{"id":"https://openalex.org/W2180845934","doi":"https://doi.org/10.1126/scitranslmed.aaa9712","title":"Smooth muscle cell progenitors are primed to muscularize in pulmonary hypertension","display_name":"Smooth muscle cell progenitors are primed to muscularize in pulmonary hypertension","publication_year":2015,"publication_date":"2015-10-07","ids":{"openalex":"https://openalex.org/W2180845934","doi":"https://doi.org/10.1126/scitranslmed.aaa9712","mag":"2180845934","pmid":"https://pubmed.ncbi.nlm.nih.gov/26446956","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4629985"},"language":"en","primary_location":{"id":"doi:10.1126/scitranslmed.aaa9712","doi":"https://doi.org/10.1126/scitranslmed.aaa9712","is_oa":false,"landing_page_url":"https://doi.org/10.1126/scitranslmed.aaa9712","pdf_url":null,"source":{"id":"https://openalex.org/S24207032","display_name":"Science Translational Medicine","issn_l":"1946-6234","issn":["1946-6234","1946-6242"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Translational Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4629985","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044941877","display_name":"Abdul Q. Sheikh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abdul Q. Sheikh","raw_affiliation_strings":["Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, 300 George Street, Room 773J, New Haven, CT 06511, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, 300 George Street, Room 773J, New Haven, CT 06511, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079414138","display_name":"Ashish Misra","orcid":"https://orcid.org/0000-0002-8901-4788","observed_orcids":["https://orcid.org/0000-0002-8901-4788"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashish Misra","raw_affiliation_strings":["Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, 300 George Street, Room 773J, New Haven, CT 06511, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, 300 George Street, Room 773J, New Haven, CT 06511, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034439885","display_name":"Iv\u00e1n O. Rosas","orcid":"https://orcid.org/0000-0003-4622-618X","observed_orcids":["https://orcid.org/0000-0003-4622-618X"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ivan O. Rosas","raw_affiliation_strings":["Division of Pulmonary and Critical Care, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Critical Care, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055656957","display_name":"Ralf H. Adams","orcid":"https://orcid.org/0000-0003-3031-7677","observed_orcids":["https://orcid.org/0000-0003-3031-7677"]},"institutions":[{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]},{"id":"https://openalex.org/I4210152666","display_name":"Max Planck Institute for Molecular Biomedicine","ror":"https://ror.org/040djv263","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210152666"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ralf H. Adams","raw_affiliation_strings":["Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine, and Faculty of Medicine, University of M\u00fcnster, 48149 M\u00fcnster, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine, and Faculty of Medicine, University of M\u00fcnster, 48149 M\u00fcnster, Germany","institution_ids":["https://openalex.org/I22465464","https://openalex.org/I4210152666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088025612","display_name":"Daniel M. Greif","orcid":"https://orcid.org/0000-0002-9842-3751","observed_orcids":["https://orcid.org/0000-0002-9842-3751"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Daniel M. Greif","raw_affiliation_strings":["Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, 300 George Street, Room 773J, New Haven, CT 06511, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, 300 George Street, Room 773J, New Haven, CT 06511, USA","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5088025612"],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":null,"apc_paid":null,"fwci":12.0424,"has_fulltext":false,"cited_by_count":175,"citation_normalized_percentile":{"value":0.990381,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"7","issue":"308","first_page":"308ra159","last_page":"308ra159"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13426","display_name":"Kruppel-like factors research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12199","display_name":"Vascular Anomalies and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pulmonary-hypertension","display_name":"pulmonary hypertension","score":0.9610000252723694},{"id":"https://openalex.org/keywords/pdgfrbeta","display_name":"PDGFR\u03b2","score":0.765999972820282},{"id":"https://openalex.org/keywords/pdgf-b","display_name":"PDGF-B","score":0.8489999771118164},{"id":"https://openalex.org/keywords/klf4","display_name":"KLF4","score":0.9800000190734863},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.9449999928474426},{"id":"https://openalex.org/keywords/smooth-muscle-dedifferentiation","display_name":"smooth