{"id":"https://openalex.org/W2182020666","doi":"https://doi.org/10.1242/dev.122.7.2189","title":"E(z): a polycomb group gene or a trithorax group gene?","display_name":"E(z): a polycomb group gene or a trithorax group gene?","publication_year":1996,"publication_date":"1996-07-01","ids":{"openalex":"https://openalex.org/W2182020666","doi":"https://doi.org/10.1242/dev.122.7.2189","mag":"2182020666","pmid":"https://pubmed.ncbi.nlm.nih.gov/8681799"},"language":"en","primary_location":{"id":"doi:10.1242/dev.122.7.2189","doi":"https://doi.org/10.1242/dev.122.7.2189","is_oa":false,"landing_page_url":"https://doi.org/10.1242/dev.122.7.2189","pdf_url":null,"source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043292120","display_name":"Dennis LaJeunesse","orcid":"https://orcid.org/0000-0001-5049-8968","observed_orcids":["https://orcid.org/0000-0001-5049-8968"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dennis LaJeunesse","raw_affiliation_strings":["The Johns Hopkins University Department of Biology , , 3400 North Charles Street, Baltimore, Maryland 21218, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Johns Hopkins University Department of Biology , , 3400 North Charles Street, Baltimore, Maryland 21218, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014808968","display_name":"Allen Shearn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Allen Shearn","raw_affiliation_strings":["The Johns Hopkins University Department of Biology , , 3400 North Charles Street, Baltimore, Maryland 21218, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Johns Hopkins University Department of Biology , , 3400 North Charles Street, Baltimore, Maryland 21218, USA","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5014808968"],"corresponding_institution_ids":["https://openalex.org/I145311948"],"apc_list":null,"apc_paid":null,"fwci":2.5248,"has_fulltext":false,"cited_by_count":101,"citation_normalized_percentile":{"value":0.90489298,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"122","issue":"7","first_page":"2189","last_page":"2197"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.8095999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.8095999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.1168999969959259,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.05609999969601631,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enhancer-of-zeste","display_name":"Enhancer of zeste","score":0.9729999899864197},{"id":"https://openalex.org/keywords/polycomb-group-genes","display_name":"Polycomb group genes","score":0.9020000100135803},{"id":"https://openalex.org/keywords/trithorax-group-genes","display_name":"trithorax group genes","score":0.9909999966621399},{"id":"https://openalex.org/keywords/antennapedia-complex","display_name":"Antennapedia complex","score":0.9369999766349792},{"id":"https://openalex.org/keywords/bithorax-complex","display_name":"bithorax complex","score":1.0},{"id":"https://openalex.org/keywords/gene-expression-inhibition","display_name":"gene expression inhibition","score":0.546999990940094},{"id":"https://openalex.org/keywords/gene-activation","display_name":"gene activation","score":0.6729999780654907},{"id":"https://openalex.org/keywords/anteroposterior-patterning","display_name":"anterior-posterior patterning","score":0.6790000200271606},{"id":"https://openalex.org/keywords/drosophila","display_name":"Drosophila","score":0.7680000066757202}],"concepts":[{"id":"https://openalex.org/C2780172944","wikidata":"https://www.wikidata.org/wiki/Q1075029","display_name":"Antennapedia","level":5,"score":0.9815510511398315},{"id":"https://openalex.org/C46751350","wikidata":"https://www.wikidata.org/wiki/Q1939530","display_name":"Homeotic gene","level":4,"score":0.9540032148361206},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8677279949188232},{"id":"https://openalex.org/C2777116130","wikidata":"https://www.wikidata.org/wiki/Q4082046","display_name":"Polycomb-group proteins","level":5,"score":0.7602411508560181},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.676791787147522},{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.655728816986084},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5788632035255432},{"id":"https://openalex.org/C197564579","wikidata":"https://www.wikidata.org/wiki/Q2019281","display_name":"Ultrabithorax","level":5,"score":0.4573310315608978},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2802330553531647},{"id":"https://openalex.org/C158448853","wikidata":"https://www.wikidata.org/wiki/Q425218","display_name":"Repressor","level":4,"score":0.14489108324050903}],"mesh":[{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001616","descriptor_name":"beta-Galactosidase","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002490","descriptor_name":"Central Nervous