{"id":"https://openalex.org/W2182187304","doi":null,"title":"Other novel molecular targets in non-small cell lung cancer: It's not all about EGFR","display_name":"Other novel molecular targets in non-small cell lung cancer: It's not all about EGFR","publication_year":2013,"publication_date":"2013-07-01","ids":{"openalex":"https://openalex.org/W2182187304","mag":"2182187304"},"language":"en","primary_location":{"id":"mag:2182187304","doi":null,"is_oa":false,"landing_page_url":"https://cancerforum.org.au/file/2013/july/forum/other_novel_molecular_targets.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306505627","display_name":"Cancer Forum","issn_l":"0311-306X","issn":["0311-306X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Cancer Forum","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020501451","display_name":"Ross P Cruikshank","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ross P Cruikshank","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5051086683","display_name":"Brett G.M. Hughes","orcid":"https://orcid.org/0000-0002-1811-0537","observed_orcids":["https://orcid.org/0000-0002-1811-0537"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brett Hughes","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1811-0537","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"37","issue":"2","first_page":"170","last_page":"174"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":1.0},{"id":"https://openalex.org/keywords/molecular-targets","display_name":"molecular targets","score":0.5889999866485596},{"id":"https://openalex.org/keywords/egfr-tyrosine-kinase-inhibitors","display_name":"EGFR tyrosine kinase inhibitors","score":0.8949999809265137},{"id":"https://openalex.org/keywords/erlotinib","display_name":"erlotinib","score":0.9279999732971191},{"id":"https://openalex.org/keywords/gefitinib","display_name":"gefitinib","score":1.0},{"id":"https://openalex.org/keywords/afatinib","display_name":"afatinib","score":1.0},{"id":"https://openalex.org/keywords/egfr-mutation","display_name":"EGFR mutation","score":0.8550000190734863},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.8230000138282776},{"id":"https://openalex.org/keywords/mutation","display_name":"genetic mutations","score":0.6850000023841858},{"id":"https://openalex.org/keywords/lung-adenocarcinoma","display_name":"lung adenocarcinoma","score":0.9549999833106995},{"id":"https://openalex.org/keywords/lung-squamous-cell-carcinoma","display_name":"lung squamous cell carcinoma","score":0.8870000243186951},{"id":"https://openalex.org/keywords/molecular-pathways","display_name":"molecular pathways","score":0.5879999995231628}],"concepts":[{"id":"https://openalex.org/C2780586478","wikidata":"https://www.wikidata.org/wiki/Q4688818","display_name":"Afatinib","level":5,"score":0.9156399965286255},{"id":"https://openalex.org/C2778087573","wikidata":"https://www.wikidata.org/wiki/Q418369","display_name":"Erlotinib","level":4,"score":0.7843152284622192},{"id":"https://openalex.org/C2780580887","wikidata":"https://www.wikidata.org/wiki/Q417824","display_name":"Gefitinib","level":4,"score":0.7695541381835938},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.7172091603279114},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.6452768445014954},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.637343168258667},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6063438653945923},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5665019750595093},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.5623886585235596},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.49146926403045654},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.48421788215637207},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.44272613525390625},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3291177451610565},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.23587745428085327}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2182187304","doi":null,"is_oa":false,"landing_page_url":"https://cancerforum.org.au/file/2013/july/forum/other_novel_molecular_targets.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306505627","display_name":"Cancer Forum","issn_l":"0311-306X","issn":["0311-306X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Cancer Forum","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1426393029","https://openalex.org/W1751232375","https://openalex.org/W1819148429","https://openalex.org/W1937853139","https://openalex.org/W1970822548","https://openalex.org/W1980497534","https://openalex.org/W1991874467","https://openalex.org/W1994225895","https://openalex.org/W2006771504","https://openalex.org/W2007661090","https://openalex.org/W2015436643","https://openalex.org/W2018178643","https://openalex.org/W2037385288","https://openalex.org/W2055402151","https://openalex.org/W2082095884","https://openalex.org/W2093613683","https://openalex.org/W2096540669","https://openalex.org/W2104830962","https://openalex.org/W2107562400","https://openalex.org/W2111662961","https://openalex.org/W2114784462","https://openalex.org/W2129172946","https://openalex.org/W2130488043","https://openalex.org/W2140126391","https://openalex.org/W2141244447","https://openalex.org/W2144918562","https://openalex.org/W2159060826","https://openalex.org/W2160304102","https://openalex.org/W2166084034","https://openalex.org/W2166262263","https://openalex.org/W2168143310","https://openalex.org/W2169276102","https://openalex.org/W2219581640","https://openalex.org/W2257265893","https://openalex.org/W2418764371"],"related_works":["https://openalex.org/W2114419702","https://openalex.org/W3165806114","https://openalex.org/W2110253596","https://openalex.org/W1981976406","https://openalex.org/W2089444383","https://openalex.org/W2799433694","https://openalex.org/W2354565891","https://openalex.org/W2094843657","https://openalex.org/W1880759340","https://openalex.org/W2051149660"],"abstract_inverted_index":{"Identification":[0],"and":[1,18,40,53,101,119],"inhibition":[2],"of":[3,20,33,91,104,116],"molecular":[4,78],"pathways":[5,79],"that":[6,83,106],"drive":[7,71],"malignant":[8,81],"cells":[9,82],"have":[10,43,108],"led":[11],"to":[12,70],"improved":[13],"outcomes":[14],"in":[15,48,57,74,80,96],"the":[16,30,34,92,102,114],"understanding":[17],"management":[19,115],"non-small":[21],"cell":[22,121],"lung":[23,55,122],"cancer.":[24],"This":[25,67],"has":[26],"been":[27,44],"illustrated":[28],"by":[29],"effective":[31],"use":[32],"EGFR-tyrosine":[35],"kinase":[36],"inhibitors":[37],"erlotinib,":[38],"gefitinib":[39],"afatinib,":[41],"which":[42],"major":[45],"steps":[46],"forward":[47],"targeted":[49,88],"therapy":[50],"for":[51,87],"advanced":[52],"metastatic":[54],"cancer":[56,123],"patients":[58],"who":[59],"harbour":[60],"specific":[61],"epithelial":[62],"growth":[63],"factor":[64],"receptor":[65],"mutations.":[66],"success":[68],"continues":[69],"ongoing":[72],"research":[73],"identifying":[75,97],"other":[76,93],"novel":[77],"may":[84,107],"be":[85],"exploited":[86],"therapy.":[89],"Some":[90],"current":[94],"advances":[95],"targetable":[98],"genetic":[99],"mutations":[100],"development":[103],"therapies":[105],"a":[109],"potential":[110],"clinical":[111],"impact":[112],"on":[113],"both":[117],"adenocarcinoma":[118],"squamous":[120],"are":[124],"reviewed.":[125]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}