{"id":"https://openalex.org/W21793809","doi":null,"title":"Objective assessment of heparin requirements for hemodialysis in humans.","display_name":"Objective assessment of heparin requirements for hemodialysis in humans.","publication_year":1984,"publication_date":"1984-04-01","ids":{"openalex":"https://openalex.org/W21793809","mag":"21793809","pmid":"https://pubmed.ncbi.nlm.nih.gov/6230409"},"language":"en","primary_location":{"id":"pmid:6230409","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6230409","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of laboratory and clinical medicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077414873","display_name":"H. Ireland","orcid":"https://orcid.org/0000-0002-9793-7662","observed_orcids":["https://orcid.org/0000-0002-9793-7662"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Ireland","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080911744","display_name":"David A. Lane","orcid":"https://orcid.org/0000-0003-4283-3695","observed_orcids":["https://orcid.org/0000-0003-4283-3695"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D A Lane","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"J R Curtis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J R Curtis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5581,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.63969249,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"103","issue":"4","first_page":"643","last_page":"52"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.725600004196167,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.725600004196167,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.10610000044107437,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.08410000056028366,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heparin-dosing","display_name":"heparin dosing","score":0.8209999799728394},{"id":"https://openalex.org/keywords/hemodialysis","display_name":"hemodialysis","score":0.9330000281333923},{"id":"https://openalex.org/keywords/anticoagulation","display_name":"anticoagulation","score":0.9110000133514404},{"id":"https://openalex.org/keywords/coagulation-activation","display_name":"coagulation activation","score":0.7129999995231628},{"id":"https://openalex.org/keywords/fibrin-formation","display_name":"fibrin formation","score":0.9580000042915344},{"id":"https://openalex.org/keywords/platelet-release-reaction","display_name":"platelet release reaction","score":0.7570000290870667},{"id":"https://openalex.org/keywords/fibrinolysis","display_name":"fibrinolysis","score":0.8220000267028809},{"id":"https://openalex.org/keywords/factor-xa","display_name":"factor Xa","score":0.42899999022483826},{"id":"https://openalex.org/keywords/platelet-factor-4","display_name":"platelet factor 4","score":0.8410000205039978},{"id":"https://openalex.org/keywords/extracorporeal-circulation","display_name":"extracorporeal circulation","score":0.7379999756813049},{"id":"https://openalex.org/keywords/subcutaneous-heparin","display_name":"subcutaneous heparin","score":0.796999990940094},{"id":"https://openalex.org/keywords/intravenous-heparin","display_name":"intravenous heparin","score":0.828000009059906},{"id":"https://openalex.org/keywords/plasma-heparin-concentration","display_name":"plasma heparin concentration","score":0.8130000233650208}],"concepts":[{"id":"https://openalex.org/C2777557582","wikidata":"https://www.wikidata.org/wiki/Q190016","display_name":"Heparin","level":2,"score":0.8472413420677185},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7193945646286011},{"id":"https://openalex.org/C2994232697","wikidata":"https://www.wikidata.org/wiki/Q1115882","display_name":"Extracorporeal circulation","level":2,"score":0.7151994705200195},{"id":"https://openalex.org/C2779978075","wikidata":"https://www.wikidata.org/wiki/Q202301","display_name":"Dialysis","level":2,"score":0.6834291815757751},{"id":"https://openalex.org/C2778063415","wikidata":"https://www.wikidata.org/wiki/Q391744","display_name":"Hemodialysis","level":2,"score":0.6757819652557373},{"id":"https://openalex.org/C2776825266","wikidata":"https://www.wikidata.org/wiki/Q1410794","display_name":"Fibrinolysis","level":2,"score":0.6046813726425171},{"id":"https://openalex.org/C43376680","wikidata":"https://www.wikidata.org/wiki/Q6580786","display_name":"Bolus (digestion)","level":2,"score":0.5891125798225403},{"id":"https://openalex.org/C54173615","wikidata":"https://www.wikidata.org/wiki/Q27205","display_name":"Fibrin","level":2,"score":0.5668221116065979},{"id":"https://openalex.org/C2779915274","wikidata":"https://www.wikidata.org/wiki/Q1115882","display_name":"Extracorporeal","level":2,"score":0.4620233476161957},{"id":"https://openalex.org/C176685330","wikidata":"https://www.wikidata.org/wiki/Q857638","display_name":"Radioimmunoassay","level":2,"score":0.4105416536331177},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.38045769929885864},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.335429310798645},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33278751373291016},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32266563177108765},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.19200289249420166}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001620","descriptor_name":"beta-Thromboglobulin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D001780","descriptor_name":"Blood