{"id":"https://openalex.org/W2179959166","doi":null,"title":"The bone-protective effect and mechanism of soluble corn fiber","display_name":"The bone-protective effect and mechanism of soluble corn fiber","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2179959166","mag":"2179959166"},"language":"en","primary_location":{"id":"pmh:oai:docs.lib.purdue.edu:open_access_theses-1513","doi":null,"is_oa":true,"landing_page_url":"https://docs.lib.purdue.edu/open_access_theses/494","pdf_url":"https://docs.lib.purdue.edu/open_access_theses/494","source":{"id":"https://openalex.org/S4377196310","display_name":"Purdue e-Pubs (Purdue University System)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801333002","host_organization_name":"Purdue University System","host_organization_lineage":["https://openalex.org/I2801333002"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Open Access Theses","raw_type":"text"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://docs.lib.purdue.edu/open_access_theses/494","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004464581","display_name":"Steven A. Jakeman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Steven A. Jakeman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5004464581"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12489","display_name":"Microbial Metabolites in Food Biotechnology","score":0.5913000106811523,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12489","display_name":"Microbial Metabolites in Food Biotechnology","score":0.5913000106811523,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.3910999894142151,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10140","display_name":"Food composition and properties","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/postmenopausal-osteoporosis","display_name":"postmenopausal osteoporosis","score":0.8149999976158142},{"id":"https://openalex.org/keywords/calcium-absorption","display_name":"calcium absorption","score":0.7009999752044678},{"id":"https://openalex.org/keywords/short-chain-fatty-acids","display_name":"short-chain fatty acids","score":0.9639999866485596},{"id":"https://openalex.org/keywords/dietary-fiber","display_name":"dietary fiber","score":0.699999988079071},{"id":"https://openalex.org/keywords/bone-formation-markers","display_name":"bone formation markers","score":0.5609999895095825},{"id":"https://openalex.org/keywords/bone-turnover-markers","display_name":"bone turnover markers","score":0.7689999938011169},{"id":"https://openalex.org/keywords/bone-loss","display_name":"bone loss","score":0.460999995470047},{"id":"https://openalex.org/keywords/osteocalcin","display_name":"osteocalcin","score":0.824999988079071},{"id":"https://openalex.org/keywords/n-telopeptide","display_name":"N-telopeptide","score":0.9279999732971191},{"id":"https://openalex.org/keywords/cecal-fermentation","display_name":"cecal fermentation","score":0.492000013589859},{"id":"https://openalex.org/keywords/women-s-health","display_name":"women's health","score":0.49399998784065247},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.5649999976158142}],"concepts":[{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.5865048170089722},{"id":"https://openalex.org/C519885992","wikidata":"https://www.wikidata.org/wiki/Q161","display_name":"Fiber","level":2,"score":0.4749239385128021},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37308430671691895},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.33884096145629883},{"id":"https://openalex.org/C6557445","wikidata":"https://www.wikidata.org/wiki/Q173113","display_name":"Agronomy","level":1,"score":0.32554861903190613},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.32261204719543457},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2713163495063782},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.11425715684890747},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:docs.lib.purdue.edu:open_access_theses-1513","doi":null,"is_oa":true,"landing_page_url":"https://docs.lib.purdue.edu/open_access_theses/494","pdf_url":"https://docs.lib.purdue.edu/open_access_theses/494","source":{"id":"https://openalex.org/S4377196310","display_name":"Purdue