{"id":"https://openalex.org/W2180154765","doi":"https://doi.org/10.1186/s12876-015-0390-3","title":"An open-label prospective randomized multicenter study of intensive versus weekly granulocyte and monocyte apheresis in active crohn\u2019s disease","display_name":"An open-label prospective randomized multicenter study of intensive versus weekly granulocyte and monocyte apheresis in active crohn\u2019s disease","publication_year":2015,"publication_date":"2015-11-19","ids":{"openalex":"https://openalex.org/W2180154765","doi":"https://doi.org/10.1186/s12876-015-0390-3","mag":"2180154765","pmid":"https://pubmed.ncbi.nlm.nih.gov/26585569","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4653849"},"language":"en","primary_location":{"id":"doi:10.1186/s12876-015-0390-3","doi":"https://doi.org/10.1186/s12876-015-0390-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12876-015-0390-3","pdf_url":"https://bmcgastroenterol.biomedcentral.com/counter/pdf/10.1186/s12876-015-0390-3","source":{"id":"https://openalex.org/S180811554","display_name":"BMC Gastroenterology","issn_l":"1471-230X","issn":["1471-230X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcgastroenterol.biomedcentral.com/counter/pdf/10.1186/s12876-015-0390-3","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045164790","display_name":"Naoki Yoshimura","orcid":"https://orcid.org/0000-0001-8070-1664","observed_orcids":["https://orcid.org/0000-0001-8070-1664"]},"institutions":[{"id":"https://openalex.org/I4210153683","display_name":"Tokyo Yamate Medical Center","ror":"https://ror.org/057edve92","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210132540","https://openalex.org/I4210153683"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naoki Yoshimura","raw_affiliation_strings":["Department of internal medicine, Division of IBD, Tokyo Yamate Medical Centre, Tokyo, Japan. ynaokun@yahoo.co.jp","Department of internal medicine, Division of IBD, Tokyo Yamate Medical Centre, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of internal medicine, Division of IBD, Tokyo Yamate Medical Centre, Tokyo, Japan. ynaokun@yahoo.co.jp","institution_ids":["https://openalex.org/I4210153683"]},{"raw_affiliation_string":"Department of internal medicine, Division of IBD, Tokyo Yamate Medical Centre, Tokyo, Japan","institution_ids":["https://openalex.org/I4210153683"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021287958","display_name":"Yoko Yokoyama","orcid":"https://orcid.org/0000-0002-4249-004X","observed_orcids":["https://orcid.org/0000-0002-4249-004X"]},"institutions":[{"id":"https://openalex.org/I137459256","display_name":"Hyogo Medical University","ror":"https://ror.org/001yc7927","country_code":"JP","type":"education","lineage":["https://openalex.org/I137459256"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoko Yokoyama","raw_affiliation_strings":["Division of Internal Medicine, Department of Inflammatory Bowel Disease, Hyogo College of Medicine, Hyogo, Japan. yoko0502@hyo-med.ac.jp","Division of Internal Medicine, Department of Inflammatory Bowel Disease, Hyogo College of Medicine, Hyogo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Internal Medicine, Department of Inflammatory Bowel Disease, Hyogo College of Medicine, Hyogo, Japan. yoko0502@hyo-med.ac.jp","institution_ids":["https://openalex.org/I137459256"]},{"raw_affiliation_string":"Division of Internal Medicine, Department of Inflammatory Bowel Disease, Hyogo College of Medicine, Hyogo, Japan","institution_ids":["https://openalex.org/I137459256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071194126","display_name":"Katsuyoshi Matsuoka","orcid":"https://orcid.org/0000-0002-2950-7660","observed_orcids":["https://orcid.org/0000-0002-2950-7660"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Katsuyoshi Matsuoka","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan. matsuoka@z2.keio.jp","Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan. matsuoka@z2.keio.jp","institution_ids":["https://openalex.org/I125602781"]},{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023093481","display_name":"Hiroki Takahashi","orcid":"https://orcid.org/0000-0003-0528-0446","observed_orcids":["https://orcid.org/0000-0003-0528-0446"]},"institutions":[{"id":"https://openalex.org/I4210116024","display_name":"Sendai Medical Center","ror":"https://ror.org/02cq51909","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210116024","https://openalex.org/I4210137409"]},{"id":"https://openalex.org/I4210137409","display_name":"National Hospital Organization","ror":"https://ror.org/03ntccx93","country_code":"JP","type":"government","lineage":["https://openalex.org/I4210137409"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroki Takahashi","raw_affiliation_strings":["Department of General Medicine, National Hospital Organization, Sendai Medical Centre, Miyagi, Japan. hiro-ki@snh.go.jp","Department of General Medicine, National Hospital Organization, Sendai Medical Centre, Miyagi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Medicine, National