{"id":"https://openalex.org/W2181484973","doi":"https://doi.org/10.1152/ajpregu.2001.281.6.r1792","title":"Substance P modulates nicotinic responses of intracardiac neurons to acetylcholine in the guinea pig","display_name":"Substance P modulates nicotinic responses of intracardiac neurons to acetylcholine in the guinea pig","publication_year":2001,"publication_date":"2001-12-01","ids":{"openalex":"https://openalex.org/W2181484973","doi":"https://doi.org/10.1152/ajpregu.2001.281.6.r1792","mag":"2181484973","pmid":"https://pubmed.ncbi.nlm.nih.gov/11705763"},"language":"en","primary_location":{"id":"doi:10.1152/ajpregu.2001.281.6.r1792","doi":"https://doi.org/10.1152/ajpregu.2001.281.6.r1792","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpregu.2001.281.6.r1792","pdf_url":null,"source":{"id":"https://openalex.org/S59702976","display_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","issn_l":"0363-6119","issn":["0363-6119","1522-1490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100461213","display_name":"Lili Zhang","orcid":"https://orcid.org/0000-0003-0935-4991","observed_orcids":["https://orcid.org/0000-0003-0935-4991"]},"institutions":[{"id":"https://openalex.org/I119443389","display_name":"East Tennessee State University","ror":"https://ror.org/05rfqv493","country_code":"US","type":"education","lineage":["https://openalex.org/I119443389"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lili Zhang","raw_affiliation_strings":["Department of Pharmacology, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614","institution_ids":["https://openalex.org/I119443389"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079848620","display_name":"John D. Tompkins","orcid":"https://orcid.org/0000-0001-9496-7930","observed_orcids":["https://orcid.org/0000-0001-9496-7930"]},"institutions":[{"id":"https://openalex.org/I119443389","display_name":"East Tennessee State University","ror":"https://ror.org/05rfqv493","country_code":"US","type":"education","lineage":["https://openalex.org/I119443389"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John D. Tompkins","raw_affiliation_strings":["Department of Pharmacology, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614","institution_ids":["https://openalex.org/I119443389"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013354311","display_name":"John C. Hancock","orcid":"https://orcid.org/0000-0002-7747-7814","observed_orcids":["https://orcid.org/0000-0002-7747-7814"]},"institutions":[{"id":"https://openalex.org/I119443389","display_name":"East Tennessee State University","ror":"https://ror.org/05rfqv493","country_code":"US","type":"education","lineage":["https://openalex.org/I119443389"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John C. Hancock","raw_affiliation_strings":["Department of Pharmacology, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614","institution_ids":["https://openalex.org/I119443389"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008488759","display_name":"Donald B. Hoover","orcid":"https://orcid.org/0000-0002-0845-2488","observed_orcids":["https://orcid.org/0000-0002-0845-2488"]},"institutions":[{"id":"https://openalex.org/I119443389","display_name":"East Tennessee State University","ror":"https://ror.org/05rfqv493","country_code":"US","type":"education","lineage":["https://openalex.org/I119443389"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald B. Hoover","raw_affiliation_strings":["Department of Pharmacology, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614","institution_ids":["https://openalex.org/I119443389"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I119443389"],"apc_list":null,"apc_paid":null,"fwci":0.6139,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.61414285,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"281","issue":"6","first_page":"R1792","last_page":"R1800"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.7470999956130981,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.7470999956130981,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.09160000085830688,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.03180000185966492,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/substance-p","display_name":"substance P","score":1.0},{"id":"https://openalex.org/keywords/acetylcholine","display_name":"acetylcholine","score":0.8930000066757202},{"id":"https://openalex.org/keywords/nicotinic-acetylcholine-receptors","display_name":"nicotinic acetylcholine