{"id":"https://openalex.org/W2181342999","doi":null,"title":"Tetracaine decreases intracellular Zn2+ concentration by inhibiting Zn2+ influx in rat thymocytes","display_name":"Tetracaine decreases intracellular Zn2+ concentration by inhibiting Zn2+ influx in rat thymocytes","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2181342999","mag":"2181342999"},"language":"en","primary_location":{"id":"pmh:oai:irdb.nii.ac.jp:00906:0006773452","doi":null,"is_oa":true,"landing_page_url":"https://tokushima-u.repo.nii.ac.jp/records/2001297","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"\u5fb3\u5cf6\u5927\u5b66\u7dcf\u5408\u79d1\u5b66\u90e8\u81ea\u7136\u79d1\u5b66\u7814\u7a76 = Natural Science Research, The University of Tokushima","raw_type":"departmental bulletin paper"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://tokushima-u.repo.nii.ac.jp/records/2001297","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086796562","display_name":"Kaori Kimura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kaori Kimura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060700088","display_name":"Yumiko H. Nishimura","orcid":"https://orcid.org/0009-0001-9138-8463","observed_orcids":["https://orcid.org/0009-0001-9138-8463"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yumiko Nishimura","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0001-9138-8463","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060976717","display_name":"Keisuke Oyama","orcid":"https://orcid.org/0000-0003-4044-5867","observed_orcids":["https://orcid.org/0000-0003-4044-5867"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Keisuke Oyama","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4044-5867","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088366793","display_name":"Takuya Kawanai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Takuya Kawanai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087373299","display_name":"Erika Hashimoto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Erika Hashimoto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5005436782","display_name":"Yasuo Oyama","orcid":"https://orcid.org/0000-0001-6393-1150","observed_orcids":["https://orcid.org/0000-0001-6393-1150"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yasuo Oyama","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6393-1150","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3209,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.52312633,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":97},"biblio":{"volume":"25","issue":"2","first_page":"7","last_page":"13"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.33469998836517334,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.33469998836517334,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.21729999780654907,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.10790000110864639,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tetracaine","display_name":"tetracaine","score":1.0},{"id":"https://openalex.org/keywords/intracellular-zinc","display_name":"intracellular zinc","score":0.7020000219345093},{"id":"https://openalex.org/keywords/zinc-influx","display_name":"zinc influx","score":0.925000011920929},{"id":"https://openalex.org/keywords/thymocytes","display_name":"thymocytes","score":0.9369999766349792},{"id":"https://openalex.org/keywords/local-anesthetics","display_name":"local anesthetics","score":0.9300000071525574},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.8759999871253967},{"id":"https://openalex.org/keywords/lidocaine","display_name":"lidocaine","score":0.9359999895095825},{"id":"https://openalex.org/keywords/fluozin-3","display_name":"FluoZin-3","score":0.8610000014305115},{"id":"https://openalex.org/keywords/dtpa","display_name":"DTPA","score":0.7300000190734863},{"id":"https://openalex.org/keywords/zinc-chelation","display_name":"zinc chelation","score":0.8619999885559082},{"id":"https://openalex.org/keywords/zinc-chloride","display_name":"zinc chloride","score":0.5099999904632568}],"concepts":[{"id":"https://openalex.org/C2778455913","wikidata":"https://www.wikidata.org/wiki/Q419608","display_name":"Tetracaine","level":3,"score":0.9746556878089905},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8080429434776306},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.7442139387130737},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.5935213565826416},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.5376248359680176},{"id":"https://openalex.org/C2780149897","wikidata":"https://www.wikidata.org/wiki/Q216935","display_name":"Lidocaine","level":2,"score":0.5223909020423889},{"id":"https://openalex.org/C25642318","wikidata":"https://www.wikidata.org/wiki/Q1992532","display_name":"Incubation","level":2,"score":0.5161114931106567},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5011005401611328},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.379948228597641},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30991798639297485},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.18979564309120178},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10217761993408203},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.06562137603759766},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:irdb.nii.ac.jp:00906:0006773452","doi":null,"is_oa":true,"landing_page_url":"https://tokushima-u.repo.nii.ac.jp/records/2001297","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"\u5fb3\u5cf6\u5927\u5b66\u7dcf\u5408\u79d1\u5b66\u90e8\u81ea\u7136\u79d1\u5b66\u7814\u7a76 = Natural Science Research, The University of Tokushima","raw_type":"departmental bulletin paper"},{"id":"mag:2916078552","doi":null,"is_oa":false,"landing_page_url":"https://repo.lib.tokushima-u.ac.jp/files/public/7/74628/20170929142850624484/LID201104261001.