Hospital Organization, Sendai Medical Centre, Miyagi, Japan. hiro-ki@snh.go.jp","institution_ids":["https://openalex.org/I4210116024","https://openalex.org/I4210137409"]},{"raw_affiliation_string":"Department of General Medicine, National Hospital Organization, Sendai Medical Centre, Miyagi, Japan","institution_ids":["https://openalex.org/I4210116024","https://openalex.org/I4210137409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050542462","display_name":"Ryuichi Iwakiri","orcid":"https://orcid.org/0000-0001-7911-9669","observed_orcids":["https://orcid.org/0000-0001-7911-9669"]},"institutions":[{"id":"https://openalex.org/I177136067","display_name":"Saga University","ror":"https://ror.org/04f4wg107","country_code":"JP","type":"education","lineage":["https://openalex.org/I177136067"]},{"id":"https://openalex.org/I4210092011","display_name":"Saga Medical School Hospital","ror":"https://ror.org/00g51j712","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210092011"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryuichi Iwakiri","raw_affiliation_strings":["Division of Gastroenterology, Department of Internal Medicine, Saga Medical School, Saga, Japan. iwakiri@cc.saga-u.ac.jp","Division of Gastroenterology, Department of Internal Medicine, Saga Medical School, Saga, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Department of Internal Medicine, Saga Medical School, Saga, Japan. iwakiri@cc.saga-u.ac.jp","institution_ids":["https://openalex.org/I177136067","https://openalex.org/I4210092011"]},{"raw_affiliation_string":"Division of Gastroenterology, Department of Internal Medicine, Saga Medical School, Saga, Japan","institution_ids":["https://openalex.org/I177136067","https://openalex.org/I4210092011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071958820","display_name":"Takayuki Yamamoto","orcid":"https://orcid.org/0000-0001-7551-5568","observed_orcids":["https://orcid.org/0000-0001-7551-5568"]},"institutions":[{"id":"https://openalex.org/I4210120488","display_name":"Yokkaichi Social Insurance Hospital","ror":"https://ror.org/02d8ncy29","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210120488","https://openalex.org/I4210132540"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takayuki Yamamoto","raw_affiliation_strings":["Inflammatory Bowel Disease Centre, Yokkaichi Hazu Medical Centre, Mie, Japan. nao-taka@sannet.ne.jp","Inflammatory Bowel Disease Centre, Yokkaichi Hazu Medical Centre, Mie, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inflammatory Bowel Disease Centre, Yokkaichi Hazu Medical Centre, Mie, Japan. nao-taka@sannet.ne.jp","institution_ids":["https://openalex.org/I4210120488"]},{"raw_affiliation_string":"Inflammatory Bowel Disease Centre, Yokkaichi Hazu Medical Centre, Mie, Japan","institution_ids":["https://openalex.org/I4210120488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000480842","display_name":"Tomoo Nakagawa","orcid":"https://orcid.org/0000-0001-6144-5343","observed_orcids":["https://orcid.org/0000-0001-6144-5343"]},"institutions":[{"id":"https://openalex.org/I4210099339","display_name":"Chiba University Hospital","ror":"https://ror.org/0126xah18","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210099339"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoo Nakagawa","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Chiba University Hospital, Chiba, Japan. tom20852@yahoo.co.jp","Department of Gastroenterology and Hepatology, Chiba University Hospital, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Chiba University Hospital, Chiba, Japan. tom20852@yahoo.co.jp","institution_ids":["https://openalex.org/I4210099339"]},{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Chiba University Hospital, Chiba, Japan","institution_ids":["https://openalex.org/I4210099339"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073672829","display_name":"Takumi Fukuchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136742","display_name":"Saiseikai Nakatsu Hospital","ror":"https://ror.org/03pj30e67","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210136742"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takumi Fukuchi","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Osakafu Saiseikai Nakatsu Hospital, Osaka, Japan. takuleotakuleo@yahoo.co.jp","Department of Gastroenterology and Hepatology, Osakafu Saiseikai Nakatsu Hospital, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Osakafu Saiseikai Nakatsu Hospital, Osaka, Japan. takuleotakuleo@yahoo.co.jp","institution_ids":["https://openalex.org/I4210136742"]},{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Osakafu Saiseikai Nakatsu Hospital, Osaka, Japan","institution_ids":["https://openalex.org/I4210136742"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057448803","display_name":"Satoshi Motoya","orcid":"https://orcid.org/0000-0002-4194-8493","observed_orcids":["https://orcid.org/0000-0002-4194-8493"]},"institutions":[{"id":"https://openalex.org/I4210121725","display_name":"Sapporo