muscle dedifferentiation","score":0.8519999980926514},{"id":"https://openalex.org/keywords/clonal-expansion","display_name":"clonal expansion","score":0.7049999833106995},{"id":"https://openalex.org/keywords/vascular-smooth-muscle","display_name":"vascular smooth muscle","score":0.4790000021457672},{"id":"https://openalex.org/keywords/progenitor-cells","display_name":"progenitor cells","score":0.42500001192092896}],"concepts":[{"id":"https://openalex.org/C2780930700","wikidata":"https://www.wikidata.org/wiki/Q1128595","display_name":"Pulmonary hypertension","level":2,"score":0.6588240265846252},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.5816347599029541},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4706639051437378},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45661845803260803},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.44184398651123047},{"id":"https://openalex.org/C2992686903","wikidata":"https://www.wikidata.org/wiki/Q208453","display_name":"Smooth muscle","level":2,"score":0.42100146412849426},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3494601249694824},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33643752336502075},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.19187462329864502},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16906288266181946}],"mesh":[{"descriptor_ui":"D000090062","descriptor_name":"Kruppel-Like Factor 4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006976","descriptor_name":"Hypertension, Pulmonary","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006976","descriptor_name":"Hypertension, Pulmonary","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D032389","descriptor_name":"Myocytes, Smooth Muscle","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D032389","descriptor_name":"Myocytes, Smooth Muscle","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051741","descriptor_name":"Kruppel-Like Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1126/scitranslmed.aaa9712","doi":"https://doi.org/10.1126/scitranslmed.aaa9712","is_oa":false,"landing_page_url":"https://doi.org/10.1126/scitranslmed.aaa9712","pdf_url":null,"source":{"id":"https://openalex.org/S24207032","display_name":"Science Translational Medicine","issn_l":"1946-6234","issn":["1946-6234","1946-6242"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Translational Medicine","raw_type":"journal-article"},{"id":"pmid:26446956","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26446956","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science translational medicine","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3791425","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4629985","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4629985","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4629985","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Sci Transl Med","raw_type":"Text"},{"id":"pmh:oai:edoc.mpg.de:717260","doi":null,"is_oa":false,"landing_page_url":"http://edoc.mpg.de/717260","pdf_url":null,"source":{"id":"https://openalex.org/S4406922265","display_name":"Max Planck Institute for Plasma Physics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sci Transl Med, v.7, 308ra159 (2015)","raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3791425","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4629985","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1486382052","display_name":"Endothelial-smooth muscle cell interactions and OCT4 in pulmonary hypertension","funder_award_id":"15IRG23150002","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"},{"id":"https://openalex.org/G2251053091","display_name":"Arteriole muscularization in pulmonary hypertension: role of pluripotency factors","funder_award_id":"15POST22930050","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"},{"id":"https://openalex.org/G4743246669","display_name":"Morphogenesis of the pulmonary artery smooth muscle layer","funder_award_id":"K08HL093362","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5022047697","display_name":null,"funder_award_id":"RG-310716","funder_id":"https://openalex.org/F4320307154","funder_display_name":"American Lung Association"},{"id":"https://openalex.org/G5379998245","display_name":null,"funder_award_id":"RT-271901","funder_id":"https://openalex.org/F4320307154","funder_display_name":"American Lung Association"},{"id":"https://openalex.org/G8052269359","display_name":"Yale University Clinical and Translational Science Award Program","funder_award_id":"UL1RR024139","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G9000289341","display_name":null,"funder_award_id":"CTSA 