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"mag:571488475","doi":null,"is_oa":false,"landing_page_url":"https://www.researchgate.net/profile/Takuya_Kawanai/publication/228474626_Tetracaine_decreases_intracellular_Zn2_concentration_by_inhibiting_Zn2_influx_in_rat_thymocytes/links/5492bd1c0cf209fc7e9f7d97.pdf?disableCoverPage=true","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:irdb.nii.ac.jp:00906:0006773452","doi":null,"is_oa":true,"landing_page_url":"https://tokushima-u.repo.nii.ac.jp/records/2001297","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"\u5fb3\u5cf6\u5927\u5b66\u7dcf\u5408\u79d1\u5b66\u90e8\u81ea\u7136\u79d1\u5b66\u7814\u7a76 = Natural Science Research, The University of Tokushima","raw_type":"departmental bulletin paper"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9074000120162964,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W77282717","https://openalex.org/W88594106","https://openalex.org/W112983849","https://openalex.org/W1568628619","https://openalex.org/W1581525334","https://openalex.org/W1607531254","https://openalex.org/W1798204859","https://openalex.org/W1912081610","https://openalex.org/W1970512651","https://openalex.org/W1981980661","https://openalex.org/W1989452037","https://openalex.org/W1990296652","https://openalex.org/W1993949519","https://openalex.org/W1997858052","https://openalex.org/W1999103491","https://openalex.org/W1999296675","https://openalex.org/W2007853535","https://openalex.org/W2025113559","https://openalex.org/W2027181851","https://openalex.org/W2037617419","https://openalex.org/W2041059461","https://openalex.org/W2042073086","https://openalex.org/W2042904461","https://openalex.org/W2051485869","https://openalex.org/W2057958952","https://openalex.org/W2079247263","https://openalex.org/W2091866793","https://openalex.org/W2098691426","https://openalex.org/W2100658303","https://openalex.org/W2100723302","https://openalex.org/W2118602240","https://openalex.org/W2124684134","https://openalex.org/W2124890716","https://openalex.org/W2126143610","https://openalex.org/W2133581650","https://openalex.org/W2138149556","https://openalex.org/W2142419903","https://openalex.org/W2159050142","https://openalex.org/W2159554322","https://openalex.org/W2162184782","https://openalex.org/W2170901098","https://openalex.org/W2338136852","https://openalex.org/W2397954748","https://openalex.org/W2444175175"],"related_works":["https://openalex.org/W1129806467","https://openalex.org/W419464882","https://openalex.org/W2181851648","https://openalex.org/W2118602240","https://openalex.org/W2082726660","https://openalex.org/W3047091491","https://openalex.org/W2037569386","https://openalex.org/W1973522109","https://openalex.org/W2028808027","https://openalex.org/W2073267077"],"abstract_inverted_index":{"In":[0],"this":[1,125],"study":[2,126],"to":[3,141,161],"examine":[4],"the":[5,13,22,47,57,71,93,101,122,135,143,146,152],"cytotoxic":[6],"property":[7],"of":[8,15,24,29,41,49,79,96,132,148,154,163],"tetracaine,":[9],"we":[10],"cytometrically":[11],"examined":[12],"effect":[14],"tetracaine":[16,45,105,155],"on":[17,156],"intracellular":[18,30,115],"Zn2+":[19,108,116],"concentration":[20,117],"by":[21,86],"use":[23],"FluoZin-3,":[25],"a":[26,36,65,89,112],"fluorescent":[27],"indicator":[28],"Zn2+.":[31],"Lidocaine":[32],"was":[33,88,159],"used":[34],"as":[35],"reference":[37],"drug.":[38],"The":[39,59,77,84],"incubation":[40,60],"rat":[42,119],"thymocytes":[43],"with":[44,54,61],"decreased":[46],"intensity":[48],"FluoZin-3":[50,82,97,157],"fluorescence":[51,75,158],"while":[52],"that":[53,104,162],"lidocaine":[55],"increased":[56],"intensity.":[58,76],"10":[62],"\u03bcM":[63],"DTPA,":[64],"chelator":[66],"for":[67,130],"extracellular":[68],"Zn2+,":[69],"attenuated":[70,92],"tetracaine-induced":[72],"decrease":[73,113],"in":[74,111,114,118,124],"application":[78],"ZnCl2":[80,87],"augmented":[81],"fluorescence.":[83,98],"augmentation":[85,95],"temperature-sensitive.":[90],"Tetracaine":[91],"ZnCl2-induced":[94],"Taken":[99],"together,":[100],"results":[102],"suggest":[103],"attenuates":[106],"membrane":[107],"influx,":[109],"resulting":[110],"thymocytes.":[120],"Although":[121],"cells":[123],"are":[127],"not":[128],"targets":[129],"actions":[131],"local":[133,149],"anesthetics,":[134],"result":[136],"may":[137],"give":[138],"one":[139],"clue":[140],"explain":[142],"difference":[144],"between":[145],"cytotoxicity":[147],"anesthetics":[150],"since":[151],"action":[153],"opposite":[160],"lidocaine.":[164]},"counts_by_year":[{"year":2012,"cited_by_count":3}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2025-10-10T00:00:00"}
