{"id":"https://openalex.org/W2181635935","doi":null,"title":"Interspecies quorum sensing as a stress- anticipation signal in E. coli","display_name":"Interspecies quorum sensing as a stress- anticipation signal in E. coli","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2181635935","mag":"2181635935"},"language":"en","primary_location":{"id":"mag:2181635935","doi":null,"is_oa":false,"landing_page_url":"http://www2.bio.ku.dk/bibliotek/phd/Nina%20Molin%20H%F8yland-Kroghsbo.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080628093","display_name":"Nina Molin H\u00f8yland\u2010Kroghsbo","orcid":"https://orcid.org/0000-0001-5904-8859","observed_orcids":["https://orcid.org/0000-0001-5904-8859"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Nina Molin H\u00f8yland\u2010Kroghsbo","raw_affiliation_strings":["K\u00f8benhavns Universitet, Faculty of Science, Department of Biology, Biomolecular Sciences, DK"],"raw_orcid":"https://orcid.org/0000-0001-5904-8859","affiliations":[{"raw_affiliation_string":"K\u00f8benhavns Universitet, Faculty of Science, Department of Biology, Biomolecular Sciences, DK","institution_ids":["https://openalex.org/I124055696"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5080628093"],"corresponding_institution_ids":["https://openalex.org/I124055696"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/quorum-sensing","display_name":"quorum sensing","score":0.8270000219345093},{"id":"https://openalex.org/keywords/interspecies-communication","display_name":"interspecies communication","score":0.7739999890327454},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9359999895095825},{"id":"https://openalex.org/keywords/sdia","display_name":"SdiA","score":0.7429999709129333},{"id":"https://openalex.org/keywords/n-acyl-homoserine-lactones","display_name":"N-acyl homoserine lactones","score":0.8389999866485596},{"id":"https://openalex.org/keywords/bacteriophage-defense","display_name":"bacteriophage defense","score":0.8149999976158142},{"id":"https://openalex.org/keywords/bacteriophage-lambda","display_name":"bacteriophage lambda","score":0.906000018119812},{"id":"https://openalex.org/keywords/h-ns","display_name":"H-NS","score":0.9599999785423279},{"id":"https://openalex.org/keywords/general-stress-response","display_name":"general stress response","score":0.9639999866485596},{"id":"https://openalex.org/keywords/persister-cells","display_name":"persister cells","score":0.878000020980835},{"id":"https://openalex.org/keywords/antibiotic-tolerance","display_name":"antibiotic tolerance","score":0.9779999852180481},{"id":"https://openalex.org/keywords/quorum-sensing-inhibitors","display_name":"quorum sensing inhibitors","score":0.718999981880188},{"id":"https://openalex.org/keywords/intercellular-communication","display_name":"intercellular communication","score":0.6269999742507935},{"id":"https://openalex.org/keywords/bacterial-stress-adaptation","display_name":"bacterial stress adaptation","score":0.3059999942779541}],"concepts":[{"id":"https://openalex.org/C118687296","wikidata":"https://www.wikidata.org/wiki/Q905754","display_name":"Quorum sensing","level":4,"score":0.9327983260154724},{"id":"https://openalex.org/C176777502","wikidata":"https://www.wikidata.org/wiki/Q4774623","display_name":"Anticipation (artificial intelligence)","level":2,"score":0.7909582853317261},{"id":"https://openalex.org/C2779843651","wikidata":"https://www.wikidata.org/wiki/Q7390335","display_name":"SIGNAL (programming language)","level":2,"score":0.5204101800918579},{"id":"https://openalex.org/C21036866","wikidata":"https://www.wikidata.org/wiki/Q181767","display_name":"Stress (linguistics)","level":2,"score":0.4846392273902893},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3231351971626282},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.32277196645736694},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27729636430740356},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.1791296899318695},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17171263694763184},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.16985628008842468},{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.09903460741043091},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.063422292470932},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2181635935","doi":null,"is_oa":false,"landing_page_url":"http://www2.bio.ku.dk/bibliotek/phd/Nina%20Molin%20H%F8yland-Kroghsbo.