{"id":"https://openalex.org/W2182022734","doi":null,"title":"Current Management and Molecular Targets of Synovial","display_name":"Current Management and Molecular Targets of Synovial","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2182022734","mag":"2182022734"},"language":"en","primary_location":{"id":"mag:2182022734","doi":null,"is_oa":false,"landing_page_url":"https://austinpublishinggroup.com/cancer-clinical-research/fulltext/cancer-v1-id1008.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035134233","display_name":"Jeff C. Kremer","orcid":"https://orcid.org/0009-0003-1841-640X","observed_orcids":["https://orcid.org/0009-0003-1841-640X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kremer Jc","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Schultze","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Schultze","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5091098703","display_name":"Brian Andrew Van Tine","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brian Andrew Van Tine","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/synovial-sarcoma","display_name":"synovial sarcoma","score":1.0},{"id":"https://openalex.org/keywords/soft-tissue-sarcoma","display_name":"soft tissue sarcoma","score":0.9819999933242798},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.8519999980926514},{"id":"https://openalex.org/keywords/p53-regulation","display_name":"p53 regulation","score":0.9679999947547913},{"id":"https://openalex.org/keywords/argininosuccinate-synthetase-1","display_name":"argininosuccinate synthetase 1","score":0.9369999766349792},{"id":"https://openalex.org/keywords/histone-deacetylase","display_name":"histone deacetylase","score":0.984000027179718},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"chemotherapy","score":0.34700000286102295},{"id":"https://openalex.org/keywords/metastatic-disease","display_name":"metastatic disease","score":0.843999981880188},{"id":"https://openalex.org/keywords/clinical-trials","display_name":"clinical trials","score":0.6439999938011169}],"concepts":[{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.6166583299636841},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5764071345329285},{"id":"https://openalex.org/C2776910622","wikidata":"https://www.wikidata.org/wiki/Q2619315","display_name":"Synovial sarcoma","level":3,"score":0.5705376863479614},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.521296501159668},{"id":"https://openalex.org/C2778629024","wikidata":"https://www.wikidata.org/wiki/Q720020","display_name":"Soft tissue sarcoma","level":3,"score":0.4295184016227722},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4169735312461853},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.4103570282459259},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.38148507475852966},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31087273359298706},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3082559406757355},{"id":"https://openalex.org/C2778256501","wikidata":"https://www.wikidata.org/wiki/Q223911","display_name":"Sarcoma","level":2,"score":0.2942371666431427},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.22102323174476624},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.14530441164970398}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2182022734","doi":null,"is_oa":false,"landing_page_url":"https://austinpublishinggroup.com/cancer-clinical-research/fulltext/cancer-v1-id1008.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":86,"referenced_works":["https://openalex.org/W61472805","https://openalex.org/W113548206","https://openalex.org/W156755223","https://openalex.org/W626893061","https://openalex.org/W1489202311","https://openalex.org/W1521924247","https://openalex.org/W1909079918","https://openalex.org/W1931140155","https://openalex.org/W1964305213","https://openalex.org/W1965613885","https://openalex.org/W1967018540","https://openalex.org/W1968822328","https://openalex.org/W1969393625","https://openalex.org/W1970421873","https://openalex.org/W1971571204","https://openalex.org/W1972035895","https://openalex.org/W1973913980","https://openalex.org/W1976295398","https://openalex.org/W1977258127","https://openalex.org/W1980877346","https://openalex.org/W1983147046","https://openalex.org/W1984740535","https://openalex.org/W1990802782","https://openalex.org/W1991953645","https://openalex.org/W2000096417","https://openalex.org/W2002885198","https://openalex.org/W2003478678","https://openalex.org