{"id":"https://openalex.org/W2181589980","doi":"https://doi.org/10.1371/journal.pone.0143588","title":"Evaluation of the Genetic Basis of Familial Aggregation of Pacemaker Implantation by a Large Next Generation Sequencing Panel","display_name":"Evaluation of the Genetic Basis of Familial Aggregation of Pacemaker Implantation by a Large Next Generation Sequencing Panel","publication_year":2015,"publication_date":"2015-12-04","ids":{"openalex":"https://openalex.org/W2181589980","doi":"https://doi.org/10.1371/journal.pone.0143588","mag":"2181589980","pmid":"https://pubmed.ncbi.nlm.nih.gov/26636822","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4670209"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0143588","doi":"https://doi.org/10.1371/journal.pone.0143588","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0143588","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0143588&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0143588&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004849126","display_name":"Patr\u00edcia B. S. Celestino-Soper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patr\u00edcia B. S. Celestino-Soper","raw_affiliation_strings":["Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, United States of America","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039196141","display_name":"Anisiia T. Doytchinova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anisiia Doytchinova","raw_affiliation_strings":["Krannert Institute of Cardiology, Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Krannert Institute of Cardiology, Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, United States of America","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130","https://openalex.org/I55769427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050547142","display_name":"Hillel A. Steiner","orcid":"https://orcid.org/0000-0003-0323-2248","observed_orcids":["https://orcid.org/0000-0003-0323-2248"]},"institutions":[{"id":"https://openalex.org/I13955877","display_name":"Bar-Ilan University","ror":"https://ror.org/03kgsv495","country_code":"IL","type":"education","lineage":["https://openalex.org/I13955877"]},{"id":"https://openalex.org/I4210138290","display_name":"Poriya Medical Center","ror":"https://ror.org/04aw32z04","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I4210138290"]},{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["IL","US"],"is_corresponding":false,"raw_author_name":"Hillel A. Steiner","raw_affiliation_strings":["Baruch Padeh Medical Center, Poriya MP Lower Galilee, Israel","Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, Israel","Krannert Institute of Cardiology, Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baruch Padeh Medical Center, Poriya MP Lower Galilee, Israel","institution_ids":["https://openalex.org/I4210138290"]},{"raw_affiliation_string":"Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, Israel","institution_ids":["https://openalex.org/I13955877"]},{"raw_affiliation_string":"Krannert Institute of Cardiology, Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, United States of America","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130","https://openalex.org/I55769427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037481503","display_name":"Andrea Uradu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrea Uradu","raw_affiliation_strings":["Krannert Institute of Cardiology, Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Krannert Institute of Cardiology, Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, United States of America","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130","https://openalex.org/I55769427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005569605","display_name":"Ty C. Lynnes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ty C. Lynnes","raw_affiliation_strings":["Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, United States of America","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023614317","display_name":"William J. Groh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William J. Groh","raw_affiliation_strings":["Krannert Institute of Cardiology, Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Krannert Institute of Cardiology, Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, United States of America","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130","https://openalex.org/I55769427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101723753","display_name":"John M. Miller","orcid":"https://orcid.org/0000-0002-1655-9621","observed_orcids":["https://orcid.org/0000-0002-1655-9621"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John M. Miller","raw_affiliation_strings":["Krannert Institute of Cardiology, Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Krannert Institute of Cardiology, Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, United States of America","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130","https://openalex.org/I55769427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012510396","display_name":"Hai Lin","orcid":"https://orcid.org/0000-0003-3376-1247","observed_orcids":["https://orcid.org/0000-0003-3376-1247"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hai Lin","raw_affiliation_strings":["Center for Computational Biology and Bioinformatics, Indiana University Purdue University Indianapolis, Indianapolis, IN, United