Kosei General Hospital","ror":"https://ror.org/029jhw134","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210121725"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoshi Motoya","raw_affiliation_strings":["IBD Center, Sapporo Kosei General Hospital, Hokkaido, Japan. sa-motoya@nifty.com","IBD Center, Sapporo Kosei General Hospital, Hokkaido, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IBD Center, Sapporo Kosei General Hospital, Hokkaido, Japan. sa-motoya@nifty.com","institution_ids":["https://openalex.org/I4210121725"]},{"raw_affiliation_string":"IBD Center, Sapporo Kosei General Hospital, Hokkaido, Japan","institution_ids":["https://openalex.org/I4210121725"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025848624","display_name":"Reiko Kunisaki","orcid":"https://orcid.org/0000-0003-3083-9600","observed_orcids":["https://orcid.org/0000-0003-3083-9600"]},"institutions":[{"id":"https://openalex.org/I2802180866","display_name":"Yokohama City University Medical Center","ror":"https://ror.org/03k95ve17","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I2802180866"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Reiko Kunisaki","raw_affiliation_strings":["Inflammatory Bowel Centre, Yokohama City University Medical Centre, Kanagawa, Japan. reikok@urahp.yokohama-cu.ac.jp","Inflammatory Bowel Centre, Yokohama City University Medical Centre, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inflammatory Bowel Centre, Yokohama City University Medical Centre, Kanagawa, Japan. reikok@urahp.yokohama-cu.ac.jp","institution_ids":["https://openalex.org/I2802180866"]},{"raw_affiliation_string":"Inflammatory Bowel Centre, Yokohama City University Medical Centre, Kanagawa, Japan","institution_ids":["https://openalex.org/I2802180866"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071163211","display_name":"Shingo Kato","orcid":"https://orcid.org/0000-0001-7522-3557","observed_orcids":["https://orcid.org/0000-0001-7522-3557"]},"institutions":[{"id":"https://openalex.org/I8588240","display_name":"Saitama Medical University","ror":"https://ror.org/04zb31v77","country_code":"JP","type":"education","lineage":["https://openalex.org/I8588240"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shingo Kato","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Department of Internal Medicine, Saitama Medical Centre, Saitama Medical University, Saitama, Japan. skato@saitama-med.ac.jp","Division of Gastroenterology and Hepatology, Department of Internal Medicine, Saitama Medical Centre, Saitama Medical University, Saitama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, Saitama Medical Centre, Saitama Medical University, Saitama, Japan. skato@saitama-med.ac.jp","institution_ids":["https://openalex.org/I8588240"]},{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, Saitama Medical Centre, Saitama Medical University, Saitama, Japan","institution_ids":["https://openalex.org/I8588240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014227547","display_name":"Fumihito Hirai","orcid":"https://orcid.org/0000-0002-5493-5675","observed_orcids":["https://orcid.org/0000-0002-5493-5675"]},"institutions":[{"id":"https://openalex.org/I31784960","display_name":"Fukuoka University","ror":"https://ror.org/04nt8b154","country_code":"JP","type":"education","lineage":["https://openalex.org/I31784960"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Fumihito Hirai","raw_affiliation_strings":["Department of Gastroenterology Fukuoka University Chikushi Hospital, Fukuoka, Japan. fuhirai@yahoo.co.jp","Department of Gastroenterology Fukuoka University Chikushi Hospital, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology Fukuoka University Chikushi Hospital, Fukuoka, Japan. fuhirai@yahoo.co.jp","institution_ids":["https://openalex.org/I31784960"]},{"raw_affiliation_string":"Department of Gastroenterology Fukuoka University Chikushi Hospital, Fukuoka, Japan","institution_ids":["https://openalex.org/I31784960"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030391629","display_name":"Yoh Ishiguro","orcid":"https://orcid.org/0000-0002-0429-5956","observed_orcids":["https://orcid.org/0000-0002-0429-5956"]},"institutions":[{"id":"https://openalex.org/I4210149837","display_name":"Hirosaki National Hospital","ror":"https://ror.org/03qrrp624","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137409","https://openalex.org/I4210149837"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoh Ishiguro","raw_affiliation_strings":["Department of Gastroenterology and Hematology, Hirosaki National Hospital, Aomori, Japan. yishihki@gmail.com","Department of Gastroenterology and Hematology, Hirosaki National Hospital, Aomori, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hematology, Hirosaki National Hospital, Aomori, Japan. yishihki@gmail.com","institution_ids":["https://openalex.org/I4210149837"]},{"raw_affiliation_string":"Department of Gastroenterology and Hematology, Hirosaki National