{"id":"https://openalex.org/W2181000133","doi":"https://doi.org/10.1016/j.drudis.2015.09.015","title":"Lost in space: design of experiments and scientific exploration in a Hogarth Universe","display_name":"Lost in space: design of experiments and scientific exploration in a Hogarth Universe","publication_year":2015,"publication_date":"2015-10-25","ids":{"openalex":"https://openalex.org/W2181000133","doi":"https://doi.org/10.1016/j.drudis.2015.09.015","mag":"2181000133","pmid":"https://pubmed.ncbi.nlm.nih.gov/26505134"},"language":"en","primary_location":{"id":"doi:10.1016/j.drudis.2015.09.015","doi":"https://doi.org/10.1016/j.drudis.2015.09.015","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.drudis.2015.09.015","pdf_url":null,"source":{"id":"https://openalex.org/S152068293","display_name":"Drug Discovery Today","issn_l":"1359-6446","issn":["1359-6446","1878-5832"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Discovery Today","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.25405/ncl.34258161","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024068279","display_name":"Dennis William Lendrem","orcid":"https://orcid.org/0000-0001-6268-5509","observed_orcids":["https://orcid.org/0000-0001-6268-5509"]},"institutions":[{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Dennis W. Lendrem","raw_affiliation_strings":["Institute of Cellular Medicine, Newcastle University, Newcastle, UK. Electronic address: dennis.lendrem@newcastle.ac.uk","Institute of Cellular Medicine, Newcastle University, Newcastle, UK"],"raw_orcid":"https://orcid.org/0000-0001-6268-5509","affiliations":[{"raw_affiliation_string":"Institute of Cellular Medicine, Newcastle University, Newcastle, UK. Electronic address: dennis.lendrem@newcastle.ac.uk","institution_ids":["https://openalex.org/I84884186"]},{"raw_affiliation_string":"Institute of Cellular Medicine, Newcastle University, Newcastle, UK","institution_ids":["https://openalex.org/I84884186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006545451","display_name":"Clare Lendrem","orcid":"https://orcid.org/0000-0002-9435-7398","observed_orcids":["https://orcid.org/0000-0002-9435-7398"]},"institutions":[{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"B. Clare Lendrem","raw_affiliation_strings":["Institute of Cellular Medicine, Newcastle University, Newcastle, UK"],"raw_orcid":"https://orcid.org/0000-0002-9435-7398","affiliations":[{"raw_affiliation_string":"Institute of Cellular Medicine, Newcastle University, Newcastle, UK","institution_ids":["https://openalex.org/I84884186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001047279","display_name":"David C. Woods","orcid":"https://orcid.org/0000-0001-7648-429X","observed_orcids":["https://orcid.org/0000-0001-7648-429X"]},"institutions":[{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David Woods","raw_affiliation_strings":["Southampton Statistical Sciences Research Institute, University of Southampton, Southampton, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southampton Statistical Sciences Research Institute, University of Southampton, Southampton, UK","institution_ids":["https://openalex.org/I43439940"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072449335","display_name":"Ruth C. Rowland\u2010Jones","orcid":"https://orcid.org/0000-0002-3678-2791","observed_orcids":["https://orcid.org/0000-0002-3678-2791"]},"institutions":[{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ruth Rowland-Jones","raw_affiliation_strings":["Centre for Bioengineering, Newcastle University, Newcastle, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Bioengineering, Newcastle University, Newcastle, UK","institution_ids":["https://openalex.org/I84884186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070831837","display_name":"Matthew Douglas Burke","orcid":"https://orcid.org/0000-0001-6782-3827","observed_orcids":["https://orcid.org/0000-0001-6782-3827"]},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Burke","raw_affiliation_strings":["GlaxoSmithKline, King of Prussia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline, King of Prussia, PA, USA","institution_ids":["https://openalex.org/I4210114143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079680797","display_name":"Marion J. Chatfield","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Marion Chatfield","raw_affiliation_strings":["Centre for Medicines Research, GlaxoSmithKline, Stevenage, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Medicines Research, GlaxoSmithKline, Stevenage, UK","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045111377","display_name":"John Dudley