{"id":"https://openalex.org/W21812911","doi":"https://doi.org/10.1016/s0021-9258(19)57115-0","title":"EFFECTS OF A VITAMIN B12 DEFICIENCY ON LIVER ENZYMES IN THE RAT","display_name":"EFFECTS OF A VITAMIN B12 DEFICIENCY ON LIVER ENZYMES IN THE RAT","publication_year":1953,"publication_date":"1953-05-01","ids":{"openalex":"https://openalex.org/W21812911","doi":"https://doi.org/10.1016/s0021-9258(19)57115-0","mag":"21812911","pmid":"https://pubmed.ncbi.nlm.nih.gov/13061440"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9258(19)57115-0","doi":"https://doi.org/10.1016/s0021-9258(19)57115-0","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)57115-0","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0021-9258(19)57115-0","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075824722","display_name":"John N. Williams","orcid":"https://orcid.org/0000-0002-5473-5382","observed_orcids":["https://orcid.org/0000-0002-5473-5382"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J.N. Williams","raw_affiliation_strings":["Department of Biochemistry, College of Agriculture, University of Wisconsin, Madison, Wisconsin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, College of Agriculture, University of Wisconsin, Madison, Wisconsin","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070405479","display_name":"William J. Monson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W.J. Monson","raw_affiliation_strings":["Department of Biochemistry, College of Agriculture, University of Wisconsin, Madison, Wisconsin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, College of Agriculture, University of Wisconsin, Madison, Wisconsin","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020349086","display_name":"Anjana Kalladathil Sreenivasan","orcid":"https://orcid.org/0000-0002-7284-5446","observed_orcids":["https://orcid.org/0000-0002-7284-5446"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Sreenivasan","raw_affiliation_strings":["Department of Biochemistry, College of Agriculture, University of Wisconsin, Madison, Wisconsin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, College of Agriculture, University of Wisconsin, Madison, Wisconsin","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046135486","display_name":"L.S. Dietrich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L.S. Dietrich","raw_affiliation_strings":["Department of Biochemistry, College of Agriculture, University of Wisconsin, Madison, Wisconsin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, College of Agriculture, University of Wisconsin, Madison, Wisconsin","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026320132","display_name":"A.E. Harper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A.E. Harper","raw_affiliation_strings":["Department of Biochemistry, College of Agriculture, University of Wisconsin, Madison, Wisconsin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, College of Agriculture, University of Wisconsin, Madison, Wisconsin","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108488607","display_name":"Conrad Arnold Elvehjem","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C.A. Elvehjem","raw_affiliation_strings":["Department of Biochemistry, College of Agriculture, University of Wisconsin, Madison, Wisconsin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, College of Agriculture, University of Wisconsin, Madison, Wisconsin","institution_ids":["https://openalex.org/I135310074"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I135310074"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":11.4372,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.98391708,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"202","issue":"1","first_page":"151","last_page":"156"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12441","display_name":"Porphyrin Metabolism and Disorders","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitamin-b12-deficiency","display_name":"vitamin B12 deficiency","score":0.9990000128746033},{"id":"https://openalex.org/keywords/liver-enzymes","display_name":"liver enzymes","score":0.9399999976158142},{"id":"https://openalex.org/keywords/xanthine-oxidase","display_name":"xanthine oxidase","score":0.9980000257492065},{"id":"https://openalex.org/keywords/choline-oxidase","display_name":"choline oxidase","score":0.9980000257492065},{"id":"https://openalex.org/keywords/endogenous-respiration","display_name":"endogenous respiration","score":0.9559999704360962},{"id":"https://openalex.org/keywords/aminopterin","display_name":"aminopterin","score":0.7580000162124634},{"id":"https://openalex.org/keywords/folic-acid","display_name":"folic acid","score":0.843999981880188},{"id":"https://openalex.org/keywords/vitamin-b12-metabolism","display_name":"vitamin B12 