{"id":"https://openalex.org/W2181479899","doi":null,"title":"Insoluble fraction of tumor cell homogenate is a useful material for eliciting cytotoxic T lymphocytes: a unique method for protein solubilization.","display_name":"Insoluble fraction of tumor cell homogenate is a useful material for eliciting cytotoxic T lymphocytes: a unique method for protein solubilization.","publication_year":2011,"publication_date":"2011-03-01","ids":{"openalex":"https://openalex.org/W2181479899","mag":"2181479899","pmid":"https://pubmed.ncbi.nlm.nih.gov/21498709"},"language":"en","primary_location":{"id":"pmid:21498709","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21498709","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046218484","display_name":"Eri Kuwada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405263801","display_name":"Medinet Co., Ltd. (Japan)","ror":"https://ror.org/003m9jr97","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405263801"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Eri Kuwada","raw_affiliation_strings":["Medinet Medical Institute, MEDINET Co., Ltd., 2-2-8 Tamagawadai, Setagayaku, Tokyo 158-0096, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medinet Medical Institute, MEDINET Co., Ltd., 2-2-8 Tamagawadai, Setagayaku, Tokyo 158-0096, Japan","institution_ids":["https://openalex.org/I4405263801"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074382103","display_name":"Kaori Kambara","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kaori Kambara","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015907223","display_name":"Toshimasa Tadaki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Toshimasa Tadaki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5049395052","display_name":"Katsuo Noguchi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Katsuo Noguchi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2633,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.53881261,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"31","issue":"3","first_page":"881","last_page":"91"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dendritic-cell-based-cancer-immunotherapy","display_name":"dendritic cell-based cancer immunotherapy","score":0.8790000081062317},{"id":"https://openalex.org/keywords/insoluble-fraction","display_name":"insoluble fraction","score":0.8450000286102295},{"id":"https://openalex.org/keywords/protein-solubilization","display_name":"protein solubilization","score":0.9729999899864197},{"id":"https://openalex.org/keywords/nucleotides","display_name":"nucleotides","score":0.7850000262260437},{"id":"https://openalex.org/keywords/cytotoxic-t-lymphocytes","display_name":"cytotoxic T lymphocytes","score":0.8830000162124634},{"id":"https://openalex.org/keywords/trp-2","display_name":"TRP-2","score":0.8920000195503235},{"id":"https://openalex.org/keywords/b16-melanoma","display_name":"B16 melanoma","score":0.996999979019165},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.8679999709129333},{"id":"https://openalex.org/keywords/tumor-lysate","display_name":"tumor lysate","score":0.5770000219345093}],"concepts":[{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.7327130436897278},{"id":"https://openalex.org/C4863142","wikidata":"https://www.wikidata.org/wiki/Q907920","display_name":"Solubilization","level":2,"score":0.6746580600738525},{"id":"https://openalex.org/C189976730","wikidata":"https://www.wikidata.org/wiki/Q3493700","display_name":"Splenocyte","level":3,"score":0.5690901875495911},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.543599009513855},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5389076471328735},{"id":"https://openalex.org/C149629883","wikidata":"https://www.wikidata.org/wiki/Q660926","display_name":"Fraction (chemistry)","level":2,"score":0.5080370903015137},{"id":"https://openalex.org/C57409179","wikidata":"https://www.wikidata.org/wiki/Q1218293","display_name":"Lysis","level":2,"score":0.5059921145439148},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.5019853115081787},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4823993444442749},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.46559250354766846},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.42719951272010803},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4209336042404175},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.41384539008140564},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3229399621486664},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.32065367698669434},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.266144722700119},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.2591261863708496},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.21873295307159424},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.1998453140258789},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.18941691517829895}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000951","descriptor_name":"Antigens, Neoplasm","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001671","descriptor_name":"Biochemistry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D002457","descriptor_name":"Cell