{"id":"https://openalex.org/W2179923903","doi":"https://doi.org/10.1161/atvb.35.suppl_1.165","title":"Abstract 165: Microrna-486 Regulates Fibroblast-to-myofibroblast Transition in Human Aortic Valve Interstitial Cells","display_name":"Abstract 165: Microrna-486 Regulates Fibroblast-to-myofibroblast Transition in Human Aortic Valve Interstitial Cells","publication_year":2015,"publication_date":"2015-05-01","ids":{"openalex":"https://openalex.org/W2179923903","doi":"https://doi.org/10.1161/atvb.35.suppl_1.165","mag":"2179923903"},"language":"en","primary_location":{"id":"doi:10.1161/atvb.35.suppl_1.165","doi":"https://doi.org/10.1161/atvb.35.suppl_1.165","is_oa":false,"landing_page_url":"https://doi.org/10.1161/atvb.35.suppl_1.165","pdf_url":null,"source":{"id":"https://openalex.org/S3485792","display_name":"Arteriosclerosis Thrombosis and Vascular Biology","issn_l":"1079-5642","issn":["1079-5642","1524-4636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis, Thrombosis, and Vascular Biology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023335489","display_name":"Rui Song","orcid":"https://orcid.org/0000-0002-5485-3741","observed_orcids":["https://orcid.org/0000-0002-5485-3741"]},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rui Song","raw_affiliation_strings":["CT Surgery, Univ of Colorado Denver, Aurora, CO","Rui Song"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CT Surgery, Univ of Colorado Denver, Aurora, CO","institution_ids":["https://openalex.org/I921990950"]},{"raw_affiliation_string":"Rui Song","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000079670","display_name":"David A. Fullerton","orcid":"https://orcid.org/0000-0002-6895-6354","observed_orcids":["https://orcid.org/0000-0002-6895-6354"]},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A. Fullerton","raw_affiliation_strings":["CT Surgery, Univ of Colorado Denver, Aurora, CO","David A. Fullerton"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CT Surgery, Univ of Colorado Denver, Aurora, CO","institution_ids":["https://openalex.org/I921990950"]},{"raw_affiliation_string":"David A. Fullerton","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110342838","display_name":"Lihua Ao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lihua Ao","raw_affiliation_strings":["CT Surgery, Univ of Colorado Denver, Aurora, CO","Lihua Ao"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CT Surgery, Univ of Colorado Denver, Aurora, CO","institution_ids":["https://openalex.org/I921990950"]},{"raw_affiliation_string":"Lihua Ao","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100901819","display_name":"Qingzhou Yao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qingzhou Yao","raw_affiliation_strings":["CT Surgery, Univ of Colorado Denver, Aurora, CO","Qingzhou Yao"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CT Surgery, Univ of Colorado Denver, Aurora, CO","institution_ids":["https://openalex.org/I921990950"]},{"raw_affiliation_string":"Qingzhou Yao","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103327047","display_name":"Kesen Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kesen Zhao","raw_affiliation_strings":["Pathophysiology, Southern Med Univ, Guangzhou, China","Kesen Zhao"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathophysiology, Southern Med Univ, Guangzhou, China","institution_ids":["https://openalex.org/I58200834"]},{"raw_affiliation_string":"Kesen Zhao","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069922286","display_name":"Xianzhong Meng","orcid":"https://orcid.org/0000-0002-0201-1008","observed_orcids":["https://orcid.org/0000-0002-0201-1008","https://orcid.org/0000-0002-3463-690X"]},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xianzhong Meng","raw_affiliation_strings":["CT Surgery, Univ of Colorado Denver, Aurora, CO","Xianzhong Meng"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CT Surgery, Univ of Colorado Denver, Aurora, CO","institution_ids":["https://openalex.org/I921990950"]},{"raw_affiliation_string":"Xianzhong Meng","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"35","issue":"suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.7865999937057495,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.7865999937057495,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.17759999632835388,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.02160000056028366,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myofibroblast-differentiation","display_name":"myofibroblast differentiation","score":0.9909999966621399},{"id":"https://openalex.org/keywords/aortic-valve-interstitial-cells","display_name":"aortic valve interstitial cells","score":0.9449999928474426},{"id":"https://openalex.org/keywords/aortic-valve-fibrosis","display_name":"aortic valve fibrosis","score":0.8859999775886536},{"id":"https://openalex.org/keywords/aortic-stenosis","display_name":"aortic stenosis","score":0.9909999966621399},{"id":"https://openalex.org/keywords/alpha-smooth-muscle-actin","display_name":"alpha-smooth muscle actin","score":0.9129999876022339},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.8080000281333923},{"id":"https://openalex.org/keywords/myosin-light-chain-kinase","display_name":"myosin light chain kinase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.9549999833106995},{"id":"https://openalex.org/keywords/bmp-2","display_name":"BMP-2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/type-i-collagen","display_name":"type I