{"id":"https://openalex.org/W2179587148","doi":"https://doi.org/10.1089/107999002753536149","title":"Comparison of Gene Expression Patterns Induced by Treatment of Human Umbilical Vein Endothelial Cells with IFN- \u03b1 2b vs. IFN- \u03b2 1a: Understanding the Functional Relationship Between Distinct Type I Interferons That Act Through a Common Receptor","display_name":"Comparison of Gene Expression Patterns Induced by Treatment of Human Umbilical Vein Endothelial Cells with IFN- \u03b1 2b vs. IFN- \u03b2 1a: Understanding the Functional Relationship Between Distinct Type I Interferons That Act Through a Common Receptor","publication_year":2002,"publication_date":"2002-02-01","ids":{"openalex":"https://openalex.org/W2179587148","doi":"https://doi.org/10.1089/107999002753536149","mag":"2179587148","pmid":"https://pubmed.ncbi.nlm.nih.gov/11911800"},"language":"en","primary_location":{"id":"doi:10.1089/107999002753536149","doi":"https://doi.org/10.1089/107999002753536149","is_oa":false,"landing_page_url":"https://doi.org/10.1089/107999002753536149","pdf_url":null,"source":{"id":"https://openalex.org/S109620152","display_name":"Journal of Interferon & Cytokine Research","issn_l":"1079-9907","issn":["1079-9907","1557-7465"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Interferon & Cytokine Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017685291","display_name":"Antonio J. da Silva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1297540436","display_name":"Biogen (United States)","ror":"https://ror.org/02jqkb192","country_code":"US","type":"company","lineage":["https://openalex.org/I1297540436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Antonio J. da Silva","raw_affiliation_strings":["Biogen, Inc., Cambridge, MA 02142"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biogen, Inc., Cambridge, MA 02142","institution_ids":["https://openalex.org/I1297540436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013583528","display_name":"Margot Brickelmaier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1297540436","display_name":"Biogen (United States)","ror":"https://ror.org/02jqkb192","country_code":"US","type":"company","lineage":["https://openalex.org/I1297540436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margot Brickelmaier","raw_affiliation_strings":["Biogen, Inc., Cambridge, MA 02142"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biogen, Inc., Cambridge, MA 02142","institution_ids":["https://openalex.org/I1297540436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038006244","display_name":"Gerard R. Majeau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1297540436","display_name":"Biogen (United States)","ror":"https://ror.org/02jqkb192","country_code":"US","type":"company","lineage":["https://openalex.org/I1297540436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gerard R. Majeau","raw_affiliation_strings":["Biogen, Inc., Cambridge, MA 02142"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biogen, Inc., Cambridge, MA 02142","institution_ids":["https://openalex.org/I1297540436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010294849","display_name":"Alexander V. Lukashin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1297540436","display_name":"Biogen (United States)","ror":"https://ror.org/02jqkb192","country_code":"US","type":"company","lineage":["https://openalex.org/I1297540436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander V. Lukashin","raw_affiliation_strings":["Biogen, Inc., Cambridge, MA 02142"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biogen, Inc., Cambridge, MA 02142","institution_ids":["https://openalex.org/I1297540436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027494051","display_name":"John A. Peyman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John Peyman","raw_affiliation_strings":["CuraGen Corporation, New Haven, CT 06511"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CuraGen Corporation, New Haven, CT 06511","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081618576","display_name":"Adrian Whitty","orcid":"https://orcid.org/0000-0002-0331-4369","observed_orcids":["https://orcid.org/0000-0002-0331-4369"]},"institutions":[{"id":"https://openalex.org/I1297540436","display_name":"Biogen (United States)","ror":"https://ror.org/02jqkb192","country_code":"US","type":"company","lineage":["https://openalex.org/I1297540436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adrian Whitty","raw_affiliation_strings":["Biogen, Inc., Cambridge, MA 02142"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biogen, Inc., Cambridge, MA 02142","institution_ids":["https://openalex.org/I1297540436"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049661638","display_name":"Paula S. Hochman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1297540436","display_name":"Biogen (United