Extracts","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D003602","descriptor_name":"Cytotoxicity, Immunologic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007114","descriptor_name":"Immunization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009711","descriptor_name":"Nucleotides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013347","descriptor_name":"Subcellular Fractions","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013347","descriptor_name":"Subcellular Fractions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013602","descriptor_name":"T-Lymphocytes, Cytotoxic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013602","descriptor_name":"T-Lymphocytes, Cytotoxic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D019746","descriptor_name":"Intramolecular Oxidoreductases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058965","descriptor_name":"MART-1 Antigen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":1,"locations":[{"id":"pmid:21498709","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21498709","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W132626948","https://openalex.org/W1584837677","https://openalex.org/W1992699637","https://openalex.org/W1995994587","https://openalex.org/W1996229842","https://openalex.org/W2018333644","https://openalex.org/W2026862785","https://openalex.org/W2034408472","https://openalex.org/W2037527105","https://openalex.org/W2043835419","https://openalex.org/W2044274117","https://openalex.org/W2045772911","https://openalex.org/W2049824129","https://openalex.org/W2050451636","https://openalex.org/W2053597753","https://openalex.org/W2054741297","https://openalex.org/W2055278554","https://openalex.org/W2111695773","https://openalex.org/W2124034595","https://openalex.org/W2128635872","https://openalex.org/W2416022073"],"related_works":["https://openalex.org/W2069834107","https://openalex.org/W2053925603","https://openalex.org/W2371222584","https://openalex.org/W2437280949","https://openalex.org/W2626149894","https://openalex.org/W2022250608","https://openalex.org/W2129980000","https://openalex.org/W2079270091","https://openalex.org/W2126322340","https://openalex.org/W2372437530"],"abstract_inverted_index":{"BACKGROUND/AIM:":[0],"Dendritic":[1],"cell":[2],"(DC)-based":[3],"cancer":[4,147],"immunotherapy":[5],"using":[6,67,106],"tumor":[7,28,46,140],"homogenate":[8],"has":[9],"been":[10,19],"evaluated.":[11],"In":[12],"all":[13],"previously":[14],"reported":[15],"cases,":[16],"DCs":[17,39,71,93,105,123],"have":[18],"pulsed":[20,40],"with":[21,41,74,91,94,103,126],"a":[22,64,143],"soluble":[23,129],"fraction":[24,44,57,110,138],"(lysate)":[25],"of":[26,32,38,45,58,87,111,133,139],"the":[27,36,75,85,107,128],"homogenate.":[29,135],"The":[30,118],"aim":[31],"this":[33],"study":[34],"was":[35,61],"evaluation":[37],"solubilized":[42,76,95,108],"insoluble":[43,109,131],"cells.":[47],"MATERIALS":[48],"AND":[49],"METHODS:":[50],"Solubilized":[51],"recombinant":[52],"murine":[53],"TRP-2":[54],"and":[55,130],"solubilized-insoluble":[56],"B16":[59,112,134],"melanoma":[60,113],"prepared":[62],"by":[63],"novel":[65],"method":[66],"nucleotides.":[68],"Bone":[69],"marrow-derived":[70],"were":[72,82,120,124],"electroloaded":[73,92,104,125],"proteins.":[77],"RESULTS:":[78],"Cytotoxic":[79],"T":[80],"lymphocytes":[81],"elicited":[83],"in":[84],"splenocytes":[86],"C57BL/6":[88],"mice":[89,102],"immunized":[90,101],"rTRP-2.":[96],"CD8(+)":[97],"T-cells":[98],"derived":[99],"from":[100],"had":[114],"specific":[115],"killing":[116],"activity.":[117],"effects":[119],"augmented":[121],"when":[122],"both":[127],"fractions":[132],"CONCLUSION:":[136],"Insoluble":[137],"cells":[141],"is":[142],"useful":[144],"material":[145],"for":[146],"immunotherapy.":[148]},"counts_by_year":[{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
