{"id":"https://openalex.org/W2182081005","doi":null,"title":"TheStressOncoproteinLEDGF/p75InteractswiththeMethyl CpG Binding Protein MeCP2 and Influences Its","display_name":"TheStressOncoproteinLEDGF/p75InteractswiththeMethyl CpG Binding Protein MeCP2 and Influences Its","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2182081005","mag":"2182081005"},"language":"en","primary_location":{"id":"mag:2182081005","doi":null,"is_oa":false,"landing_page_url":"https://mcr.aacrjournals.org/content/10/3/378.full.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049638428","display_name":"Lai Sum Leoh","orcid":"https://orcid.org/0000-0003-0932-4872","observed_orcids":["https://orcid.org/0000-0003-0932-4872"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lai Sum Leoh","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0932-4872","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071513112","display_name":"Bart van Heertum","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bart van Heertum","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001999006","display_name":"Jan De Rijck","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jan De Rijck","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103133068","display_name":"Maria Filippova","orcid":"https://orcid.org/0000-0002-7559-6713","observed_orcids":["https://orcid.org/0000-0002-7559-6713"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria Filippova","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7559-6713","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052461867","display_name":"Leslimar R\u00edos-Col\u00f3n","orcid":"https://orcid.org/0000-0002-4849-3399","observed_orcids":["https://orcid.org/0000-0002-4849-3399"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Leslimar R\u00edos-Col\u00f3n","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4849-3399","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022377766","display_name":"Anamika Basu","orcid":"https://orcid.org/0000-0002-8551-0354","observed_orcids":["https://orcid.org/0000-0002-8551-0354"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anamika Basu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8551-0354","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038468497","display_name":"Shannalee R. Martinez","orcid":"https://orcid.org/0000-0002-9682-0227","observed_orcids":["https://orcid.org/0000-0002-9682-0227"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shannalee R. Martinez","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9682-0227","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076385006","display_name":"Sandy S. Tungteakkhun","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sandy S. Tungteakkhun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022835640","display_name":"Valeri Filippov","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Valeri Filippov","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036165439","display_name":"Frauke Christ","orcid":"https://orcid.org/0000-0001-9580-3874","observed_orcids":["https://orcid.org/0000-0001-9580-3874"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Frauke Christ","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9580-3874","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022663291","display_name":"Marino A. De Leo\u0301n","orcid":"https://orcid.org/0000-0001-6576-785X","observed_orcids":["https://orcid.org/0000-0001-6576-785X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marino De Le\u00f3n","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044112097","display_name":"Zeger Debyser","orcid":"https://orcid.org/0000-0002-3982-1565","observed_orcids":["https://orcid.org/0000-0002-3982-1565","https://orcid.org/0000-0003-0849-8715"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zeger Debyser","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3982-1565","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5015631803","display_name":"Carlos A. Casiano","orcid":"https://orcid.org/0000-0002-7320-4333","observed_orcids":["https://orcid.org/0000-0002-7320-4333"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carlos A. Casiano","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7320-4333","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.13680895,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.4787999987602234,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.4787999987602234,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.2533999979496002,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.2046000063419342,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ledgf-p75","display_name":"LEDGF/p75","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mecp2","display_name":"MeCP2","score":0.7680000066757202},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.8019999861717224},{"id":"https://openalex.org/keywords/pwwp-domain","display_name":"PWWP domain","score":0.7540000081062317},{"id":"https://openalex.org/keywords/transcriptional-activation","display_name":"transcriptional activation","score":0.8330000042915344},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.7540000081062317},{"id":"https://openalex.org/keywords/transcriptional-coactivator","display_name":"transcriptional coactivator","score":0.7440000176429749},{"id":"https://openalex.org/keywords/oxidative-stress-tolerance","display_name":"oxidative stress resistance","score":0.6259999871253967},{"id":"https://openalex.org/keywords/splice-variants","display_name":"splice variants","score":0.3659999966621399}],"concepts":[{"id":"https://openalex.org/C1292079","wikidata":"https://www.wikidata.org/wiki/Q3817769","display_name":"Transactivation","level":4,"score":0.7506675720214844},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5256465673446655},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.520652711391449},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.43647003173828125},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4193267822265625},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3839890956878662},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32997995615005493},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15652698278427124},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13050153851509094}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2182081005","doi":null,"is_oa":false,"landing_page_url":"https://mcr.aacrjournals.org/content/10/3/378.full.