{"id":"https://openalex.org/W2180679472","doi":"https://doi.org/10.3892/etm.2015.2883","title":"Hydrogen-rich saline attenuates steroid-associated femoral head necrosis through inhibition of oxidative stress in a rabbit model","display_name":"Hydrogen-rich saline attenuates steroid-associated femoral head necrosis through inhibition of oxidative stress in a rabbit model","publication_year":2015,"publication_date":"2015-11-19","ids":{"openalex":"https://openalex.org/W2180679472","doi":"https://doi.org/10.3892/etm.2015.2883","mag":"2180679472","pmid":"https://pubmed.ncbi.nlm.nih.gov/26889236","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4726855"},"language":"en","primary_location":{"id":"doi:10.3892/etm.2015.2883","doi":"https://doi.org/10.3892/etm.2015.2883","is_oa":true,"landing_page_url":"https://doi.org/10.3892/etm.2015.2883","pdf_url":"http://www.spandidos-publications.com/10.3892/etm.2015.2883/download","source":{"id":"https://openalex.org/S151424340","display_name":"Experimental and Therapeutic Medicine","issn_l":"1792-0981","issn":["1792-0981","1792-1015"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and Therapeutic Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://www.spandidos-publications.com/10.3892/etm.2015.2883/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043314217","display_name":"Sheng\u2010Li Huang","orcid":"https://orcid.org/0000-0002-5003-6904","observed_orcids":["https://orcid.org/0000-0002-5003-6904"]},"institutions":[{"id":"https://openalex.org/I4210131893","display_name":"Second Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/03aq7kf18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131893"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"SHENG-LI HUANG","raw_affiliation_strings":["Department of Orthopedics, The Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, The Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China","institution_ids":["https://openalex.org/I4210131893","https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108740524","display_name":"Jian Jiao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131893","display_name":"Second Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/03aq7kf18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131893"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"JIAN JIAO","raw_affiliation_strings":["Department of Orthopedics, The Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, The Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China","institution_ids":["https://openalex.org/I4210131893","https://openalex.org/I87445476"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100901876","display_name":"HONG-WEI YAN","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131893","display_name":"Second Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/03aq7kf18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131893"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"HONG-WEI YAN","raw_affiliation_strings":["Department of Orthopedics, The Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, The Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China","institution_ids":["https://openalex.org/I4210131893","https://openalex.org/I87445476"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.3519,"has_fulltext":true,"cited_by_count":31,"citation_normalized_percentile":{"value":0.88070573,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"11","issue":"1","first_page":"177","last_page":"182"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13775","display_name":"Hydrogen's biological and therapeutic effects","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13775","display_name":"Hydrogen's biological and therapeutic effects","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12209","display_name":"Bone and Joint Diseases","score":0.013199999928474426,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10736","display_name":"Hydrogen embrittlement and corrosion behaviors in metals","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2506","display_name":"Metals and Alloys"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hydrogen-rich-saline","display_name":"hydrogen-rich saline","score":0.9929999709129333},{"id":"https://openalex.org/keywords/hydrogen-therapy","display_name":"hydrogen treatment","score":0.7129999995231628},{"id":"https://openalex.org/keywords/steroid-associated-osteonecrosis","display_name":"steroid-associated osteonecrosis","score":0.8460000157356262},{"id":"https://openalex.org/keywords/avascular-necrosis-of-the-femoral-head","display_name":"osteonecrosis of the femoral head","score":0.9520000219345093},{"id":"https://openalex.org/keywords/prednisolone","display_name":"prednisolone","score":0.9259999990463257},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9480000138282776},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.8420000076293945},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.8999999761581421},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9829999804496765},{"id":"https://openalex.org/keywords/thrombomodulin","display_name":"thrombomodulin","score":1.0},{"id":"https://openalex.org/keywords/microvessel-density","display_name":"microvessel density","score":0.9559999704360962}],"concepts":[{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.7954599857330322},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.7152920961380005},{"id":"https://openalex.org/C2780902042","wikidata":"https://www.wikidata.org/wiki/Q177911","display_name":"Steroid","level":3,"score":0.5862223505973816},{"id":"https://openalex.org/C503630168","wikidata":"https://www.wikidata.org/wiki/Q178069","display_name":"Necrosis","level":2,"score":0.5804962515830994},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.49587282538414},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.4645054042339325},{"id":"https://openalex.org/C2779884254","wikidata":"https://www.wikidata.org/wiki/Q492162","display_name":"Rabbit (cipher)","level":2,"score":0.4634544551372528},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4580714702606201},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4148826599121094},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3379843235015869},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.3326101005077362},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.31105417013168335},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2755216956138611},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26946619153022766},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.18805503845214844},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15836679935455322},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3892/etm.2015.2883","doi":"https://doi.org/10.3892/etm.2015.2883","is_oa":true,"landing_page_url":"https://doi.org/10.3892/etm.2015.2883","pdf_url":"http://www.spandidos-publications.com/10.3892/etm.2015.2883/download","source":{"id":"https://openalex.org/S151424340","display_name":"Experimental and Therapeutic Medicine","issn_l":"1792-0981","issn":["1792-0981","1792-1015"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and Therapeutic Medicine","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3717036","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4726855","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4726855","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4726855","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Exp Ther Med","raw_type":"Text"},{"id":"pmid:26889236","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26889236","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and therapeutic medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3892/etm.2015.2883","doi":"https://doi.org/10.3892/etm.2015.2883","is_oa":true,"landing_page_url":"https://doi.org/10.3892/etm.2015.2883","pdf_url":"http://www.spandidos-publications.com/10.3892/etm.2015.2883/download","source":{"id":"https://openalex.org/S151424340","display_name":"Experimental and Therapeutic Medicine","issn_l":"1792-0981","issn":["1792-0981","1792-1015"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and Therapeutic Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2180679472.pdf","grobid_xml":"https://content.openalex.org/works/W2180679472.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W171290770","https://openalex.org/W1963789809","https://openalex.org/W1973569463","https://openalex.org/W1988939685","https://openalex.org/W1990325505","https://openalex.org/W1991270465","https://openalex.org/W1996999696","https://openalex.org/W2000095292","https://openalex.org/W2000786890","https://openalex.org/W2001685999","https://openalex.org/W2015356704","https://openalex.org/W2018210856","https://openalex.org/W2037761545","https://openalex.org/W2047016241","https://openalex.org/W2056373522","https://openalex.org/W2058282467","https://openalex.org/W2064417120","https://openalex.org/W2108242102","https://openalex.org/W2120881481","https://openalex.org/W2121897940","https://openalex.org/W2140477809","https://openalex.org/W2142640723","https://openalex.org/W2146494391","https://openalex.org/W2149239535","https://openalex.org/W2157611444","https://openalex.org/W2169657429","https://openalex.org/W2319962899","https://openalex.org/W2350130263","https://openalex.org/W2463667808","https://openalex.org/W4236624299","https://openalex.org/W6719267045"],"related_works":["https://openalex.org/W2583214585","https://openalex.org/W2060862711","https://openalex.org/W2085710126","https://openalex.org/W2046775682","https://openalex.org/W2386187374","https://openalex.org/W4391951527","https://openalex.org/W2357470330","https://openalex.org/W3199009304","https://openalex.org/W2056373522","https://openalex.org/W2103357839"],"abstract_inverted_index":{"A":[0,44,149],"growing":[1],"body":[2],"of":[3,27,33,46,82,93,128,141,168,197],"evidence":[4],"suggests":[5],"that":[6,13,121,176],"hydrogen":[7,177],"is":[8],"a":[9,15,89],"novel,":[10],"selective":[11],"antioxidant":[12],"exerts":[14],"protective":[16],"effect":[17,26],"against":[18],"organ":[19],"damage.":[20],"The":[21,118,172],"present":[22,173],"study":[23,174],"investigated":[24],"the":[25,34,77,80,83,91,108,113,126,135,142,146,153,159,166,169,198],"hydrogen-rich":[28,65,122,160],"saline":[29,62,66,123,161,188],"on":[30],"corticosteroid-induced":[31],"necrosis":[32,140,196],"femoral":[35,84,143,199],"head":[36,85,144],"in":[37,107,138,145,152,158],"an":[38,191],"animal":[39],"model":[40],"established":[41],"using":[42,88],"prednisolone.":[43],"total":[45],"30":[47],"healthy,":[48],"male,":[49],"adult":[50],"New":[51],"Zealand":[52],"white":[53],"rabbits":[54],"were":[55,110],"randomly":[56],"divided":[57],"into":[58],"two":[59],"groups:":[60],"Hydrogen-rich":[61,187],"(treated":[63,72],"with":[64,73],"via":[67],"intraperitoneal":[68],"injection)":[69],"and":[70,104,112,131,133],"placebo":[71],"normal":[74],"saline).":[75],"At":[76],"set":[78],"time-points,":[79],"structure":[81],"was":[86,116,156],"examined":[87],"microscope;":[90],"concentrations":[92],"glutathione":[94],"(GSH),":[95],"lipid":[96],"peroxide":[97],"(LPO),":[98],"vascular":[99],"endothelial":[100],"growth":[101],"factor":[102],"(VEGF)":[103],"thrombomodulin":[105],"(TM)":[106],"plasma":[109],"measured":[111],"microvessel":[114,154],"density":[115,155],"quantified.":[117],"results":[119,167],"showed":[120],"significantly":[124],"decreased":[125],"levels":[127],"VEGF,":[129],"TM":[130],"LPO":[132],"increased":[134],"GSH":[136],"level":[137],"steroid-associated":[139,181,195],"rabbit":[147],"model.":[148],"significant":[150],"increase":[151],"observed":[157],"group.":[162],"Histopathological":[163],"staining":[164],"confirmed":[165],"biochemical":[170],"analysis.":[171],"demonstrates":[175],"treatment":[178,193],"may":[179,189],"alleviate":[180],"osteonecrosis":[182],"by":[183],"inhibiting":[184],"oxidative":[185],"stress.":[186],"provide":[190],"alternative":[192],"for":[194],"head.":[200]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":8},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}
