{"id":"https://openalex.org/W2181444673","doi":"https://doi.org/10.1093/toxsci/kfv252","title":"Common Polymorphisms in the Solute Carrier SLC30A10 are Associated With Blood Manganese and Neurological Function","display_name":"Common Polymorphisms in the Solute Carrier SLC30A10 are Associated With Blood Manganese and Neurological Function","publication_year":2015,"publication_date":"2015-12-01","ids":{"openalex":"https://openalex.org/W2181444673","doi":"https://doi.org/10.1093/toxsci/kfv252","mag":"2181444673","pmid":"https://pubmed.ncbi.nlm.nih.gov/26628504","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4725612"},"language":"en","primary_location":{"id":"doi:10.1093/toxsci/kfv252","doi":"https://doi.org/10.1093/toxsci/kfv252","is_oa":true,"landing_page_url":"https://doi.org/10.1093/toxsci/kfv252","pdf_url":"https://academic.oup.com/toxsci/article-pdf/149/2/473/16690898/kfv252.pdf","source":{"id":"https://openalex.org/S186282544","display_name":"Toxicological Sciences","issn_l":"1096-0929","issn":["1096-0929","1096-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicological Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/toxsci/article-pdf/149/2/473/16690898/kfv252.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001545459","display_name":"Karin E. Wahlberg","orcid":"https://orcid.org/0000-0003-0613-0212","observed_orcids":["https://orcid.org/0000-0003-0613-0212"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Karin Wahlberg","raw_affiliation_strings":["*Division of Occupational and Environmental Medicine, Lund University, 221 85 Lund, Sweden; karin.broberg@ki.se","**Division of Occupational and Environmental Medicine, Lund University, 221 85 Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Division of Occupational and Environmental Medicine, Lund University, 221 85 Lund, Sweden; karin.broberg@ki.se","institution_ids":["https://openalex.org/I187531555"]},{"raw_affiliation_string":"**Division of Occupational and Environmental Medicine, Lund University, 221 85 Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027246591","display_name":"Maria J. Kippler","orcid":"https://orcid.org/0000-0002-9010-9821","observed_orcids":["https://orcid.org/0000-0002-9010-9821"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Maria Kippler","raw_affiliation_strings":["\u2020Institute of Environmental Medicine, Karolinska Institutet, 171 65 Solna, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2020Institute of Environmental Medicine, Karolinska Institutet, 171 65 Solna, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015381273","display_name":"Ayman Alhamdow","orcid":"https://orcid.org/0000-0002-3643-0518","observed_orcids":["https://orcid.org/0000-0002-3643-0518"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Ayman Alhamdow","raw_affiliation_strings":["**Division of Occupational and Environmental Medicine, Lund University, 221 85 Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"**Division of Occupational and Environmental Medicine, Lund University, 221 85 Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039284670","display_name":"Syed Moshfiqur Rahman","orcid":"https://orcid.org/0000-0002-9441-0590","observed_orcids":["https://orcid.org/0000-0002-9441-0590"]},"institutions":[{"id":"https://openalex.org/I205889620","display_name":"International Centre for Diarrhoeal Disease Research","ror":"https://ror.org/04vsvr128","country_code":"BD","type":"facility","lineage":["https://openalex.org/I205889620"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["BD","SE"],"is_corresponding":false,"raw_author_name":"Syed Moshfiqur Rahman","raw_affiliation_strings":["Institute of Environmental Medicine, Karolinska Institutet, 171 65 Solna, Sweden; International Centre for Diarrhoeal Disease Research, Bangladesh (icddr, b), Mohakhali, Dhaka 1000, Bangladesh;","\u2020Institute of Environmental Medicine, Karolinska Institutet, 171 65 Solna, Sweden","\u2021International Centre for Diarrhoeal Disease Research, Bangladesh (icddr, b), Mohakhali, Dhaka 1000, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Environmental Medicine, Karolinska Institutet, 171 65 Solna, Sweden; International Centre for Diarrhoeal Disease Research, Bangladesh (icddr, b), Mohakhali, Dhaka 1000, Bangladesh;","institution_ids":["https://openalex.org/I205889620","https://openalex.org/I28166907"]},{"raw_affiliation_string":"\u2020Institute of Environmental Medicine, Karolinska Institutet, 171 65 Solna, Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"\u2021International Centre for Diarrhoeal Disease Research, Bangladesh (icddr, b), Mohakhali, Dhaka 1000, Bangladesh","institution_ids":["https://openalex.org/I205889620"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074940124","display_name":"Donald R. Smith","orcid":"https://orcid.org/0000-0002-4919-1042","observed_orcids":["https://orcid.org/0000-0002-4919-1042"]},"institutions":[{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald R. Smith","raw_affiliation_strings":["\u00a7Microbiology and Environmental Toxicology, University of California, 1156 High Street, Santa Cruz, California 95064"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u00a7Microbiology and Environmental Toxicology, University of