{"id":"https://openalex.org/W2180794874","doi":null,"title":"Tonic glucocorticoids suppress stress-induced MKP-1 gene expression within parvocellular neurons","display_name":"Tonic glucocorticoids suppress stress-induced MKP-1 gene expression within parvocellular neurons","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2180794874","mag":"2180794874"},"language":"en","primary_location":{"id":"pmh:oai:cuscholar:vm40xs105","doi":null,"is_oa":true,"landing_page_url":"https://scholar.colorado.edu/concern/undergraduate_honors_theses/vm40xs105","pdf_url":"http://scholar.colorado.edu/downloads/5712m701v","source":{"id":"https://openalex.org/S4306401957","display_name":"CU Scholar (University of Colorado Boulder)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I188538660","host_organization_name":"University of Colorado Boulder","host_organization_lineage":["https://openalex.org/I188538660"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Undergraduate Honors Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://scholar.colorado.edu/downloads/5712m701v","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Vanessa M. Thompson","orcid":"https://orcid.org/0000-0003-0431-4923","observed_orcids":["https://orcid.org/0000-0003-0431-4923"]},"institutions":[{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Vanessa M. Thompson","raw_affiliation_strings":["University of Colorado Boulder"],"raw_orcid":"https://orcid.org/0000-0003-0431-4923","affiliations":[{"raw_affiliation_string":"University of Colorado Boulder","institution_ids":["https://openalex.org/I188538660"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I188538660"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mkp-1","display_name":"MKP-1","score":0.9879999756813049},{"id":"https://openalex.org/keywords/glucocorticoids","display_name":"glucocorticoids","score":0.8889999985694885},{"id":"https://openalex.org/keywords/restraint-stress","display_name":"restraint stress","score":0.7039999961853027},{"id":"https://openalex.org/keywords/hypothalamic-paraventricular-nucleus","display_name":"hypothalamic paraventricular nucleus","score":0.8429999947547913},{"id":"https://openalex.org/keywords/anterior-pituitary","display_name":"anterior pituitary","score":0.8339999914169312},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-adrenal-axis","display_name":"hypothalamic-pituitary-adrenal axis","score":0.9589999914169312},{"id":"https://openalex.org/keywords/corticotropin-releasing-factor","display_name":"corticotropin-releasing factor","score":0.902999997138977},{"id":"https://openalex.org/keywords/erk1-2","display_name":"ERK1/2","score":0.8309999704360962},{"id":"https://openalex.org/keywords/adrenalectomy","display_name":"adrenalectomy","score":0.902999997138977},{"id":"https://openalex.org/keywords/prelimbic-cortex","display_name":"prelimbic cortex","score":0.8230000138282776},{"id":"https://openalex.org/keywords/infralimbic-cortex","display_name":"infralimbic cortex","score":0.9990000128746033},{"id":"https://openalex.org/keywords/stress-responsive-gene-expression","display_name":"stress-responsive gene expression","score":0.6140000224113464},{"id":"https://openalex.org/keywords/negative-feedback","display_name":"negative feedback","score":0.7269999980926514}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6126032471656799},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6040490865707397},{"id":"https://openalex.org/C2780841215","wikidata":"https://www.wikidata.org/wiki/Q422549","display_name":"Glucocorticoid","level":2,"score":0.5505457520484924},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5286968946456909},{"id":"https://openalex.org/C2778458438","wikidata":"https://www.wikidata.org/wiki/Q386664","display_name":"Corticotropin-releasing hormone","level":3,"score":0.5193813443183899},{"id":"https://openalex.org/C2779555244","wikidata":"https://www.wikidata.org/wiki/Q409638","display_name":"Immediate early