Isaacs","orcid":"https://orcid.org/0000-0002-6103-7056","observed_orcids":["https://orcid.org/0000-0002-6103-7056"]},"institutions":[{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"John D. Isaacs","raw_affiliation_strings":["Institute of Cellular Medicine, Newcastle University, Newcastle, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cellular Medicine, Newcastle University, Newcastle, UK","institution_ids":["https://openalex.org/I84884186"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046805937","display_name":"Martin R. Owen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Martin R. Owen","raw_affiliation_strings":["Centre for Medicines Research, GlaxoSmithKline, Stevenage, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Medicines Research, GlaxoSmithKline, Stevenage, UK","institution_ids":["https://openalex.org/I188950975"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5024068279"],"corresponding_institution_ids":["https://openalex.org/I84884186"],"apc_list":{"value":4720,"currency":"USD","value_usd":4720},"apc_paid":null,"fwci":0.3301,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.56862745,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"20","issue":"11","first_page":"1365","last_page":"1371"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11798","display_name":"Optimal Experimental Design Methods","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1803","display_name":"Management Science and Operations Research"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T11798","display_name":"Optimal Experimental Design Methods","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1803","display_name":"Management Science and Operations Research"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11195","display_name":"Simulation Techniques and Applications","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1803","display_name":"Management Science and Operations Research"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/experimental-design","display_name":"experimental design","score":0.9570000171661377},{"id":"https://openalex.org/keywords/wicked-problems","display_name":"wicked problems","score":0.652999997138977},{"id":"https://openalex.org/keywords/scientific-intuition","display_name":"scientific intuition","score":0.7900000214576721},{"id":"https://openalex.org/keywords/simulation-software","display_name":"simulation software","score":0.8840000033378601},{"id":"https://openalex.org/keywords/research-confidence","display_name":"research confidence","score":0.35199999809265137},{"id":"https://openalex.org/keywords/scientific-exploration","display_name":"scientific exploration","score":0.3440000116825104}],"concepts":[{"id":"https://openalex.org/C132010649","wikidata":"https://www.wikidata.org/wiki/Q189222","display_name":"Intuition","level":2,"score":0.8661235570907593},{"id":"https://openalex.org/C184047640","wikidata":"https://www.wikidata.org/wiki/Q182593","display_name":"Illusion","level":2,"score":0.6542165279388428},{"id":"https://openalex.org/C84999194","wikidata":"https://www.wikidata.org/wiki/Q1","display_name":"Universe","level":2,"score":0.5863133072853088},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5116303563117981},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.5056195259094238},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.465915709733963},{"id":"https://openalex.org/C2992562121","wikidata":"https://www.wikidata.org/wiki/Q3817808","display_name":"Scientific reasoning","level":2,"score":0.44770246744155884},{"id":"https://openalex.org/C2984917352","wikidata":"https://www.wikidata.org/wiki/Q12772819","display_name":"Scientific discovery","level":2,"score":0.44319653511047363},{"id":"https://openalex.org/C2778572836","wikidata":"https://www.wikidata.org/wiki/Q380933","display_name":"Space (punctuation)","level":2,"score":0.4187161922454834},{"id":"https://openalex.org/C188147891","wikidata":"https://www.wikidata.org/wiki/Q147638","display_name":"Cognitive science","level":1,"score":0.32423627376556396},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3003498315811157},{"id":"https://openalex.org/C180747234","wikidata":"https://www.wikidata.org/wiki/Q23373","display_name":"Cognitive psychology","level":1,"score":0.21545439958572388},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1559777855873108},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.15006095170974731},{"id":"https://openalex.org/C44870925","wikidata":"https://www.wikidata.org/wiki/Q37547","display_name":"Astrophysics","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004777","descriptor_name":"Environment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012586","descriptor_name":"Science","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.drudis.2015.09.015","doi":"https://doi.org/10.1016/j.drudis.2015.09.015","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.drudis.2015.09.015","pdf_url":null,"source":{"id":"https://openalex.org/S152068293","display_name":"Drug