Coagulation Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005342","descriptor_name":"Fibrinolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005344","descriptor_name":"Fibrinopeptide A","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005345","descriptor_name":"Fibrinopeptide B","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006435","descriptor_name":"Renal Dialysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006493","descriptor_name":"Heparin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D006493","descriptor_name":"Heparin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010978","descriptor_name":"Platelet Factor 4","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011863","descriptor_name":"Radioimmunoassay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012306","descriptor_name":"Risk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:6230409","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6230409","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of laboratory and clinical medicine","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:107073","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/107073/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J LAB CLIN MED , 103 (4) 643 - 652. (1984)","raw_type":"Article"},{"id":"mag:21793809","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6230409","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1489875083","https://openalex.org/W1504828685","https://openalex.org/W1592674309","https://openalex.org/W1965043353","https://openalex.org/W1968418164","https://openalex.org/W1977431042","https://openalex.org/W1985439569","https://openalex.org/W2003731635","https://openalex.org/W2058177009","https://openalex.org/W2063955121","https://openalex.org/W2069358240","https://openalex.org/W2094312255","https://openalex.org/W2097390840","https://openalex.org/W2098222886","https://openalex.org/W2105171531","https://openalex.org/W2109849900","https://openalex.org/W2110780859","https://openalex.org/W2114644090","https://openalex.org/W2119516822","https://openalex.org/W2122328334","https://openalex.org/W2127798451","https://openalex.org/W2141624880"],"related_works":["https://openalex.org/W2417158550","https://openalex.org/W1404042","https://openalex.org/W2051917024","https://openalex.org/W2884796842","https://openalex.org/W1977816875","https://openalex.org/W2571946339","https://openalex.org/W2399506915","https://openalex.org/W2401192803","https://openalex.org/W2269813397","https://openalex.org/W576564078"],"abstract_inverted_index":{"The":[0,201],"abilities":[1],"of":[2,9,29,36,51,54,71,88,111,130,163,167,172,182,190,203,217,223,242,244,248,285],"four":[3],"heparin":[4,55,91,131,168,230,257,271],"regimens":[5],"to":[6,38,67,140,146,228,234,263,297,302],"inhibit":[7],"activation":[8,243],"blood":[10],"coagulation,":[11],"fibrinolysis,":[12],"and":[13,33,46,80,106,116,151,157,187,220,246,287,301],"the":[14,30,124,161,195,204,218,221,249,288,298,303],"platelet":[15,250,289],"release":[16,251,290],"reaction":[17,252],"in":[18,61,93,99,123,149,194,198,215,226,278],"humans":[19],"during":[20,85,184,268],"renal":[21],"dialysis":[22,60,69,98,186,277,299],"have":[23],"been":[24],"assessed":[25],"by":[26,34],"visible":[27,191],"examination":[28],"extracorporeal":[31,125,196],"circulation":[32,197],"use":[35],"radioimmunoassays":[37],"FPA,":[39,112],"beta":[40,43,81,113,152,208],"15-42":[41,209],"antigen,":[42],"gamma":[44,82,114,153],"G,":[45,115],"PF4.":[47],"A":[48,127],"subcutaneous":[49],"injection":[50],"5000":[52,173],"IU":[53,90,135,174],"administered":[56,132],"1":[57],"hour":[58],"before":[59],"two":[62],"patients":[63,95,102,142],"was":[64,143,188],"either":[65],"unable":[66,145],"sustain":[68,97],"because":[70],"excess":[72],"fibrin":[73,121,192,286],"formation":[74,193],"or":[75,261],"allowed":[76,107],"elevated":[77],"plasma":[78,256],"FPA":[79,150,183],"G":[83,154],"concentrations":[84,110],"dialysis.":[86,164],"Injection":[87],"10,000":[89],"s.c.":[92],"five":[94],"could":[96],"only":[100],"three":[101],"for":[103],"5":[104,158],"hours,":[105],"progressively":[108],"increasing":[109],"PF4,":[117],"as":[118,120,231,233],"well":[119,232],"formation,":[122],"circulation.":[126],"lower":[128,270],"dose":[129,171],"intravenously":[133],"(2500":[134],"bolus":[136,175],"plus":[137,176],"1000":[138],"IU/hr)":[139],"six":[141],"also":[144],"prevent":[147],"elevations":[148],"4":[155],"hours":[156,159],"after":[160],"initiation":[162],"Intravenous":[165],"administration":[166],"at":[169],"a":[170,294],"1500":[177],"IU/hr":[178],"completely":[179],"suppressed":[180],"generation":[181,284],"5-hour":[185],"free":[189],"13":[199],"patients.":[200],"concentration":[202,222],"fibrinolytic":[205],"system":[206],"marker":[207],"antigen":[210],"did":[211],"not":[212],"change":[213],"significantly":[214],"any":[216],"regimens,":[219],"PF4":[224],"altered":[225],"response":[227],"infused":[229],"inadequate":[235],"heparinization.":[236],"We":[237],"conclude":[238],"that":[239],"complete":[240],"inhibition":[241],"coagulation":[245],"suppression":[247],"occurs":[253],"when":[254],"high":[255],"levels":[258,272],"(greater":[259],"than":[260],"equal":[262],"0.5":[264],"IU/ml)":[265],"are":[266],"maintained":[267],"dialysis:":[269],"may":[273],"be":[274],"compatible":[275],"with":[276],"some":[279],"patients,":[280],"but":[281],"they":[282],"allow":[283],"reaction,":[291],"which":[292],"pose":[293],"potential":[295],"risk":[296],"procedure":[300],"patient.":[304]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}