{"id":"https://openalex.org/W2180456503","doi":"https://doi.org/10.1016/j.cell.2015.10.047","title":"Htr2a-Expressing Cells in the Central Amygdala Control the Hierarchy between Innate and Learned Fear","display_name":"Htr2a-Expressing Cells in the Central Amygdala Control the Hierarchy between Innate and Learned Fear","publication_year":2015,"publication_date":"2015-11-01","ids":{"openalex":"https://openalex.org/W2180456503","doi":"https://doi.org/10.1016/j.cell.2015.10.047","mag":"2180456503","pmid":"https://pubmed.ncbi.nlm.nih.gov/26590419"},"language":"en","primary_location":{"id":"doi:10.1016/j.cell.2015.10.047","doi":"https://doi.org/10.1016/j.cell.2015.10.047","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cell.2015.10.047","pdf_url":"http://www.cell.com/article/S0092867415014038/pdf","source":{"id":"https://openalex.org/S110447773","display_name":"Cell","issn_l":"0092-8674","issn":["0092-8674","1097-4172"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.cell.com/article/S0092867415014038/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082930665","display_name":"Tomoko Isosaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126884977","display_name":"Kansai Medical University","ror":"https://ror.org/001xjdh50","country_code":"JP","type":"education","lineage":["https://openalex.org/I126884977"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoko Isosaka","raw_affiliation_strings":["Institute of Biomedical Science, Kansai Medical University, Osaka 573-1010, Japan; Department of Functional Neuroscience, Osaka Bioscience Institute, Osaka 565-0874, Japan","Department of Functional Neuroscience, Osaka Bioscience Institute, Osaka 565-0874, Japan","Institute of Biomedical Science, Kansai Medical University, Osaka 573-1010, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Science, Kansai Medical University, Osaka 573-1010, Japan; Department of Functional Neuroscience, Osaka Bioscience Institute, Osaka 565-0874, Japan","institution_ids":["https://openalex.org/I126884977"]},{"raw_affiliation_string":"Department of Functional Neuroscience, Osaka Bioscience Institute, Osaka 565-0874, Japan","institution_ids":[]},{"raw_affiliation_string":"Institute of Biomedical Science, Kansai Medical University, Osaka 573-1010, Japan","institution_ids":["https://openalex.org/I126884977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109526451","display_name":"Tomohiko Matsuo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126884977","display_name":"Kansai Medical University","ror":"https://ror.org/001xjdh50","country_code":"JP","type":"education","lineage":["https://openalex.org/I126884977"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomohiko Matsuo","raw_affiliation_strings":["Institute of Biomedical Science, Kansai Medical University, Osaka 573-1010, Japan; Department of Functional Neuroscience, Osaka Bioscience Institute, Osaka 565-0874, Japan","Department of Functional Neuroscience, Osaka Bioscience Institute, Osaka 565-0874, Japan","Institute of Biomedical Science, Kansai Medical University, Osaka 573-1010, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Science, Kansai Medical University, Osaka 573-1010, Japan; Department of Functional Neuroscience, Osaka Bioscience Institute, Osaka 565-0874, Japan","institution_ids":["https://openalex.org/I126884977"]},{"raw_affiliation_string":"Department of Functional Neuroscience, Osaka Bioscience Institute, Osaka 565-0874, Japan","institution_ids":[]},{"raw_affiliation_string":"Institute of Biomedical Science, Kansai Medical University, Osaka 573-1010, Japan","institution_ids":["https://openalex.org/I126884977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048025014","display_name":"Takashi Yamaguchi","orcid":"https://orcid.org/0000-0001-5153-940X","observed_orcids":["https://orcid.org/0000-0001-5153-940X","https://orcid.org/0009-0004-6294-8005"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Takashi Yamaguchi","raw_affiliation_strings":["Department of Systems Biology, Osaka Bioscience Institute, Osaka 565-0874, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Systems Biology, Osaka Bioscience Institute, Osaka 565-0874, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049055799","display_name":"Kazuo Funabiki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kazuo Funabiki","raw_affiliation_strings":["Department of Systems Biology, Osaka Bioscience Institute, Osaka 565-0874, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Systems Biology, Osaka Bioscience Institute, Osaka 565-0874, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110880571","display_name":"Shigetada Nakanishi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shigetada Nakanishi","raw_affiliation_strings":["Department of Systems Biology, Osaka Bioscience Institute, Osaka 