{"id":"https://openalex.org/W2180293274","doi":"https://doi.org/10.1289/ehp.1409200","title":"Parabens and Human Epidermal Growth Factor Receptor Ligand Cross-Talk in Breast Cancer Cells","display_name":"Parabens and Human Epidermal Growth Factor Receptor Ligand Cross-Talk in Breast Cancer Cells","publication_year":2015,"publication_date":"2015-10-27","ids":{"openalex":"https://openalex.org/W2180293274","doi":"https://doi.org/10.1289/ehp.1409200","mag":"2180293274","pmid":"https://pubmed.ncbi.nlm.nih.gov/26502914","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4858398"},"language":"en","primary_location":{"id":"doi:10.1289/ehp.1409200","doi":"https://doi.org/10.1289/ehp.1409200","is_oa":true,"landing_page_url":"https://doi.org/10.1289/ehp.1409200","pdf_url":"https://ehp.niehs.nih.gov/doi/pdf/10.1289/ehp.1409200","source":{"id":"https://openalex.org/S10446503","display_name":"Environmental Health Perspectives","issn_l":"0091-6765","issn":["0091-6765","1552-9924"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319799","host_organization_name":"National Institute of Environmental Health Sciences","host_organization_lineage":["https://openalex.org/P4310319799","https://openalex.org/P4310316754"],"host_organization_lineage_names":["National Institute of Environmental Health Sciences","National Institutes of Health"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Health Perspectives","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://ehp.niehs.nih.gov/doi/pdf/10.1289/ehp.1409200","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089580950","display_name":"Shawn Pan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shawn Pan","raw_affiliation_strings":["Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, California, USA","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083301324","display_name":"Chaoshen Yuan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chaoshen Yuan","raw_affiliation_strings":["Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, California, USA","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016989715","display_name":"Abderrahmane Tagmount","orcid":"https://orcid.org/0000-0002-5415-8618","observed_orcids":["https://orcid.org/0000-0002-5415-8618"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abderrahmane Tagmount","raw_affiliation_strings":["Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, California, USA","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027621073","display_name":"Ruthann A. Rudel","orcid":"https://orcid.org/0000-0002-1809-4127","observed_orcids":["https://orcid.org/0000-0002-1809-4127"]},"institutions":[{"id":"https://openalex.org/I2802688450","display_name":"Silent Spring Institute","ror":"https://ror.org/05mm0yq33","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2802688450"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruthann A. Rudel","raw_affiliation_strings":["Silent Spring Institute, Newton, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Silent Spring Institute, Newton, Massachusetts, USA","institution_ids":["https://openalex.org/I2802688450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009253780","display_name":"Janet M. Ackerman","orcid":"https://orcid.org/0000-0003-4525-818X","observed_orcids":["https://orcid.org/0000-0003-4525-818X"]},"institutions":[{"id":"https://openalex.org/I2802688450","display_name":"Silent Spring Institute","ror":"https://ror.org/05mm0yq33","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2802688450"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Janet M. Ackerman","raw_affiliation_strings":["Silent Spring Institute, Newton, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Silent Spring Institute, Newton, Massachusetts, USA","institution_ids":["https://openalex.org/I2802688450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054902187","display_name":"Paul Yaswen","orcid":"https://orcid.org/0000-0001-6603-640X","observed_orcids":["https://orcid.org/0000-0001-6603-640X"]},"institutions":[{"id":"https://openalex.org/I148283060","display_name":"Lawrence Berkeley National Laboratory","ror":"https://ror.org/02jbv0t02","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I148283060","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Yaswen","raw_affiliation_strings":["Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA","institution_ids":["https://openalex.org/I148283060"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064631905","display_name":"Chris D. Vulpe","orcid":"https://orcid.org/0000-0001-5134-8929","observed_orcids":["https://orcid.org/0000-0001-5134-8929"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chris