States of America","Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Computational Biology and Bioinformatics, Indiana University Purdue University Indianapolis, Indianapolis, IN, United States of America","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I55769427"]},{"raw_affiliation_string":"Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, United States of America","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053600307","display_name":"Hongyu Gao","orcid":"https://orcid.org/0000-0001-7179-7705","observed_orcids":["https://orcid.org/0000-0001-7179-7705"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hongyu Gao","raw_affiliation_strings":["Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, United States of America","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060338311","display_name":"Zhiping Paul Wang","orcid":"https://orcid.org/0000-0002-3796-3164","observed_orcids":["https://orcid.org/0000-0002-3796-3164"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhiping Wang","raw_affiliation_strings":["Center for Computational Biology and Bioinformatics, Indiana University Purdue University Indianapolis, Indianapolis, IN, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Computational Biology and Bioinformatics, Indiana University Purdue University Indianapolis, Indianapolis, IN, United States of America","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I55769427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100337355","display_name":"Yunlong Liu","orcid":"https://orcid.org/0000-0002-2699-626X","observed_orcids":["https://orcid.org/0000-0002-2699-626X"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yunlong Liu","raw_affiliation_strings":["Center for Computational Biology and Bioinformatics, Indiana University Purdue University Indianapolis, Indianapolis, IN, United States of America","Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Computational Biology and Bioinformatics, Indiana University Purdue University Indianapolis, Indianapolis, IN, United States of America","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I55769427"]},{"raw_affiliation_string":"Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, United States of America","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032091908","display_name":"Peng\u2010Sheng Chen","orcid":"https://orcid.org/0000-0002-4150-5836","observed_orcids":["https://orcid.org/0000-0002-4150-5836"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peng-Sheng Chen","raw_affiliation_strings":["Krannert Institute of Cardiology, Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Krannert Institute of Cardiology, Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, United States of America","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130","https://openalex.org/I55769427"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004240247","display_name":"Matteo Vatta","orcid":"https://orcid.org/0000-0003-0962-8163","observed_orcids":["https://orcid.org/0000-0003-0962-8163","https://orcid.org/0000-0002-1742-7719"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Matteo Vatta","raw_affiliation_strings":["Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, United States of America","Krannert Institute of Cardiology, Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, United States of America","institution_ids":["https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Krannert Institute of Cardiology, Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, United States of America","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130","https://openalex.org/I55769427"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5004240247"],"corresponding_institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130","https://openalex.org/I55769427"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":0.6791,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.7463919,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"10","issue":"12","first_page":"e0143588","last_page":"e0143588"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10598","display_name":"Cardiac pacing and defibrillation studies","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/permanent-pacemaker","display_name":"permanent pacemaker","score":0.824999988079071},{"id":"https://openalex.org/keywords/sinus-node-dysfunction","display_name":"sick sinus syndrome","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cardiac-conduction-disorders","display_name":"cardiac conduction disorders","score":0.7149999737739563},{"id":"https://openalex.org/keywords/genetic-variants","display_name":"genetic variants","score":0.7450000047683716},{"id":"https://openalex.org/keywords/ldb3","display_name":"LDB3","score":0.8930000066757202},{"id":"https://openalex.org/keywords/trpm4","display_name":"TRPM4","score":1.0},{"id":"https://openalex.org/keywords/abcc9","display_name":"ABCC9","score":0.9959999918937683},{"id":"https://openalex.org/keywords/scn5a","display_name":"SCN5A","score":0.9990000128746033},{"id":"https://openalex.org/keywords/apolipoprotein-b","display_name":"apolipoprotein B","score":0.9919999837875366}],"concepts":[{"id":"https://openalex.org/C137627325","wikidata":"https://www.wikidata.org/wiki/Q156318","display_name":"Etiology","level":2,"score":0.6624866724014282},{"id":"https://openalex.org/C2780024892","wikidata":"https://www.wikidata.org/wiki/Q103397599","display_name":"Sick sinus