Hospital, Aomori, Japan","institution_ids":["https://openalex.org/I4210149837"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076408477","display_name":"Satoshi Tanida","orcid":"https://orcid.org/0000-0003-0068-1283","observed_orcids":["https://orcid.org/0000-0003-0068-1283"]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoshi Tanida","raw_affiliation_strings":["Department of Gastroenterology and Metabolism, Nagoya City University, Graduate School of Medical Sciences, Nagoya, Japan. stanida@med.nagoya-cu.ac.jp","Department of Gastroenterology and Metabolism, Nagoya City University, Graduate School of Medical Sciences, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Metabolism, Nagoya City University, Graduate School of Medical Sciences, Nagoya, Japan. stanida@med.nagoya-cu.ac.jp","institution_ids":["https://openalex.org/I33858575"]},{"raw_affiliation_string":"Department of Gastroenterology and Metabolism, Nagoya City University, Graduate School of Medical Sciences, Nagoya, Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006080006","display_name":"Sakiko Hiraoka","orcid":"https://orcid.org/0000-0002-9796-6930","observed_orcids":["https://orcid.org/0000-0002-9796-6930"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Sakiko Hiraoka","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Okayama, Japan. sakikoh@cc.okayama-u.ac.jp","Department of Gastroenterology and Hepatology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Okayama, Japan. sakikoh@cc.okayama-u.ac.jp","institution_ids":["https://openalex.org/I163770644"]},{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065128587","display_name":"Keiichi Mitsuyama","orcid":"https://orcid.org/0000-0002-5959-9607","observed_orcids":["https://orcid.org/0000-0002-5959-9607"]},"institutions":[{"id":"https://openalex.org/I105296287","display_name":"Kurume University","ror":"https://ror.org/057xtrt18","country_code":"JP","type":"education","lineage":["https://openalex.org/I105296287"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keiichi Mitsuyama","raw_affiliation_strings":["Division of Gastroenterology, Department of Medicine, Inflammatory Bowel Disease Centre, Kurume University School of Medicine, Fukuoka, Japan. ibd@med.kurume-u.ac.jp","Division of Gastroenterology, Department of Medicine, Inflammatory Bowel Disease Centre, Kurume University School of Medicine, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Department of Medicine, Inflammatory Bowel Disease Centre, Kurume University School of Medicine, Fukuoka, Japan. ibd@med.kurume-u.ac.jp","institution_ids":["https://openalex.org/I105296287"]},{"raw_affiliation_string":"Division of Gastroenterology, Department of Medicine, Inflammatory Bowel Disease Centre, Kurume University School of Medicine, Fukuoka, Japan","institution_ids":["https://openalex.org/I105296287"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024130517","display_name":"Shunji Ishihara","orcid":"https://orcid.org/0000-0002-8228-1912","observed_orcids":["https://orcid.org/0000-0002-8228-1912"]},"institutions":[{"id":"https://openalex.org/I169016828","display_name":"Shimane University","ror":"https://ror.org/01jaaym28","country_code":"JP","type":"education","lineage":["https://openalex.org/I169016828"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shunji Ishihara","raw_affiliation_strings":["Department of Internal Medicine II, Faculty of Medicine, Shimane University, Izumo, Japan. si360405@med.shimane-u.ac.jp","Department of Internal Medicine II, Faculty of Medicine, Shimane University, Izumo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine II, Faculty of Medicine, Shimane University, Izumo, Japan. si360405@med.shimane-u.ac.jp","institution_ids":["https://openalex.org/I169016828"]},{"raw_affiliation_string":"Department of Internal Medicine II, Faculty of Medicine, Shimane University, Izumo, Japan","institution_ids":["https://openalex.org/I169016828"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086850753","display_name":"Shinji Tanaka","orcid":"https://orcid.org/0000-0002-0480-3957","observed_orcids":["https://orcid.org/0000-0002-0480-3957"]},"institutions":[{"id":"https://openalex.org/I4210125056","display_name":"Hiroshima University Hospital","ror":"https://ror.org/038dg9e86","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210125056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shinji Tanaka","raw_affiliation_strings":["Department of Endoscopy, Hiroshima University Hospital, Hiroshima, Japan. colon@hiroshima-u.ac.jp","Department of Endoscopy, Hiroshima University Hospital, Hiroshima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endoscopy, Hiroshima University Hospital, Hiroshima, Japan. colon@hiroshima-u.ac.jp","institution_ids":["https://openalex.org/I4210125056"]},{"raw_affiliation_string":"Department of Endoscopy, Hiroshima University Hospital, Hiroshima, Japan","institution_ids":["https://openalex.org/I4210125056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109841505","display_name":"Michiro Otaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34077901","display_name":"Juntendo University","ror":"https://ror.org/01692sz90","country_code":"JP","type":"education","lineage":["https://openalex.org/I34077901"]},{"id":"https://openalex.org/I4210151746","display_name":"Kobari General Hospital","ror":"https://ror.org/04yn2he76","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210151746"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Michiro Otaka","raw_affiliation_strings":["Division of Gastroenterology, Kobari General Hospital & Juntendo University, Chiba, Japan. mootaka@juntendo.ac.jp","Division of Gastroenterology, Kobari General Hospital & Juntendo University, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Kobari General Hospital & Juntendo University, Chiba, Japan. mootaka@juntendo.ac.jp","institution_ids":["https://openalex.org/I34077901","https://openalex.org/I4210151746"]},{"raw_affiliation_string":"Division of Gastroenterology, Kobari General Hospital & Juntendo University, Chiba, Japan","institution_ids":["https://openalex.org/I34077901","https://openalex.org/I4210151746"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050400651","display_name":"Taro Osada","orcid":"https://orcid.org/0000-0002-2260-8047","observed_orcids":["https://orcid.org/0000-0002-2260-8047"]},"institutions":[{"id":"https://openalex.org/I34077901","display_name":"Juntendo University","ror":"https://ror.org/01692sz90","country_code":"JP","type":"education","lineage":["https://openalex.org/I34077901"]},{"id":"https://openalex.org/I4210145596","display_name":"Juntendo University Hospital","ror":"https://ror.org/04g0m2d49","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210145596"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Taro Osada","raw_affiliation_strings":["Department of Gastroenterology, Juntendo University School of Medicine, Tokyo, Japan. otaro@juntendo.ac.jp","Department of Gastroenterology, Juntendo University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Juntendo University School of Medicine, Tokyo, Japan. otaro@juntendo.ac.jp","institution_ids":["https://openalex.org/I34077901"]},{"raw_affiliation_string":"Department of Gastroenterology, Juntendo University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I34077901","https://openalex.org/I4210145596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028587571","display_name":"Takashi Kagaya","orcid":"https://orcid.org/0000-0003-0819-632X","observed_orcids":["https://orcid.org/0000-0003-0819-632X"]},"institutions":[{"id":"https://openalex.org/I4210104330","display_name":"Kanazawa University Hospital","ror":"https://ror.org/00xsdn005","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210104330"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Kagaya","raw_affiliation_strings":["Department of Gastroenterology, Kanazawa University Hospital, Ishikawa, Japan. kagaya@m-kanazawa.jp","Department of Gastroenterology, Kanazawa University Hospital, Ishikawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Kanazawa University Hospital, Ishikawa, Japan. kagaya@m-kanazawa.jp","institution_ids":["https://openalex.org/I4210104330"]},{"raw_affiliation_string":"Department of Gastroenterology, Kanazawa University Hospital, Ishikawa, Japan","institution_ids":["https://openalex.org/I4210104330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101787157","display_name":"Yasuo Suzuki","orcid":"https://orcid.org/0000-0002-9813-9793","observed_orcids":["https://orcid.org/0000-0002-9813-9793"]},"institutions":[{"id":"https://openalex.org/I129634264","display_name":"Toho University","ror":"https://ror.org/02hcx7n63","country_code":"JP","type":"education","lineage":["https://openalex.org/I129634264"]},{"id":"https://openalex.org/I4210125448","display_name":"Toho University Medical Center Sakura Hospital","ror":"https://ror.org/02xrm8w90","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210125448"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuo Suzuki","raw_affiliation_strings":["Internal Medicine, Toho University Sakura Medical Centre, Chiba, Japan. yasuo-suzuki@sakura.med.toho-u.ac.jp","Internal Medicine, Toho University Sakura Medical Centre, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine, Toho University Sakura Medical Centre, Chiba, Japan. yasuo-suzuki@sakura.med.toho-u.ac.jp","institution_ids":["https://openalex.org/I129634264","https://openalex.org/I4210125448"]},{"raw_affiliation_string":"Internal Medicine, Toho University Sakura Medical Centre, Chiba, Japan","institution_ids":["https://openalex.org/I129634264","https://openalex.org/I4210125448"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002391399","display_name":"Hiroshi Nakase","orcid":"https://orcid.org/0000-0003-2848-6586","observed_orcids":["https://orcid.org/0000-0003-2848-6586"]},"institutions":[{"id":"https://openalex.org/I4210150196","display_name":"Kyoto University Hospital","ror":"https://ror.org/04k6gr834","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210150196"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Nakase","raw_affiliation_strings":["Department