e-Pubs (Purdue University System)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801333002","host_organization_name":"Purdue University System","host_organization_lineage":["https://openalex.org/I2801333002"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Open Access Theses","raw_type":"text"},{"id":"pmh:oai:docs.lib.purdue.edu:dissertations-16553","doi":null,"is_oa":false,"landing_page_url":"https://docs.lib.purdue.edu/dissertations/AAI1599828","pdf_url":null,"source":{"id":"https://openalex.org/S4377196310","display_name":"Purdue e-Pubs (Purdue University System)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801333002","host_organization_name":"Purdue University System","host_organization_lineage":["https://openalex.org/I2801333002"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Theses and Dissertations Available from ProQuest","raw_type":"text"},{"id":"mag:2179959166","doi":null,"is_oa":false,"landing_page_url":"https://docs.lib.purdue.edu/cgi/viewcontent.cgi?article=1513&context=open_access_theses","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:docs.lib.purdue.edu:open_access_theses-1513","doi":null,"is_oa":true,"landing_page_url":"https://docs.lib.purdue.edu/open_access_theses/494","pdf_url":"https://docs.lib.purdue.edu/open_access_theses/494","source":{"id":"https://openalex.org/S4377196310","display_name":"Purdue e-Pubs (Purdue University System)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801333002","host_organization_name":"Purdue University System","host_organization_lineage":["https://openalex.org/I2801333002"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Open Access Theses","raw_type":"text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092},{"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2","score":0.40450000762939453}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2179959166.pdf","grobid_xml":"https://content.openalex.org/works/W2179959166.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2492156829","https://openalex.org/W2095211990","https://openalex.org/W2412296926","https://openalex.org/W74925818","https://openalex.org/W2255216831","https://openalex.org/W2122411439","https://openalex.org/W2004227683","https://openalex.org/W4229951964","https://openalex.org/W408984386","https://openalex.org/W2301519551"],"abstract_inverted_index":{"Postmenopausal":[0],"women":[1,103],"are":[2],"at":[3,206,317],"greatest":[4],"risk":[5],"among":[6],"healthy":[7],"individuals":[8],"of":[9,53,78,91,112,119,127,141,144,175,200,203,214,254,320,393,434,507],"developing":[10],"osteoporosis":[11],"and":[12,28,56,104,147,169,178,225,281,294,305,311,324,327,346,443,521],"associated":[13],"fractures.":[14],"Nondigestible,":[15],"fermentable":[16],"dietary":[17,466],"carbohydrates":[18],"have":[19],"been":[20],"shown":[21],"to":[22,62,95,105,137,211,249,395,424,440,503],"improve":[23,372],"calcium":[24,58,110,153,190,287,397,512,541],"absorption":[25,59,111,513],"in":[26,31,50,64,83,116,121,155,259,342,361,403,448,464,470,474,483,528],"adolescents":[27],"bone-strength":[29],"parameters":[30],"the":[32,48,69,76,84,107,125,139,212,215,262,318,321,331,334,386,391,412,432,484,490,500,505],"rat":[33,45],"model.":[34],"Of":[35,330],"particular":[36],"interest":[37],"is":[38,365,468,497,514],"soluble":[39],"corn":[40],"fiber":[41],"(SCF),":[42],"which":[43,165],"improved":[44,57],"bone":[46,152,189,255,270,286,306,359,373,472],"strength":[47],"most":[49],"a":[51,113,129,173,404,428,526],"survey":[52],"novel":[54],"fibers,":[55],"by":[60,198,231,240,289,375],"up":[61],"13%":[63],"teen":[65],"girls.":[66],"Hypotheses":[67],"about":[68],"mechanism":[70,492],"behind":[71],"this":[72,92,494],"effect":[73,108,126,274,387,506],"revolve":[74],"around":[75],"production":[77],"short-chain":[79],"fatty":[80],"acids":[81],"(SCFAs)":[82],"large":[85,485],"intestine":[86,486],"during":[87,265],"fermentation.":[88],"The":[89],"purpose":[90],"work":[93],"was":[94,135,159,170,223,228,238,247,275,340,438,446,455],"determine":[96,250],"if":[97,385],"SCF":[98,150,158,280,284,349,355,370],"would":[99,371],"also":[100,478],"benefit":[101],"postmenopausal":[102,156,362,475],"assess":[106,138,390,504],"on":[109,151,511,540],"chronic":[114,508],"increase":[115,396],"cecal":[117,429],"concentrations":[118],"SCFAs":[120,394],"rats.