gene","level":4,"score":0.5168986320495605},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.5111234784126282},{"id":"https://openalex.org/C2779934784","wikidata":"https://www.wikidata.org/wiki/Q16259058","display_name":"Infralimbic cortex","level":4,"score":0.4833204746246338},{"id":"https://openalex.org/C121731113","wikidata":"https://www.wikidata.org/wiki/Q7141373","display_name":"Parvocellular cell","level":3,"score":0.46539175510406494},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4459710717201233},{"id":"https://openalex.org/C59493245","wikidata":"https://www.wikidata.org/wiki/Q14877410","display_name":"Glucocorticoid receptor","level":3,"score":0.42013972997665405},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.39304986596107483},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.36934375762939453},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33096349239349365},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.21333155035972595},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19864118099212646},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.18563401699066162},{"id":"https://openalex.org/C2781195155","wikidata":"https://www.wikidata.org/wiki/Q18680","display_name":"Prefrontal cortex","level":3,"score":0.17001959681510925},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10910889506340027},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06771916151046753},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:cuscholar:vm40xs105","doi":null,"is_oa":true,"landing_page_url":"https://scholar.colorado.edu/concern/undergraduate_honors_theses/vm40xs105","pdf_url":"http://scholar.colorado.edu/downloads/5712m701v","source":{"id":"https://openalex.org/S4306401957","display_name":"CU Scholar (University of Colorado Boulder)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I188538660","host_organization_name":"University of Colorado Boulder","host_organization_lineage":["https://openalex.org/I188538660"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Undergraduate Honors Thesis"},{"id":"pmh:oai:scholar.colorado.edu:honr_theses-1898","doi":null,"is_oa":true,"landing_page_url":"https://scholar.colorado.edu/honr_theses/703","pdf_url":"https://scholar.colorado.edu/honr_theses/703","source":{"id":"https://openalex.org/S4306401957","display_name":"CU Scholar (University of Colorado Boulder)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I188538660","host_organization_name":"University of Colorado Boulder","host_organization_lineage":["https://openalex.org/I188538660"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Undergraduate Honors Theses","raw_type":"text"},{"id":"mag:2180794874","doi":null,"is_oa":false,"landing_page_url":"https://scholar.colorado.edu/honr_theses/703/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:cuscholar:vm40xs105","doi":null,"is_oa":true,"landing_page_url":"https://scholar.colorado.edu/concern/undergraduate_honors_theses/vm40xs105","pdf_url":"http://scholar.colorado.edu/downloads/5712m701v","source":{"id":"https://openalex.org/S4306401957","display_name":"CU Scholar (University of Colorado Boulder)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I188538660","host_organization_name":"University of Colorado Boulder","host_organization_lineage":["https://openalex.org/I188538660"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Undergraduate Honors Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2180794874.pdf","grobid_xml":"https://content.openalex.org/works/W2180794874.