{"id":"https://openalex.org/W2181515467","doi":null,"title":"The role of shellfish proteases in allergic diseases and inflammation","display_name":"The role of shellfish proteases in allergic diseases and inflammation","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2181515467","mag":"2181515467"},"language":"en","primary_location":{"id":"pmh:oai:researchonline.jcu.edu.au:28331","doi":null,"is_oa":false,"landing_page_url":"https://researchonline.jcu.edu.au/28331/1/Role%20of%20shellfish%20Proteases-CACI-2010.pdf","pdf_url":"https://researchonline.jcu.edu.au/28331/1/Role%20of%20shellfish%20Proteases-CACI-2010.pdf","source":{"id":"https://openalex.org/S4377196350","display_name":"ResearchOnline - JCU (James Cook University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86467917","host_organization_name":"James Cook University","host_organization_lineage":["https://openalex.org/I86467917"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005087081","display_name":"Shansun Sun","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shansun Sun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5079654252","display_name":"Andreas Ludwig Lopata","orcid":"https://orcid.org/0000-0002-2940-9235","observed_orcids":["https://orcid.org/0000-0002-2940-9235"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andreas L. Lopata","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2940-9235","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6388,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.68843006,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"23","issue":"4","first_page":"174","last_page":"179"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10634","display_name":"Food Allergy and Anaphylaxis Research","score":0.9413999915122986,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10634","display_name":"Food Allergy and Anaphylaxis Research","score":0.9413999915122986,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.018799999728798866,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.008200000040233135,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/shellfish-allergens","display_name":"shellfish allergens","score":0.8809999823570251},{"id":"https://openalex.org/keywords/protease","display_name":"proteolytic enzymes","score":0.8349999785423279},{"id":"https://openalex.org/keywords/allergic-reactions","display_name":"allergic reactions","score":0.4620000123977661},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.8050000071525574},{"id":"https://openalex.org/keywords/protease-activated-receptors","display_name":"protease-activated receptors","score":0.953000009059906},{"id":"https://openalex.org/keywords/non-ige-mediated-allergy","display_name":"non-IgE-mediated allergy","score":0.8550000190734863},{"id":"https://openalex.org/keywords/trypsin-like-activity","display_name":"trypsin-like activity","score":0.8019999861717224},{"id":"https://openalex.org/keywords/spiny-lobster","display_name":"spiny lobster","score":0.953000009059906},{"id":"https://openalex.org/keywords/shrimp","display_name":"shrimp","score":0.9309999942779541},{"id":"https://openalex.org/keywords/inhalation-exposure","display_name":"inhalation exposure","score":0.5730000138282776},{"id":"https://openalex.org/keywords/occupational-exposure","display_name":"occupational exposure","score":0.6110000014305115},{"id":"https://openalex.org/keywords/food-allergy","display_name":"food allergy","score":0.4729999899864197}],"concepts":[{"id":"https://openalex.org/C182220744","wikidata":"https://www.wikidata.org/wiki/Q7251226","display_name":"Proteases","level":3,"score":0.973070502281189},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.5109637975692749},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4979979991912842},{"id":"https://openalex.org/C2779675166","wikidata":"https://www.wikidata.org/wiki/Q4732119","display_name":"Allergic inflammation","level":3,"score":0.4942004978656769},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4834369122982025},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4643360376358032},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4394621253013611},{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.4151410460472107},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3974305987358093},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3825991153717041},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3135303854942322},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.27001458406448364}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:researchonline.jcu.edu.au:28331","doi":null,"is_oa":false,"landing_page_url":"https://researchonline.jcu.edu.au/28331/1/Role%20of%20shellfish%20Proteases-CACI-2010.pdf","pdf_url":"https://researchonline.jcu.edu.au/28331/1/Role%20of%20shellfish%20Proteases-CACI-2010.pdf","source":{"id":"https://openalex.org/S4377196350","display_name":"ResearchOnline - JCU (James Cook University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86467917","host_organization_name":"James Cook University","host_organization_lineage":["https://openalex.org/I86467917"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"mag:2181515467","doi":null,"is_oa":false,"landing_page_url":"http://reference.sabinet.co.za/webx/access/electronic_journals/caci/caci_v23_n4_a6.