{"id":"https://openalex.org/W2180413055","doi":"https://doi.org/10.1016/j.cgh.2015.11.005","title":"Variants in the LGALS9 Gene Are Associated With Development of Liver Disease in Heavy Consumers of Alcohol","display_name":"Variants in the LGALS9 Gene Are Associated With Development of Liver Disease in Heavy Consumers of Alcohol","publication_year":2015,"publication_date":"2015-11-18","ids":{"openalex":"https://openalex.org/W2180413055","doi":"https://doi.org/10.1016/j.cgh.2015.11.005","mag":"2180413055","pmid":"https://pubmed.ncbi.nlm.nih.gov/26598225"},"language":"en","primary_location":{"id":"doi:10.1016/j.cgh.2015.11.005","doi":"https://doi.org/10.1016/j.cgh.2015.11.005","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cgh.2015.11.005","pdf_url":null,"source":{"id":"https://openalex.org/S6642600","display_name":"Clinical Gastroenterology and Hepatology","issn_l":"1542-3565","issn":["1542-3565","1542-7714"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Gastroenterology and Hepatology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012197289","display_name":"Hugo R. Rosen","orcid":"https://orcid.org/0000-0002-1110-6914","observed_orcids":["https://orcid.org/0000-0002-1110-6914"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hugo R. Rosen","raw_affiliation_strings":["Division of Gastroenterology/Hepatology, University of Colorado, Aurora, Colorado. Electronic address: Hugo.Rosen@ucdenver.edu","Division of Gastroenterology/Hepatology, University of Colorado, Aurora, Colorado"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology/Hepatology, University of Colorado, Aurora, Colorado. Electronic address: Hugo.Rosen@ucdenver.edu","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]},{"raw_affiliation_string":"Division of Gastroenterology/Hepatology, University of Colorado, Aurora, Colorado","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024757944","display_name":"Lucy Golden\u2010Mason","orcid":"https://orcid.org/0000-0002-2087-4405","observed_orcids":["https://orcid.org/0000-0002-2087-4405","https://orcid.org/0000-0003-3347-4192"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lucy Golden-Mason","raw_affiliation_strings":["Division of Gastroenterology/Hepatology, University of Colorado, Aurora, Colorado"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology/Hepatology, University of Colorado, Aurora, Colorado","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009017786","display_name":"Ann K. Daly","orcid":"https://orcid.org/0000-0002-7321-0629","observed_orcids":["https://orcid.org/0000-0002-7321-0629"]},"institutions":[{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ann K. Daly","raw_affiliation_strings":["Institute of Cellular Medicine, Newcastle University Medical School, Newcastle upon Tyne, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cellular Medicine, Newcastle University Medical School, Newcastle upon Tyne, United Kingdom","institution_ids":["https://openalex.org/I84884186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042472677","display_name":"Ivana V. Yang","orcid":"https://orcid.org/0000-0002-1018-489X","observed_orcids":["https://orcid.org/0000-0002-1018-489X"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ivana Yang","raw_affiliation_strings":["Division of Pulmonary Medicine, University of Colorado, Aurora, Colorado"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary Medicine, University of Colorado, Aurora, Colorado","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101918789","display_name":"Christopher Paul Day","orcid":"https://orcid.org/0000-0001-7161-0293","observed_orcids":["https://orcid.org/0000-0001-7161-0293","https://orcid.org/0000-0003-1458-0045"]},"institutions":[{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Christopher P. Day","raw_affiliation_strings":["Institute of Cellular Medicine, Newcastle University Medical School, Newcastle upon Tyne, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cellular Medicine, Newcastle University Medical School, Newcastle upon Tyne, United Kingdom","institution_ids":["https://openalex.org/I84884186"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5012197289"],"corresponding_institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"],"apc_list":{"value":4470,"currency":"USD","value_usd":4470},"apc_paid":null,"fwci":0.484,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.66110529,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"14","issue":"5","first_page":"762","last_page":"768.e1"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/galectin-9","display_name":"galectin-9","score":1.0},{"id":"https://openalex.org/keywords/alcoholic-liver-disease","display_name":"alcoholic liver disease","score":0.968999981880188},{"id":"https://openalex.org/keywords/heavy-alcohol-consumption","display_name":"heavy