{"id":"https://openalex.org/W2182155357","doi":null,"title":"Oral signs of intravenous chemotherapy with 5-Fluorouracil and Leucovorin calcium in colon cancer treatment.","display_name":"Oral signs of intravenous chemotherapy with 5-Fluorouracil and Leucovorin calcium in colon cancer treatment.","publication_year":2009,"publication_date":"2009-03-01","ids":{"openalex":"https://openalex.org/W2182155357","mag":"2182155357","pmid":"https://pubmed.ncbi.nlm.nih.gov/19242388"},"language":"en","primary_location":{"id":"pmid:19242388","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19242388","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicina oral, patologia oral y cirugia bucal","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10550/60553","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014553839","display_name":"Marcelo Adrian Mazzeo","orcid":"https://orcid.org/0000-0002-7950-613X","observed_orcids":["https://orcid.org/0000-0002-7950-613X"]},"institutions":[{"id":"https://openalex.org/I166401450","display_name":"Universidad Nacional de C\u00f3rdoba","ror":"https://ror.org/056tb7j80","country_code":"AR","type":"education","lineage":["https://openalex.org/I166401450"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Marcelo A Mazzeo","raw_affiliation_strings":["C\u00e1tedra de Fisiolog\u00eda, Facultad de Odontolog\u00eda, Universidad Nacional de C\u00f3rdoba, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"C\u00e1tedra de Fisiolog\u00eda, Facultad de Odontolog\u00eda, Universidad Nacional de C\u00f3rdoba, Argentina","institution_ids":["https://openalex.org/I166401450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047806286","display_name":"Jorge-Alberto Linares","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jorge A Linares","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075105746","display_name":"Mar\u00eda Luisa Vilches Campos","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria L Campos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059839631","display_name":"Beatriz Busamia","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Beatriz E Busamia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035906420","display_name":"Claudio Gast\u00f3n Dubersarsky","orcid":"https://orcid.org/0009-0009-7777-6695","observed_orcids":["https://orcid.org/0009-0009-7777-6695"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Claudio Dubersarsky","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044045552","display_name":"Marcelo Lavarda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marcelo Lavarda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043632370","display_name":"Gustavo D. Jarchum","orcid":"https://orcid.org/0000-0001-6253-9317","observed_orcids":["https://orcid.org/0000-0001-6253-9317"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gustavo Jarchum","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113759797","display_name":"Ana Beatriz Finkelberg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ana B Finkelberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":29,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"14","issue":"3","first_page":"E108","last_page":"13"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12198","display_name":"Oral health in cancer treatment","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12198","display_name":"Oral health in cancer treatment","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11521","display_name":"Salivary Gland Disorders and Functions","score":0.008100000210106373,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13761","display_name":"HIV/AIDS oral health manifestations","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.9760000109672546},{"id":"https://openalex.org/keywords/intravenous-chemotherapy","display_name":"intravenous chemotherapy","score":0.753000020980835},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.9369999766349792},{"id":"https://openalex.org/keywords/salivary-gland-hypofunction","display_name":"salivary gland hypofunction","score":0.8700000047683716},{"id":"https://openalex.org/keywords/hyposialia","display_name":"hyposialia","score":0.7990000247955322},{"id":"https://openalex.org/keywords/salivary-flow","display_name":"salivary flow","score":0.8230000138282776},{"id":"https://openalex.org/keywords/salivary-ph","display_name":"salivary pH","score":0.7480000257492065},{"id":"https://openalex.org/keywords/salivary-electrolytes","display_name":"salivary electrolytes","score":0.8450000286102295},{"id":"https://openalex.org/keywords/oral-health","display_name":"oral health","score":0.6660000085830688},{"id":"https://openalex.org/keywords/gingival-bleeding","display_name":"gingival bleeding","score":0.8259999752044678},{"id":"https://openalex.org/keywords/periodontal-disease","display_name":"periodontal disease","score":0.6729999780654907},{"id":"https://openalex.org/keywords/stomatognathic-system","display_name":"stomatognathic system","score":0.7850000262260437}],"concepts":[{"id":"https://openalex.org/C504460877","wikidata":"https://www.wikidata.org/wiki/Q155925","display_name":"Saliva","level":2,"score":0.7740974426269531},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6600476503372192},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.6154741048812866},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5498971939086914},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5347949862480164},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.41443729400634766},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3753235936164856},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3495047688484192},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.32796943187713623},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000964","descriptor_name":"Antimetabolites, Antineoplastic","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000964","descriptor_name":"Antimetabolites, Antineoplastic","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D002955","descriptor_name":"Leucovorin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002955","descriptor_name":"Leucovorin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012466","descriptor_name":"Salivary