States)","ror":"https://ror.org/02jqkb192","country_code":"US","type":"company","lineage":["https://openalex.org/I1297540436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paula S. Hochman","raw_affiliation_strings":["Biogen, Inc., Cambridge, MA 02142"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biogen, Inc., Cambridge, MA 02142","institution_ids":["https://openalex.org/I1297540436"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.4244,"has_fulltext":false,"cited_by_count":65,"citation_normalized_percentile":{"value":0.89284217,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"22","issue":"2","first_page":"173","last_page":"188"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interferon-alpha-2b","display_name":"interferon alfa-2b","score":0.9739999771118164},{"id":"https://openalex.org/keywords/interferon-beta-1a","display_name":"interferon beta-1a","score":1.0},{"id":"https://openalex.org/keywords/type-i-interferon","display_name":"type I interferon","score":0.9599999785423279},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.6840000152587891},{"id":"https://openalex.org/keywords/human-umbilical-vein-endothelial-cells","display_name":"human umbilical vein endothelial cells","score":0.9079999923706055},{"id":"https://openalex.org/keywords/interferon-signaling","display_name":"interferon signaling","score":0.5849999785423279}],"concepts":[{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6357629895210266},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5965780019760132},{"id":"https://openalex.org/C2777411675","wikidata":"https://www.wikidata.org/wiki/Q1232438","display_name":"Umbilical vein","level":3,"score":0.5559195876121521},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5522369146347046},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.509849488735199},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4854719936847687},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.46221110224723816},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.45630520582199097},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4469239413738251},{"id":"https://openalex.org/C64943373","wikidata":"https://www.wikidata.org/wiki/Q2651003","display_name":"Alpha (finance)","level":4,"score":0.4138997793197632},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.4132877588272095},{"id":"https://openalex.org/C2909179924","wikidata":"https://www.wikidata.org/wiki/Q6046488","display_name":"Alpha interferon","level":3,"score":0.4128051996231079},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3600672781467438},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3260146975517273},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.28493863344192505},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22271087765693665},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12170109152793884},{"id":"https://openalex.org/C2775944032","wikidata":"https://www.wikidata.org/wiki/Q22907659","display_name":"Patient satisfaction","level":2,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C49453240","wikidata":"https://www.wikidata.org/wiki/Q1592163","display_name":"Construct validity","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000068556","descriptor_name":"Interferon beta-1a","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077190","descriptor_name":"Interferon alpha-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005796","descriptor_name":"Genes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007370","descriptor_name":"Interferon Type I","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014471","descriptor_name":"Umbilical Veins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016898","descriptor_name":"Interferon-alpha","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016899","descriptor_name":"Interferon-beta","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017471","descriptor_name":"Receptors, Interferon","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D053633","descriptor_name":"Receptor, Interferon alpha-beta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1089/107999002753536149","doi":"https://doi.org/10.1089/107999002753536149","is_oa":false,"landing_page_url":"https://doi.org/10.1089/107999002753536149","pdf_url":null,"source":{"id":"https://openalex.org/S109620152","display_name":"Journal of Interferon & Cytokine Research","issn_l":"1079-9907","issn":["1079-9907","1557-7465"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Interferon & Cytokine