California, 1156 High Street, Santa Cruz, California 95064","institution_ids":["https://openalex.org/I185103710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111673569","display_name":"Marie Vahter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Marie Vahter","raw_affiliation_strings":["**Division of Occupational and Environmental Medicine, Lund University, 221 85 Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"**Division of Occupational and Environmental Medicine, Lund University, 221 85 Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066321470","display_name":"Roberto G. Lucchini","orcid":"https://orcid.org/0000-0002-9723-0237","observed_orcids":["https://orcid.org/0000-0002-9723-0237"]},"institutions":[{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]},{"id":"https://openalex.org/I79940851","display_name":"University of Brescia","ror":"https://ror.org/02q2d2610","country_code":"IT","type":"education","lineage":["https://openalex.org/I79940851"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"Roberto G. Lucchini","raw_affiliation_strings":["Microbiology and Environmental Toxicology, University of California, 1156 High Street, Santa Cruz, California 95064; Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, New York 10029-5674; and Occupational Health Institute, University of Brescia, Viale Europa, 11, 25123 Brescia BS, Italy","||Occupational Health Institute, University of Brescia, Viale Europa, 11, 25123 Brescia BS, Italy","\u00a7Microbiology and Environmental Toxicology, University of California, 1156 High Street, Santa Cruz, California 95064","\u00b6Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, New York 10029-5674"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology and Environmental Toxicology, University of California, 1156 High Street, Santa Cruz, California 95064; Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, New York 10029-5674; and Occupational Health Institute, University of Brescia, Viale Europa, 11, 25123 Brescia BS, Italy","institution_ids":["https://openalex.org/I185103710","https://openalex.org/I79940851","https://openalex.org/I98704320"]},{"raw_affiliation_string":"||Occupational Health Institute, University of Brescia, Viale Europa, 11, 25123 Brescia BS, Italy","institution_ids":["https://openalex.org/I79940851"]},{"raw_affiliation_string":"\u00a7Microbiology and Environmental Toxicology, University of California, 1156 High Street, Santa Cruz, California 95064","institution_ids":["https://openalex.org/I185103710"]},{"raw_affiliation_string":"\u00b6Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, New York 10029-5674","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069893701","display_name":"Karin Br\u00f6berg","orcid":"https://orcid.org/0000-0002-5862-468X","observed_orcids":["https://orcid.org/0000-0002-5862-468X"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Karin Broberg","raw_affiliation_strings":["*Division of Occupational and Environmental Medicine, Lund University, 221 85 Lund, Sweden; Institute of Environmental Medicine, Karolinska Institutet, 171 65 Solna, Sweden; karin.broberg@ki.se","**Division of Occupational and Environmental Medicine, Lund University, 221 85 Lund, Sweden","\u2020Institute of Environmental Medicine, Karolinska Institutet, 171 65 Solna, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Division of Occupational and Environmental Medicine, Lund University, 221 85 Lund, Sweden; Institute of Environmental Medicine, Karolinska Institutet, 171 65 Solna, Sweden; karin.broberg@ki.se","institution_ids":["https://openalex.org/I187531555","https://openalex.org/I28166907"]},{"raw_affiliation_string":"**Division of Occupational and Environmental Medicine, Lund University, 221 85 Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]},{"raw_affiliation_string":"\u2020Institute of Environmental Medicine, Karolinska Institutet, 171 65 Solna, Sweden","institution_ids":["https://openalex.org/I28166907"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5069893701"],"corresponding_institution_ids":["https://openalex.org/I187531555","https://openalex.org/I28166907"],"apc_list":{"value":4671,"currency":"USD","value_usd":4671},"apc_paid":null,"fwci":2.8797,"has_fulltext":true,"cited_by_count":43,"citation_normalized_percentile":{"value":0.89619122,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"149","issue":"2","first_page":"473","last_page":"483"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.014700000174343586,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/slc30a10","display_name":"SLC30A10","score":1.0},{"id":"https://openalex.org/keywords/manganese-transporter","display_name":"manganese transporter","score":0.8769999742507935},{"id":"https://openalex.org/keywords/blood-manganese","display_name":"blood manganese","score":0.6919999718666077},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9559999704360962},{"id":"https://openalex.org/keywords/manganese-neurotoxicity","display_name":"manganese neurotoxicity","score":0.8560000061988831},{"id":"https://openalex.org/keywords/neurological-function","display_name":"neurological function","score":0.6899999976158142},{"id":"https://openalex.org/keywords/postural-sway","display_name":"postural