Gland Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D014803","descriptor_name":"Vitamin B Complex","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014803","descriptor_name":"Vitamin B Complex","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:19242388","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19242388","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicina oral, patologia oral y cirugia bucal","raw_type":"Journal Article"},{"id":"pmh:oai:roderic.uv.es:10550/60553","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10550/60553","pdf_url":"http://hdl.handle.net/10550/60553","source":{"id":"https://openalex.org/S4306400245","display_name":"Repository of Digital Objects for Teaching Research and Culture (University of Valencia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I16097986","host_organization_name":"Universitat de Val\u00e8ncia","host_organization_lineage":["https://openalex.org/I16097986"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"}],"best_oa_location":{"id":"pmh:oai:roderic.uv.es:10550/60553","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10550/60553","pdf_url":"http://hdl.handle.net/10550/60553","source":{"id":"https://openalex.org/S4306400245","display_name":"Repository of Digital Objects for Teaching Research and Culture (University of Valencia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I16097986","host_organization_name":"Universitat de Val\u00e8ncia","host_organization_lineage":["https://openalex.org/I16097986"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2182155357.pdf","grobid_xml":"https://content.openalex.org/works/W2182155357.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W13732663","https://openalex.org/W137212987","https://openalex.org/W1483585477","https://openalex.org/W1522224377","https://openalex.org/W1541104889","https://openalex.org/W1555447270","https://openalex.org/W1742102714","https://openalex.org/W1764386078","https://openalex.org/W1880102547","https://openalex.org/W1980568993","https://openalex.org/W2021792184","https://openalex.org/W2028027436","https://openalex.org/W2036249439","https://openalex.org/W2046680977","https://openalex.org/W2069164490","https://openalex.org/W2076445828","https://openalex.org/W2083738828","https://openalex.org/W2086066882","https://openalex.org/W2090237280","https://openalex.org/W2092536965","https://openalex.org/W2105382071","https://openalex.org/W2107228383","https://openalex.org/W2120465240","https://openalex.org/W2123497410","https://openalex.org/W2144610619","https://openalex.org/W2416666583","https://openalex.org/W4250820190"],"related_works":["https://openalex.org/W7096270211","https://openalex.org/W80149671","https://openalex.org/W2410758039","https://openalex.org/W7083089838","https://openalex.org/W2000886540","https://openalex.org/W2905807851","https://openalex.org/W2417272007","https://openalex.org/W2952332989","https://openalex.org/W2945907182","https://openalex.org/W2751318493"],"abstract_inverted_index":{"UNLABELLED:":[0],"Several":[1],"studies":[2],"have":[3],"shown":[4],"how":[5],"cytostatics":[6],"may":[7,216,252],"cause":[8],"hypofunction":[9],"of":[10,31,36,42,76,83,168,173,204,232,245,271,283],"salivary":[11,192,264],"glands":[12],"but":[13,163,183],"failed":[14],"to":[15,46,54,104,219,254,260],"elucidate":[16],"any":[17],"potentially":[18],"related":[19],"side":[20],"effects.":[21],"Keeping":[22],"in":[23,51,129,213,228,263,267],"mind":[24],"the":[25,29,34,37,40,74,81,130,148,166,169,174,180,209,268,272],"sialochemical":[26],"assistance":[27],"and":[28,58,88,100,115,125,144,152,199,202,230,247,249],"role":[30],"saliva":[32,119,134,206,234],"on":[33],"homeostasis":[35],"stomatognathic":[38],"system,":[39],"aim":[41],"this":[43,84],"study":[44],"was":[45,86],"establish":[47],"potential":[48],"gland":[49,193],"disorders":[50,71,194],"patients":[52,91],"submitted":[53,103],"5-":[55],"Fluorouracil":[56],"(5-Fu)":[57],"Leucovorin":[59],"calcium":[60],"(LV)":[61],"as":[62,64,155,157,195,239],"well":[63,156],"their":[65],"correlation":[66],"with":[67,93,279],"certain":[68],"oral":[69,112],"health":[70,113],"that":[72],"diminish":[73],"quality":[75],"life.":[77],"MATERIALS":[78],"AND":[79],"METHODS:":[80],"focus":[82],"research":[85],"observational":[87],"longitudinal.":[89],"Twenty-five":[90],"diagnosed":[92],"colon":[94],"cancer":[95],"at":[96],"an":[97],"initial,":[98],"intermediate":[99,131,149,181,210],"late":[101],"phase":[102,182],"specifically":[105],"devised":[106],"therapy":[107,162],"were":[108,121],"assessed.":[109],"Clinical":[110],"history,":[111],"indexes":[114],"basal":[116,140,198,214,233],"or":[117,225],"stimulated":[118,126,200,205],"samples":[120],"recorded.":[122],"RESULTS:":[123],"Basal":[124],"flow":[127],"dropped":[128],"stage.":[132],"Stimulated":[133],"pH":[135,207],"decreased":[136],"during":[137,147,161,179,208],"treatment.":[138,170],"On":[139],"saliva,":[141],"urea,":[142],"sodium":[143],"potassium":[145],"rose":[146,178],"phase.":[150,211],"L\u00f6e":[151,248],"Silness":[153,250],"rates":[154,251,270],"simplified":[158],"bleeding":[159,246],"increased":[160],"reverted":[164],"by":[165,197],"end":[167],"Depth":[171],"index":[172],"vestibular":[175,274],"gingival":[176],"sulcus":[177,275],"did":[184],"not":[185],"return.":[186],"CONCLUSION:":[187],"This":[188],"treatment":[189],"caused":[190],"functional":[191],"evidenced":[196],"hyposialia,":[201],"acidification":[203],"Increase":[212,266],"urea":[215],"be":[217,237,277],"due":[218],"proteic":[220],"catabolism":[221],"arising":[222],"from":[223],"plasma":[224],"glands.":[226],"Variation":[227],"Na+":[229],"K+":[231],"concentrates":[235],"might":[236],"assumed":[238],"a":[240,255,261,280],"possible":[241],"duct":[242],"disorder.":[243],"Recovery":[244],"point":[253],"transient":[256],"inflammatory":[257],"effect":[258],"associated":[259],"decrease":[262],"flow.":[265],"depth":[269],"periodontal":[273,284],"could":[276],"correlated":[278],"higher":[281],"risk":[282],"disease.":[285]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}