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8700000047683716,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W181090678","https://openalex.org/W1896222878","https://openalex.org/W1966515818","https://openalex.org/W1973413376","https://openalex.org/W1984598132","https://openalex.org/W1987480357","https://openalex.org/W2001366457","https://openalex.org/W2002073949","https://openalex.org/W2005202590","https://openalex.org/W2012197353","https://openalex.org/W2012589152","https://openalex.org/W2023461806","https://openalex.org/W2033577436","https://openalex.org/W2033958009","https://openalex.org/W2036681136","https://openalex.org/W2038070445","https://openalex.org/W2042822047","https://openalex.org/W2059636071","https://openalex.org/W2059740818","https://openalex.org/W2068229533","https://openalex.org/W2082485360","https://openalex.org/W2082798259","https://openalex.org/W2088819616","https://openalex.org/W2090073257","https://openalex.org/W2093230830","https://openalex.org/W2093783786","https://openalex.org/W2094799740","https://openalex.org/W2097778167","https://openalex.org/W2118906222","https://openalex.org/W2118921541","https://openalex.org/W2123025266","https://openalex.org/W2124156684","https://openalex.org/W2128071342","https://openalex.org/W2133337718","https://openalex.org/W2140812363","https://openalex.org/W2145002880","https://openalex.org/W2152684744","https://openalex.org/W2160783048","https://openalex.org/W2165978081","https://openalex.org/W2167997151","https://openalex.org/W2329458316"],"related_works":["https://openalex.org/W2096810404","https://openalex.org/W7100714411","https://openalex.org/W1993603297","https://openalex.org/W4404721009","https://openalex.org/W1984400774","https://openalex.org/W2051816907","https://openalex.org/W168194700","https://openalex.org/W2120269064","https://openalex.org/W4405484664","https://openalex.org/W2046898933"],"abstract_inverted_index":{"The":[0],"lens":[1],"epithelium\u2013derived":[2],"growth":[3],"factor":[4,111],"p75":[5],"(LEDGF/p75)":[6],"is":[7,22],"a":[8,90],"transcription":[9,67,110],"coactivator":[10],"that":[11,80,211],"promotes":[12],"resistance":[13],"to":[14,128,148,238],"oxidative":[15],"stress-":[16],"and":[17,35,43,69,82,96,115,119,137,149,223],"chemotherapy-induced":[18],"cell":[19],"death.":[20],"LEDGF/p75":[21,52,136,155,187],"also":[23],"known":[24],"as":[25],"the":[26,70,131,141,151,212,221,233,239],"dense":[27],"fine":[28],"speckles":[29],"autoantigen":[30],"of":[31,62,72,186,206,229,235,241],"70":[32],"kDa":[33],"(DFS70)":[34],"has":[36],"been":[37],"implicated":[38],"in":[39,94,97,161,171,180,188,202,231],"cancer,":[40],"HIV-AIDS,":[41],"autoimmunity,":[42],"inflammation.":[44],"To":[45],"gain":[46],"insights":[47],"into":[48],"mechanisms":[49],"by":[50,106,122,135],"which":[51],"protects":[53],"cancer":[54,100,174],"cells":[55,190,204],"against":[56],"stress,":[57],"we":[58],"initiated":[59],"an":[60],"analysis":[61],"its":[63,83],"interactions":[64,74,103],"with":[65,88,130,140],"other":[66],"factors":[68],"influence":[71],"these":[73],"on":[75,220],"stress":[76,242],"geneactivation.":[77],"We":[78],"reporthere":[79],"bothLEDGF/p75":[81],"short":[84],"splicevariant":[85],"LEDGF/p52":[86,176],"interact":[87,129],"MeCP2,":[89],"methylation-associated":[91],"transcriptional":[92],"modulator,":[93],"vitro":[95],"various":[98],"human":[99],"cells.":[101,175,182],"These":[102,208,226],"were":[104],"established":[105],"several":[107],"complementary":[108],"approaches:":[109],"protein":[112],"arrays,":[113],"pull-down":[114],"AlphaScreen":[116],"assays,":[117],"coimmunoprecipitation,":[118],"nuclear":[120],"colocalization":[121],"confocal":[123],"microscopy.":[124],"MeCP2":[125,146],"was":[126,168,199],"found":[127],"N-terminal":[132],"region":[133],"shared":[134],"p52,":[138],"particularly":[139],"PWWP-CR1":[142],"domain.":[143],"Like":[144],"LEDGF/p75,":[145],"bound":[147],"transactivated":[150],"Hsp27":[152],"promoter":[153],"(Hsp27pr).":[154],"modestly":[156],"enhanced":[157],"MeCP2-induced":[158],"Hsp27pr":[159,178,194,217],"transactivation":[160],"U2OS":[162,181,189],"osteosarcoma":[163],"cells,":[164],"whereas":[165,196],"this":[166,197,236],"effect":[167,198],"more":[169],"pronounced":[170,201],"PC3":[172,203],"prostate":[173],"repressed":[177],"activity":[179],"Interestingly,":[183],"siRNA-induced":[184],"silencing":[185],"dramatically":[191],"elevated":[192],"MeCP2-mediated":[193],"transactivation,":[195],"less":[200],"depleted":[205],"LEDGF/p75.":[207],"results":[209],"suggest":[210],"LEDGF/p75\u2013MeCP2":[213],"interaction":[214,237],"differentially":[215],"influences":[216],"activation":[218,240],"depending":[219],"cellular":[222],"molecular":[224],"context.":[225],"findings":[227],"are":[228],"significance":[230],"understanding":[232],"contribution":[234],"survival":[243],"genes.":[244],"Mol":[245],"Cancer":[246],"Res;":[247],"10(3);":[248],"378\u201391.":[249],"\ufffd":[250],"2012":[251],"AACR.":[252]},"counts_by_year":[],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2016-06-24T00:00:00"}