syndrome","level":2,"score":0.6551315188407898},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5545008182525635},{"id":"https://openalex.org/C64618202","wikidata":"https://www.wikidata.org/wiki/Q3733697","display_name":"Genetic heterogeneity","level":4,"score":0.4995415210723877},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.46975448727607727},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.4275248646736145},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4197543263435364},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.38647782802581787},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3862198293209076},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38197237253189087},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3358137607574463},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.32735514640808105},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.29720672965049744},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.07619911432266235}],"mesh":[{"descriptor_ui":"D000075224","descriptor_name":"Cardiac Conduction System Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010138","descriptor_name":"Pacemaker, Artificial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012804","descriptor_name":"Sick Sinus Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012804","descriptor_name":"Sick Sinus Syndrome","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053840","descriptor_name":"Brugada Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D053840","descriptor_name":"Brugada Syndrome","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":11,"locations":[{"id":"doi:10.1371/journal.pone.0143588","doi":"https://doi.org/10.1371/journal.pone.0143588","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0143588","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0143588&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3651934","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4670209","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4670209","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4670209","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:26636822","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26636822","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmid:26771585","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26771585","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Published Erratum"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.785.8075","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.785.8075","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/9b/22/pone.0143588.PMC4670209.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:671e576e314343f9af53efa7ab3c57d5","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/671e576e314343f9af53efa7ab3c57d5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 10, Iss 12, p e0143588 (2015)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/1619530","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Evaluation_of_the_Genetic_Basis_of_Familial_Aggregation_of_Pacemaker_Implantation_by_a_Large_Next_Generation_Sequencing_Panel_/1619530","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:scholarworks.indianapolis.iu.edu:1805/11761","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1805/11761","pdf_url":null,"source":{"id":"https://openalex.org/S4306400987","display_name":"IUScholarWorks (Indiana University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I592451","host_organization_name":"Indiana University","host_organization_lineage":["https://openalex.org/I592451"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PMC","raw_type":"Article"},{"id":"pmh:oai:scholarworks.iupui.edu:1805/11761","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1805/11761","pdf_url":null,"source":{"id":"https://openalex.org/S4306400987","display_name":"IUScholarWorks (Indiana University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I592451","host_organization_name":"Indiana University","host_organization_lineage":["https://openalex.org/I592451"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PMC","raw_type":"Article"},{"id":"mag:2586274390","doi":null,"is_oa":false,"landing_page_url":"https://scholarworks.iupui.edu/handle/1805/11761","pdf_url":null,"source":{"id":"https://openalex.org/S4306522653","display_name":"PMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PMC","raw_type":null}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0143588","doi":"https://doi.org/10.1371/journal.pone.0143588","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0143588","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0143588&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G2560545833","display_name":"Indiana Clinical and Translational Sciences Institute","funder_award_id":"UL1TR001108","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4226004022","display_name":null,"funder_award_id":"HL78931","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4378690080","display_name":"Autonomic Nerve Activity and Paroxysmal Atrial Fibrillation","funder_award_id":"R01HL071140","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7906628923","display_name":"Indiana Clinical and Translational Science Institute (UL1)","funder_award_id":"UL1TR000006","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8628524073","display_name":"Cardiac Fibrillation: Mechanisms and