D. Vulpe","raw_affiliation_strings":["Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, California, USA","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003353514","display_name":"Dale C. Leitman","orcid":"https://orcid.org/0000-0003-3178-4904","observed_orcids":["https://orcid.org/0000-0003-3178-4904"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dale C. Leitman","raw_affiliation_strings":["Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, California, USA","institution_ids":["https://openalex.org/I95457486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5003353514"],"corresponding_institution_ids":["https://openalex.org/I95457486"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":2.6117,"has_fulltext":true,"cited_by_count":74,"citation_normalized_percentile":{"value":0.88234026,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"124","issue":"5","first_page":"563","last_page":"569"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.5663999915122986,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.5663999915122986,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.41110000014305115,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.013000000268220901,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parabens","display_name":"parabens","score":1.0},{"id":"https://openalex.org/keywords/butylparaben","display_name":"butylparaben","score":0.8960000276565552},{"id":"https://openalex.org/keywords/xenoestrogens","display_name":"xenoestrogens","score":0.9480000138282776},{"id":"https://openalex.org/keywords/estrogen-receptor-alpha","display_name":"estrogen receptor alpha","score":0.8610000014305115},{"id":"https://openalex.org/keywords/her2","display_name":"HER2","score":0.6499999761581421},{"id":"https://openalex.org/keywords/neuregulin-1","display_name":"neuregulin-1","score":0.8939999938011169},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.6930000185966492},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.6269999742507935},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.8529999852180481},{"id":"https://openalex.org/keywords/synergistic-toxicity","display_name":"synergistic toxicity","score":0.7239999771118164},{"id":"https://openalex.org/keywords/antiestrogens","display_name":"antiestrogens","score":0.7440000176429749},{"id":"https://openalex.org/keywords/bt474-cells","display_name":"BT474 cells","score":0.7889999747276306},{"id":"https://openalex.org/keywords/cosmetics","display_name":"cosmetics","score":0.37599998712539673},{"id":"https://openalex.org/keywords/personal-care-products","display_name":"personal care products","score":0.6840000152587891}],"concepts":[{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.6713398694992065},{"id":"https://openalex.org/C2779370918","wikidata":"https://www.wikidata.org/wiki/Q410780","display_name":"Paraben","level":3,"score":0.5753904581069946},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5111337304115295},{"id":"https://openalex.org/C2779272402","wikidata":"https://www.wikidata.org/wiki/Q423964","display_name":"Xenoestrogen","level":5,"score":0.48852741718292236},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4591722786426544},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.4515314996242523},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4398577809333801},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.37883493304252625},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3403346538543701},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3291252851486206},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.29255014657974243},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.28320199251174927},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17405298352241516},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C67031304","wikidata":"https://www.wikidata.org/wiki/Q274579","display_name":"Preservative","level":2,"score":0.0},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010226","descriptor_name":"Parabens","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D016259","descriptor_name":"Genes, myc","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016271","descriptor_name":"Proto-Oncogene Proteins c-myc","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016271","descriptor_name":"Proto-Oncogene Proteins c-myc","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020890","descriptor_name":"Neuregulin-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047628","descriptor_name":"Estrogen Receptor alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1289/ehp.1409200","doi":"https://doi.org/10.1289/ehp.1409200","is_oa":true,"landing_page_url":"https://doi.org/10.1289/ehp.1409200","pdf_url":"https://ehp.niehs.nih.gov/doi/pdf/10.1289/ehp.1409200","source":{"id":"https://openalex.org/S10446503","display_name":"Environmental Health Perspectives","issn_l":"0091-6765","issn":["0091-6765","1552-9924"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319799","host_organization_name":"National Institute of Environmental Health Sciences","host_organization_lineage":["https://openalex.org/P4310319799","https://openalex.org/P4310316754"],"host_organization_lineage_names":["National Institute of Environmental Health Sciences","National Institutes of Health"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Health Perspectives","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4858398","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4858398","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environ Health Perspect","raw_type":"Text"},{"id":"pmid:26502914","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26502914","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental health perspectives","raw_type":"Journal Article"},{"id":"pmh:oai:osti.gov:1627112","doi":null,"is_oa":true,"landing_page_url":"https://www.osti.gov/biblio/1627112","pdf_url":"https://www.osti.gov/servlets/purl/1627112","source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:escholarship.org/ark:/13030/qt42k5929h","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/42k5929h","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Environmental Health Perspectives, vol 124, iss 5","raw_type":"article"},{"id":"pmh:qt42k5929h","doi":null,"is_oa":false,"landing_page_url":"http://www.escholarship.org/uc/item/42k5929h","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pan, Shawn; Yuan, Chaoshen; Tagmount, Abderrahmane; Rudel, Ruthann A; Ackerman, Janet M; Yaswen, Paul; \u00c2\u00a0et al.(2015). Parabens and Human Epidermal Growth Factor Receptor Ligand Cross-Talk in Breast Cancer Cells. Environmental Health Perspectives, 124(5). doi: 10.1289/ehp.1409200. UC Office of the President: California Breast Cancer Research Program. Retrieved from: http://www.escholarship.org/uc/item/42k5929h","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1289/ehp.1409200","doi":"https://doi.org/10.1289/ehp.1409200","is_oa":true,"landing_page_url":"https://doi.org/10.1289/ehp.1409200","pdf_url":"https://ehp.niehs.nih.gov/doi/pdf/10.1289/ehp.1409200","source":{"id":"https://openalex.org/S10446503","display_name":"Environmental Health Perspectives","issn_l":"0091-6765","issn":["0091-6765","1552-9924"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319799","host_organization_name":"National Institute of Environmental Health Sciences","host_organization_lineage":["https://openalex.org/P4310319799","https://openalex.org/P4310316754"],"host_organization_lineage_names":["National Institute of Environmental Health Sciences","National Institutes of Health"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Health Perspectives","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2180293274.pdf","grobid_xml":"https://content.openalex.org/works/W2180293274.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W1616357803","https://openalex.org/W1894221679","https://openalex.org/W1907519626","https://openalex.org/W1966878363","https://openalex.org/W1967647822","https://openalex.org/W1973371801","https://openalex.org/W1975688052","https://openalex.org/W1981711832","https://openalex.org/W1996478622","https://openalex.org/W1997285329","https://openalex.org/W1998352081","https://openalex.org/W1999057925","https://openalex.org/W2003997116","https://openalex.org/W2007888807","https://openalex.org/W2009758715","https://openalex.org/W2011611385","https://openalex.org/W2015629450","https://openalex.org/W2016569614","https://openalex.org/W2022438662","https://openalex.org/W2024882103","https://openalex.org/W2030678473","https://openalex.org/W2031836978","https://openalex.org/W2032789267","https://openalex.org/W2038933398","https://openalex.org/W2042124938","https://openalex.org/W2053037610","https://openalex.org/W2061674718","https://openalex.org/W2061933800","https://openalex.org/W2070417409","https://openalex.org/W2078475954","https://openalex.org/W2079370846","https://openalex.org/W2083200046","https://openalex.org/W2086468341","https://openalex.org/W2094218749","https://openalex.org/W2097327668","https://openalex.org/W2097349743","https://openalex.org/W2098435470","https://openalex.org/W2098924171","https://openalex.org/W2120543755","https://openalex.org/W2122910688","https://openalex.org/W2124712330","https://openalex.org/W2125608197","https://openalex.org/W2125959465","https://openalex.org/W2130490785","https://openalex.org/W2133105825","https://openalex.org/W2140321480","https://openalex.org/W2142739240","https://openalex.org/W2143015731","https://openalex.org/W2151995827","https://openalex.org/W2154472114","https://openalex.org/W2156130552","https://openalex.org/W2157485558","https://openalex.org/W2161062193","https://openalex.org/W2163678250","https://openalex.org/W2169782526","https://openalex.org/W2170488030","https://openalex.org/W2329387328","https://openalex.org/W2398152164"],"related_works":["https://openalex.org/W7142516177","https://openalex.org/W1979849644","https://openalex.org/W1996598875","https://openalex.org/W2086468341","https://openalex.org/W2166935373","https://openalex.org/W2943358186","https://openalex.org/W1966492717","https://openalex.org/W2125959465","https://openalex.org/W2921551548","https://openalex.org/W4211192595"],"abstract_inverted_index":{"BACKGROUND:":[0],"Xenoestrogens":[1],"are":[2,41,54],"synthetic":[3],"compounds":[4],"that":[5,91,235,257],"mimic":[6],"endogenous":[7],"estrogens":[8,18],"by":[9,123],"binding":[10],"to":[11,17,20,227,243],"and":[12,19,29,50,53,77,118,132,138,148,157,178,205,218,247,296],"activating":[13],"estrogen":[14,73],"receptors.":[15],"Exposure":[16],"some":[21],"xenoestrogens":[22,47],"has":[23],"been":[24],"associated":[25],"with":[26,62,99,187],"cell":[27,119,206,250],"proliferation":[28,120,182,251],"an":[30],"increased":[31,98],"risk":[32],"of":[33,38,94,109,115,176,183,190,201,212,241],"breast":[34,142,248,305],"cancer.":[35],"Despite":[36],"evidence":[37],"estrogenicity,":[39],"parabens":[40,63,95,258],"among":[42],"the":[43,69,78,89,92,167,188,195,210,228,239],"most":[44],"widely":[45],"used":[46],"in":[48,136,154,160,170,215,224,252,275,304],"cosmetics":[49],"personal-care":[51],"products":[52],"generally":[55],"considered":[56,267],"safe.":[57],"However,":[58],"previous":[59],"cell-based":[60],"studies":[61,271],"do":[64],"not":[65,265],"take":[66],"into":[67],"account":[68],"signaling":[70],"cross-talk":[71,303],"between":[72],"receptor":[74,83,164,301],"\u03b1":[75],"(ER\u03b1)":[76],"human":[79,140,297],"epidermal":[80,298],"growth":[81,299],"factor":[82,300],"(HER)":[84],"family.":[85],"OBJECTIVES:":[86],"We":[87],"investigated":[88],"hypothesis":[90],"potency":[93,240],"can":[96],"be":[97,260],"HER":[100,110,236],"ligands,":[101],"such":[102],"as":[103],"heregulin":[104],"(HRG).":[105],"METHODS:":[106],"The":[107,174],"effects":[108,189,274],"ligands":[111,237],"on":[112],"paraben":[113],"activation":[114],"c-Myc":[116,155,171,202,229],"expression":[117,204,246],"were":[121],"determined":[122],"real-time":[124],"polymerase":[125],"chain":[126],"reaction,":[127],"Western":[128],"blots,":[129],"flow":[130],"cytometry,":[131],"chromatin":[133],"immunoprecipitation":[134],"assays":[135],"ER\u03b1-":[137],"HER2-positive":[139],"BT-474":[141,161,184],"cancer":[143,249,306],"cells.":[144,162,307],"RESULTS:":[145],"Butylparaben":[146],"(BP)":[147],"HRG":[149,179,193,208,219],"produced":[150,220],"a":[151,221],"synergistic":[152,168,222],"increase":[153,169,223],"mRNA":[156,203],"protein":[158,172],"levels":[159,264],"Estrogen":[163],"antagonists":[165],"blocked":[166],"levels.":[173],"combination":[175],"BP":[177,191,217,242],"also":[180],"stimulated":[181],"cells":[185],"compared":[186],"alone.":[192],"decreased":[194],"dose":[196],"required":[197],"for":[198],"BP-mediated":[199],"stimulation":[200],"proliferation.":[207],"caused":[209],"phosphorylation":[211],"serine":[213],"167":[214],"ER\u03b1.":[216],"ER\u03b1":[225],"recruitment":[226],"gene.":[230],"CONCLUSION:":[231],"Our":[232],"results":[233],"show":[234],"enhanced":[238],"stimulate":[244],"oncogene":[245],"vitro":[253],"via":[254],"ER\u03b1,":[255],"suggesting":[256],"might":[259],"active":[261],"at":[262],"exposure":[263],"previously":[266],"toxicologically":[268],"relevant":[269],"from":[270],"testing":[272],"their":[273],"isolation.":[276],"CITATION:":[277],"Pan":[278],"S,":[279],"Yuan":[280],"C,":[281],"Tagmount":[282],"A,":[283],"Rudel":[284],"RA,":[285],"Ackerman":[286],"JM,":[287],"Yaswen":[288],"P,":[289],"Vulpe":[290],"CD,":[291],"Leitman":[292],"DC.":[293],"2016.":[294],"Parabens":[295],"ligand":[302],"Environ":[308],"Health":[309],"Perspect":[310],"124:563-569;":[311],"http://dx.doi.org/10.1289/ehp.1409200.":[312]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}