5UL1RR024139-08","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320307053","display_name":"Pulmonary Hypertension Association","ror":"https://ror.org/05awtjt98"},{"id":"https://openalex.org/F4320307154","display_name":"American Lung Association","ror":"https://ror.org/01p3rh655"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1237363190","https://openalex.org/W1821665499","https://openalex.org/W1979129486","https://openalex.org/W1981790371","https://openalex.org/W1984662275","https://openalex.org/W1986624570","https://openalex.org/W1997303582","https://openalex.org/W1998486974","https://openalex.org/W1999800789","https://openalex.org/W2000949542","https://openalex.org/W2004127755","https://openalex.org/W2019961938","https://openalex.org/W2026299035","https://openalex.org/W2039971229","https://openalex.org/W2044762564","https://openalex.org/W2045450215","https://openalex.org/W2046957688","https://openalex.org/W2067561562","https://openalex.org/W2070114011","https://openalex.org/W2070255306","https://openalex.org/W2073468758","https://openalex.org/W2081006617","https://openalex.org/W2104010513","https://openalex.org/W2104135721","https://openalex.org/W2108373798","https://openalex.org/W2110153861","https://openalex.org/W2117339256","https://openalex.org/W2121822802","https://openalex.org/W2125987139","https://openalex.org/W2136978968","https://openalex.org/W2137720222","https://openalex.org/W2141814949","https://openalex.org/W2147011107","https://openalex.org/W2150949973","https://openalex.org/W2155062899","https://openalex.org/W2159545748","https://openalex.org/W2163323710","https://openalex.org/W2165946847","https://openalex.org/W2166871205","https://openalex.org/W2183644045","https://openalex.org/W2582602949","https://openalex.org/W2614800967","https://openalex.org/W3103761932","https://openalex.org/W7056864468"],"related_works":["https://openalex.org/W3008903621","https://openalex.org/W2800122917","https://openalex.org/W4387270314","https://openalex.org/W1978496494","https://openalex.org/W2129104904","https://openalex.org/W2234452149","https://openalex.org/W2144258645","https://openalex.org/W4395082976","https://openalex.org/W2020034906","https://openalex.org/W2045450215"],"abstract_inverted_index":{"Excess":[0],"and":[1,59,64,92,102,123,126,135,172,177],"ectopic":[2],"smooth":[3,38,148],"muscle":[4,39],"cells":[5,77],"(SMCs)":[6],"are":[7,16,51,129,165],"central":[8],"to":[9,40,107,185],"cardiovascular":[10],"disease":[11,33],"pathogenesis,":[12],"but":[13],"underlying":[14],"mechanisms":[15],"poorly":[17],"defined.":[18],"For":[19],"instance,":[20],"pulmonary":[21,26,43,55,146],"hypertension":[22],"(PH)":[23],"or":[24],"elevated":[25],"artery":[27],"blood":[28],"pressure":[29],"is":[30,142],"a":[31,159],"devastating":[32],"with":[34],"distal":[35,109,132],"extension":[36],"of":[37,97,114,161,170],"normally":[41],"unmuscularized":[42],"arterioles.":[44],"We":[45,74],"identify":[46],"novel":[47],"SMC":[48,62,162],"progenitors":[49,163],"that":[50,164],"located":[52],"at":[53],"the":[54,65,85,108,115,168],"arteriole":[56,133,147],"muscular-unmuscular":[57],"border":[58],"express":[60,84],"both":[61],"markers":[63],"undifferentiated":[66],"mesenchyme":[67],"marker":[68],"platelet-derived":[69],"growth":[70],"factor":[71,87,89],"receptor-\u03b2":[72],"(PDGFR-\u03b2).":[73],"term":[75],"these":[76],"\"primed\"":[78],"because":[79],"in":[80,93,138,145,151],"hypoxia-induced":[81,112],"PH,":[82,171],"they":[83],"pluripotency":[86],"Kruppel-like":[88],"4":[90],"(KLF4),":[91],"each":[94],"arteriole,":[95],"one":[96],"them":[98],"migrates":[99],"distally,":[100],"dedifferentiates,":[101],"clonally":[103],"expands,":[104],"giving":[105],"rise":[106],"SMCs.":[110,153],"Furthermore,":[111],"expression":[113],"ligand":[116],"PDGF-B":[117,125],"regulates":[118],"primed":[119],"cell":[120,182],"KLF4":[121,127,141],"expression,":[122],"enhanced":[124],"levels":[128],"required":[130],"for":[131,167],"muscularization":[134],"PH.":[136],"Finally,":[137],"PH":[139],"patients,":[140],"markedly":[143],"up-regulated":[144],"muscle,":[149],"especially":[150],"proliferating":[152],"In":[154],"sum,":[155],"we":[156],"have":[157,186],"identified":[158],"pool":[160],"critical":[166],"pathogenesis":[169],"perhaps":[173],"other":[174],"vascular":[175],"disorders,":[176],"therapeutic":[178],"strategies":[179],"targeting":[180],"this":[181],"type":[183],"promise":[184],"profound":[187],"implications.":[188]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":19},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":22},{"year":2021,"cited_by_count":27},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":16},{"year":2018,"cited_by_count":26},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":11}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}