sway","score":0.7580000162124634},{"id":"https://openalex.org/keywords/finger-tapping-speed","display_name":"finger tapping speed","score":0.9539999961853027},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.8370000123977661},{"id":"https://openalex.org/keywords/manganese-homeostasis","display_name":"manganese homeostasis","score":0.6890000104904175},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.628000020980835}],"concepts":[{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.7227317094802856},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6532727479934692},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.5068581700325012},{"id":"https://openalex.org/C528890316","wikidata":"https://www.wikidata.org/wiki/Q731","display_name":"Manganese","level":2,"score":0.48237600922584534},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.46624985337257385},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3397290110588074},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2406008541584015},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24054613709449768},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22747087478637695},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20696118474006653},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10639864206314087},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000075703","descriptor_name":"Zinc Transporter 8","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006579","descriptor_name":"Heterozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008345","descriptor_name":"Manganese","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015032","descriptor_name":"Zinc","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020258","descriptor_name":"Neurotoxicity Syndromes","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D027682","descriptor_name":"Cation Transport Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":9,"locations":[{"id":"doi:10.1093/toxsci/kfv252","doi":"https://doi.org/10.1093/toxsci/kfv252","is_oa":true,"landing_page_url":"https://doi.org/10.1093/toxsci/kfv252","pdf_url":"https://academic.oup.com/toxsci/article-pdf/149/2/473/16690898/kfv252.pdf","source":{"id":"https://openalex.org/S186282544","display_name":"Toxicological Sciences","issn_l":"1096-0929","issn":["1096-0929","1096-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicological Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3716560","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4725612","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4725612","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4725612","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicol Sci","raw_type":"Text"},{"id":"pmid:26628504","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26628504","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicological sciences : an official journal of the Society of Toxicology","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unimore.it:11380/1318807","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11380/1318807","pdf_url":"https://iris.unimore.it/bitstream/11380/1318807/1/kfv252.pdf","source":{"id":"https://openalex.org/S4306400718","display_name":"IRIS UNIMORE (University of Modena and Reggio Emilia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122346577","host_organization_name":"University of Modena and Reggio Emilia","host_organization_lineage":["https://openalex.org/I122346577"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.770.7138","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.770.7138","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/e0/d0/kfv252.PMC4725612.pdf","raw_type":"text"},{"id":"pmh:oai:iris.unibs.it:11379/463977","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11379/463977","pdf_url":null,"source":{"id":"https://openalex.org/S4306400804","display_name":"Institutional Research Information System (Universit\u00e0 degli Studi di Brescia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I66752286","host_organization_name":"University of Milano-Bicocca","host_organization_lineage":["https://openalex.org/I66752286"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:lup.lub.lu.se:05e26ac2-8394-4d97-b3ec-bf7236871d4f","doi":null,"is_oa":false,"landing_page_url":"https://lup.lub.lu.se/record/8505849","pdf_url":null,"source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1096-0929","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:open-archive.highwire.org:toxsci:149/2/473","doi":null,"is_oa":false,"landing_page_url":"http://toxsci.oxfordjournals.org/cgi/content/short/149/2/473","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":{"id":"doi:10.1093/toxsci/kfv252","doi":"https://doi.org/10.1093/toxsci/kfv252","is_oa":true,"landing_page_url":"https://doi.org/10.1093/toxsci/kfv252","pdf_url":"https://academic.oup.com/toxsci/article-pdf/149/2/473/16690898/kfv252.pdf","source":{"id":"https://openalex.org/S186282544","display_name":"Toxicological Sciences","issn_l":"1096-0929","issn":["1096-0929","1096-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicological Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G9000890648","display_name":"Metal mixtures, exposure windows, and neurodevelopmental trajectories from adolescence to adulthood","funder_award_id":"R01ES019222","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2181444673.pdf","grobid_xml":"https://content.openalex.org/works/W2181444673.