of Gastroenterology and Endoscopic Medicine, Kyoto University Hospital, Kyoto, Japan. hiropy_n@kuhp.kyoto-u.ac.jp","Department of Gastroenterology and Endoscopic Medicine, Kyoto University Hospital, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Endoscopic Medicine, Kyoto University Hospital, Kyoto, Japan. hiropy_n@kuhp.kyoto-u.ac.jp","institution_ids":["https://openalex.org/I4210150196"]},{"raw_affiliation_string":"Department of Gastroenterology and Endoscopic Medicine, Kyoto University Hospital, Kyoto, Japan","institution_ids":["https://openalex.org/I4210150196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062910921","display_name":"Hiroyuki Hanai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiroyuki Hanai","raw_affiliation_strings":["Centre for Gastroenterology and Inflammatory Bowel Disease Research, Hamamatsu South Hospital, Shizuoka, Japan. hanai@hamamatsu-minami.com","Centre for Gastroenterology and Inflammatory Bowel Disease Research, Hamamatsu South Hospital, Shizuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Gastroenterology and Inflammatory Bowel Disease Research, Hamamatsu South Hospital, Shizuoka, Japan. hanai@hamamatsu-minami.com","institution_ids":[]},{"raw_affiliation_string":"Centre for Gastroenterology and Inflammatory Bowel Disease Research, Hamamatsu South Hospital, Shizuoka, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045329864","display_name":"Kenji Watanabe","orcid":"https://orcid.org/0000-0002-3781-4724","observed_orcids":["https://orcid.org/0000-0002-3781-4724","https://orcid.org/0000-0003-3701-8119"]},"institutions":[{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenji Watanabe","raw_affiliation_strings":["Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan. kenjiw@med.osaka-cu.ac.jp","Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan. kenjiw@med.osaka-cu.ac.jp","institution_ids":["https://openalex.org/I317356780"]},{"raw_affiliation_string":"Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan","institution_ids":["https://openalex.org/I317356780","https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046297391","display_name":"Nobuhito Kashiwagi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152131","display_name":"JIMRO (Japan)","ror":"https://ror.org/04qknqs93","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210152131"]},{"id":"https://openalex.org/I4405264461","display_name":"JIMRO Co., Ltd. (Japan)","ror":"https://ror.org/020b0y443","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405264461"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nobuhito Kashiwagi","raw_affiliation_strings":["Research division, JIMRO Co., Ltd, Gunma, Japan. kashiwagin@jimro.co.jp","Research division, JIMRO Co., Ltd, Gunma, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research division, JIMRO Co., Ltd, Gunma, Japan. kashiwagin@jimro.co.jp","institution_ids":["https://openalex.org/I4210152131","https://openalex.org/I4405264461"]},{"raw_affiliation_string":"Research division, JIMRO Co., Ltd, Gunma, Japan","institution_ids":["https://openalex.org/I4210152131","https://openalex.org/I4405264461"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026205612","display_name":"Toshifumi Hibi\u2225","orcid":"https://orcid.org/0000-0002-6256-1204","observed_orcids":["https://orcid.org/0000-0002-6256-1204"]},"institutions":[{"id":"https://openalex.org/I4210154200","display_name":"Kitasato Institute Hospital","ror":"https://ror.org/05js82y61","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210154200"]},{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Toshifumi Hibi","raw_affiliation_strings":["Kitasato Institute Hospital, Centre for Advanced IBD Research and Treatment, Kitasato University, 108-8642 Minato-ku, Tokyo, Japan. thibi@insti.kitasato-u.ac.jp","Kitasato Institute Hospital, Centre for Advanced IBD Research and Treatment, Kitasato University, 108-8642 Minato-ku, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kitasato Institute Hospital, Centre for Advanced IBD Research and Treatment, Kitasato University, 108-8642 Minato-ku, Tokyo, Japan. thibi@insti.kitasato-u.ac.jp","institution_ids":["https://openalex.org/I4210154200","https://openalex.org/I64189623"]},{"raw_affiliation_string":"Kitasato Institute Hospital, Centre for Advanced IBD Research and Treatment, Kitasato University, 108-8642 Minato-ku, Tokyo, Japan","institution_ids":["https://openalex.org/I4210154200","https://openalex.org/I64189623"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":33,"corresponding_author_ids":["https://openalex.org/A5026205612"],"corresponding_institution_ids":["https://openalex.org/I4210154200","https://openalex.org/I64189623"],"apc_list":{"value":3190,"currency":"USD","value_usd":3190},"apc_paid":{"value":3190,"currency":"USD","value_usd":3190},"fwci":2.2811,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.88517477,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"15","issue":"1","first_page":"163","last_page":"163"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11865","display_name":"Anorectal