{"id":"https://openalex.org/W2180141563","doi":"https://doi.org/10.1186/s12986-015-0045-y","title":"Bacterial metabolites directly modulate farnesoid X receptor activity","display_name":"Bacterial metabolites directly modulate farnesoid X receptor activity","publication_year":2015,"publication_date":"2015-11-24","ids":{"openalex":"https://openalex.org/W2180141563","doi":"https://doi.org/10.1186/s12986-015-0045-y","mag":"2180141563","pmid":"https://pubmed.ncbi.nlm.nih.gov/26604978","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4657204"},"language":"en","primary_location":{"id":"doi:10.1186/s12986-015-0045-y","doi":"https://doi.org/10.1186/s12986-015-0045-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12986-015-0045-y","pdf_url":"https://nutritionandmetabolism.biomedcentral.com/track/pdf/10.1186/s12986-015-0045-y","source":{"id":"https://openalex.org/S69338484","display_name":"Nutrition & Metabolism","issn_l":"1743-7075","issn":["1743-7075"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrition &amp; Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://nutritionandmetabolism.biomedcentral.com/track/pdf/10.1186/s12986-015-0045-y","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001600433","display_name":"Xianqin Zhang","orcid":"https://orcid.org/0000-0002-0103-2341","observed_orcids":["https://orcid.org/0000-0002-0103-2341"]},"institutions":[{"id":"https://openalex.org/I150744194","display_name":"Waseda University","ror":"https://ror.org/00ntfnx83","country_code":"JP","type":"education","lineage":["https://openalex.org/I150744194"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Xianqin Zhang","raw_affiliation_strings":["Department of Life Science and Medical Bioscience, Waseda University, Tokyo, 162-8480, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Life Science and Medical Bioscience, Waseda University, Tokyo, 162-8480, Japan","institution_ids":["https://openalex.org/I150744194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049679567","display_name":"Toshifumi Osaka","orcid":"https://orcid.org/0000-0003-3628-698X","observed_orcids":["https://orcid.org/0000-0003-3628-698X"]},"institutions":[{"id":"https://openalex.org/I150744194","display_name":"Waseda University","ror":"https://ror.org/00ntfnx83","country_code":"JP","type":"education","lineage":["https://openalex.org/I150744194"]},{"id":"https://openalex.org/I4210136522","display_name":"Tokyo Women's Medical University","ror":"https://ror.org/03kjjhe36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210136522"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshifumi Osaka","raw_affiliation_strings":["Department of Life Science and Medical Bioscience, Waseda University, Tokyo, 162-8480, Japan","Department of Microbiology and Immunology, Tokyo Women's Medical University, Tokyo, 162-8666 Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Life Science and Medical Bioscience, Waseda University, Tokyo, 162-8480, Japan","institution_ids":["https://openalex.org/I150744194"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, Tokyo Women's Medical University, Tokyo, 162-8666 Japan","institution_ids":["https://openalex.org/I4210136522"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081485824","display_name":"Satoshi Tsuneda","orcid":"https://orcid.org/0000-0002-4624-5359","observed_orcids":["https://orcid.org/0000-0002-4624-5359"]},"institutions":[{"id":"https://openalex.org/I150744194","display_name":"Waseda University","ror":"https://ror.org/00ntfnx83","country_code":"JP","type":"education","lineage":["https://openalex.org/I150744194"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Satoshi Tsuneda","raw_affiliation_strings":["Department of Life Science and Medical Bioscience, Waseda University, Tokyo, 162-8480, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Life Science and Medical Bioscience, Waseda University, Tokyo, 162-8480, Japan","institution_ids":["https://openalex.org/I150744194"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5081485824"],"corresponding_institution_ids":["https://openalex.org/I150744194"],"apc_list":{"value":3590,"currency":"USD","value_usd":3590},"apc_paid":{"value":3590,"currency":"USD","value_usd":3590},"fwci":1.3845,"has_fulltext":true,"cited_by_count":36,"citation_normalized_percentile":{"value":0.80572318,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"12","issue":"1","first_page":"48","last_page":"48"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.8906000256538391,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.8906000256538391,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.09239999949932098,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12059","display_name":"Berberine and alkaloids research","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/farnesoid-x-receptor","display_name":"farnesoid