{"id":"https://openalex.org/W2180191687","doi":"https://doi.org/10.1089/oli.1.1997.7.503","title":"Inhibition of Coagulation by a Phosphorothioate Oligonucleotide","display_name":"Inhibition of Coagulation by a Phosphorothioate Oligonucleotide","publication_year":1997,"publication_date":"1997-10-01","ids":{"openalex":"https://openalex.org/W2180191687","doi":"https://doi.org/10.1089/oli.1.1997.7.503","mag":"2180191687","pmid":"https://pubmed.ncbi.nlm.nih.gov/9361909"},"language":"en","primary_location":{"id":"doi:10.1089/oli.1.1997.7.503","doi":"https://doi.org/10.1089/oli.1.1997.7.503","is_oa":false,"landing_page_url":"https://doi.org/10.1089/oli.1.1997.7.503","pdf_url":null,"source":{"id":"https://openalex.org/S92216883","display_name":"Antisense and Nucleic Acid Drug Development","issn_l":"1087-2906","issn":["1087-2906","2168-6599"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antisense and Nucleic Acid Drug Development","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083254716","display_name":"Scott P. Henry","orcid":"https://orcid.org/0000-0001-5817-0369","observed_orcids":["https://orcid.org/0000-0001-5817-0369"]},"institutions":[{"id":"https://openalex.org/I2800035258","display_name":"Ionis Pharmaceuticals (United States)","ror":"https://ror.org/00t8bew53","country_code":"US","type":"company","lineage":["https://openalex.org/I2800035258"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"SCOTT P. HENRY","raw_affiliation_strings":["Department of Toxicology, Isis Pharmaceuticals, Inc., Carlsbad, CA 92008, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Toxicology, Isis Pharmaceuticals, Inc., Carlsbad, CA 92008, USA","institution_ids":["https://openalex.org/I2800035258"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060799552","display_name":"William F. Novotny","orcid":"https://orcid.org/0009-0000-3857-9829","observed_orcids":["https://orcid.org/0009-0000-3857-9829"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"WILLIAM NOVOTNY","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"JANET LEEDS","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"JANET LEEDS","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042019484","display_name":"Carol S. Auletta","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"CAROL AULETTA","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084958659","display_name":"Douglas J. Kornbrust","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"DOUGLAS J. KORNBRUST","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.3719,"has_fulltext":false,"cited_by_count":122,"citation_normalized_percentile":{"value":0.96358406,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"7","issue":"5","first_page":"503","last_page":"510"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phosphorothioate-oligonucleotides","display_name":"phosphorothioate oligonucleotides","score":0.972000002861023},{"id":"https://openalex.org/keywords/antisense-therapeutics","display_name":"antisense therapeutics","score":0.7879999876022339},{"id":"https://openalex.org/keywords/coagulation-inhibition","display_name":"coagulation inhibition","score":0.8180000185966492},{"id":"https://openalex.org/keywords/activated-partial-thromboplastin-time","display_name":"activated partial thromboplastin time","score":0.9390000104904175},{"id":"https://openalex.org/keywords/intrinsic-coagulation-pathway","display_name":"intrinsic coagulation pathway","score":0.9139999747276306},{"id":"https://openalex.org/keywords/extrinsic-coagulation-pathway","display_name":"extrinsic coagulation pathway","score":0.9210000038146973},{"id":"https://openalex.org/keywords/thrombin","display_name":"thrombin","score":0.5109999775886536},{"id":"https://openalex.org/keywords/fibrinogen","display_name":"fibrinogen","score":0.9610000252723694},{"id":"https://openalex.org/keywords/cynomolgus-monkeys","display_name":"Macaca fascicularis","score":0.7490000128746033},{"id":"https://openalex.org/keywords/phosphodiester-linkage","display_name":"phosphodiester linkage","score":0.7170000076293945}],"concepts":[{"id":"https://openalex.org/C2778261982","wikidata":"https://www.wikidata.org/wiki/Q1755136","display_name":"Partial thromboplastin time","level":3,"score":0.7137072086334229},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6696709990501404},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6107895374298096},{"id":"https://openalex.org/C77171857","wikidata":"https://www.wikidata.org/wiki/Q5135593","display_name":"Clotting time","level":3,"score":0.5690158009529114},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5287871956825256},{"id":"https://openalex.org/C129312508","wikidata":"https://www.wikidata.org/wiki/Q133686","display_name":"Oligonucleotide","level":3,"score":0.49844956398010254},{"id":"https://openalex.org/C2780077467","wikidata":"https://www.wikidata.org/wiki/Q2520736","display_name":"Thrombin time","level":4,"score":0.46776527166366577},{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.4216023087501526},{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.40559566020965576},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3663428723812103},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19135794043540955},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1816069781780243},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.1789737045764923},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.14243808388710022},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1359066665172577},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.09638366103172302}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001777","descriptor_name":"Blood Coagulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001780","descriptor_name":"Blood Coagulation Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008252","descriptor_name":"Macaca fascicularis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013873","descriptor_name":"Thionucleotides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016376","descriptor_name":"Oligonucleotides, Antisense","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018799","descriptor_name":"Intercellular Adhesion Molecule-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020319","descriptor_name":"Oligodeoxyribonucleotides, Antisense","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D054735","descriptor_name":"Phosphorothioate Oligonucleotides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1089/oli.1.1997.7.503","doi":"https://doi.org/10.1089/oli.1.1997.7.503","is_oa":false,"landing_page_url":"https://doi.org/10.1089/oli.1.1997.7.503","pdf_url":null,"source":{"id":"https://openalex.org/S92216883","display_name":"Antisense and Nucleic Acid Drug Development","issn_l":"1087-2906","issn":["1087-2906","2168-6599"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antisense and Nucleic Acid Drug Development","raw_type":"journal-article"},{"id":"pmid:9361909","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9361909","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antisense & nucleic acid drug development","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8560000061988831,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W87984184","https://openalex.org/W1240040893","https://openalex.org/W1441718521","https://openalex.org/W1496645167","https://openalex.org/W1607595973","https://openalex.org/W1670899815","https://openalex.org/W1868355974","https://openalex.org/W1906809867","https://openalex.org/W1969617808","https://openalex.org/W1987360507","https://openalex.org/W2002400264","https://openalex.org/W2006239014","https://openalex.org/W2036801946","https://openalex.org/W2047366876","https://openalex.org/W2050561208","https://openalex.org/W2058165751","https://openalex.org/W2069070280","https://openalex.org/W2097346090","https://openalex.org/W2117984921","https://openalex.org/W2155320970","https://openalex.org/W2187213934","https://openalex.org/W2309961304","https://openalex.org/W2320948705","https://openalex.org/W4230542440"],"related_works":["https://openalex.org/W92700363","https://openalex.org/W2023452194","https://openalex.org/W2056412962","https://openalex.org/W2070832716","https://openalex.org/W2029829519","https://openalex.org/W2566428684","https://openalex.org/W2115570439","https://openalex.org/W1978903221","https://openalex.org/W2412836350","https://openalex.org/W2547776812"],"abstract_inverted_index":{"In":[0,34],"the":[1,22,45,81,84,97,107,144,193,209,215,232,260],"development":[2],"of":[3,11,25,31,38,48,57,64,71,83,86,113,130,152,161,171,195,199,201,208,220,231,235],"antisense":[4],"therapeutics,":[5],"there":[6,226],"have":[7],"been":[8],"a":[9,169,249],"number":[10,170],"hybridization-independent":[12],"effects":[13],"characterized":[14,42],"for":[15,168,262],"phosphorothioate":[16,173],"oligodeoxynucleotides.":[17],"One":[18],"such":[19],"effect":[20,165],"is":[21],"transient":[23,120],"prolongation":[24,112,132],"clotting":[26,39,162,217,222,253],"times":[27,40],"following":[28,54],"intravenous":[29,55],"infusion":[30,56,148],"high":[32],"doses.":[33],"this":[35,92],"study,":[36],"inhibition":[37,87,105,160,196,207,230],"was":[41,66,101,115,166,197,227,257],"by":[43,69,136],"determining":[44],"time":[46,254],"course":[47],"both":[49],"APTT":[50,65,114,131],"and":[51,121,180,203],"plasma":[52,125,139],"oligonucleotide":[53,126,140],"ISIS":[58,72,153,245],"2302":[59,73,154,246],"in":[60,88,188,252],"cynomolgus":[61],"monkeys.":[62],"Prolongation":[63],"also":[67,116],"achieved":[68],"addition":[70,151],"to":[74,104,118,155],"citrated":[75],"blood":[76,156],"from":[77,91],"untreated":[78],"monkeys,":[79],"allowing":[80],"investigation":[82],"mechanism":[85,194],"vitro.":[89],"Results":[90],"study":[93],"clearly":[94],"indicate":[95],"that":[96,192,200,225],"intrinsic":[98,210],"pathway":[99,109,211],"(APTT)":[100],"more":[102],"sensitive":[103],"than":[106],"extrinsic":[108],"(PT).":[110],"The":[111,128],"shown":[117],"be":[119,134],"closely":[122],"correlated":[123],"with":[124],"concentrations.":[127],"extent":[129],"can":[133],"controlled":[135],"minimizing":[137],"peak":[138],"concentrations":[141],"through":[142],"lowering":[143],"dose":[145],"or":[146,239],"prolonging":[147],"duration.":[149],"Direct":[150],"produced":[157],"quantitatively":[158],"similar":[159,167],"times.":[163],"This":[164],"different":[172],"oligodeoxynucleotides,":[174],"but":[175],"oligonucleotides":[176],"containing":[177],"phosphodiester":[178],"linkages":[179,182],"2'-propoxy":[181],"were":[183],"much":[184],"less":[185],"inhibitory.":[186],"Additional":[187],"vitro":[189],"studies":[190],"indicated":[191,224],"independent":[198],"heparin":[202],"possibly":[204],"involved":[205],"selective":[206,221],"as":[212,214,259],"well":[213],"common":[216],"pathway.":[218],"Investigation":[219],"factors":[223],"no":[228],"direct":[229],"enzymatic":[233],"activity":[234],"factor":[236],"Xa,":[237],"XIa,":[238],"thrombin":[240],"using":[241],"chromogenic":[242],"substrates.":[243],"However,":[244],"did":[247],"produce":[248],"concentration-dependent":[250],"increase":[251],"when":[255],"fibrinogen":[256],"used":[258],"substrate":[261],"thrombin.":[263]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}