receptors","score":0.7860000133514404},{"id":"https://openalex.org/keywords/intracardiac-neurons","display_name":"intracardiac neurons","score":0.9900000095367432},{"id":"https://openalex.org/keywords/neuronal-excitability","display_name":"neuronal excitability","score":0.7110000252723694},{"id":"https://openalex.org/keywords/neuromodulation","display_name":"neuromodulation","score":0.7099999785423279},{"id":"https://openalex.org/keywords/action-potential-generation","display_name":"action potential generation","score":0.7120000123977661},{"id":"https://openalex.org/keywords/cardiac-innervation","display_name":"cardiac innervation","score":0.5189999938011169},{"id":"https://openalex.org/keywords/guinea-pig-heart","display_name":"guinea pig heart","score":0.718999981880188}],"concepts":[{"id":"https://openalex.org/C4141045","wikidata":"https://www.wikidata.org/wiki/Q83183","display_name":"Depolarization","level":2,"score":0.8257447481155396},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.7041153907775879},{"id":"https://openalex.org/C2775910092","wikidata":"https://www.wikidata.org/wiki/Q180623","display_name":"Acetylcholine","level":2,"score":0.6904944777488708},{"id":"https://openalex.org/C80093799","wikidata":"https://www.wikidata.org/wiki/Q366155","display_name":"Intracardiac injection","level":2,"score":0.5778650641441345},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4913457930088043},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.473032683134079},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.45307183265686035},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.44476401805877686},{"id":"https://openalex.org/C188987157","wikidata":"https://www.wikidata.org/wiki/Q7030581","display_name":"Nicotinic agonist","level":3,"score":0.4407656788825989},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.38492727279663086},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3407227396965027},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.32782483100891113},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28399425745010376},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26426249742507935},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.05441126227378845}],"mesh":[{"descriptor_ui":"D000109","descriptor_name":"Acetylcholine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000294","qualifier_name":"innervation","is_major_topic":true},{"descriptor_ui":"D006329","descriptor_name":"Heart Conduction System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008839","descriptor_name":"Microelectrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011978","descriptor_name":"Receptors, Nicotinic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011978","descriptor_name":"Receptors, Nicotinic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013373","descriptor_name":"Substance P","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1152/ajpregu.2001.281.6.r1792","doi":"https://doi.org/10.1152/ajpregu.2001.281.6.r1792","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpregu.2001.281.6.r1792","pdf_url":null,"source":{"id":"https://openalex.org/S59702976","display_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","issn_l":"0363-6119","issn":["0363-6119","1522-1490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","raw_type":"journal-article"},{"id":"pmid:11705763","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11705763","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Regulatory, integrative and comparative physiology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.984.7410","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.984.7410","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://ajpregu.physiology.org/content/ajpregu/281/6/R1792.full.pdf","raw_type":"text"},{"id":"pmh:oai:dc.etsu.edu:etsu-works-20413","doi":null,"is_oa":false,"landing_page_url":"https://dc.etsu.edu/etsu-works/19147","pdf_url":null,"source":{"id":"https://openalex.org/S4377196424","display_name":"Digital Commons - East Tennessee State University (East Tennessee State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I119443389","host_organization_name":"East Tennessee State University","host_organization_lineage":["https://openalex.org/I119443389"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ETSU Faculty Works","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.7400000095367432,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4126721319","display_name":"Role of Nonclassical Transmitters in Cardiac