Disease Treatments and Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/crohn-s-disease","display_name":"Crohn's disease","score":0.9850000143051147},{"id":"https://openalex.org/keywords/clinical-remission","display_name":"clinical remission","score":0.7839999794960022},{"id":"https://openalex.org/keywords/time-to-remission","display_name":"time to remission","score":0.9359999895095825},{"id":"https://openalex.org/keywords/treatment-efficacy","display_name":"treatment efficacy","score":0.4819999933242798},{"id":"https://openalex.org/keywords/treatment-safety","display_name":"treatment safety","score":0.800000011920929},{"id":"https://openalex.org/keywords/erythrocyte-sedimentation-rate","display_name":"erythrocyte sedimentation rate","score":0.8339999914169312},{"id":"https://openalex.org/keywords/white-blood-cell-count","display_name":"white blood cell count","score":0.7459999918937683}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.958355188369751},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6532236933708191},{"id":"https://openalex.org/C2776738589","wikidata":"https://www.wikidata.org/wiki/Q618446","display_name":"Apheresis","level":3,"score":0.565766453742981},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.549592912197113},{"id":"https://openalex.org/C2987404301","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care","level":2,"score":0.5105815529823303},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.49184727668762207},{"id":"https://openalex.org/C41260117","wikidata":"https://www.wikidata.org/wiki/Q668064","display_name":"Hepatology","level":2,"score":0.45396551489830017},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4258174002170563},{"id":"https://openalex.org/C2778143017","wikidata":"https://www.wikidata.org/wiki/Q111208","display_name":"Erythrocyte sedimentation rate","level":2,"score":0.4150426387786865},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.37790337204933167},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.14951705932617188},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.08428829908370972}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000327","descriptor_name":"Adsorption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006098","descriptor_name":"Granulocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007937","descriptor_name":"Leukapheresis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012074","descriptor_name":"Remission Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12876-015-0390-3","doi":"https://doi.org/10.1186/s12876-015-0390-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12876-015-0390-3","pdf_url":"https://bmcgastroenterol.biomedcentral.com/counter/pdf/10.1186/s12876-015-0390-3","source":{"id":"https://openalex.org/S180811554","display_name":"BMC Gastroenterology","issn_l":"1471-230X","issn":["1471-230X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Gastroenterology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4653849","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4653849","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Gastroenterol","raw_type":"Text"},{"id":"pmid:26585569","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26585569","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC gastroenterology","raw_type":"Journal Article"},{"id":"pmh:oai:irdb.nii.ac.jp:01221:0000168777","doi":null,"is_oa":true,"landing_page_url":"https://repository.kulib.kyoto-u.ac.jp/bitstreams/546e37b4-6f1a-4834-9716-344a60c8b3dd/download","pdf_url":"https://repository.kulib.kyoto-u.ac.jp/bitstreams/546e37b4-6f1a-4834-9716-344a60c8b3dd/download","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Gastroenterology","raw_type":"journal article"},{"id":"pmh:oai:repository.kulib.kyoto-u.ac.jp:2433/212476","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2433/212476","pdf_url":null,"source":{"id":"https://openalex.org/S4306401454","display_name":"Kyoto University Research Information Repository (Kyoto University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I22299242","host_organization_name":"Kyoto University","host_organization_lineage":["https://openalex.org/I22299242"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"}],"best_oa_location":{"id":"doi:10.1186/s12876-015-0390-3","doi":"https://doi.org/10.1186/s12876-015-0390-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12876-015-0390-3","pdf_url":"https://bmcgastroenterol.biomedcentral.com/counter/pdf/10.1186/s12876-015-0390-3","source":{"id":"https://openalex.org/S180811554","display_name":"BMC Gastroenterology","issn_l":"1471-230X","issn":["1471-230X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Gastroenterology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[{"id":"https://openalex.org/G7908567840","display_name":"Elucidation of the molecular mechanism of induction/activation of regulatory B cells and its application to regulation of intestinal inflammation","funder_award_id":"26460970","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2180154765.pdf","grobid_xml":"https://content.openalex.org/works/W2180154765.