565-0874, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Systems Biology, Osaka Bioscience Institute, Osaka 565-0874, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081761454","display_name":"Reiko Kobayakawa","orcid":"https://orcid.org/0000-0001-6613-5969","observed_orcids":["https://orcid.org/0000-0001-6613-5969"]},"institutions":[{"id":"https://openalex.org/I126884977","display_name":"Kansai Medical University","ror":"https://ror.org/001xjdh50","country_code":"JP","type":"education","lineage":["https://openalex.org/I126884977"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Reiko Kobayakawa","raw_affiliation_strings":["Institute of Biomedical Science, Kansai Medical University, Osaka 573-1010, Japan; Department of Functional Neuroscience, Osaka Bioscience Institute, Osaka 565-0874, Japan. Electronic address: kobayakr@hirakata.kmu.ac.jp","Department of Functional Neuroscience, Osaka Bioscience Institute, Osaka 565-0874, Japan","Institute of Biomedical Science, Kansai Medical University, Osaka 573-1010, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Science, Kansai Medical University, Osaka 573-1010, Japan; Department of Functional Neuroscience, Osaka Bioscience Institute, Osaka 565-0874, Japan. Electronic address: kobayakr@hirakata.kmu.ac.jp","institution_ids":["https://openalex.org/I126884977"]},{"raw_affiliation_string":"Department of Functional Neuroscience, Osaka Bioscience Institute, Osaka 565-0874, Japan","institution_ids":[]},{"raw_affiliation_string":"Institute of Biomedical Science, Kansai Medical University, Osaka 573-1010, Japan","institution_ids":["https://openalex.org/I126884977"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011195208","display_name":"Ko Kobayakawa","orcid":"https://orcid.org/0000-0001-6406-5610","observed_orcids":["https://orcid.org/0000-0001-6406-5610"]},"institutions":[{"id":"https://openalex.org/I126884977","display_name":"Kansai Medical University","ror":"https://ror.org/001xjdh50","country_code":"JP","type":"education","lineage":["https://openalex.org/I126884977"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Ko Kobayakawa","raw_affiliation_strings":["Institute of Biomedical Science, Kansai Medical University, Osaka 573-1010, Japan; Department of Functional Neuroscience, Osaka Bioscience Institute, Osaka 565-0874, Japan. Electronic address: kobayakk@hirakata.kmu.ac.jp","Department of Functional Neuroscience, Osaka Bioscience Institute, Osaka 565-0874, Japan","Institute of Biomedical Science, Kansai Medical University, Osaka 573-1010, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Science, Kansai Medical University, Osaka 573-1010, Japan; Department of Functional Neuroscience, Osaka Bioscience Institute, Osaka 565-0874, Japan. Electronic address: kobayakk@hirakata.kmu.ac.jp","institution_ids":["https://openalex.org/I126884977"]},{"raw_affiliation_string":"Department of Functional Neuroscience, Osaka Bioscience Institute, Osaka 565-0874, Japan","institution_ids":[]},{"raw_affiliation_string":"Institute of Biomedical Science, Kansai Medical University, Osaka 573-1010, Japan","institution_ids":["https://openalex.org/I126884977"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5011195208","https://openalex.org/A5081761454"],"corresponding_institution_ids":["https://openalex.org/I126884977"],"apc_list":{"value":11400,"currency":"USD","value_usd":11400},"apc_paid":null,"fwci":5.0892,"has_fulltext":false,"cited_by_count":191,"citation_normalized_percentile":{"value":0.96212335,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"163","issue":"5","first_page":"1153","last_page":"1164"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/htr2a","display_name":"HTR2A","score":0.7850000262260437},{"id":"https://openalex.org/keywords/5-ht2a-receptor","display_name":"5-HT2A receptor","score":0.875},{"id":"https://openalex.org/keywords/central-nucleus-of-the-amygdala","display_name":"central amygdala","score":0.9990000128746033},{"id":"https://openalex.org/keywords/innate-fear","display_name":"innate fear","score":0.996999979019165},{"id":"https://openalex.org/keywords/learned-fear","display_name":"learned fear","score":0.9959999918937683},{"id":"https://openalex.org/keywords/fear-hierarchy","display_name":"fear hierarchy","score":0.8080000281333923},{"id":"https://openalex.org/keywords/olfactory-fear-conditioning","display_name":"olfactory fear conditioning","score":0.7149999737739563},{"id":"https://openalex.org/keywords/freezing-behavior","display_name":"freezing behavior","score":0.8510000109672546}],"concepts":[{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.8030460476875305},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6118597388267517},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5653214454650879},{"id":"https://openalex.org/C47742525","wikidata":"https://www.wikidata.org/wiki/Q13418826","display_name":"Innate