{"id":"https://openalex.org/W2180466547","doi":null,"title":"The role of GPCR localization and putative tau-tubulin kinases in the transduction of environmental stimuli in Caenorhabditis elegans","display_name":"The role of GPCR localization and putative tau-tubulin kinases in the transduction of environmental stimuli in Caenorhabditis elegans","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2180466547","mag":"2180466547"},"language":"en","primary_location":{"id":"pmh:oai:bir.brandeis.edu:10192/27000","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10192/27000","pdf_url":null,"source":{"id":"https://openalex.org/S4406922578","display_name":"Brandeis Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080643282","display_name":"Jason T. Yoon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jason Yoon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5080643282"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.017400000244379044,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ciliogenesis","display_name":"ciliogenesis","score":0.7250000238418579},{"id":"https://openalex.org/keywords/primary-cilia","display_name":"primary cilia","score":0.9509999752044678},{"id":"https://openalex.org/keywords/sensory-transduction","display_name":"sensory transduction","score":0.8510000109672546},{"id":"https://openalex.org/keywords/pheromone-response","display_name":"pheromone response","score":0.9430000185966492},{"id":"https://openalex.org/keywords/dauer-formation","display_name":"dauer formation","score":0.8619999885559082},{"id":"https://openalex.org/keywords/trans-acting-regulation","display_name":"trans-acting regulation","score":0.6420000195503235},{"id":"https://openalex.org/keywords/caenorhabditis-elegans","display_name":"Caenorhabditis elegans","score":0.8949999809265137},{"id":"https://openalex.org/keywords/sensory-neurons","display_name":"sensory neurons","score":0.5490000247955322}],"concepts":[{"id":"https://openalex.org/C195267511","wikidata":"https://www.wikidata.org/wiki/Q5119969","display_name":"Ciliogenesis","level":3,"score":0.9780688285827637},{"id":"https://openalex.org/C100094513","wikidata":"https://www.wikidata.org/wiki/Q180436","display_name":"Cilium","level":2,"score":0.8920689821243286},{"id":"https://openalex.org/C2778944004","wikidata":"https://www.wikidata.org/wiki/Q91703","display_name":"Caenorhabditis elegans","level":3,"score":0.8341900110244751},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8239191770553589},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.610687255859375},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5332683324813843},{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.5021681785583496},{"id":"https://openalex.org/C25194021","wikidata":"https://www.wikidata.org/wiki/Q17157162","display_name":"Mechanosensation","level":4,"score":0.4992716312408447},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.43842920660972595},{"id":"https://openalex.org/C131151476","wikidata":"https://www.wikidata.org/wiki/Q809753","display_name":"Basal body","level":4,"score":0.4150456190109253},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.35060417652130127},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3434455990791321},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.20666849613189697},{"id":"https://openalex.org/C115811362","wikidata":"https://www.wikidata.org/wiki/Q189998","display_name":"Flagellum","level":3,"score":0.15426060557365417},{"id":"https://openalex.org/C50254741","wikidata":"https://www.wikidata.org/wiki/Q62536","display_name":"Ion channel","level":3,"score":0.1116003692150116}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:bir.brandeis.edu:10192/27000","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10192/27000","pdf_url":null,"source":{"id":"https://openalex.org/S4406922578","display_name":"Brandeis Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:2180466547","doi":null,"is_oa":false,"landing_page_url":"http://bir.brandeis.edu/bitstream/10192/27000/1/YoonThesis2014.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":68,"referenced_works":["https://openalex.org/W1556819342","https://openalex.org/W1567294259","https://openalex.org/W1956137678","https://openalex.org/W1964599441","https://openalex.org/W1966657957","https://openalex.org/W1973204941","https://openalex.org/W1973485093","https://openalex.org/W1982164848","https://openalex.org/W1986113142","https://openalex.org/W1995560695","https://openalex.org/W1999989614","https://openalex.org/W2005619876","https://openalex.org/W2006467843","https://openalex.org/W2009071652","https://openalex.org/W2014128649","https://openalex.org/W2018710614","https://openalex.org/W2022221238","https://openalex.org/W2022891138","https://openalex.org/W2025142458","https://openalex.org/W2030614715","https://openalex.org/W2032686835","https://openalex.org/W2033052818","https://openalex.org/W2036853345","https://openalex.org/W2040707602","https://openalex.org/W2043966795","https://openalex.org/W2051301625","https://openalex.org/W2051971014","