Ganglia","funder_award_id":"R01HL054633","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G563969557","display_name":null,"funder_award_id":"HL54633","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W17546384","https://openalex.org/W619070191","https://openalex.org/W1540477849","https://openalex.org/W1825886678","https://openalex.org/W1860985526","https://openalex.org/W1966193155","https://openalex.org/W1973013584","https://openalex.org/W1977495357","https://openalex.org/W1988003878","https://openalex.org/W1988593402","https://openalex.org/W1995575495","https://openalex.org/W1998211252","https://openalex.org/W1998657985","https://openalex.org/W2004264169","https://openalex.org/W2014109746","https://openalex.org/W2034572815","https://openalex.org/W2039310983","https://openalex.org/W2060461617","https://openalex.org/W2064765935","https://openalex.org/W2076282756","https://openalex.org/W2076658540","https://openalex.org/W2082796494","https://openalex.org/W2094542138","https://openalex.org/W2122521547","https://openalex.org/W2123379095","https://openalex.org/W2162316700","https://openalex.org/W2184046189","https://openalex.org/W2196466700","https://openalex.org/W2204138544","https://openalex.org/W2214068110","https://openalex.org/W2266678863","https://openalex.org/W2310502267","https://openalex.org/W2323492642","https://openalex.org/W2409569707","https://openalex.org/W2416271113","https://openalex.org/W2425649105","https://openalex.org/W4252039959"],"related_works":["https://openalex.org/W2010537804","https://openalex.org/W2406369721","https://openalex.org/W2082796494","https://openalex.org/W1973013584","https://openalex.org/W2072490606","https://openalex.org/W2977908669","https://openalex.org/W2206252531","https://openalex.org/W17546384","https://openalex.org/W1992148854","https://openalex.org/W2023002363"],"abstract_inverted_index":{"Application":[0],"of":[1,8,28,34,47,54,66,79,92,98,106,132,142,154,188,191,212,237,243,264],"substance":[2],"P":[3,182],"(SP)":[4],"to":[5,24,37,44,137,194,204,223],"intracardiac":[6,35,48,107,143,214,262],"neurons":[7,36,49,81,108,144,215],"the":[9,26,93,116,192,213,250,265],"guinea":[10,60,266],"pig":[11,61],"causes":[12],"slow":[13,77],"depolarization":[14,78,105,157,240],"and":[15,85,225,229,259],"increases":[16],"neuronal":[17],"excitability.":[18],"The":[19],"present":[20],"study":[21],"was":[22,230],"done":[23],"determine":[25],"influence":[27],"SP":[29,69,99,123,164,177,209,228,253],"on":[30],"fast":[31,156,239],"excitatory":[32],"responses":[33,46,126,203],"ACh.":[38],"Intracellular":[39],"recording":[40],"methods":[41],"were":[42,206],"used":[43],"measure":[45],"in":[50,90,140,152,198,210,235,261],"whole":[51],"mount":[52],"preparations":[53],"atrial":[55],"ganglionated":[56],"nerve":[57],"plexus":[58],"from":[59,72],"hearts.":[62],"Local":[63],"pressure":[64,130],"ejection":[65],"100":[67,226],"microM":[68,163,227],"(1":[70],"s)":[71],"a":[73,103,233,257],"glass":[74],"micropipette":[75],"caused":[76,102],"all":[80],"(n":[82,146],"=":[83,147,180,183],"38)":[84],"triggered":[86],"action":[87,112,199,245],"potential":[88,200],"generation":[89],"47%":[91],"cells":[94],"tested.":[95],"Bath":[96],"application":[97],"(0.5-100":[100],"microM)":[101],"dose-dependent":[104],"but":[109],"rarely":[110],"evoked":[111,127],"potentials,":[113],"even":[114],"at":[115],"highest":[117],"concentration.":[118],"However,":[119,202],"such":[120],"treatment":[121,160],"with":[122,161,176],"enhanced":[124],"nicotinic":[125,238],"by":[128,208],"local":[129],"ejections":[131],"ACh":[133,195,205],"(10":[134],"mM,":[135],"10-":[136],"100-ms":[138],"duration)":[139],"77%":[141],"studied":[145],"52).":[148],"A":[149],"significant":[150],"increase":[151],"amplitude":[153,236],"ACh-evoked":[155,244],"occurred":[158,219],"during":[159,221],"0.5":[162],"(13.0":[165],"+/-":[166,173],"1.8":[167],"mV":[168,175],"for":[169],"control":[170],"vs.":[171],"17.7":[172],"1.9":[174],"present,":[178],"n":[179],"7,":[181],"0.019).":[184],"At":[185],"higher":[186],"concentrations":[187],"SP,":[189],"enhancement":[190],"response":[193],"resulted":[196],"mainly":[197],"generation.":[201],"attenuated":[207],"15%":[211],"studied.":[216],"This":[217],"attenuation":[218],"primarily":[220],"exposure":[222],"10":[224],"manifest":[231],"as":[232,256],"reduction":[234],"or":[241],"inhibition":[242],"potentials.":[246],"These":[247],"findings":[248],"support":[249],"conclusion":[251],"that":[252],"could":[254],"function":[255],"neuromodulator":[258],"neurotransmitter":[260],"ganglia":[263],"pig.":[267]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