metabolism","score":0.7160000205039978},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.32199999690055847}],"concepts":[{"id":"https://openalex.org/C2779750884","wikidata":"https://www.wikidata.org/wiki/Q187706","display_name":"Vitamin B12","level":2,"score":0.8061951398849487},{"id":"https://openalex.org/C2780829489","wikidata":"https://www.wikidata.org/wiki/Q252251","display_name":"Cyanocobalamin","level":3,"score":0.627785861492157},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5810412168502808},{"id":"https://openalex.org/C3020359197","wikidata":"https://www.wikidata.org/wiki/Q1359801","display_name":"Liver enzyme","level":2,"score":0.5300787687301636},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.470941424369812},{"id":"https://openalex.org/C2908801736","wikidata":"https://www.wikidata.org/wiki/Q9368","display_name":"Liver metabolism","level":2,"score":0.44821470975875854},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4206007719039917},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3293098211288452},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2868030071258545}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014806","descriptor_name":"Vitamin B 12 Deficiency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0021-9258(19)57115-0","doi":"https://doi.org/10.1016/s0021-9258(19)57115-0","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)57115-0","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:13061440","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/13061440","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0021-9258(19)57115-0","doi":"https://doi.org/10.1016/s0021-9258(19)57115-0","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)57115-0","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W86676327","https://openalex.org/W106640766","https://openalex.org/W137630491","https://openalex.org/W159690656","https://openalex.org/W178275399","https://openalex.org/W185478901","https://openalex.org/W204841571","https://openalex.org/W1480600374","https://openalex.org/W1556372327","https://openalex.org/W1985206639","https://openalex.org/W2027919016","https://openalex.org/W2042420363","https://openalex.org/W2063363129","https://openalex.org/W2063592794","https://openalex.org/W2106159037","https://openalex.org/W2124823471","https://openalex.org/W2224293408","https://openalex.org/W2313826478","https://openalex.org/W2315900827","https://openalex.org/W2327607977","https://openalex.org/W4255979237"],"related_works":["https://openalex.org/W2318510381","https://openalex.org/W615270","https://openalex.org/W2318427668","https://openalex.org/W2349065738","https://openalex.org/W2336818918","https://openalex.org/W2111876436","https://openalex.org/W32213666","https://openalex.org/W779759942","https://openalex.org/W2164596722","https://openalex.org/W1598880644"],"abstract_inverted_index":{"Certain":[0],"general":[1],"functions":[2],"of":[3,35,53,83,96,105,124,127,133,179,190],"vitamin":[4,30,85,111,135,167,180,201],"Blz":[5,31,86,112,136,168,181,202],"and":[6,26,29,50,56,72,156],"folic":[7,18,54],"acid":[8,19,55],"in":[9,24,32,48,51,102,142,204],"intermediary":[10],"metabolism":[11,28],"are":[12],"now":[13],"well":[14,131],"recognized.":[15],"For":[16],"example,":[17],"appears":[20],"to":[21,110],"be":[22,196],"involved":[23],"purine":[25],"formate":[27],"the":[33,46,81,94,99,103,118,125,143,177,188,191,205],"utilization":[34],"methyl":[36],"groups.":[37],"However,":[38],"while":[39],"there":[40,76],"have":[41,120,159],"been":[42,160],"several":[43],"reports":[44],"concerning":[45],"influence":[47],"viva":[49],"vitro":[52],"its":[57],"antagonist,":[58],"aminopterin,":[59],"on":[60,80,87,98,138,176],"specific":[61,108,183],"enzyme":[62,91,140,184],"systems":[63,141],"such":[64],"as":[65,130,132],"xanthine":[66,152],"oxidase":[67,70],"(l-4),":[68],"choline":[69,157],"(58),":[71],"transmethylase":[73],"(9,":[74],"lo),":[75],"is":[77],"scant":[78],"information":[79],"effects":[82,126,189],"dietary":[84],"these":[88],"or":[89],"other":[90],"systems.":[92,185],"In":[93,186],"course":[95],"work":[97],"biological":[100],"action":[101],"rat":[104],"a":[106,122,199],"reported":[107],"antagonist":[109,129,194],"for":[113,149],"Lactobacillus":[114],"leichmannii":[115],"4797":[116],"(ll),":[117],"authors":[119],"undertaken":[121],"study":[123],"this":[128],"simple":[134,200],"deficiency":[137,203],"certain":[139],"rat.":[144,206],"The":[145],"liver":[146],"enzymes":[147],"chosen":[148],"study,":[150],"transmethylase,":[151],"oxidase,":[153,158],"endogenous":[154],"respiration,":[155],"implicated":[161],"indirectly":[162],"by":[163],"various":[164],"workers":[165],"with":[166,182,198],"metabolism.":[169],"These":[170],"investigations":[171],"should":[172],"throw":[173],"some":[174],"light":[175],"involvement":[178],"addition,":[187],"L.":[192],"leichrnannii":[193],"can":[195],"compared":[197]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