https://openalex.org/W2054712073","https://openalex.org/W2057104531","https://openalex.org/W2059230843","https://openalex.org/W2061812391","https://openalex.org/W2062938087","https://openalex.org/W2066660409","https://openalex.org/W2078625410","https://openalex.org/W2081291985","https://openalex.org/W2083026402","https://openalex.org/W2098770288","https://openalex.org/W2102701326","https://openalex.org/W2106937415","https://openalex.org/W2110455514","https://openalex.org/W2113585283","https://openalex.org/W2124173075","https://openalex.org/W2126902054","https://openalex.org/W2131999768","https://openalex.org/W2132800912","https://openalex.org/W2133956002","https://openalex.org/W2134467496","https://openalex.org/W2139886150","https://openalex.org/W2140864413","https://openalex.org/W2144498949","https://openalex.org/W2148226984","https://openalex.org/W2149804574","https://openalex.org/W2152072269","https://openalex.org/W2152619982","https://openalex.org/W2154795752","https://openalex.org/W2159434269","https://openalex.org/W2159779491","https://openalex.org/W2163428220","https://openalex.org/W2164405838","https://openalex.org/W2164540688","https://openalex.org/W2167350922","https://openalex.org/W2169126888","https://openalex.org/W2169202446","https://openalex.org/W2170087992","https://openalex.org/W2170339840","https://openalex.org/W2171999245","https://openalex.org/W2184527515","https://openalex.org/W7075658468"],"related_works":["https://openalex.org/W2098428340","https://openalex.org/W2253544210","https://openalex.org/W7096777865","https://openalex.org/W2954193793","https://openalex.org/W2386149847","https://openalex.org/W6941270307","https://openalex.org/W2292550688","https://openalex.org/W2010318745","https://openalex.org/W1036974311","https://openalex.org/W2583678016"],"abstract_inverted_index":{"Coordinated":[0],"behavior":[1],"in":[2,12,63,77,86,95,102,136,169,179,194,239,255,271],"response":[3,64],"to":[4,34,65,112,155,210],"environmental":[5,30],"stimuli":[6],"is":[7,18,253],"a":[8,78],"fundamental":[9],"biological":[10],"process":[11],"eukaryotes.":[13],"The":[14],"nematode":[15],"Caenorhabditis":[16],"elegans":[17,143,273],"an":[19,53],"excellent":[20],"model":[21],"organism":[22],"for":[23,52,80,124],"investigating":[24],"the":[25,119,165,195,211,264],"mechanism":[26],"underlying":[27],"transduction":[28,139],"of":[29,40,56,83,91,115,121,249,266],"stimuli,":[31],"partly":[32],"due":[33],"its":[35,92],"302":[36],"stereotypically-connected":[37],"neurons.":[38],"Sixty":[39],"these":[41,183,190,205,232,267],"neurons":[42,180,197],"feature":[43],"primary":[44],"cilia":[45,125,177],"\u2013":[46],"highly":[47,268],"conserved":[48,269],"sensory":[49,137,196,274],"organelles":[50],"necessary":[51,123],"immense":[54],"repertoire":[55],"behaviors":[57],"such":[58],"as":[59,236],"dauer":[60,96,157],"diapause":[61],"entry":[62],"cilia-dependent":[66],"inputs":[67],"including":[68],"pheromones.":[69],"Ser/Thr":[70],"kinase":[71,106],"encoding":[72],"gene":[73],"F32B6.10":[74,100,130],"was":[75],"identified":[76],"screen":[79],"novel":[81],"regulators":[82],"pheromone":[84,240,251],"responses":[85],"C.":[87,142,272],"elegans,":[88],"and":[89,131,152,176,199,223,227],"disruption":[90],"function":[93,135,168,193,235],"manifests":[94],"formation":[97],"defects.":[98],"An":[99],"ortholog":[101],"mammals,":[103],"Tau":[104],"tubulin":[105],"2":[107],"(ttbk-2)":[108],"has":[109],"been":[110],"shown":[111],"regulate":[113],"initiation":[114],"ciliogenesis":[116,170],"by":[117,140],"promoting":[118],"recruitment":[120],"proteins":[122,270],"assembly.":[126],"I":[127,145,228],"hypothesized":[128],"that":[129,164,189,231],"other":[132],"ttbk-2":[133],"homologs":[134],"signal":[138],"regulating":[141],"ciliogenesis.":[144],"confirmed":[146],"three":[147],"putative":[148,166,233],"ttbks":[149,167],"(F32B6.10,":[150],"W01B6.2,":[151],"C04G2.2)":[153],"contribute":[154],"pheromone-induced":[156],"formation,":[158],"but":[159],"found":[160],"no":[161],"evidence":[162],"suggesting":[163],"based":[171],"on":[172,221],"wildtype":[173],"lipophilic":[174],"dye-uptake":[175],"morphology":[178],"natively":[181],"expressing":[182],"molecules.":[184],"While":[185],"rescue":[186],"experiments":[187,244,259],"show":[188],"genes":[191],"mainly":[192],"ASK":[198],"ASI,":[200],"sub-cellular":[201],"localization":[202,219,248],"data":[203],"suggest":[204],"molecules":[206],"do":[207],"not":[208],"localize":[209],"cilia.":[212],"My":[213],"previous":[214],"work":[215],"demonstrated":[216],"ciliary":[217],"GPCR":[218],"relies":[220],"cell-":[222],"receptor-specific":[224],"trans-acting":[225,237],"mechanisms":[226],"therefore":[229],"hypothesize":[230],"TTBKs":[234],"factors":[238],"receptor":[241],"localization.":[242],"Future":[243],"will":[245,260],"address":[246],"whether":[247],"known":[250],"receptors":[252],"affected":[254],"ttbk":[256],"mutants.":[257],"These":[258],"provide":[261],"insight":[262],"into":[263],"contribution":[265],"transduction.":[275]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}