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":123,"referenced_works":["https://openalex.org/W84733630","https://openalex.org/W85050023","https://openalex.org/W86041602","https://openalex.org/W201727952","https://openalex.org/W1486807157","https://openalex.org/W1502461125","https://openalex.org/W1512374553","https://openalex.org/W1520297488","https://openalex.org/W1544013284","https://openalex.org/W1546783991","https://openalex.org/W1562814008","https://openalex.org/W1571561217","https://openalex.org/W1576074336","https://openalex.org/W1591770463","https://openalex.org/W1616230851","https://openalex.org/W1619808619","https://openalex.org/W1813389134","https://openalex.org/W1822209500","https://openalex.org/W1838917369","https://openalex.org/W1888737815","https://openalex.org/W1895584462","https://openalex.org/W1965175092","https://openalex.org/W1966597734","https://openalex.org/W1971004618","https://openalex.org/W1978057171","https://openalex.org/W1983100789","https://openalex.org/W1983373334","https://openalex.org/W1983573298","https://openalex.org/W1984317216","https://openalex.org/W1984628925","https://openalex.org/W1985108077","https://openalex.org/W1987210208","https://openalex.org/W1989838936","https://openalex.org/W1990072082","https://openalex.org/W1990575687","https://openalex.org/W1991894713","https://openalex.org/W1992572387","https://openalex.org/W1993810129","https://openalex.org/W1998409894","https://openalex.org/W1998566510","https://openalex.org/W2002104214","https://openalex.org/W2002543601","https://openalex.org/W2017165733","https://openalex.org/W2017522869","https://openalex.org/W2019197162","https://openalex.org/W2021296860","https://openalex.org/W2021354930","https://openalex.org/W2028544954","https://openalex.org/W2028748650","https://openalex.org/W2030426089","https://openalex.org/W2031840883","https://openalex.org/W2038340418","https://openalex.org/W2042984507","https://openalex.org/W2043302089","https://openalex.org/W2049455719","https://openalex.org/W2049821596","https://openalex.org/W2051349181","https://openalex.org/W2055114795","https://openalex.org/W2059572695","https://openalex.org/W2060415998","https://openalex.org/W2062997771","https://openalex.org/W2063107514","https://openalex.org/W2063307415","https://openalex.org/W2064158324","https://openalex.org/W2066556718","https://openalex.org/W2067335755","https://openalex.org/W2068541829","https://openalex.org/W2070934708","https://openalex.org/W2073944837","https://openalex.org/W2092194560","https://openalex.org/W2092345495","https://openalex.org/W2094177464","https://openalex.org/W2096901958","https://openalex.org/W2097393614","https://openalex.org/W2100580791","https://openalex.org/W2100955083","https://openalex.org/W2103650497","https://openalex.org/W2104324648","https://openalex.org/W2105063611","https://openalex.org/W2105192434","https://openalex.org/W2105353470","https://openalex.org/W2106997643","https://openalex.org/W2107870682","https://openalex.org/W2109277022","https://openalex.org/W2110235509","https://openalex.org/W2110820790","https://openalex.org/W2111967267","https://openalex.org/W2112735187","https://openalex.org/W2115778087","https://openalex.org/W2116137883","https://openalex.org/W2118508162","https://openalex.org/W2118521369","https://openalex.org/W2124152757","https://openalex.org/W2124753857","https://openalex.org/W2124786260","https://openalex.org/W2125755185","https://openalex.org/W2126945584","https://openalex.org/W2127347791","https://openalex.org/W2130212719","https://openalex.org/W2130502159","https://openalex.org/W2134346985","https://openalex.org/W2134382101","https://openalex.org/W2135133274","https://openalex.org/W2138391117","https://openalex.org/W2140405224","https://openalex.org/W2141689686","https://openalex.org/W2142307902","https://openalex.org/W2143123756","https://openalex.org/W2145401678","https://openalex.org/W2146398613","https://openalex.org/W2147484502","https://openalex.org/W2154488487","https://openalex.org/W2156270624","https://openalex.org/W2157676942","https://openalex.org/W2157961554","https://openalex.org/W2158408911","https://openalex.org/W2159620582","https://openalex.org/W2161075828","https://openalex.org/W2163928116","https://openalex.org/W2165202736","https://openalex.org/W2166890714","https://openalex.org/W2168167613","https://openalex.org/W2319781286"],"related_works":["https://openalex.org/W2021296860","https://openalex.org/W7098715853","https://openalex.org/W1988153827","https://openalex.org/W4234089209","https://openalex.org/W2218780754","https://openalex.org/W7008439846","https://openalex.org/W55958298","https://openalex.org/W129343306","https://openalex.org/W120894467","https://openalex.org/W1973761827"],"abstract_inverted_index":{"Abstract":[0],"Uncovering":[1],"how":[2,8,40],"bacteria":[3,61,106],"perceive":[4],"environmental":[5,183,364],"signals":[6,104,170,341],"and":[7,63,80,97,100,111,208,243,361,406,408,418],"they":[9],"interpret":[10],"these,":[11],"in":[12,19,47,122,142,277,301,313,316,322,338,378],"order":[13,48],"to":[14,17,39,49,107,144,162,164,176,197,222,333,359,363,380,384,397,399],"constantly":[15],"adapt":[16,362],"changes":[18],"their":[20,381],"environment,":[21],"is":[22,128,140],"important":[23,90,370],"for":[24],"understanding":[25],"not":[26,344],"only":[27],"microbial":[28,116],"ecology":[29],"but":[30],"also":[31,311],"bacterial":[32,52,91,124,391],"pathogenesis.":[33],"Furthermore,":[34],"it":[35,260,281,342],"provides":[36,329],"cues":[37],"as":[38,58,271,373],"we":[41],"might":[42],"interfere":[43],"with":[44,237],"these":[45],"systems,":[46],"prevent":[50],"undesirable":[51],"behavior.":[53],"In":[54,325],"a":[55,71,115,272,330,400],"process":[56],"known":[57],"quorum":[59,77,102,136,146,168,190,216,353,374],"sensing,":[60],"emit":[62],"detect":[64],"small":[65],"diffusible":[66],"molecules,":[67],"which":[68,195],"upon":[69],"reaching":[70],"certain":[72],"extracellular":[73],"concentration,":[74],"activate":[75],"cellular":[76],"sensing":[78,88,103,137,147,169,217,354],"receptors":[79],"thereby":[81],"turn":[82],"on":[83,339],"group":[84],"behavior":[85],"genes.":[86],"Quorum":[87],"controls":[89],"behaviors,":[92],"including":[93],"bioluminescence,":[94],"biofilm":[95],"formation,":[96],"virulence.":[98],"Inter-":[99],"intraspecies":[101],"enable":[105],"estimate":[108],"the":[109,123,188,204,211,215,223,238,250,278,288,293,297,307,412],"abundance":[110],"species":[112],"complexity":[113],"of":[114,157,180,229,275,296,306,350,387,414,421],"community.":[117],"A":[118],"long":[119],"standing":[120],"question":[121],"cell-cell":[125],"communication":[126],"field":[127],"why":[129,334],"E.":[130,174,199,255,269,302,323,335,356],"coli":[131,175,200,256,270,336,357],"harbors":[132],"SdiA,":[133],"an":[134,232,314,424],"orphan":[135],"receptor":[138],"that":[139,225,235,252,263,284,348],"activated":[141],"response":[143,300,310],"AHL":[145,167,226,253,264,285,340,352],"molecules":[148],"produced":[149],"by":[150,173,203,249,268,355],"other":[151],"Gram-negative":[152],"species.":[153],"The":[154],"overall":[155],"aim":[156],"this":[158,327],"PhD":[159],"thesis":[160,186,328],"was":[161,261,282],"investigate":[163],"what":[165],"degree":[166],"are":[171],"exploited":[172],"increase":[177,315],"its":[178,246],"chances":[179],"surviving":[181],"potential":[182],"threats.":[184],"This":[185,366],"uncovers":[187],"first":[189],"sensing-regulated":[191],"bacteriophage":[192,205,258],"defense":[193,219],"mechanism,":[194,220],"serves":[196,358],"protect":[198],"against":[201],"infection":[202,422],"viruses":[206],"\u03bb":[207],"\u03c7.":[209],"Investigating":[210],"regulatory":[212,240],"mechanism":[213],"underlying":[214],"regulated":[218],"led":[221],"discovery":[224,251,367],"activates":[227],"expression":[228],"cnu,":[230],"encoding":[231],"Hha-family":[233],"protein":[234,241],"interacts":[236],"global":[239],"H-NS,":[242],"potentially":[244],"modifies":[245],"functions.":[247],"Inspired":[248],"protects":[254],"from":[257],"attacks,":[259],"hypothesized":[262],"may":[265,368],"be":[266],"perceived":[267],"general":[273,298,308],"signal":[274],"stress":[276,299,309],"environment.":[279],"Indeed,":[280],"discovered":[283],"signaling":[286],"upregulates":[287],"alternative":[289],"sigma":[290],"factor":[291],"\u03b4S,":[292],"master":[294],"regulator":[295],"coli.":[303,324],"AHL-mediated":[304],"activation":[305],"resulted":[312],"transiently":[317],"antibiotic":[318,425],"tolerant":[319],"persister":[320,415],"cells":[321],"conclusion,":[326],"key":[331],"answer":[332],"listens":[337],"does":[343],"itself":[345],"produce,":[346],"namely":[347],"detection":[349],"interspecies":[351],"anticipate-":[360],"stresses.":[365],"have":[369],"clinical":[371],"implications,":[372],"sensing-inhibitory":[375],"drugs":[376],"may,":[377],"addition":[379],"primary":[382],"purpose":[383],"decrease":[385],"virulence":[386],"pathogens,":[388],"additionally":[389,410],"weaken":[390],"defenses":[392],"thus":[393,419],"making":[394],"them":[395],"prone":[396],"succumb":[398],"patient\u2019s":[401],"own":[402],"immune":[403],"system,":[404],"bacteriophages,":[405],"antibiotics,":[407],"would":[409],"reduce":[411],"risk":[413],"cell":[416],"formation":[417],"relapse":[420],"after":[423],"treatment.":[426]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