X receptor","score":1.0},{"id":"https://openalex.org/keywords/bacterial-metabolites","display_name":"bacterial metabolites","score":0.9100000262260437},{"id":"https://openalex.org/keywords/bacteroides-dorei","display_name":"Bacteroides dorei","score":0.949999988079071},{"id":"https://openalex.org/keywords/eubacterium-limosum","display_name":"Eubacterium limosum","score":1.0},{"id":"https://openalex.org/keywords/fxr-activation","display_name":"FXR activation","score":0.5759999752044678},{"id":"https://openalex.org/keywords/ileal-bile-acid-binding-protein","display_name":"ileal bile acid binding protein","score":0.8569999933242798},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.6169999837875366},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.6380000114440918},{"id":"https://openalex.org/keywords/liver-injury","display_name":"liver injury","score":0.5809999704360962},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.7559999823570251},{"id":"https://openalex.org/keywords/intestinal-epithelial-cells","display_name":"intestinal epithelial cells","score":0.8529999852180481},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.734000027179718}],"concepts":[{"id":"https://openalex.org/C203862802","wikidata":"https://www.wikidata.org/wiki/Q14905041","display_name":"Farnesoid X receptor","level":5,"score":0.9865283370018005},{"id":"https://openalex.org/C89673097","wikidata":"https://www.wikidata.org/wiki/Q14907373","display_name":"Cholesterol 7 alpha-hydroxylase","level":3,"score":0.536949872970581},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46072840690612793},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4392293393611908},{"id":"https://openalex.org/C161733203","wikidata":"https://www.wikidata.org/wiki/Q911828","display_name":"Reporter gene","level":4,"score":0.42083457112312317},{"id":"https://openalex.org/C39321552","wikidata":"https://www.wikidata.org/wiki/Q18052005","display_name":"G protein-coupled bile acid receptor","level":3,"score":0.41232770681381226},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.38416099548339844},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3575110137462616},{"id":"https://openalex.org/C63932345","wikidata":"https://www.wikidata.org/wiki/Q422500","display_name":"Nuclear receptor","level":4,"score":0.3357471823692322},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3339022994041443},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.33059465885162354},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.31223297119140625},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.24819040298461914},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11241713166236877},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09197604656219482}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1186/s12986-015-0045-y","doi":"https://doi.org/10.1186/s12986-015-0045-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12986-015-0045-y","pdf_url":"https://nutritionandmetabolism.biomedcentral.com/track/pdf/10.1186/s12986-015-0045-y","source":{"id":"https://openalex.org/S69338484","display_name":"Nutrition & Metabolism","issn_l":"1743-7075","issn":["1743-7075"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrition &amp; Metabolism","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4657204","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4657204","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutr Metab (Lond)","raw_type":"Text"},{"id":"pmid:26604978","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26604978","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrition & metabolism","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1186/s12986-015-0045-y","doi":"https://doi.org/10.1186/s12986-015-0045-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12986-015-0045-y","pdf_url":"https://nutritionandmetabolism.biomedcentral.com/track/pdf/10.1186/s12986-015-0045-y","source":{"id":"https://openalex.org/S69338484","display_name":"Nutrition & Metabolism","issn_l":"1743-7075","issn":["1743-7075"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrition &amp; Metabolism","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2180141563.pdf","grobid_xml":"https://content.openalex.org/works/W2180141563.