{"id":"https://openalex.org/W2181532764","doi":null,"title":"Micro bioreactor for muliwell plates with an active micro fluidic system for 3D cultivation","display_name":"Micro bioreactor for muliwell plates with an active micro fluidic system for 3D cultivation","publication_year":2008,"publication_date":"2008-06-01","ids":{"openalex":"https://openalex.org/W2181532764","mag":"2181532764"},"language":"en","primary_location":{"id":"mag:2181532764","doi":null,"is_oa":false,"landing_page_url":"https://briefs.techconnect.org/wp-content/volumes/Nanotech2008v3/pdf/630.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306531643","display_name":"TechConnect Briefs","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"TechConnect Briefs","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060216300","display_name":"Frank Weise","orcid":"https://orcid.org/0000-0002-4513-987X","observed_orcids":["https://orcid.org/0000-0002-4513-987X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Frank Weise","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072527488","display_name":"Caroline Augspurger","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Caroline Augspurger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041920290","display_name":"Maren Klett","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maren Klett","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072845554","display_name":"Stefan Giselbrecht","orcid":"https://orcid.org/0000-0002-1354-0167","observed_orcids":["https://orcid.org/0000-0002-1354-0167"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stefan Giselbrecht","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1354-0167","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064393604","display_name":"Gregor Schlingloff","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gregor Schlingloff","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5101976554","display_name":"Andreas Schober","orcid":"https://orcid.org/0000-0002-1818-4878","observed_orcids":["https://orcid.org/0000-0002-1818-4878"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andreas Schober","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1818-4878","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"3","issue":"2008","first_page":"288","last_page":"291"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.67330002784729,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.67330002784729,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.31619998812675476,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microbioreactors","display_name":"microbioreactors","score":0.9340000152587891},{"id":"https://openalex.org/keywords/microfluidics","display_name":"microfluidics","score":0.7160000205039978},{"id":"https://openalex.org/keywords/3d-cell-culture","display_name":"3D cell culture","score":0.8429999947547913},{"id":"https://openalex.org/keywords/microtiter-plates","display_name":"microplates","score":0.722000002861023},{"id":"https://openalex.org/keywords/micropumps","display_name":"micropumps","score":0.6399999856948853},{"id":"https://openalex.org/keywords/hepg2-cells","display_name":"HepG2 cells","score":0.8199999928474426},{"id":"https://openalex.org/keywords/oxygen-consumption","display_name":"oxygen consumption","score":0.8040000200271606},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.9890000224113464},{"id":"https://openalex.org/keywords/drug-screening","display_name":"drug screening","score":0.828000009059906},{"id":"https://openalex.org/keywords/miniaturization","display_name":"miniaturization","score":0.527999997138977}],"concepts":[{"id":"https://openalex.org/C168170006","wikidata":"https://www.wikidata.org/wiki/Q864699","display_name":"Bioreactor","level":2,"score":0.7174091339111328},{"id":"https://openalex.org/C132651336","wikidata":"https://www.wikidata.org/wiki/Q185571","display_name":"Fluidics","level":2,"score":0.642460286617279},{"id":"https://openalex.org/C2778012447","wikidata":"https://www.wikidata.org/wiki/Q1034415","display_name":"Scope (computer science)","level":2,"score":0.6175209283828735},{"id":"https://openalex.org/C138942068","wikidata":"https://www.wikidata.org/wiki/Q633261","display_name":"Lab-on-a-chip","level":3,"score":0.4682641625404358},{"id":"https://openalex.org/C21880701","wikidata":"https://www.wikidata.org/wiki/Q2144042","display_name":"Process engineering","level":1,"score":0.45678624510765076},{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.4190223813056946},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4114544689655304},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3942904770374298},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.389245867729187},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.3850623071193695},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.3574722409248352},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.2936762571334839},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1890764832496643},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.13911926746368408},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2181532764","doi":null,"is_oa":false,"landing_page_url":"https://briefs.techconnect.org/wp-content/volumes/Nanotech2008v3/pdf/630.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306531643","display_name":"TechConnect Briefs","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"TechConnect Briefs","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":3,"referenced_works":["https://openalex.org/W1981079112","https://openalex.org/W2033530021","https://openalex.org/W2140723257"],"related_works":["https://openalex.org/W2107684565","https://openalex.org/W2051494648","https://openalex.org/W7204646707","https://openalex.org/W3010972031","https://openalex.org/W2161349337","https://openalex.org/W4206616520","https://openalex.org/W2925880270","https://openalex.org/W2972703858","https://openalex.org/W6980952785","https://openalex.org/W2019249427"],"abstract_inverted_index":{"Recently":[0],"it":[1,69],"has":[2],"been":[3],"shown":[4],"that":[5,68],"3D":[6],"cultivation":[7],"of":[8,24,93,98,105,150],"cells":[9,45,114,123,132,152],"and":[10,102,153],"tissues":[11],"show":[12],"great":[13],"potential":[14],"for":[15,41],"bio/medical":[16],"research":[17],"[1].":[18],"Within":[19],"this":[20,120,139],"scope":[21],"are":[22,124,157],"developments":[23],"micro":[25,28,37,84],"bioreactors":[26],"with":[27,81,145],"fluidic":[29],"support":[30],"structures":[31],"[2].":[32],"We":[33],"have":[34],"designed":[35],"a":[36,66,73,89],"system":[38,49,61,80,95,109,142],"-":[39],"suitable":[40],"parallelization":[42],"to":[43,112,129,147],"cultivate":[44],"three":[46,117],"dimensionally.":[47,118],"This":[48,108],"is":[50,62,70,86,96,143],"based":[51],"on":[52],"the":[53,103,122,151],"CellChip":[54],"bioreactor":[55],"from":[56],"FZK":[57],"(Forschungszentrum":[58],"Karlsruhe).":[59],"Our":[60],"miniaturized":[63],"in":[64,126,138],"such":[65],"way":[67],"implementable":[71],"into":[72],"24":[74],"well":[75],"plate.":[76],"A":[77],"single":[78],"channel":[79],"an":[82],"integrated":[83],"pump":[85],"manufactured":[87],"as":[88],"prototype.":[90],"The":[91,141],"aim":[92],"our":[94],"reduction":[97],"costs,":[99],"animal":[100],"experiments":[101],"acceleration":[104],"drug":[106],"screening.":[107],"uses":[110],"CellChips":[111],"grow":[113],"organ-like,":[115],"i.e.":[116],"In":[119],"chip":[121],"located":[125],"containers.":[127],"Up":[128],"2":[130],"million":[131],"like":[133],"HepG2":[134],"can":[135],"be":[136],"cultivated":[137],"system.":[140],"characterized":[144],"respect":[146],"oxygen":[148],"consumption":[149],"cell":[154],"viability.":[155],"24-channel-systems":[156],"under":[158],"construction.":[159]},"counts_by_year":[],"updated_date":"2025-10-10T17:16:08.811792","created_date":"2016-06-24T00:00:00"}