alcohol consumption","score":0.8360000252723694},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9150000214576721},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.8809999823570251},{"id":"https://openalex.org/keywords/alcoholic-cirrhosis","display_name":"alcoholic cirrhosis","score":0.796999990940094},{"id":"https://openalex.org/keywords/alcoholic-hepatitis","display_name":"alcoholic hepatitis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/chronic-liver-disease","display_name":"chronic liver disease","score":0.6320000290870667},{"id":"https://openalex.org/keywords/peripheral-blood-mononuclear-cells","display_name":"peripheral blood mononuclear cells","score":0.8169999718666077},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.7390000224113464}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8928117752075195},{"id":"https://openalex.org/C2777075537","wikidata":"https://www.wikidata.org/wiki/Q929737","display_name":"Liver disease","level":2,"score":0.4669927656650543},{"id":"https://openalex.org/C3019635848","wikidata":"https://www.wikidata.org/wiki/Q154","display_name":"Alcohol consumption","level":3,"score":0.4549815058708191},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4384959042072296},{"id":"https://openalex.org/C2777575235","wikidata":"https://www.wikidata.org/wiki/Q558404","display_name":"Alcoholic liver disease","level":3,"score":0.4342972934246063},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4334256649017334},{"id":"https://openalex.org/C2781066024","wikidata":"https://www.wikidata.org/wiki/Q156","display_name":"Alcohol","level":2,"score":0.4272370934486389},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3292771577835083},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.32019490003585815},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3175238370895386},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.12357670068740845},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06538721919059753},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000437","descriptor_name":"Alcoholism","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008104","descriptor_name":"Liver Cirrhosis, Alcoholic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D037161","descriptor_name":"Galectins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D037161","descriptor_name":"Galectins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.cgh.2015.11.005","doi":"https://doi.org/10.1016/j.cgh.2015.11.005","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cgh.2015.11.005","pdf_url":null,"source":{"id":"https://openalex.org/S6642600","display_name":"Clinical Gastroenterology and Hepatology","issn_l":"1542-3565","issn":["1542-3565","1542-7714"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Gastroenterology and Hepatology","raw_type":"journal-article"},{"id":"pmid:26598225","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26598225","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G418728563","display_name":"Midcareer Investigator Award in Patient-Oriented Research (K24)","funder_award_id":"K24AI083742","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8284246707","display_name":"Human Group 2 Innate Lympohocyte Cell (ILC2) populations contribute to Hepatic Fibrosis","funder_award_id":"R01DK106491","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1891170386","https://openalex.org/W1976849547","https://openalex.org/W1985565168","https://openalex.org/W1994875987","https://openalex.org/W2001123056","https://openalex.org/W2010472060","https://openalex.org/W2012303274","https://openalex.org/W2018588367","https://openalex.org/W2020540515","https://openalex.org/W2031082289","https://openalex.org/W2036574174","https://openalex.org/W2038425480","https://openalex.org/W2038946905","https://openalex.org/W2044381985","https://openalex.org/W2060637877","https://openalex.org/W2061200329","https://openalex.org/W2088373848","https://openalex.org/W2128016314","https://openalex.org/W2139379592","https://openalex.org/W2139825247","https://openalex.org/W2152044035","https://openalex.org/W2152358904","https://openalex.org/W2153909270","https://openalex.org/W2162664755","https://openalex.org/W2166501262","https://openalex.org/W2171777347","https://openalex.org/W2314673390","https://openalex.org/W2885727518"],"related_works":["https://openalex.org/W7220987007","https://openalex.org/W2888049150","https://openalex.org/W2978548060","https://openalex.org/W2791614605","https://openalex.org/W3187951987","https://openalex.org/W6966756462","https://openalex.org/W2055452745","https://openalex.org/W3176617646","https://openalex.org/W7097152255","https://openalex.org/W3048581333"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}