{"id":"https://openalex.org/W2182116387","doi":null,"title":"Bevacizumab does not affect autophagy clearance during proteasomal inhibition in human retinal pigment epithelial cells","display_name":"Bevacizumab does not affect autophagy clearance during proteasomal inhibition in human retinal pigment epithelial cells","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2182116387","mag":"2182116387"},"language":"en","primary_location":{"id":"mag:2182116387","doi":null,"is_oa":false,"landing_page_url":"http://researchpub.org/journal/jbpr/number/vol2-no1/vol2-no1-5.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022005561","display_name":"Niko Kivinen","orcid":"https://orcid.org/0000-0002-8562-9574","observed_orcids":["https://orcid.org/0000-0002-8562-9574","https://orcid.org/0009-0004-0074-1762"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Niko Kivinen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8562-9574","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079126043","display_name":"Michaela Dithmer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michaela Dithmer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002292292","display_name":"Kati Kinnunen","orcid":"https://orcid.org/0000-0002-1641-0552","observed_orcids":["https://orcid.org/0000-0002-1641-0552"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kati Kinnunen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1641-0552","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019897740","display_name":"Ralph Lucius","orcid":"https://orcid.org/0000-0002-2782-1760","observed_orcids":["https://orcid.org/0000-0002-2782-1760"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ralph Lucius","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2782-1760","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110137134","display_name":"Johann Baptist Roider","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Johann Roider","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021448617","display_name":"Kai Kaarniranta","orcid":"https://orcid.org/0000-0003-2600-8679","observed_orcids":["https://orcid.org/0000-0003-2600-8679"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kai Kaarniranta","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2600-8679","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5047272633","display_name":"Alexa Klettner","orcid":"https://orcid.org/0000-0002-2709-1059","observed_orcids":["https://orcid.org/0000-0002-2709-1059"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexa Klettner","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2709-1059","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.863,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.75212745,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.7139000296592712,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.7139000296592712,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.2615000009536743,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11438","display_name":"Retinal Imaging and Analysis","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bevacizumab","display_name":"bevacizumab","score":1.0},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9959999918937683},{"id":"https://openalex.org/keywords/proteasome-inhibition","display_name":"proteasome inhibition","score":0.9490000009536743},{"id":"https://openalex.org/keywords/retinal-pigment-epithelial-cells","display_name":"retinal pigment epithelial cells","score":0.9589999914169312},{"id":"https://openalex.org/keywords/age-related-macular-degeneration","display_name":"age-related macular degeneration","score":0.9679999947547913},{"id":"https://openalex.org/keywords/vegf-inhibition","display_name":"VEGF inhibition","score":0.7009999752044678},{"id":"https://openalex.org/keywords/protein-aggregation","display_name":"protein aggregation","score":0.8069999814033508},{"id":"https://openalex.org/keywords/lysosomal-clearance","display_name":"lysosomal clearance","score":0.8640000224113464},{"id":"https://openalex.org/keywords/arpe-19-cells","display_name":"ARPE-19 cells","score":0.9089999794960022},{"id":"https://openalex.org/keywords/choroidal-neovascularization","display_name":"choroidal neovascularization","score":0.8569999933242798},{"id":"https://openalex.org/keywords/photoreceptor-degeneration","display_name":"photoreceptor degeneration","score":0.6499999761581421}],"concepts":[{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.838225245475769},{"id":"https://openalex.org/C2776403814","wikidata":"https://www.wikidata.org/wiki/Q27429789","display_name":"Macular degeneration","level":2,"score":0.8239977359771729},{"id":"https://openalex.org/C2778749236","wikidata":"https://www.wikidata.org/wiki/Q4689286","display_name":"Aflibercept","level":4,"score":0.7052208781242371},{"id":"https://openalex.org/C2777802072","wikidata":"https://www.wikidata.org/wiki/Q413299","display_name":"Bevacizumab","level":3,"score":0.688209593296051},{"id":"https://openalex.org/C2781100027","wikidata":"https://www.wikidata.org/wiki/Q414270","display_name":"Ranibizumab","level":4,"score":0.6566401720046997},{"id":"https://openalex.org/C2781359195","wikidata":"https://www.wikidata.org/wiki/Q5105209","display_name":"Choroidal neovascularization","level":3,"score":0.6299302577972412},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.6129617094993591},{"id":"https://openalex.org/C2778024200","wikidata":"https://www.wikidata.org/wiki/Q2346242","display_name":"Retinal pigment epithelium","level":3,"score":0.5610471367835999},{"id":"https://openalex.org/C2778367456","wikidata":"https://www.wikidata.org/wiki/Q7251235","display_name":"Proteasome