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W141982433","https://openalex.org/W1546288213","https://openalex.org/W1568601713","https://openalex.org/W1780646802","https://openalex.org/W1817978154","https://openalex.org/W1922237507","https://openalex.org/W1966124643","https://openalex.org/W1968371772","https://openalex.org/W1970936253","https://openalex.org/W1976660351","https://openalex.org/W1977960537","https://openalex.org/W1983562234","https://openalex.org/W1986751239","https://openalex.org/W1998271947","https://openalex.org/W2002325311","https://openalex.org/W2002874275","https://openalex.org/W2009217122","https://openalex.org/W2009859733","https://openalex.org/W2011929503","https://openalex.org/W2028662420","https://openalex.org/W2036239299","https://openalex.org/W2036619779","https://openalex.org/W2036738893","https://openalex.org/W2036860239","https://openalex.org/W2037415356","https://openalex.org/W2042063368","https://openalex.org/W2051448185","https://openalex.org/W2067354437","https://openalex.org/W2076238713","https://openalex.org/W2081383061","https://openalex.org/W2082210712","https://openalex.org/W2085452364","https://openalex.org/W2095908732","https://openalex.org/W2102965718","https://openalex.org/W2104845348","https://openalex.org/W2107504607","https://openalex.org/W2108493196","https://openalex.org/W2108886647","https://openalex.org/W2122761602","https://openalex.org/W2124735319","https://openalex.org/W2126385616","https://openalex.org/W2126779745","https://openalex.org/W2147421171","https://openalex.org/W2148923431","https://openalex.org/W2151438638","https://openalex.org/W2152014584","https://openalex.org/W2162530578","https://openalex.org/W2277842998","https://openalex.org/W2398870997","https://openalex.org/W3022411112","https://openalex.org/W4211123396","https://openalex.org/W4232723971"],"related_works":["https://openalex.org/W2922751507","https://openalex.org/W2905343767","https://openalex.org/W2755056238","https://openalex.org/W2768331874","https://openalex.org/W2744769444","https://openalex.org/W2904338229","https://openalex.org/W4361304873","https://openalex.org/W7166086609","https://openalex.org/W2950574347","https://openalex.org/W7134824219"],"abstract_inverted_index":{"Manganese":[0],"(Mn)":[1],"is":[2],"an":[3,39],"essential":[4],"nutrient":[5],"in":[6,21,34,72,95,101,119,133,150,206,227,235],"humans,":[7],"but":[8,146],"excessive":[9],"exposure":[10],"to":[11,254],"Mn":[12,19,40,44,52,131,203,233,261,269],"may":[13,243],"cause":[14],"neurotoxicity.":[15],"Despite":[16],"homeostatic":[17],"regulation,":[18],"concentrations":[20,45,53,132,234],"blood":[22,43,51,97,232,260],"vary":[23],"considerably":[24],"among":[25],"individuals.":[26],"We":[27,49,90,222],"evaluated":[28],"if":[29],"common":[30,225],"single-nucleotide":[31],"polymorphisms":[32],"(SNPs)":[33],"SLC30A10,":[35],"which":[36],"likely":[37],"encodes":[38],"transporter,":[41],"influence":[42,242,255],"and":[46,60,67,85,111,116,140,163,182,184,214,239],"neurological":[47,112,256],"function.":[48],"measured":[50,92],"by":[54,69,98,246],"ICP-MS":[55],"or":[56],"atomic":[57],"absorption":[58],"spectroscopy":[59],"genotyped":[61],"2":[62],"SLC30A10":[63,93,186,228,248,265],"non-coding":[64],"SNPs":[65,226,252],"(rs2275707":[66],"rs12064812)":[68],"TaqMan":[70,99],"PCR":[71,100],"cohorts":[73,238],"from":[74,107],"Bangladesh":[75,151],"(N":[76,82,87,104],"=":[77,83,88,105,138,144,154,177,190,212,220],"406),":[78],"the":[79,108,120,134,194,207,251],"Argentinean":[80],"Andes":[81,135],"198),":[84],"Italy":[86,141],"238).":[89],"also":[91,169],"expression":[94,187],"whole":[96],"a":[102],"sub-group":[103],"101)":[106],"Andean":[109],"cohort,":[110],"parameters":[113],"(sway":[114],"velocity":[115,174],"finger-tapping":[117,216],"speed)":[118],"Italian":[121,208],"cohort.":[122],"The":[123],"rs2275707":[124],"variant":[125,196],"allele":[126,167],"was":[127,168,199],"associated":[128,170,200,230],"with":[129,171,201,231],"increased":[130,172,215],"(8%,":[136],"P":[137,143,153,176,189,211,219],".027)":[139],"(10.6%,":[142],".012),":[145],"not":[147],"as":[148],"clear":[149],"(3.4%,":[152],".21;":[155],"linear":[156],"regression":[157],"analysis":[158],"adjusted":[159,179],"for":[160,180],"age,":[161],"gender,":[162],"plasma":[164],"ferritin).":[165],"This":[166],"sway":[173],"(15%,":[175],".033;":[178],"age":[181],"sex)":[183],"reduced":[185,202],"(-24.6%,":[188],".029).":[191],"In":[192],"contrast,":[193],"rs12064812":[195],"homozygous":[197],"genotype":[198],"concentrations,":[204,262],"particularly":[205],"cohort":[209],"(-18.4%,":[210],".04),":[213],"speed":[217],"(8.7%,":[218],".025).":[221],"show":[223],"that":[224,240,264],"are":[229],"3":[236],"unrelated":[237],"their":[241],"be":[244],"mediated":[245],"altered":[247],"expression.":[249],"Moreover,":[250],"appeared":[253],"functions":[257],"independent":[258],"of":[259],"suggesting":[263],"could":[266],"regulate":[267],"brain":[268],"levels.":[270]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}