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W1677336966","https://openalex.org/W1714141503","https://openalex.org/W1962935964","https://openalex.org/W1964823824","https://openalex.org/W1966922165","https://openalex.org/W1976621716","https://openalex.org/W1985151726","https://openalex.org/W1988012657","https://openalex.org/W1989357395","https://openalex.org/W2003905949","https://openalex.org/W2009938323","https://openalex.org/W2016716035","https://openalex.org/W2021998283","https://openalex.org/W2024685706","https://openalex.org/W2024803958","https://openalex.org/W2029730391","https://openalex.org/W2047711197","https://openalex.org/W2049506766","https://openalex.org/W2049515100","https://openalex.org/W2053581007","https://openalex.org/W2065147071","https://openalex.org/W2074545460","https://openalex.org/W2082184791","https://openalex.org/W2086648828","https://openalex.org/W2087168352","https://openalex.org/W2087369082","https://openalex.org/W2093457972","https://openalex.org/W2100125821","https://openalex.org/W2106678312","https://openalex.org/W2107051699","https://openalex.org/W2109127510","https://openalex.org/W2119543164","https://openalex.org/W2122478167","https://openalex.org/W2125109896","https://openalex.org/W2125524268","https://openalex.org/W2132302780","https://openalex.org/W2132593028","https://openalex.org/W2134059673","https://openalex.org/W2134897177","https://openalex.org/W2142427646","https://openalex.org/W2150815379","https://openalex.org/W2152035679","https://openalex.org/W2156933673","https://openalex.org/W2162200550","https://openalex.org/W2167628071","https://openalex.org/W2170658085","https://openalex.org/W2171398834","https://openalex.org/W4249387963"],"related_works":["https://openalex.org/W7100293485","https://openalex.org/W6902452286","https://openalex.org/W6977943380","https://openalex.org/W2899717591","https://openalex.org/W2592703928","https://openalex.org/W2530047389","https://openalex.org/W2794373470","https://openalex.org/W4414011303","https://openalex.org/W2231949068","https://openalex.org/W4408243936"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,45,67,133],"farnesoid":[2],"X":[3],"receptor":[4],"(FXR),":[5],"a":[6,56,85],"ligand-activated":[7],"transcription":[8],"factor":[9],"belonging":[10],"to":[11,95,208,253],"the":[12,24,39,114,121,152,238,243,259,272,280,291],"adopted":[13],"orphan":[14],"receptor,":[15],"plays":[16],"an":[17],"important":[18],"role":[19],"in":[20,97,106,151,192,204,217,242,279,302],"maintaining":[21],"health":[22],"of":[23,41,49,69,102,124,136,184,212,220,285],"liver":[25,202,298],"and":[26,139,145,170,196,231,245,247,268],"intestine.":[27],"In":[28,83],"this":[29,107],"study,":[30],"we":[31],"identified":[32],"individual":[33],"bacterial":[34,51,103,126,199,214,235,287],"strains":[35,52],"that":[36,120,275],"directly":[37,276],"modulated":[38],"activation":[40],"intestinal":[42,63,281],"FXR.":[43],"METHODS:":[44],"FXR":[46,58,70,75,99,115,143,148,153,278],"stimulatory":[47,76,100],"potential":[48,101],"38":[50],"was":[53,78,93,129],"determined":[54,79],"using":[55],"stable":[57],"reporter":[59,116,154],"system":[60],"derived":[61,187,261],"from":[62,262],"epithelial":[64,282],"cells":[65],"(IEC).":[66],"induction":[68],"target":[71,149],"genes":[72],"by":[73,80,256],"screened":[74,105],"bacteria":[77],"real-time":[81],"PCR.":[82],"addition,":[84],"high":[86],"fat":[87],"diet":[88],"(HFD)-induced":[89],"obese":[90,205],"mouse":[91],"model":[92],"used":[94],"evaluate":[96],"vivo":[98],"metabolites":[104,160,188,200,215,236,260,289],"study.":[108],"RESULTS:":[109],"A":[110],"luciferase":[111],"assay":[112],"with":[113,157,178,258],"cell":[117,127],"line":[118],"demonstrated":[119],"FXR-stimulatory":[122,288],"activity":[123,144],"most":[125],"samples":[128],"less":[130],"than":[131],"2-fold.":[132],"culture":[134],"supernatants":[135],"Bacteroides":[137],"dorei":[138,186,267],"Eubacterium":[140],"limosum":[141,270],"induced":[142,162],"selectively":[146],"regulated":[147],"expression":[150,241,251],"system.":[155],"Treatment":[156],"B.":[158,185,263,266],"dorei-derived":[159],"strongly":[161],"ileal":[163,248],"bile":[164],"acid":[165],"binding":[166],"protein":[167],"(IBABP)":[168],"(8.4-fold)":[169],"organic":[171],"solute":[172],"transporter":[173],"(OST)":[174],"\u03b1":[175],"(3.1-fold)":[176],"compared":[177,207],"E.":[179,269],"limosum-derived":[180],"metabolites.":[181],"Furthermore,":[182,233],"administration":[183],"showed":[189],"significant":[190],"reduction":[191],"body":[193,295],"weight":[194,203,296],"gain,":[195,297],"both":[197],"two":[198,234],"reduced":[201],"mice":[206],"PBS-treated":[209],"controls.":[210],"Administration":[211,284],"each":[213],"improved":[216],"serum":[218],"levels":[219],"obesity-related":[221],"metabolic":[222],"biochemical":[223],"markers":[224],"such":[225],"as":[226],"ALT,":[227],"AST,":[228],"total":[229],"cholesterol,":[230],"triglyceride.":[232],"enhanced":[237],"Fxr":[239],"gene":[240,250],"intestine":[244],"liver,":[246],"Shp":[249],"tended":[252],"be":[254],"increased":[255],"treatment":[257],"dorei.":[264],"CONCLUSIONS:":[265],"secreted":[271],"bioactive":[273],"substances":[274],"stimulate":[277],"cells.":[283],"these":[286],"improves":[290],"obesity":[292],"phenotype":[293],"including":[294],"damage,":[299],"lipid":[300],"metabolism":[301],"DIO":[303],"mice.":[304]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