Therapy","funder_award_id":"P01HL078931","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000332534","display_name":null,"funder_award_id":"HL71140","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G961236872","display_name":null,"funder_award_id":"HL-71140","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320307160","display_name":"American Physicians Fellowship for Medicine in Israel","ror":"https://ror.org/04w2t4465"},{"id":"https://openalex.org/F4320307758","display_name":"Eli Lilly and Company","ror":"https://ror.org/01qat3289"},{"id":"https://openalex.org/F4320309409","display_name":"Lilly Endowment","ror":"https://ror.org/00cpsd622"},{"id":"https://openalex.org/F4320312111","display_name":"Indiana University Health","ror":"https://ror.org/01aaptx40"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332450","display_name":"Bureau of Safety and Environmental Enforcement","ror":"https://ror.org/03v0pmy70"},{"id":"https://openalex.org/F4320332961","display_name":"School of Medicine, Indiana University","ror":null},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2181589980.pdf","grobid_xml":"https://content.openalex.org/works/W2181589980.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1491803208","https://openalex.org/W1507105217","https://openalex.org/W1966394599","https://openalex.org/W1968938328","https://openalex.org/W1976817880","https://openalex.org/W1980291961","https://openalex.org/W1983824705","https://openalex.org/W1993190948","https://openalex.org/W1997198528","https://openalex.org/W2012437009","https://openalex.org/W2025760921","https://openalex.org/W2027684356","https://openalex.org/W2037158044","https://openalex.org/W2039807612","https://openalex.org/W2046209699","https://openalex.org/W2051978340","https://openalex.org/W2057152418","https://openalex.org/W2063707906","https://openalex.org/W2070541908","https://openalex.org/W2072709438","https://openalex.org/W2078410619","https://openalex.org/W2093214695","https://openalex.org/W2093274439","https://openalex.org/W2093817369","https://openalex.org/W2100266916","https://openalex.org/W2108820485","https://openalex.org/W2109474924","https://openalex.org/W2116051448","https://openalex.org/W2129037083","https://openalex.org/W2151432329","https://openalex.org/W2156109088","https://openalex.org/W2160903094","https://openalex.org/W2172033623","https://openalex.org/W2547287502","https://openalex.org/W4238589708"],"related_works":["https://openalex.org/W7100917353","https://openalex.org/W2109474924","https://openalex.org/W2530946186","https://openalex.org/W4210354542","https://openalex.org/W4400485386","https://openalex.org/W2518671917","https://openalex.org/W3193195892","https://openalex.org/W2316059801","https://openalex.org/W4377983874","https://openalex.org/W7161752664"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,114,192],"etiology":[2],"of":[3,17,40,59,89,96,103,112,187,194,203,211],"conduction":[4,121],"disturbances":[5],"necessitating":[6],"permanent":[7],"pacemaker":[8],"(PPM)":[9],"implantation":[10],"is":[11],"often":[12],"unknown,":[13],"although":[14],"familial":[15],"aggregation":[16],"PPM":[18,70,189],"(faPPM)":[19],"suggests":[20],"a":[21,27,37,49,101,107,199,207,231],"possible":[22],"genetic":[23,227],"basis.":[24],"We":[25,45,67],"developed":[26],"pan-cardiovascular":[28],"next":[29],"generation":[30],"sequencing":[31,197],"(NGS)":[32],"panel":[33,52,86,202],"to":[34,78],"genetically":[35],"characterize":[36],"selected":[38,73,201],"cohort":[39],"faPPM.":[41,234],"MATERIALS":[42],"AND":[43],"METHODS:":[44],"designed":[46],"and":[47,56,72,156,165,172,175],"validated":[48],"custom":[50],"NGS":[51,85],"targeting":[53],"the":[54,90,212],"coding":[55],"splicing":[57],"regions":[58],"246":[60],"genes":[61,205],"with":[62,76,93,118,215],"involvement":[63],"in":[64,147,160,169,179,185,220,233],"cardiac":[65,120,150,223],"pathogenicity.":[66],"enrolled":[68],"112":[69],"patients":[71,116,139,214],"nine":[74],"(8%)":[75],"faPPM":[77,115,213],"be":[79],"analyzed":[80],"by":[81],"NGS.":[82],"RESULTS:":[83],"Our":[84],"covers":[87],"95%":[88],"intended":[91],"target":[92],"an":[94],"average":[95],"229x":[97],"read":[98],"depth":[99],"at":[100],"minimum":[102],"15-fold":[104],"depth,":[105],"reaching":[106],"SNP":[108],"true":[109],"positive":[110],"rate":[111],"98%.":[113],"presented":[117],"isolated":[119],"disease":[122,133],"(ICCD)":[123],"or":[124,134],"sick":[125],"sinus":[126],"syndrome":[127],"(SSS)":[128],"without":[129],"overt":[130],"structural":[131],"heart":[132],"identifiable":[135],"secondary":[136],"etiology.":[137],"Three":[138],"(33.3%)":[140,210],"had":[141],"heterozygous":[142],"deleterious":[143,216],"variants":[144,159,168,178,217,228],"previously":[145,218],"reported":[146,219],"autosomal":[148,221],"dominant":[149,222],"diseases":[151],"including":[152],"CCD:":[153],"LDB3":[154],"(p.D117N)":[155],"TRPM4":[157,163],"(p.G844D)":[158,164],"patient":[161,170,180],"4;":[162],"ABCC9":[166],"(p.V734I)":[167],"6;":[171],"SCN5A":[173],"(p.T220I)":[174],"APOB":[176],"(p.R3527Q)":[177],"7.":[181],"CONCLUSION:":[182],"FaPPM":[183],"occurred":[184],"8%":[186],"our":[188],"clinic":[190],"population.":[191],"employment":[193],"massive":[195],"parallel":[196],"for":[198],"large":[200],"cardiovascular":[204],"identified":[206],"high":[208],"percentage":[209],"diseases,":[224],"suggesting":[225],"that":[226],"may":[229],"play":[230],"role":[232]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