^":[122],"To":[123,186,389],"study":[124],"SCF,":[128,164,463],"randomized,":[130,405],"double-blind,":[131],"placebo-controlled":[132,406],"crossover":[133],"design":[134],"used":[136,248,502],"effects":[140,539],"daily":[142,182],"consumption":[143,356],"0,":[145,415],"10,":[146],"20":[148,282,347,368],"g":[149],"retention":[154,288,360],"women.":[157,363],"provided":[160],"as":[161,172,525],"PROMITOR\u00ae":[162],"85":[163],"provides":[166],"85%":[167],"fiber,":[168],"consumed":[171],"constituent":[174],"one":[176,179],"muffin":[177],"fruit-flavored":[180],"drink":[181],"for":[183,537],"50":[184,376],"days.":[185],"measure":[187],"net":[188],"loss,":[191],"participants'":[192],"bones":[193],"were":[194,315,400],"labeled":[195],"with":[196,277,408],"41Ca":[197,204,226],"administration":[199],"\u226550":[201],"nCi":[202],"intravenously":[205],"least":[207],"100":[208],"d":[209],"prior":[210],"start":[213],"study.":[216],"Every":[217],"10":[218,278],"days,":[219,436],"24":[220],"h":[221],"urine":[222],"collected,":[224],"appearance":[227,445],"measured":[229,239,316,341,447],"sensitively":[230],"Accelerator":[232],"Mass":[233],"Spectrometry,":[234],"while":[235],"total":[236,380],"Ca":[237],"ICP-MS.":[241],"Urinary":[242],"41Ca:Ca":[243],"from":[244,261],"nonintervention":[245],"periods":[246,267],"an":[251],"expected":[252,263],"rate":[253],"loss.":[256],"A":[257,272],"decrease":[258],"urinary41Ca:Ca":[260],"amount":[264],"intervention":[266,328],"reflected":[268],"increased":[269,358],"retention.":[271],"dose-response":[273],"demonstrated,":[276],"g/d":[279,283,348,369],"improving":[285],"4.8%":[290],"(P":[291],"=":[292,352],"0.013)":[293],"7%":[295],"(0.007)":[296],"respectively.":[297],"Bone":[298],"formation":[299],"marker":[300],"bone-specific":[301],"alkaline":[302],"phosphatase":[303],"(BAP),":[304],"turnover":[307],"markers":[308],"osteocalcin":[309],"(OC)":[310],"N-terminal":[312],"telopeptide":[313],"(NTx),":[314],"ends":[319],"baseline":[322],"period":[323],"each":[325],"washout":[326],"period.":[329],"biomarkers":[332],"measured,":[333],"only":[335,491],"statistically":[336,452],"significant":[337,453],"difference":[338,454],"detected":[339],"BAP,":[343],"between":[344,457],"placebo":[345],"(8%,":[350],"P":[351],"0.035).":[353],"Daily":[354],"significantly":[357],"It":[364,496],"estimated":[366],"that":[367,462,479,499],"balance":[374],"mg/d,":[377],"or":[378,417,531],"2.5%":[379],"body":[381],"BMC":[382],"per":[383],"year":[384],"persists.^":[388],"effectiveness":[392],"absorption,":[398],"rats":[399,413],"chronically":[401],"dosed":[402],"trial":[407],"SCFAs.":[409],"Twice":[410],"daily,":[411],"received":[414],"300,":[416],"600":[418],"umol":[419],"SCFA":[420,481,509],"conjugate":[421],"base":[422],"directly":[423],"their":[425,441,449,538],"ceca":[426],"through":[427],"catheter.":[430],"At":[431],"end":[433],"11":[435],"45Ca":[437,444],"administered":[439],"ceca,":[442],"plasma.":[450],"No":[451],"observed":[456],"treatments.^":[458],"These":[459],"studies":[460],"indicate":[461],"achievable":[465],"intakes,":[467],"effective":[469],"supporting":[471],"health":[473],"women,":[476],"but":[477],"increasing":[480],"concentration":[482],"may":[487],"not":[488],"be":[489,519,535],"causing":[493],"benefit.":[495],"possible":[498],"protocol":[501],"dosing":[510],"inadequate.":[515],"New":[516],"protocols":[517],"should":[518,534],"considered,":[520],"other":[522],"mechanisms,":[523],"such":[524],"shift":[527],"gut":[529],"pH":[530],"microbial":[532],"populations,":[533],"assessed":[536],"absorption.":[542]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}