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"mag:2253148060","doi":null,"is_oa":false,"landing_page_url":"https://journals.co.za/content/caci/23/4/EJC21687","pdf_url":null,"source":{"id":"https://openalex.org/S947814336","display_name":"Current allergy & clinical immunology","issn_l":"1609-3607","issn":["1609-3607"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dhet","poland-20","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Current allergy & clinical immunology","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.46810001134872437,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1489193873","https://openalex.org/W1533133853","https://openalex.org/W1966477298","https://openalex.org/W1972307445","https://openalex.org/W1979525944","https://openalex.org/W1985375860","https://openalex.org/W1994927844","https://openalex.org/W2004075329","https://openalex.org/W2012472171","https://openalex.org/W2025233478","https://openalex.org/W2028012838","https://openalex.org/W2032226763","https://openalex.org/W2037344361","https://openalex.org/W2037438618","https://openalex.org/W2041062445","https://openalex.org/W2043345697","https://openalex.org/W2044164764","https://openalex.org/W2060062557","https://openalex.org/W2062322706","https://openalex.org/W2085319206","https://openalex.org/W2087988433","https://openalex.org/W2088009410","https://openalex.org/W2091153860","https://openalex.org/W2097863533","https://openalex.org/W2103127771","https://openalex.org/W2103826062","https://openalex.org/W2106104066","https://openalex.org/W2107355870","https://openalex.org/W2109960877","https://openalex.org/W2110665952","https://openalex.org/W2114295911","https://openalex.org/W2116809392","https://openalex.org/W2125842347","https://openalex.org/W2135563623","https://openalex.org/W2145896572","https://openalex.org/W2149546317","https://openalex.org/W2171694182","https://openalex.org/W3135773419"],"related_works":["https://openalex.org/W4321004790","https://openalex.org/W2092701738","https://openalex.org/W7096908385","https://openalex.org/W1977056120","https://openalex.org/W4235542589","https://openalex.org/W2077331559","https://openalex.org/W4283721667","https://openalex.org/W2070864160","https://openalex.org/W1969235413","https://openalex.org/W2560627435"],"abstract_inverted_index":{"Proteases":[0],"are":[1,31,91],"well-known":[2],"proteins":[3],"involved":[4,110],"in":[5,13,111,122,144,160,194,204],"the":[6,14,117,134,137,156,166,178,184,190,205],"enzymatic":[7],"digestion":[8],"of":[9,16,62,83,120,139,142,177,192],"food":[10],"but":[11,71],"also":[12,23,72],"regulation":[15],"blood":[17],"coagulation":[18],"and":[19,27,36,55,74,108,124,147,196,207],"homeostasis.":[20],"However,":[21,57],"proteases":[22,44,68,78,121,143,193],"have":[24],"allergenic":[25,43],"potential":[26],"about":[28],"60":[29],"allergens":[30,50,203],"currently":[32],"characterised":[33,47],"from":[34,129],"plant":[35],"animal":[37],"sources.":[38],"IgE-mediated":[39],"allergic":[40,112,123,195],"sensitisation":[41],"to":[42,154,175,201],"is":[45,59,183],"well":[46],"for":[48,133,186],"inhaled":[49],"such":[51],"as":[52],"moulds,":[53],"cockroaches":[54],"mites.":[56],"there":[58],"growing":[60],"evidence":[61],"non-IgE-mediated":[63],"inflammation":[64],"triggered":[65],"by":[66],"exogenous":[67],"via":[69],"inhalation":[70],"ingestion":[73],"skin":[75],"contact.":[76],"These":[77],"can":[79],"activate":[80],"a":[81],"set":[82],"four":[84,140],"distinct":[85],"receptors":[86,88],"(protease-activated":[87],"(PAR)),":[89],"which":[90],"found":[92],"on":[93],"virtually":[94],"all":[95,161],"cells":[96],"(mast":[97],"cells,":[98],"epithelium,":[99],"eosinophils,":[100],"neutrophils,":[101],"monocytes-macrophages,":[102],"lymphocytes,":[103],"smooth":[104],"muscle,":[105],"endothelium,":[106],"fibroblasts":[107],"neurons)":[109],"reactions.":[113,126],"This":[114,181],"review":[115],"outlines":[116],"different":[118],"roles":[119],"inflammatory":[125,197],"Preliminary":[127],"data":[128],"our":[130],"group":[131],"demonstrate":[132],"first":[135],"time":[136],"presence":[138],"types":[141],"rock":[145],"lobster":[146],"two":[148],"shrimp":[149],"species.":[150],"Trypsin-like":[151],"activity":[152,169],"seems":[153],"be":[155],"major":[157],"enzyme":[158],"action":[159],"three":[162],"shellfish":[163,202],"species,":[164],"with":[165],"highest":[167],"proteolytic":[168],"occurring":[170],"under":[171],"physiological":[172],"conditions":[173],"similar":[174],"those":[176],"lung":[179],"environment.":[180,209],"study":[182],"foundation":[185],"further":[187],"investigations":[188],"into":[189],"role":[191],"reactions":[198],"towards":[199],"exposure":[200],"occupational":[206],"domestic":[208]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}