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W20284704","https://openalex.org/W124461014","https://openalex.org/W1498494065","https://openalex.org/W1540225236","https://openalex.org/W1821495885","https://openalex.org/W1910488559","https://openalex.org/W1972368286","https://openalex.org/W1988157043","https://openalex.org/W1988321620","https://openalex.org/W2003192779","https://openalex.org/W2023514678","https://openalex.org/W2036568860","https://openalex.org/W2042159742","https://openalex.org/W2045441934","https://openalex.org/W2056945381","https://openalex.org/W2063625099","https://openalex.org/W2064315281","https://openalex.org/W2074802748","https://openalex.org/W2078131594","https://openalex.org/W2079998168","https://openalex.org/W2085124463","https://openalex.org/W2093358121","https://openalex.org/W2095905991","https://openalex.org/W2107866517","https://openalex.org/W2125088870","https://openalex.org/W2125099281","https://openalex.org/W2132014973","https://openalex.org/W2132539548","https://openalex.org/W2134428950","https://openalex.org/W2134879766","https://openalex.org/W2145906341","https://openalex.org/W2159932176","https://openalex.org/W2163538945","https://openalex.org/W4255304519"],"related_works":["https://openalex.org/W2129541316","https://openalex.org/W2171096160","https://openalex.org/W2057542375","https://openalex.org/W2519755604","https://openalex.org/W3164107429","https://openalex.org/W2121738155","https://openalex.org/W2995112400","https://openalex.org/W1967015515","https://openalex.org/W2163538945","https://openalex.org/W2001430604"],"abstract_inverted_index":{"Mitogen-activated":[0],"kinase":[1,11],"phosophatase-1":[2],"(MKP-1)":[3],"inhibits":[4],"the":[5,56,101,111,129,170,181,190,195,208,227,233,251],"activity":[6],"of":[7,83,110,221],"extracellular":[8],"signaling":[9],"regulated":[10],"(ERK-1/2)":[12],"via":[13],"dephosphorylation.ERK-1/2":[14],"has":[15,34],"been":[16,35],"shown":[17,36],"to":[18,37,81,128,133,232],"be":[19,75],"important":[20],"for":[21],"membrane":[22],"excitability":[23],"that":[24,79,124,162,201,212],"results":[25,210],"in":[26,116,158,226,236],"corticotropin":[27],"releasing":[28],"hormone":[29],"(CRH)":[30],"peptide":[31],"secretion":[32,50],"and":[33,51,93,106,115,121,142,151,177,180,229],"regulate":[38],"CRH":[39,49,52],"gene":[40,53,70,78,98,166,186,214,248],"transcription.Glucocorticoid":[41],"hormones":[42],"produce":[43],"negative":[44,85],"feedback":[45,86],"by":[46,218],"suppressing":[47],"both":[48],"transcription,":[54],"although":[55],"specific":[57],"molecular":[58],"mechanism":[59],"is":[60,216],"unknown.In":[61],"some":[62,82,237],"peripheral":[63,238],"tissue":[64],"cell":[65],"types,":[66],"glucocorticoids":[67,95,241],"induce":[68,245],"MKP-1":[69,73,97,152,165,185,205,213,247],"transcription;":[71],"therefore,":[72],"could":[74],"a":[76],"target":[77],"contributes":[80],"glucocorticoid":[84],"actions.We":[87],"examined":[88,173,193],"whether":[89],"acute":[90],"stress":[91,135,140],"(restraint)":[92],"tonic":[94,240],"affect":[96],"transcription":[99,215],"within":[100,168,188,207,250],"hypothalamic":[102],"paraventricular":[103],"nucleus":[104],"(PVN)":[105],"anterior":[107],"pituitary":[108],"elements":[109],"hypothalamic-pituitary-adrenal":[112],"(HPA)":[113],"axis":[114],"select":[117],"brain":[118,171,228],"regions":[119,172,191],"(prelimbic":[120],"infralimbic":[122,178],"cortex)":[123,179],"provide":[125],"neural":[126],"input":[127],"HPA-axis.Rats":[130],"were":[131,143,149],"exposed":[132],"no":[134],"or":[136,148],"30":[137],"min":[138],"restraint":[139,163],"(RS)":[141],"left":[144],"either":[145],"adrenal":[146],"intact":[147],"adrenalectomized,":[150],"mRNA":[153],"was":[154],"then":[155],"measured":[156],"using":[157],"situ":[159],"hybridization.We":[160],"found":[161,200],"induced":[164,184],"expression":[167,187,206,249],"all":[169,189],"(PVN,":[174],"prelimbic":[175,196],"cortex,":[176],"pituitary.Adrenalectomy":[182],"also":[183,199],"we":[192,198],"except":[194],"cortex.Lastly,":[197],"adrenalectomy":[202],"augmented":[203],"stress-induced":[204,219,246],"pituitary.These":[209],"indicate":[211],"upregulated":[217],"activation":[220],"intracellular":[222],"signal":[223],"transduction":[224],"pathways":[225],"pituitary.However,":[230],"contrary":[231],"previous":[234],"findings":[235],"tissues,":[239],"suppress":[242],"rather":[243],"than":[244],"PVN.":[252]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}