System","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004625","descriptor_name":"Embryo, Nonmammalian","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005801","descriptor_name":"Genes, Homeobox","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005809","descriptor_name":"Genes, Regulator","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007301","descriptor_name":"Insect Hormones","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009698","descriptor_name":"Nucleoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014921","descriptor_name":"Wings, Animal","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D017344","descriptor_name":"Genes, Insect","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D063150","descriptor_name":"Polycomb Repressive Complex 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1242/dev.122.7.2189","doi":"https://doi.org/10.1242/dev.122.7.2189","is_oa":false,"landing_page_url":"https://doi.org/10.1242/dev.122.7.2189","pdf_url":null,"source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},{"id":"pmid:8681799","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8681799","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development (Cambridge, England)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1815410177","display_name":null,"funder_award_id":"GM53058","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8082920839","display_name":"ROLE OF SPECIFIC GENES IN IMAGINAL DISC DETERMINATION","funder_award_id":"R01GM053058","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W24949964","https://openalex.org/W33805216","https://openalex.org/W129013773","https://openalex.org/W277446671","https://openalex.org/W1575147957","https://openalex.org/W1593505069","https://openalex.org/W1605923556","https://openalex.org/W1790706710","https://openalex.org/W1792088282","https://openalex.org/W1798260048","https://openalex.org/W1845773031","https://openalex.org/W1846251345","https://openalex.org/W1850811236","https://openalex.org/W1855977133","https://openalex.org/W1885374531","https://openalex.org/W1891332773","https://openalex.org/W1919607811","https://openalex.org/W1961490449","https://openalex.org/W1966053497","https://openalex.org/W1972748490","https://openalex.org/W1977024243","https://openalex.org/W1986021728","https://openalex.org/W1990342419","https://openalex.org/W1995112067","https://openalex.org/W1999757459","https://openalex.org/W2004553881","https://openalex.org/W2011192730","https://openalex.org/W2020727913","https://openalex.org/W2030233815","https://openalex.org/W2031204518","https://openalex.org/W2032328426","https://openalex.org/W2034019749","https://openalex.org/W2035169037","https://openalex.org/W2036159140","https://openalex.org/W2057475298","https://openalex.org/W2067461033","https://openalex.org/W2075754851","https://openalex.org/W2084767452","https://openalex.org/W2107275307","https://openalex.org/W2108709755","https://openalex.org/W2120021898","https://openalex.org/W2121735594","https://openalex.org/W2123327077","https://openalex.org/W2128802089","https://openalex.org/W2152778316","https://openalex.org/W2161248275","https://openalex.org/W2168148516","https://openalex.org/W2169333252","https://openalex.org/W2188261290","https://openalex.org/W2887703191","https://openalex.org/W3180850036","https://openalex.org/W6635289417"],"related_works":["https://openalex.org/W1790706710","https://openalex.org/W1823770435","https://openalex.org/W2120021898","https://openalex.org/W2174739588","https://openalex.org/W2057855370","https://openalex.org/W2078917215","https://openalex.org/W1940912229","https://openalex.org/W1855977133","https://openalex.org/W277446671","https://openalex.org/W1986381098"],"abstract_inverted_index":{"The":[0,47,127],"products":[1,48],"of":[2,6,14,19,25,30,39,49,53,62,72,77,85,95,103,114,123,131],"the":[3,36,50,104,124,145],"Polycomb":[4,31,105,140],"group":[5,32,52,79,138,141],"genes":[7,17,33,54,65,80],"are":[8,55],"cooperatively":[9,56],"involved":[10,57],"in":[11,35,58,82,107],"repressing":[12],"expression":[13,38,61,84],"homeotic":[15,63,146],"selector":[16,64,147],"outside":[18],"their":[20,67],"appropriate":[21,68],"anterior/posterior":[22,69],"boundaries.":[23,70],"Loss":[24,71],"maternal":[26,73],"and/or":[27,74],"zygotic":[28,75],"function":[29,76],"results":[34,81],"ectopic":[37],"both":[40,86],"Antennapedia":[41,87],"Complex":[42,45,88,91],"and":[43,89,155],"Bithorax":[44,90],"genes.":[46,92],"trithorax":[51,78,125,137],"maintaining":[59],"active":[60],"within":[66],"reduced":[83],"Although":[93],"Enhancer":[94,113,130],"zeste":[96,115,132],"has":[97],"been":[98],"classified":[99,119],"as":[100,120,134,150,152],"a":[101,121,136],"member":[102,122],"group,":[106],"this":[108],"paper":[109],"we":[110],"show":[111],"that":[112],"can":[116],"also":[117],"be":[118],"group.":[126],"requirement":[128],"for":[129],"activity":[133],"either":[135],"or":[139],"gene":[142,148],"depends":[143],"on":[144,153],"locus":[149],"well":[151],"spatial":[154],"temporal":[156],"cues.":[157]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}