{"id":"https://openalex.org/W21813825","doi":null,"title":"Apoptosis, myocardial fibrosis and angiotensin II in the left ventricle of hypertensive rats treated with fosinopril or losartan.","display_name":"Apoptosis, myocardial fibrosis and angiotensin II in the left ventricle of hypertensive rats treated with fosinopril or losartan.","publication_year":2002,"publication_date":"2002-09-01","ids":{"openalex":"https://openalex.org/W21813825","mag":"21813825","pmid":"https://pubmed.ncbi.nlm.nih.gov/12411096"},"language":"en","primary_location":{"id":"pmid:12411096","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12411096","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese medical journal","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044176396","display_name":"Guolong Yu","orcid":"https://orcid.org/0000-0002-0016-7770","observed_orcids":["https://orcid.org/0000-0002-0016-7770"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guolong Yu","raw_affiliation_strings":["Department of Geriatric Cardiology, Xiangya Hospital, Hunan Medical University, Changsha 410008, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Geriatric Cardiology, Xiangya Hospital, Hunan Medical University, Changsha 410008, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073490927","display_name":"Xiaoqiu Liang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaoqiu Liang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102070335","display_name":"Xiu-Mei Xie","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiumei Xie","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085135147","display_name":"Tianlun Yang","orcid":"https://orcid.org/0000-0001-9835-1279","observed_orcids":["https://orcid.org/0000-0001-9835-1279"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tianlun Yang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112108444","display_name":"Ming Sun","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ming Sun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5009923346","display_name":"Shui\u2010Ping Zhao","orcid":"https://orcid.org/0000-0001-8152-652X","observed_orcids":["https://orcid.org/0000-0001-8152-652X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shuiping Zhao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4228,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.67225355,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"115","issue":"9","first_page":"1287","last_page":"91"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.6815999746322632,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.6815999746322632,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.3149000108242035,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myocardial-fibrosis","display_name":"myocardial fibrosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":0.9950000047683716},{"id":"https://openalex.org/keywords/left-ventricle","display_name":"left ventricle","score":0.8700000047683716},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.7450000047683716},{"id":"https://openalex.org/keywords/losartan","display_name":"losartan","score":0.8050000071525574},{"id":"https://openalex.org/keywords/fosinopril","display_name":"fosinopril","score":0.996999979019165},{"id":"https://openalex.org/keywords/angiotensin-receptor-blockers","display_name":"angiotensin receptor blockers","score":0.9229999780654907},{"id":"https://openalex.org/keywords/ace-inhibitors","display_name":"ACE inhibitors","score":0.9580000042915344},{"id":"https://openalex.org/keywords/spontaneously-hypertensive-rats","display_name":"spontaneously hypertensive rats","score":0.8560000061988831},{"id":"https://openalex.org/keywords/collagen-volume-fraction","display_name":"collagen volume fraction","score":0.7879999876022339},{"id":"https://openalex.org/keywords/left-ventricular-mass","display_name":"left ventricular mass","score":0.7929999828338623},{"id":"https://openalex.org/keywords/antihypertensive-therapy","display_name":"antihypertensive therapy","score":0.6909999847412109},{"id":"https://openalex.org/keywords/plasma-angiotensin-ii","display_name":"plasma angiotensin II","score":0.7710000276565552}],"concepts":[{"id":"https://openalex.org/C2780436477","wikidata":"https://www.wikidata.org/wiki/Q425293","display_name":"Fosinopril","level":4,"score":0.9531487226486206},{"id":"https://openalex.org/C2780288358","wikidata":"https://www.wikidata.org/wiki/Q410074","display_name":"Losartan","level":4,"score":0.9370859265327454},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7198065519332886},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7102887034416199},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7081629037857056},{"id":"https://openalex.org/C2778921608","wikidata":"https://www.wikidata.org/wiki/Q2002035","display_name":"Ventricle","level":2,"score":0.6829564571380615},{"id":"https://openalex.org/C3018763269","wikidata":"https://www.wikidata.org/wiki/Q5038318","display_name":"Myocardial fibrosis","level":3,"score":0.5793859958648682},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.5458491444587708},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.5138766765594482},{"id":"https://openalex.org/C2779537366","wikidata":"https://www.wikidata.org/wiki/Q7920323","display_name":"Ventricular remodeling","level":3,"score":0.4173985719680786},{"id":"https://openalex.org/C27016395","wikidata":"https://www.wikidata.org/wiki/Q128861","display_name":"Angiotensin-converting enzyme","level":3,"score":0.36080968379974365},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.3340497314929962},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.28796643018722534}],"mesh":[{"descriptor_ui":"D000804","descriptor_name":"Angiotensin