Discovery Today","issn_l":"1359-6446","issn":["1359-6446","1878-5832"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Discovery Today","raw_type":"journal-article"},{"id":"pmid:26505134","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26505134","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug discovery today","raw_type":"Journal Article"},{"id":"doi:10.25405/ncl.34258161","doi":"https://doi.org/10.25405/ncl.34258161","is_oa":true,"landing_page_url":"https://doi.org/10.25405/ncl.34258161","pdf_url":null,"source":{"id":"https://openalex.org/S4306402485","display_name":"Newcastle University ePrints (Newcastle Univesity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84884186","host_organization_name":"Newcastle University","host_organization_lineage":["https://openalex.org/I84884186"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.25405/ncl.34258161.v1","doi":"https://doi.org/10.25405/ncl.34258161.v1","is_oa":true,"landing_page_url":"https://doi.org/10.25405/ncl.34258161.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306402485","display_name":"Newcastle University ePrints (Newcastle Univesity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84884186","host_organization_name":"Newcastle University","host_organization_lineage":["https://openalex.org/I84884186"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.25405/ncl.34258161","doi":"https://doi.org/10.25405/ncl.34258161","is_oa":true,"landing_page_url":"https://doi.org/10.25405/ncl.34258161","pdf_url":null,"source":{"id":"https://openalex.org/S4306402485","display_name":"Newcastle University ePrints (Newcastle Univesity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84884186","host_organization_name":"Newcastle University","host_organization_lineage":["https://openalex.org/I84884186"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"score":0.6899999976158142,"id":"https://metadata.un.org/sdg/11","display_name":"Sustainable cities and communities"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2672862473","display_name":null,"funder_award_id":"EP/J018317/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G3308056627","display_name":null,"funder_award_id":"EP/G018502/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G7329224357","display_name":"Statistical Design of Experiments for Complex Nonparametric and Mechanistic Models","funder_award_id":"EP/J018317/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W3489370","https://openalex.org/W36227095","https://openalex.org/W603930255","https://openalex.org/W1489893690","https://openalex.org/W1534446504","https://openalex.org/W1558412013","https://openalex.org/W1570416687","https://openalex.org/W1968226729","https://openalex.org/W1989801492","https://openalex.org/W1991618236","https://openalex.org/W1996796805","https://openalex.org/W2006998103","https://openalex.org/W2012785955","https://openalex.org/W2028894937","https://openalex.org/W2031904534","https://openalex.org/W2051190588","https://openalex.org/W2072649736","https://openalex.org/W2075585362","https://openalex.org/W2076996435","https://openalex.org/W2077285487","https://openalex.org/W2085705680","https://openalex.org/W2089238821","https://openalex.org/W2093851560","https://openalex.org/W2101160109","https://openalex.org/W2107872096","https://openalex.org/W2115704439","https://openalex.org/W2120179935","https://openalex.org/W2120554597","https://openalex.org/W2138001336","https://openalex.org/W2160891611","https://openalex.org/W2169042394","https://openalex.org/W2402925541","https://openalex.org/W2587072524","https://openalex.org/W2752099845","https://openalex.org/W2904438153","https://openalex.org/W2924515003","https://openalex.org/W2993459580","https://openalex.org/W3004335124","https://openalex.org/W3086685252","https://openalex.org/W3121529264","https://openalex.org/W3122910577","https://openalex.org/W4237866497"],"related_works":["https://openalex.org/W2136854744","https://openalex.org/W4392735412","https://openalex.org/W33135318","https://openalex.org/W2917505564","https://openalex.org/W7099783910","https://openalex.org/W587917063","https://openalex.org/W6941629540","https://openalex.org/W2500742456","https://openalex.org/W201947868","https://openalex.org/W2005273090"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":11},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