inhibitor","level":3,"score":0.5276896953582764},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.492005318403244},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4590761363506317},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.44059619307518005},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4294431805610657},{"id":"https://openalex.org/C27740335","wikidata":"https://www.wikidata.org/wiki/Q14878333","display_name":"Proteasome","level":2,"score":0.4190688133239746},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.41894856095314026},{"id":"https://openalex.org/C2778271429","wikidata":"https://www.wikidata.org/wiki/Q1281049","display_name":"Neovascularization","level":3,"score":0.418761670589447},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.40574556589126587},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.32197028398513794},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.30414319038391113},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2429983913898468},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1481623649597168},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.13590991497039795},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.11062881350517273},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10941576957702637},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.07714849710464478},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.07204064726829529}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2182116387","doi":null,"is_oa":false,"landing_page_url":"http://researchpub.org/journal/jbpr/number/vol2-no1/vol2-no1-5.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W44237636","https://openalex.org/W1041957737","https://openalex.org/W1481978003","https://openalex.org/W1509930999","https://openalex.org/W1524697338","https://openalex.org/W1553154837","https://openalex.org/W1604547442","https://openalex.org/W1835151879","https://openalex.org/W1963705625","https://openalex.org/W1965259073","https://openalex.org/W1968189763","https://openalex.org/W1970528463","https://openalex.org/W1971240175","https://openalex.org/W1973729541","https://openalex.org/W1985648029","https://openalex.org/W1988233478","https://openalex.org/W2004112218","https://openalex.org/W2005487633","https://openalex.org/W2007121200","https://openalex.org/W2007973129","https://openalex.org/W2008649656","https://openalex.org/W2015703878","https://openalex.org/W2018777580","https://openalex.org/W2032217161","https://openalex.org/W2034041091","https://openalex.org/W2034411501","https://openalex.org/W2047572109","https://openalex.org/W2070181056","https://openalex.org/W2081930185","https://openalex.org/W2085366579","https://openalex.org/W2085433832","https://openalex.org/W2101212248","https://openalex.org/W2110428590","https://openalex.org/W2112809493","https://openalex.org/W2119399459","https://openalex.org/W2122595579","https://openalex.org/W2145642577","https://openalex.org/W2146124002","https://openalex.org/W2146673937","https://openalex.org/W2154770697","https://openalex.org/W2159764938","https://openalex.org/W2164778558","https://openalex.org/W2166926836","https://openalex.org/W2319259593","https://openalex.org/W2333616114"],"related_works":["https://openalex.org/W2889959895","https://openalex.org/W2518833625","https://openalex.org/W2084101217","https://openalex.org/W2885161087","https://openalex.org/W2022931766","https://openalex.org/W2015744969","https://openalex.org/W2173240499","https://openalex.org/W2032217161","https://openalex.org/W2623846156","https://openalex.org/W6966908261"],"abstract_inverted_index":{"The":[0,33],"most":[1],"common":[2],"reason":[3],"for":[4],"blindness":[5],"in":[6,47,53,103,119,124,136,168],"developed":[7],"countries":[8],"is":[9,41,58,66,99],"age-related":[10],"macular":[11],"degeneration":[12,142],"(AMD)":[13],"that":[14,108,147,161],"can":[15,134],"be":[16],"classified":[17],"into":[18],"two":[19],"main":[20],"categories:":[21],"the":[22,28,42,54,76,81,87],"atrophic,":[23],"or":[24,30],"dry":[25,37],"form":[26],"and":[27,38,86,110,143,153,174],"exudative,":[29],"wet":[31,39,48,71],"form.":[32],"diagnostic":[34],"difference":[35],"between":[36],"AMD":[40],"development":[43,55],"of":[44,56,122,138],"choroidal":[45],"neovascularization":[46,57],"AMD.":[49,72,120],"A":[50],"master":[51],"regulator":[52],"Vascular":[59],"Endothelial":[60],"Growth":[61],"Factor":[62],"(VEGF)":[63],"A,":[64],"which":[65],"therapeutically":[67],"inhibited":[68],"to":[69,94,150],"treat":[70],"Current":[73],"VEGF-antagonists":[74],"are":[75],"Fab-":[77],"Fragment":[78],"ranibizumab":[79],"(Lucentis),":[80],"fusion":[82],"protein":[83,175],"aflibercept":[84],"(Eylea)":[85],"off-label":[88],"used":[89,101],"antibody":[90],"bevacizumab":[91,162],"(Avastin).":[92],"Due":[93],"its":[95],"low":[96],"costs,":[97],"Avastin":[98],"largely":[100],"worldwide":[102],"clinics.":[104],"Recent":[105],"findings":[106],"reveal":[107],"proteasomal":[109],"lysosomal":[111],"clearance":[112,167],"systems":[113],"including":[114,128],"autophagy":[115,123,166],"have":[116],"been":[117],"disturbed":[118],"Failure":[121],"aged":[125],"postmitotic":[126],"cells,":[127,133],"retinal":[129],"pigment":[130],"epithelial":[131],"(RPE)":[132],"result":[135],"accumulation":[137],"aggregate-prone":[139],"proteins,":[140],"cellular":[141],"finally,":[144],"cell":[145,170],"death":[146],"secondarily":[148],"lead":[149],"photoreceptor":[151],"damage":[152],"visual":[154],"loss.":[155],"In":[156],"this":[157],"study,":[158],"we":[159],"show":[160],"does":[163],"not":[164],"affect":[165],"ARPE-19":[169],"during":[171],"proteasome":[172],"inhibition":[173],"aggregation.":[176]},"counts_by_year":[{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}