lymphoid cell","level":4,"score":0.5385433435440063},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2722418010234833},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07075980305671692}],"mesh":[{"descriptor_ui":"D000679","descriptor_name":"Amygdala","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005239","descriptor_name":"Fear","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D005239","descriptor_name":"Fear","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009434","descriptor_name":"Neural Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010487","descriptor_name":"Periaqueductal Gray","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012903","descriptor_name":"Smell","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019426","descriptor_name":"Integrases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044402","descriptor_name":"Receptor, Serotonin, 5-HT2A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044402","descriptor_name":"Receptor, Serotonin, 5-HT2A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.cell.2015.10.047","doi":"https://doi.org/10.1016/j.cell.2015.10.047","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cell.2015.10.047","pdf_url":"http://www.cell.com/article/S0092867415014038/pdf","source":{"id":"https://openalex.org/S110447773","display_name":"Cell","issn_l":"0092-8674","issn":["0092-8674","1097-4172"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell","raw_type":"journal-article"},{"id":"pmid:26590419","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26590419","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.cell.2015.10.047","doi":"https://doi.org/10.1016/j.cell.2015.10.047","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cell.2015.10.047","pdf_url":"http://www.cell.com/article/S0092867415014038/pdf","source":{"id":"https://openalex.org/S110447773","display_name":"Cell","issn_l":"0092-8674","issn":["0092-8674","1097-4172"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309807","display_name":"Takeda Science Foundation","ror":"https://ror.org/02y123g31"},{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320334789","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2180456503.pdf"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W1526796115","https://openalex.org/W1573973507","https://openalex.org/W1738778520","https://openalex.org/W1964797580","https://openalex.org/W1967887989","https://openalex.org/W1968562435","https://openalex.org/W1973788414","https://openalex.org/W1976898002","https://openalex.org/W1979913437","https://openalex.org/W1981044491","https://openalex.org/W1986879730","https://openalex.org/W1987098819","https://openalex.org/W1994389924","https://openalex.org/W2003870213","https://openalex.org/W2021850631","https://openalex.org/W2026480577","https://openalex.org/W2026537517","https://openalex.org/W2032212320","https://openalex.org/W2032721791","https://openalex.org/W2038296323","https://openalex.org/W2038616736","https://openalex.org/W2040619338","https://openalex.org/W2041519359","https://openalex.org/W2046015860","https://openalex.org/W2059216322","https://openalex.org/W2062730861","https://openalex.org/W2064629564","https://openalex.org/W2069977347","https://openalex.org/W2070440962","https://openalex.org/W2072346842","https://openalex.org/W2076132050","https://openalex.org/W2081177852","https://openalex.org/W2082435140","https://openalex.org/W2083162388","https://openalex.org/W2087180408","https://openalex.org/W2088389081","https://openalex.org/W2098553579","https://openalex.org/W2108845151","https://openalex.org/W2115115342","https://openalex.org/W2118826874","https://openalex.org/W2121379737","https://openalex.org/W2121852278","https://openalex.org/W2126187217","https://openalex.org/W2143532600","https://openalex.org/W2153171566","https://openalex.org/W2158553737","https://openalex.org/W2164712597","https://openalex.org/W2167095271","https://openalex.org/W2168385754","https://openalex.org/W4235300309","https://openalex.org/W4388295514","https://openalex.org/W7097805110"],"related_works":["https://openalex.org/W2751764506","https://openalex.org/W2949605266","https://openalex.org/W2783288392","https://openalex.org/W2818647472","https://openalex.org/W6983340754","https://openalex.org/W2580493263","https://openalex.org/W2004517381","https://openalex.org/W2966982187","https://openalex.org/W4292707894","https://openalex.org/W4392602689"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":15},{"year":2024,"cited_by_count":28},{"year":2023,"cited_by_count":25},{"year":2022,"cited_by_count":28},{"year":2021,"cited_by_count":23},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":19},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":7}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