Research","raw_type":"journal-article"},{"id":"pmid:11911800","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11911800","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":72,"referenced_works":["https://openalex.org/W175910702","https://openalex.org/W1504277962","https://openalex.org/W1505071696","https://openalex.org/W1510533289","https://openalex.org/W1548472503","https://openalex.org/W1554187319","https://openalex.org/W1557316591","https://openalex.org/W1605977136","https://openalex.org/W1680217275","https://openalex.org/W1752988765","https://openalex.org/W1830966545","https://openalex.org/W1842123981","https://openalex.org/W1937799317","https://openalex.org/W1964036834","https://openalex.org/W1970156673","https://openalex.org/W1978754899","https://openalex.org/W1989807793","https://openalex.org/W1996120614","https://openalex.org/W1997740923","https://openalex.org/W2001230470","https://openalex.org/W2002127029","https://openalex.org/W2007139863","https://openalex.org/W2008940139","https://openalex.org/W2012062825","https://openalex.org/W2024060531","https://openalex.org/W2025783409","https://openalex.org/W2037024435","https://openalex.org/W2038260402","https://openalex.org/W2040587518","https://openalex.org/W2040699811","https://openalex.org/W2042326065","https://openalex.org/W2043683764","https://openalex.org/W2046629546","https://openalex.org/W2047182217","https://openalex.org/W2050613383","https://openalex.org/W2054419682","https://openalex.org/W2070597700","https://openalex.org/W2073520378","https://openalex.org/W2073760887","https://openalex.org/W2075256922","https://openalex.org/W2075413744","https://openalex.org/W2075739751","https://openalex.org/W2075989712","https://openalex.org/W2078899906","https://openalex.org/W2080320061","https://openalex.org/W2081350964","https://openalex.org/W2082783596","https://openalex.org/W2087144342","https://openalex.org/W2087684630","https://openalex.org/W2090690157","https://openalex.org/W2094220982","https://openalex.org/W2096492217","https://openalex.org/W2099748840","https://openalex.org/W2103565638","https://openalex.org/W2109113173","https://openalex.org/W2109397495","https://openalex.org/W2120056767","https://openalex.org/W2122312331","https://openalex.org/W2130494035","https://openalex.org/W2135000328","https://openalex.org/W2135187880","https://openalex.org/W2138084582","https://openalex.org/W2150926065","https://openalex.org/W2165298438","https://openalex.org/W2165862139","https://openalex.org/W2170778160","https://openalex.org/W2267832341","https://openalex.org/W2412021792","https://openalex.org/W2615531293","https://openalex.org/W4239029175","https://openalex.org/W4247420482","https://openalex.org/W4313347820"],"related_works":["https://openalex.org/W2031163071","https://openalex.org/W1605977136","https://openalex.org/W2100935357","https://openalex.org/W2103465511","https://openalex.org/W1997388148","https://openalex.org/W2058141206","https://openalex.org/W58373629","https://openalex.org/W7056857197","https://openalex.org/W2003907443","https://openalex.org/W2087223044"],"abstract_inverted_index":{"We":[0],"analyzed":[1],"whether":[2],"interferon-alpha":[3],"2b":[4,38,117,158],"(IFN-alpha":[5],"2b)":[6],"and":[7,55,118,180,208,213],"IFN-beta":[8,33,110,128,162],"1a":[9,34,111],"engage":[10],"their":[11],"common":[12],"receptor":[13,17,189],"to":[14,32,36,51,124,143,152],"generate":[15,187,200],"activated":[16,188],"complexes":[18,190],"possessing":[19,191],"distinct":[20,192,210],"signaling":[21,70,193],"properties.":[22,194],"Human":[23],"vascular":[24],"endothelial":[25],"cells":[26],"(HUVEC)":[27],"are":[28,171,205],"100-1000-fold":[29],"more":[30,216],"sensitive":[31],"than":[35],"IFN-alpha":[37,116,157],"in":[39,40],"vitro":[41],"assays.":[42],"An":[43],"nonarray-based":[44],"expression":[45,59],"profiling":[46],"(GeneCalling)":[47],"technology":[48],"was":[49,83],"employed":[50],"compare":[52],"the":[53,65,106,168,197],"patterns":[54,203],"levels":[56,126,145],"of":[57,91,105,141,146,174],"gene":[58,177,201],"induced":[60,108,114,123,137,154],"by":[61,68,109,115,127,156,161],"these":[62],"IFN":[63,170,199],"as":[64],"broadest":[66],"means":[67],"which":[69],"events":[71],"could":[72],"be":[73,153],"measured.":[74],"To":[75],"distinguish":[76],"subtype-related":[77],"differences":[78],"from":[79,85],"dose-related":[80],"effects,":[81],"RNA":[82],"prepared":[84],"HUVEC":[86],"treated":[87],"with":[88],"50-5000":[89],"pg/ml":[90,100],"each":[92],"IFN.":[93],"The":[94,164],"results":[95,165],"showed":[96],"that":[97,119,167,185,204],"at":[98,132,211],"50":[99],"IFN,":[101],"only":[102],"a":[103],"subset":[104],"genes":[107,121,142,149],"were":[112,122,150],"also":[113],"individual":[120],"higher":[125],"1a.":[129,163],"In":[130,195],"contrast,":[131,196],"5000":[133],"pg/ml,":[134],"both":[135,206],"subtypes":[136],"essentially":[138],"identical":[139],"sets":[140],"similar":[144,176],"expression.":[147],"No":[148],"seen":[151],"uniquely":[155],"but":[159],"not":[160,182],"show":[166],"two":[169,198],"intrinsically":[172],"capable":[173],"inducing":[175],"induction":[178,202],"responses":[179],"do":[181],"provide":[183],"evidence":[184],"they":[186],"qualitatively":[207],"quantitatively":[209],"subsaturating":[212],"potentially":[214],"physiologically":[215],"relevant":[217],"concentrations.":[218]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":7},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}