II","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011918","descriptor_name":"Rats, Inbred SHR","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017328","descriptor_name":"Fosinopril","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D017379","descriptor_name":"Hypertrophy, Left Ventricular","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D019808","descriptor_name":"Losartan","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:12411096","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12411096","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese medical journal","raw_type":"Journal Article"},{"id":"mag:21813825","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12411096","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W2145632027","https://openalex.org/W2082439879","https://openalex.org/W2136557329","https://openalex.org/W2124673248","https://openalex.org/W2184105969","https://openalex.org/W2079901425","https://openalex.org/W1969369541","https://openalex.org/W2141869043","https://openalex.org/W1987473934","https://openalex.org/W2082236694","https://openalex.org/W2096743139","https://openalex.org/W2042293234","https://openalex.org/W2124176097","https://openalex.org/W2055864845","https://openalex.org/W101667153","https://openalex.org/W2093352601","https://openalex.org/W2139368070","https://openalex.org/W1991344869","https://openalex.org/W2057796247","https://openalex.org/W70693205","https://openalex.org/W1557332402","https://openalex.org/W2165222873","https://openalex.org/W2149753940","https://openalex.org/W2083403848","https://openalex.org/W2157706051","https://openalex.org/W2080555359","https://openalex.org/W1980239112","https://openalex.org/W2028325688","https://openalex.org/W2127331211","https://openalex.org/W2169506520"],"related_works":["https://openalex.org/W2382030073","https://openalex.org/W1967107185","https://openalex.org/W2362713581","https://openalex.org/W2371228085","https://openalex.org/W2388876552","https://openalex.org/W2051732956","https://openalex.org/W2187010443","https://openalex.org/W2382477298","https://openalex.org/W2413135421","https://openalex.org/W2382084877"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"investigate":[2],"the":[3,35,92,122,125,156,160,170,176,181,190,195,200,210,218,222,228,230,241,250,259,264,268,276,281,295,312,321,352,360],"different":[4],"effects":[5,353],"of":[6,38,45,79,113,209,217,354,362],"an":[7,17],"angiotensin":[8,18,30],"II":[9,31,111,289,301,309],"type":[10],"1":[11],"(AT(1))":[12],"receptor":[13],"antagonist,":[14],"losartan,":[15,56],"and":[16,29,71,94,109,115,127,143,198,236,243,286,306,314,327,334,337],"converting":[19],"enzyme":[20],"(ACE)":[21],"inhibitor,":[22],"fosinopril,":[23,64],"on":[24],"cardiomyocyte":[25,332],"apoptosis,":[26,100],"myocardial":[27,335],"fibrosis,":[28],"(Ang":[32],"II)":[33],"in":[34,136,151,169,175,194,203,249,267,275,294,320,346],"left":[36,144,231],"ventricle":[37],"spontaneously":[39],"hypertensive":[40],"rats":[41],"(SHRs).":[42],"METHODS:":[43],"SHRs":[44,251],"16-week-old":[46],"were":[47,89,117,133,148,246,291,303,317],"randomly":[48,84],"divided":[49],"into":[50],"3":[51],"groups:":[52],"SHR-L":[53],"(treated":[54,62,73],"with":[55,63,74,121,180,227,253,280],"30":[57],"mg.kg(-1)":[58],"x":[59,67,69],"d(-1)),":[60,70],"SHR-F":[61],"10":[65,80],"mg":[66],"kg(-1)":[68],"SHR-C":[72],"placebo).":[75],"Each":[76],"group":[77,172,212,220,270],"consisted":[78],"rats.":[81],"Five":[82],"rats,":[83],"selected":[85],"from":[86],"each":[87],"group,":[88,197],"killed":[90],"at":[91,124,159,189,199,221,240,263,283,311],"8th":[93,126,191,242,313],"16th":[95,128,161,201,244,315],"week":[96,162,192,202],"after":[97],"treatment.":[98],"Cardiomyocyte":[99],"collagen":[101,106,233,238,260],"volume":[102,234,261],"fraction":[103,235,262],"(CVF),":[104],"perivascular":[105,237],"area":[107,239],"(PVCA)":[108],"Ang":[110,288,300,308],"concentrations":[112,302,310],"plasma":[114,285,299],"myocardium":[116,287,307,363],"examined.":[118,225],"RESULTS:":[119],"Compared":[120,179,226,279],"controls":[123,282],"week,":[129],"systolic":[130],"blood":[131],"pressures":[132],"similarly":[134],"decreased":[135],"both":[137,152,204,355],"treatment":[138,153,205],"groups.":[139,154,206],"Left":[140],"ventricular":[141,145,232],"weight":[142],"mass":[146],"indexes":[147],"significantly":[149,187,247,292,318],"lower":[150,214,272],"However,":[155,258,298],"latter":[157,223,265],"parameter":[158],"was":[163,186,213,271],"reduced":[164,188,248,319],"to":[165,359],"a":[166],"less":[167],"extent":[168],"fosinopril":[171,196,211,255,269,322,328],"than":[173,215,273],"that":[174,216,274,351],"losartan":[177,219,277,296,326],"group.":[178,278,297,323],"controls,":[182,229],"cardiomycyte":[183],"apoptotic":[184],"index":[185,208],"only":[193],"The":[207],"endpoint":[224,266],"weeks":[245,316],"treated":[252],"either":[254],"or":[256],"losartan.":[257],"endpoints,":[284],"levels":[290],"increased":[293],"not":[304],"altered,":[305],"CONCLUSIONS:":[324],"Both":[325],"could":[329],"effectively":[330],"inhibit":[331],"apoptosis":[333],"fibrosis":[336],"reverse":[338],"heart":[339],"hypertrophy.":[340],"Fosinopril":[341],"may":[342],"be":[343],"more":[344],"effective":[345],"these":[347],"cardioprotective":[348],"effects,":[349],"suggesting":[350],"drugs":[356],"are":[357],"related":[358],"inhibition":[361],"renin-angiotension-aldsterone":[364],"system.":[365]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