/W2004447916","https://openalex.org/W2005076200","https://openalex.org/W2009616940","https://openalex.org/W2009913150","https://openalex.org/W2011017763","https://openalex.org/W2013696012","https://openalex.org/W2020031759","https://openalex.org/W2020387213","https://openalex.org/W2021683914","https://openalex.org/W2023786212","https://openalex.org/W2026907678","https://openalex.org/W2027449497","https://openalex.org/W2028017544","https://openalex.org/W2031936148","https://openalex.org/W2033176001","https://openalex.org/W2034846292","https://openalex.org/W2049360086","https://openalex.org/W2055426891","https://openalex.org/W2055901277","https://openalex.org/W2056651145","https://openalex.org/W2057492132","https://openalex.org/W2063669247","https://openalex.org/W2064257430","https://openalex.org/W2065871963","https://openalex.org/W2066136639","https://openalex.org/W2072765381","https://openalex.org/W2079548558","https://openalex.org/W2080243787","https://openalex.org/W2080579763","https://openalex.org/W2090614481","https://openalex.org/W2093247476","https://openalex.org/W2097733224","https://openalex.org/W2101253475","https://openalex.org/W2101776780","https://openalex.org/W2103030360","https://openalex.org/W2104842253","https://openalex.org/W2107230638","https://openalex.org/W2110735158","https://openalex.org/W2113370608","https://openalex.org/W2114673700","https://openalex.org/W2115771116","https://openalex.org/W2118475754","https://openalex.org/W2121955475","https://openalex.org/W2126199679","https://openalex.org/W2132926900","https://openalex.org/W2134483979","https://openalex.org/W2141172512","https://openalex.org/W2141745968","https://openalex.org/W2145462268","https://openalex.org/W2149285292","https://openalex.org/W2155978618","https://openalex.org/W2158193323","https://openalex.org/W2163261207","https://openalex.org/W2169853162","https://openalex.org/W2181364979","https://openalex.org/W2314012478","https://openalex.org/W2318344307","https://openalex.org/W2323707457","https://openalex.org/W2614370965"],"related_works":["https://openalex.org/W2773879876","https://openalex.org/W2032102970","https://openalex.org/W2605508826","https://openalex.org/W2014997217","https://openalex.org/W620734541","https://openalex.org/W2072765381","https://openalex.org/W2967046715","https://openalex.org/W3161211885","https://openalex.org/W4387826175","https://openalex.org/W4403402053"],"abstract_inverted_index":{"Synovial":[0],"Sarcoma":[1],"(SS)":[2],"is":[3,20],"a":[4,15,23,58],"rare":[5],"and":[6,31,44,118,129,145,158],"aggressive":[7],"form":[8],"of":[9,38,53,71,97,104,154],"soft":[10],"tissue":[11],"sarcoma":[12],"(STS)":[13],"with":[14,49,125],"high":[16],"metastatic":[17,50],"potential":[18,135],"that":[19,164],"characterized":[21],"by":[22],"unique":[24],"translocation":[25],"between":[26],"SYT":[27],"on":[28,33],"chromosome":[29,34],"18":[30],"SSX":[32],"X.":[35],"Presently,":[36],"standard":[37,52],"care":[39,54],"involves":[40],"surgery,":[41],"radiation":[42],"therapy":[43,157],"chemotherapy.":[45],"For":[46],"those":[47],"patients":[48],"disease,":[51],"remains":[55],"enrollment":[56],"in":[57,73,112,171],"clinical":[59,66,75,168],"trial.":[60],"While":[61],"there":[62],"are":[63,123,165],"numerous":[64],"open":[65],"trials":[67,76],"for":[68,79,95,101,167],"the":[69,93,115,155,159],"treatment":[70],"STS":[72],"general,":[74],"designed":[77],"specifically":[78],"SS":[80],"remain":[81],"limited.":[82],"The":[83],"overall":[84],"low":[85],"response":[86],"rate":[87],"to":[88],"cytotoxic":[89],"chemotherapies":[90],"has":[91],"necessitated":[92],"need":[94],"development":[96,170],"pathway-specific":[98],"targeted":[99],"therapies":[100],"SS.":[102,172],"Deregulation":[103],"several":[105,134],"cell":[106,126],"signaling":[107,120],"pathways":[108],"have":[109,138],"been":[110,139],"identified":[111],"SS,":[113],"including":[114,141],"SRC,":[116],"Bcl-2,":[117],"MDM2":[119],"pathways,":[121],"which":[122],"involved":[124],"growth,":[127],"apoptosis,":[128],"p53":[130],"regulation,":[131],"respectively.":[132],"Additionally,":[133],"enzymatic":[136],"targets":[137,163],"identified,":[140],"argininosuccinate":[142],"synthetase":[143],"1":[144],"histone":[146],"deacetylases.":[147],"Here":[148],"we":[149],"present":[150],"an":[151],"updated":[152],"review":[153],"current":[156],"prospective":[160],"molecular":[161],"therapeutic":[162],"available":[166],"trial":[169]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2016-06-24T00:00:00"}