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W97459010","https://openalex.org/W134031355","https://openalex.org/W1481475489","https://openalex.org/W1774343840","https://openalex.org/W1843989750","https://openalex.org/W1963701987","https://openalex.org/W1964562488","https://openalex.org/W1970265625","https://openalex.org/W1979039222","https://openalex.org/W1984802220","https://openalex.org/W1987974049","https://openalex.org/W1989011067","https://openalex.org/W1989947339","https://openalex.org/W1994420290","https://openalex.org/W2003492229","https://openalex.org/W2020846595","https://openalex.org/W2030574089","https://openalex.org/W2034997602","https://openalex.org/W2037918467","https://openalex.org/W2039283137","https://openalex.org/W2042727833","https://openalex.org/W2042757960","https://openalex.org/W2047522682","https://openalex.org/W2052416186","https://openalex.org/W2071284044","https://openalex.org/W2073387523","https://openalex.org/W2081134502","https://openalex.org/W2085191137","https://openalex.org/W2086318131","https://openalex.org/W2089736060","https://openalex.org/W2090568923","https://openalex.org/W2097741655","https://openalex.org/W2121692285","https://openalex.org/W2127693350","https://openalex.org/W2143904760","https://openalex.org/W2154117979","https://openalex.org/W2162268056","https://openalex.org/W2165726201","https://openalex.org/W2166714084","https://openalex.org/W2171495193","https://openalex.org/W2319895888","https://openalex.org/W3145518845","https://openalex.org/W4255149626"],"related_works":["https://openalex.org/W2131934819","https://openalex.org/W4380876112","https://openalex.org/W2060770395","https://openalex.org/W1987974049","https://openalex.org/W1982158699","https://openalex.org/W2326036944","https://openalex.org/W4390542880","https://openalex.org/W7100786081","https://openalex.org/W4396661548","https://openalex.org/W2891327615"],"abstract_inverted_index":{"BACKGROUND:":[0],"Granulocyte":[1],"and":[2,38,140,161,188,202,219,237],"monocyte":[3],"adsorptive":[4],"apheresis":[5],"(GMA)":[6],"has":[7],"shown":[8],"efficacy":[9,37,129],"in":[10,43,96,135,142,150,157,162,168,184,193,267],"patients":[11,44,57,154],"with":[12,18,45,58,246],"active":[13,46],"Crohn's":[14],"disease":[15],"(CD).":[16],"However,":[17,106],"routine":[19],"weekly":[20,137,159,186,257],"therapy,":[21],"it":[22],"may":[23],"take":[24],"several":[25],"weeks":[26],"to":[27,34,65,102,115,177,214,223,248,256,262],"achieve":[28],"remission.":[29],"This":[30],"study":[31],"was":[32,88,148,179,234,238,253,264],"performed":[33],"assess":[35],"clinical":[36],"safety":[39,240],"of":[40,63,152,164,274],"intensive":[41,68,144,170,195,210,251],"GMA":[42,104,107,138,145,160,171,187,196,233,252],"CD.":[47],"METHODS:":[48],"In":[49,230,243],"an":[50],"open-label,":[51],"prospective,":[52],"randomized":[53],"multicentre":[54],"setting,":[55],"104":[56,123],"CD":[59],"activity":[60],"index":[61],"(CDAI)":[62],"200":[64],"450":[66],"received":[67],"GMA,":[69,211,258],"at":[70],"two":[71],"sessions":[72],"per":[73,81,132],"week":[74,82],"(n":[75,83],"=":[76,84,198,217,227],"55)":[77],"or":[78],"one":[79],"session":[80],"49).":[85],"Clinical":[86],"remission":[87,118,178,249,263],"defined":[89],"as":[90,131],"a":[91],"CDAI":[92,113],"score":[93],"<150.":[94],"Patients":[95],"each":[97],"arm":[98],"could":[99,109],"receive":[100],"up":[101],"10":[103],"sessions.":[105],"treatment":[108],"be":[110],"discontinued":[111],"when":[112],"decreased":[114],"<150":[116],"(clinical":[117],"level).":[119],"RESULTS:":[120],"Of":[121],"the":[122,136,143,158,169,174,185,194,260,268,272],"patients,":[124],"99":[125],"were":[126,206],"available":[127],"for":[128],"evaluation":[130],"protocol,":[133],"45":[134,153],"group,":[139],"54":[141,165],"group.":[146],"Remission":[147],"achieved":[149],"16":[151],"(35.6":[155],"%)":[156,167],"19":[163],"(35.2":[166],"(NS).":[172],"Further,":[173],"mean":[175],"time":[176,261],"35.4":[180],"\u00b1":[181,190],"5.3":[182],"days":[183,192],"21.7":[189],"2.7":[191],"(P":[197,216,226],"0.0373).":[199],"Elevated":[200],"leucocytes":[201],"erythrocyte":[203],"sedimentation":[204],"rate":[205],"significantly":[207,265],"improved":[208],"by":[209],"from":[212,220],"8005/\u03bcL":[213],"6950/\u03bcL":[215],"0.0461)":[218],"54.5":[221],"mm/hr":[222,225],"30.0":[224],"0.0059),":[228],"respectively.":[229],"both":[231],"arms,":[232],"well":[235],"tolerated":[236],"without":[239,270],"concern.":[241],"CONCLUSIONS:":[242],"this":[244],"study,":[245],"respect":[247],"rate,":[250],"not":[254],"superior":[255],"but":[259],"shorter":[266],"former":[269],"increasing":[271],"incidence":[273],"side":[275],"effects.":[276],"UMIN":[277],"registration":[278],"#":[279],"000003666.":[280]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}