{"id":"https://openalex.org/W2180959366","doi":null,"title":"Antifungal agents induces alteration in the matrix composition of candida glabrata biofilms","display_name":"Antifungal agents induces alteration in the matrix composition of candida glabrata biofilms","publication_year":2014,"publication_date":"2014-05-11","ids":{"openalex":"https://openalex.org/W2180959366","mag":"2180959366"},"language":"en","primary_location":{"id":"pmh:oai:repositorium.sdum.uminho.pt:1822/38247","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1822/38247","pdf_url":"http://hdl.handle.net/1822/38247","source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"conference object"},"volume":null,"type":"conference-paper","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/1822/38247","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047444267","display_name":"Celia Fortuna Rodrigues","orcid":"https://orcid.org/0000-0001-8633-2230","observed_orcids":["https://orcid.org/0000-0001-8633-2230","https://orcid.org/0000-0001-5300-3254"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C\u00e9lia F. Rodrigues","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8633-2230","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068512602","display_name":"Elza S. S. Fonseca","orcid":"https://orcid.org/0000-0001-8955-2108","observed_orcids":["https://orcid.org/0000-0001-8955-2108"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elza Fonseca","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8955-2108","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007126369","display_name":"Bruna Gon\u00e7alves","orcid":"https://orcid.org/0000-0003-4308-7567","observed_orcids":["https://orcid.org/0000-0003-4308-7567"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bruna Gon\u00e7alves","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4308-7567","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087028271","display_name":"Diana Bogas","orcid":"https://orcid.org/0000-0002-1037-5784","observed_orcids":["https://orcid.org/0000-0002-1037-5784"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Diana Bogas","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1037-5784","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100713706","display_name":"S\u00f3nia Marina Silva","orcid":"https://orcid.org/0000-0003-0000-7387","observed_orcids":["https://orcid.org/0000-0003-0000-7387"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S\u00f3nia Silva","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0000-7387","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029481092","display_name":"Joana Azeredo","orcid":"https://orcid.org/0000-0002-5180-7133","observed_orcids":["https://orcid.org/0000-0002-5180-7133"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joana Azeredo","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5180-7133","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5060670302","display_name":"Mariana Henriques","orcid":"https://orcid.org/0000-0003-0317-4877","observed_orcids":["https://orcid.org/0000-0003-0317-4877","https://orcid.org/0009-0007-3597-9000","https://orcid.org/0009-0009-2090-449X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mariana Henriques","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0317-4877","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.08185841,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"44","last_page":"44"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/candida-glabrata","display_name":"Candida glabrata","score":0.9990000128746033},{"id":"https://openalex.org/keywords/biofilm","display_name":"biofilm","score":0.7599999904632568},{"id":"https://openalex.org/keywords/antifungal-agents","display_name":"antifungal agents","score":0.7979999780654907},{"id":"https://openalex.org/keywords/biofilm-matrix-composition","display_name":"biofilm matrix composition","score":0.8450000286102295},{"id":"https://openalex.org/keywords/fluconazole","display_name":"fluconazole","score":0.7749999761581421},{"id":"https://openalex.org/keywords/voriconazole","display_name":"voriconazole","score":1.0},{"id":"https://openalex.org/keywords/amphotericin-b","display_name":"amphotericin B","score":1.0},{"id":"https://openalex.org/keywords/ergosterol","display_name":"ergosterol","score":0.8970000147819519},{"id":"https://openalex.org/keywords/erg11","display_name":"ERG11","score":0.9760000109672546},{"id":"https://openalex.org/keywords/erg6","display_name":"ERG6","score":0.9980000257492065},{"id":"https://openalex.org/keywords/polysaccharides","display_name":"polysaccharides","score":0.7570000290870667},{"id":"https://openalex.org/keywords/antifungal-resistance","display_name":"antifungal resistance","score":0.7730000019073486},{"id":"https://openalex.org/keywords/invasive-fungal-infections","display_name":"invasive fungal infections","score":0.48899999260902405}],"concepts":[{"id":"https://openalex.org/C2780670043","wikidata":"https://www.wikidata.org/wiki/Q139137","display_name":"Candida glabrata","level":3,"score":0.7755094766616821},{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.7078571319580078},{"id":"https://openalex.org/C2779548794","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal","level":2,"score":0.6612387299537659},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.556950569152832},{"id":"https://openalex.org/C40231798","wikidata":"https://www.wikidata.org/wiki/Q1333743","display_name":"Composition (language)","level":2,"score":0.42936909198760986},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42632532119750977},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3438203036785126},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.213921457529068},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08708149194717407},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:repositorium.sdum.uminho.pt:1822/38247","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1822/38247","pdf_url":"http://hdl.handle.net/1822/38247","source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"conference object"},{"id":"pmh:oai:repositorium.uminho.pt:1822/38247","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1822/38247","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"other"},{"id":"mag:2180959366","doi":null,"is_oa":false,"landing_page_url":"http://repositorium.sdum.uminho.pt/bitstream/1822/38247/1/document_26492_1.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:repositorium.sdum.uminho.pt:1822/38247","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1822/38247","pdf_url":"http://hdl.handle.net/1822/38247","source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"conference object"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2180959366.pdf","grobid_xml":"https://content.openalex.org/works/W2180959366.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W203116817","https://openalex.org/W2262122962","https://openalex.org/W6885027339","https://openalex.org/W2252263759","https://openalex.org/W2517264731","https://openalex.org/W2282572530","https://openalex.org/W2607982074","https://openalex.org/W2798073876","https://openalex.org/W2227503572","https://openalex.org/W7084291728"],"abstract_inverted_index":{"Candida":[0,11],"glabrata":[1,62,84,98,137],"has":[2,24],"emerged":[3],"as":[4,304],"the":[5,29,56,68,76,88,103,161,164,173,182,196,199,205,219,228,231,243,247,262,268,326,358],"second":[6],"most":[7,30],"prevalent":[8],"pathogen,":[9],"after":[10],"albicans,":[12],"in":[13,44,90,102,119,152,160,166,172,190,204,214,217,222,267,311,325,354,357],"mucosal":[14],"and":[15,87,110,124,126,145,177,221,252,306],"invasive":[16],"fungal":[17,45],"infection.":[18],"Its":[19],"ability":[20],"to":[21,40,64,74,142,168,181,242,259,299,319,334,341,349,351],"form":[22],"biofilms":[23,63,99,138],"been":[25],"considered":[26],"one":[27,315],"of":[28,53,60,70,78,105,121,163,175,184,201,230,239,254,265,278,328],"important":[31],"virulence":[32],"factors,":[33],"since":[34],"they":[35],"present":[36,216],"a":[37,51,153],"high":[38],"resistance":[39,92],"antifungal":[41,65,80,342],"agents":[42,81,186,343],"used":[43],"infections":[46],"treatment.":[47],"Moreover,":[48],"there":[49,234],"is":[50,235,296],"lack":[52],"information":[54],"about":[55],"physiolo":[57],"gical":[58],"response":[59],"C.":[61,83,97,136],"agents.":[66],"Thus,":[67],"aim":[69],"this":[71,202],"study":[72],"was":[73,117,130,209,271,286,292,297,317,331],"evaluate":[75],"effect":[77],"different":[79,191,248],"on":[82],"biofilm":[85,240,269,312,337,359],"composition":[86,116],"influence":[89],"related":[91],"genes":[93,128,322],"expression.":[94],"For":[95],"that":[96,211,250,301,336],"were":[100,158,309],"formed":[101],"presence":[104,162,174,200,229,327],"fluconazole":[106],"(Flu),":[107],"voriconazole":[108],"(Vrz)":[109],"amphotericin":[111],"B":[112],"(AmB).":[113],"Biofilm":[114],"matrix":[115,255,270],"evaluated":[118],"terms":[120],"polysaccharides,":[122],"proteins":[123,279],"ergosterol":[125,212,266,282,355],"ERG":[127,284,289,321,345],"expression":[129,285,291],"also":[131],"assessed.":[132],"As":[133],"expec":[134],"ted":[135],"are":[139],"more":[140],"resistant":[141],"Flu,":[143],"Vrz":[144],"AmB":[146,176],"than":[147],"planktonic":[148],"cells.":[149,313],".":[150],"Although":[151,288],"strain":[154,294,316],"dependent":[155,295],"manner,":[156],"polysaccharides":[157],"increased":[159,226,263],"antifungals,":[165],"opposition":[167],"proteins,":[169],"which":[170,347],"decreased":[171],"Vrz.":[178,329],"D":[179],"ue":[180],"interaction":[183],"these":[185],"with":[187,227],"ergosterol,":[188],"even":[189],"ways,":[192],"we":[193],"evaluated,":[194],"for":[195,281],"first":[197],"time,":[198],"compound":[203],"extracelluar":[206],"matrix.":[207,360],"It":[208,330],"noticed":[210],"was,":[213],"fact,":[215],"all":[218],"matrices":[220],"gener":[223],"al":[224],"it":[225],"drugs.":[232],"Therefore,":[233],"an":[236,274,352],"obvious":[237],"answer":[238],"cells":[241,338],"stress":[244],"induced":[245],"by":[246,273],"agents,":[249],"caused":[251,272],"alteration":[253],"composition.":[256],"In":[257],"order":[258],"determine":[260],"if":[261],"concentration":[264,356],"up":[275],"-":[276],"regulation":[277],"responsible":[280],"synthesis,":[283],"evaluated..":[287],"gene":[290],"very":[293],"possible":[298,333],"verify":[300],"some":[302],"genes,":[303,346],"ERG11":[305],"ERG6":[307],",":[308],"upregulated":[310],"Interestingly":[314],"unable":[318],"express":[320],"when":[323],"grown":[324],"then":[332],"conclude":[335],"upon":[339],"exposure":[340],"overexpress":[344],"seems":[348],"contribute":[350],"increase":[353]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}