.org/0000-0002-7684-1792"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fausto Berti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064484679","display_name":"Michael N\u00fcsse","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael N\u00fcsse","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108586565","display_name":"Giorgio Cantelli\u2010Forti","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Giorgio Cantelli-Fortii","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5010795108","display_name":"Patrizia Hrelia","orcid":"https://orcid.org/0000-0002-8415-3711","observed_orcids":["https://orcid.org/0000-0002-8415-3711"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patrizia Hrelia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3412,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.53956405,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"25","issue":"4","first_page":"2837","last_page":"40"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.8154000043869019,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.8154000043869019,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.03350000083446503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12330","display_name":"Botanical Research and Applications","score":0.025299999862909317,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anthocyanins","display_name":"anthocyanins","score":0.9959999918937683},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.8489999771118164},{"id":"https://openalex.org/keywords/chemoprevention","display_name":"chemoprevention","score":0.8690000176429749},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8659999966621399},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.9860000014305115},{"id":"https://openalex.org/keywords/genotoxicity","display_name":"genotoxicity","score":0.7639999985694885},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9070000052452087},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.949999988079071},{"id":"https://openalex.org/keywords/micronucleus-test","display_name":"micronucleus test","score":0.824999988079071}],"concepts":[{"id":"https://openalex.org/C2778959862","wikidata":"https://www.wikidata.org/wiki/Q1009245","display_name":"Genotoxicity","level":3,"score":0.8615657091140747},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.8443213701248169},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.7138311266899109},{"id":"https://openalex.org/C45080847","wikidata":"https://www.wikidata.org/wiki/Q1658004","display_name":"Micronucleus test","level":3,"score":0.7058806419372559},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5345888137817383},{"id":"https://openalex.org/C2777667348","wikidata":"https://www.wikidata.org/wiki/Q417606","display_name":"Cyanidin","level":3,"score":0.5091390013694763},{"id":"https://openalex.org/C36681516","wikidata":"https://www.wikidata.org/wiki/Q1700733","display_name":"Micronucleus","level":4,"score":0.4813131093978882},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.447353720664978},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4298696517944336},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3993048667907715},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.39452236890792847},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3726639449596405},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.33936458826065063},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3341470956802368},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.13039499521255493},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000872","descriptor_name":"Anthocyanins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002461","descriptor_name":"Cell Line, Transformed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005960","descriptor_name":"Glucosides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010835","descriptor_name":"Phytohemagglutinins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019169","descriptor_name":"Jurkat Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051028","descriptor_name":"bcl-2-Associated X Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmid:16080535","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16080535","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},{"id":"pmh:oai:cris.unibo.it:11585/5619","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11585/5619","pdf_url":null,"source":{"id":"https://openalex.org/S4306402579","display_name":"Archivio istituzionale della ricerca (Alma Mater Studiorum Universit\u00e0 di Bologna)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210117483","host_organization_name":"Istituto di Ematologia di Bologna","host_organization_lineage":["https://openalex.org/I4210117483"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:cris.unibo.it:11585/7031","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11585/7031","pdf_url":null,"source":{"id":"https://openalex.org/S4306402579","display_name":"Archivio istituzionale della ricerca (Alma Mater Studiorum Universit\u00e0 di Bologna)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210117483","host_organization_name":"Istituto di Ematologia di Bologna","host_organization_lineage":["https://openalex.org/I4210117483"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/conferenceObject"},{"id":"mag:2182195867","doi":null,"is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pubmed/16080535","pdf_url":null,"source":{"id":"https://openalex.org/S157347057","display_name":"Anticancer Research","issn_l":"0250-7005","issn":["0250-7005","1791-7530"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4320800545","host_organization_name":"International Institute of Anticancer Research (IIAR) Conferences 1997. Athens, Greece. Abstracts","host_organization_lineage":["https://openalex.org/P4320800545"],"host_organization_lineage_names":["International Institute of Anticancer Research (IIAR) Conferences 1997. Athens, Greece. Abstracts"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Anticancer Research","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1576516151","https://openalex.org/W1975202491","https://openalex.org/W1979737844","https://openalex.org/W1981145469","https://openalex.org/W1983785443","https://openalex.org/W1986527680","https://openalex.org/W1997388033","https://openalex.org/W2056204961","https://openalex.org/W2057427022","https://openalex.org/W2078450742","https://openalex.org/W2096378733","https://openalex.org/W2103870459","https://openalex.org/W2106188989","https://openalex.org/W2126178679","https://openalex.org/W2153473625","https://openalex.org/W2154801407","https://openalex.org/W2481968646"],"related_works":["https://openalex.org/W2079429160","https://openalex.org/W6988043190","https://openalex.org/W2020563548","https://openalex.org/W2164953216","https://openalex.org/W4287833894","https://openalex.org/W2073003808","https://openalex.org/W2067253455","https://openalex.org/W2124810583","https://openalex.org/W7098418193","https://openalex.org/W2349002249"],"abstract_inverted_index":{"BACKGROUND:":[0],"Little":[1],"is":[2],"known":[3,61],"regarding":[4],"the":[5,12,17,51,56,80,88,97,132,145],"potentially":[6],"chemopreventive":[7,133],"activity":[8,139],"of":[9,19,32,58,75,90,99,117,135],"cyanidin-3-O-beta-glucopyranoside":[10],"(Cy-g),":[11],"main":[13],"anthocyanin":[14],"present":[15],"in":[16,65,96,109,140],"juice":[18],"pigmented":[20],"oranges,":[21],"apart":[22],"from":[23],"its":[24,34,138],"antioxidant":[25],"activity.":[26],"After":[27],"excluding":[28],"a":[29],"potential":[30,134],"genotoxicity":[31,76],"Cy-g,":[33],"ability":[35],"to":[36,49,54,62],"induce":[37],"apoptosis":[38,108],"on":[39],"transformed":[40],"and":[41,93,119],"normal":[42,141],"T":[43,142],"cells":[44,92,143],"was":[45,67,77,85,103],"analysed.":[46],"In":[47],"order":[48],"delineate":[50],"events":[52],"leading":[53],"apoptosis,":[55,66],"expression":[57],"different":[59],"proteins,":[60],"be":[63],"involved":[64,95],"also":[68],"measured.":[69],"MATERIALS":[70],"AND":[71],"METHODS:":[72],"The":[73],"evaluation":[74],"performed":[78],"by":[79,114],"micronucleus":[81],"test.":[82],"Flow":[83],"cytometry":[84],"used":[86],"for":[87,147],"analysis":[89],"apoptotic":[91],"proteins":[94],"modulation":[98],"apoptosis.":[100],"RESULTS:":[101],"Cy-g":[102],"nongenotoxic.":[104],"Moreover,":[105],"it":[106],"induced":[107],"both":[110],"cell":[111],"systems,":[112],"modulated":[113],"an":[115],"increase":[116],"p53":[118],"bax":[120],"proteins.":[121],"CONCLUSION:":[122],"These":[123],"interesting":[124],"biological":[125],"properties":[126],"should":[127],"encourage":[128],"further":[129],"studies":[130],"into":[131],"Cy-g.":[136],"Nevertheless,":[137],"underlines":[144],"need":[146],"extensive":[148],"toxicological":[149],"investigation.":[150]},"counts_by_year":[{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}