collagen","score":0.5519999861717224},{"id":"https://openalex.org/keywords/mmp-2","display_name":"MMP-2","score":0.8479999899864197},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.9990000128746033},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.8999999761581421}],"concepts":[{"id":"https://openalex.org/C207865475","wikidata":"https://www.wikidata.org/wiki/Q1467330","display_name":"Myofibroblast","level":3,"score":0.7519479990005493},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.5267887711524963},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.5169055461883545},{"id":"https://openalex.org/C161921814","wikidata":"https://www.wikidata.org/wiki/Q493743","display_name":"SMA*","level":2,"score":0.4999430179595947},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4906724691390991},{"id":"https://openalex.org/C2779368916","wikidata":"https://www.wikidata.org/wiki/Q425022","display_name":"Antagomir","level":4,"score":0.4807526767253876},{"id":"https://openalex.org/C2777534427","wikidata":"https://www.wikidata.org/wiki/Q6057165","display_name":"Interstitial cell","level":2,"score":0.4717705249786377},{"id":"https://openalex.org/C2780714102","wikidata":"https://www.wikidata.org/wiki/Q616071","display_name":"Aortic valve","level":2,"score":0.4608878791332245},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.3653950095176697},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.3156805634498596},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2891840934753418},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.28098809719085693},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23472511768341064},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21060216426849365},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19319525361061096},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07635897397994995},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/atvb.35.suppl_1.165","doi":"https://doi.org/10.1161/atvb.35.suppl_1.165","is_oa":false,"landing_page_url":"https://doi.org/10.1161/atvb.35.suppl_1.165","pdf_url":null,"source":{"id":"https://openalex.org/S3485792","display_name":"Arteriosclerosis Thrombosis and Vascular Biology","issn_l":"1079-5642","issn":["1079-5642","1524-4636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis, Thrombosis, and Vascular Biology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.4300000071525574,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4236365649","https://openalex.org/W2608962373","https://openalex.org/W2318702787","https://openalex.org/W1536747002","https://openalex.org/W2136118033","https://openalex.org/W3087686075","https://openalex.org/W2152739288","https://openalex.org/W2058856426","https://openalex.org/W4409467436","https://openalex.org/W4395040013"],"abstract_inverted_index":{"Myofibroblasts":[0],"play":[1],"an":[2,60],"important":[3],"role":[4],"in":[5,26,50,67,108,119,136,152,217,246,258,267,276,284],"aortic":[6,11,28,40,71,86,112,286,308],"valve":[7],"fibrosis.":[8],"In":[9],"normal":[10,137,153,192,207],"valves,":[12],"the":[13,37,43,47,64,197,279,305],"interstitial":[14],"cells":[15,247],"(VICs)":[16],"are":[17,22],"primarily":[18],"fibroblasts":[19],"while":[20],"myofibroblasts":[21],"dominant":[23],"among":[24],"VICs":[25,52,68,82,109,121,138,154,193,208,283],"stenotic":[27,285],"valves.":[29,72,113,287],"Suppression":[30],"of":[31,39,69,83,91,106,110,116,133,149,161,168,178,191,199,206,271,282,294,307],"VIC":[32],"phenotypic":[33,65],"change":[34],"may":[35],"prevent":[36],"progression":[38,306],"stenosis.":[41,309],"However,":[42],"molecular":[44],"mechanism":[45,62],"underlying":[46],"fibroblast-to-myofibroblast":[48,256],"transition":[49,66,243,257],"human":[51,70,85,259],"is":[53],"not":[54],"well":[55],"understood.":[56],"We":[57],"hypothesized":[58],"that":[59,81,221,292],"epigenetic":[61],"controls":[63],"Methods":[73],"and":[74,77,93,99,126,142,157,203,231,244,261],"results:":[75],"Immunoblotting":[76],"immunofluorescence":[78],"staining":[79],"confirmed":[80],"diseased":[84,111,120],"valves":[87],"had":[88],"higher":[89,104],"levels":[90,105,141,160,270],"\u03b1-SMA":[92,94,124,127,140,144,171,182,187,226,228],"fibers.":[95],"MicroRNA":[96],"(miR)":[97],"microarray":[98],"real-time":[100],"qPCR":[101],"analysis":[102],"revealed":[103],"miR-486":[107,117,134,150,175,195,219,265,272,295],"Lentiviral":[114],"expression":[115,125,132,148,172,266,296],"antagomir":[118,236],"markedly":[122],"suppressed":[123,237],"fiber":[128,145,183,229],"formation.":[129,146],"Conversely,":[130],"lentiviral":[131],"mimic":[135,151],"increased":[139,196],"enhanced":[143],"Further,":[147],"activated":[155],"Akt":[156,169],"up-regulated":[158,225],"cellular":[159,218],"myosin":[162],"light":[163],"chain":[164],"(MLC)":[165],"kinase.":[166],"Inhibition":[167,177],"reduced":[170],"induced":[173],"by":[174,224],"mimic.":[176],"MLC":[179],"kinase":[180],"attenuated":[181],"formation":[184,230],"without":[185],"affecting":[186],"levels.":[188],"Prolonged":[189],"treatment":[190],"with":[194,209,241],"production":[198],"collagen":[200],"I,":[201],"MMP-2":[202],"MMP-9.":[204],"Stimulation":[205],"TGF-\u03b21":[210,250],"or":[211,251],"BMP-2":[212],"caused":[213],"a":[214],"marked":[215],"increase":[216],"level":[220],"was":[222],"accompanied":[223],"expression,":[227],"matrix":[232],"protein":[233],"production.":[234],"MiR-486":[235,254],"these":[238],"changes":[239],"associated":[240],"myofibroblastic":[242,280],"activity":[245],"exposed":[248],"to":[249],"BMP-2.":[252],"Conclusions:":[253],"regulates":[255],"VICs,":[260],"pro-fibrogenic":[262],"factors":[263],"up-regulate":[264],"VICs.":[268],"Elevated":[269],"accounts,":[273],"at":[274],"least":[275],"part,":[277],"for":[278,302],"phenotype":[281],"These":[288],"novel":[289],"findings":[290],"indicate":[291],"modulation":[293],"and/or":[297],"function":[298],"has":[299],"therapeutic":[300],"potential":[301],"slowing":[303],"down":[304]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}