{"id":"https://openalex.org/W2179216099","doi":"https://doi.org/10.1016/j.immuni.2015.10.013","title":"Superoxide Dismutase 1 Protects Hepatocytes from Type I Interferon-Driven Oxidative Damage","display_name":"Superoxide Dismutase 1 Protects Hepatocytes from Type I Interferon-Driven Oxidative Damage","publication_year":2015,"publication_date":"2015-11-01","ids":{"openalex":"https://openalex.org/W2179216099","doi":"https://doi.org/10.1016/j.immuni.2015.10.013","mag":"2179216099","pmid":"https://pubmed.ncbi.nlm.nih.gov/26588782","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4658338"},"language":"en","primary_location":{"id":"doi:10.1016/j.immuni.2015.10.013","doi":"https://doi.org/10.1016/j.immuni.2015.10.013","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.immuni.2015.10.013","pdf_url":"http://www.cell.com/article/S1074761315004380/pdf","source":{"id":"https://openalex.org/S199671312","display_name":"Immunity","issn_l":"1074-7613","issn":["1074-7613","1097-4180"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunity","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.cell.com/article/S1074761315004380/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089819891","display_name":"Anannya Bhattacharya","orcid":"https://orcid.org/0000-0001-6385-4028","observed_orcids":["https://orcid.org/0000-0001-6385-4028"]},"institutions":[{"id":"https://openalex.org/I138211613","display_name":"Austrian Academy of Sciences","ror":"https://ror.org/03anc3s24","country_code":"AT","type":"government","lineage":["https://openalex.org/I138211613"]},{"id":"https://openalex.org/I4210127611","display_name":"CeMM Research Center for Molecular Medicine","ror":"https://ror.org/02z2dfb58","country_code":"AT","type":"facility","lineage":["https://openalex.org/I138211613","https://openalex.org/I4210127611"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Anannya Bhattacharya","raw_affiliation_strings":["CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14 AKH BT25.3, 1090 Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14 AKH BT25.3, 1090 Vienna, Austria","institution_ids":["https://openalex.org/I138211613","https://openalex.org/I4210127611"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059225038","display_name":"Ahmed Nabil Hegazy","orcid":"https://orcid.org/0000-0002-2946-8251","observed_orcids":["https://orcid.org/0000-0002-2946-8251"]},"institutions":[{"id":"https://openalex.org/I2802742124","display_name":"John Radcliffe Hospital","ror":"https://ror.org/0080acb59","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802742124","https://openalex.org/I4210127145","https://openalex.org/I4210147381"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210095248","display_name":"German Rheumatism Research Centre","ror":"https://ror.org/00shv0x82","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210095248"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE","GB"],"is_corresponding":false,"raw_author_name":"Ahmed\u00a0N. Hegazy","raw_affiliation_strings":["Experimental Immunology, Department of Rheumatology and Clinical Immunology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Charit\u00e9platz 1, 10117 Berlin, Germany; German Rheumatism Research Center (DRFZ), a Leibniz Institute, 10117 Berlin, Germany; Translational Gastroenterology Unit, Experimental Medicine Division Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, OX3 9DU Oxford, UK","Experimental Immunology, Department of Rheumatology and Clinical Immunology, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, Charit\u00e9platz 1, 10117 Berlin, Germany","German Rheumatism Research Center (DRFZ), a Leibniz Institute, 10117 Berlin, Germany","Translational Gastroenterology Unit, Experimental Medicine Division Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, OX3 9DU Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental Immunology, Department of Rheumatology and Clinical Immunology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Charit\u00e9platz 1, 10117 Berlin, Germany; German Rheumatism Research Center (DRFZ), a Leibniz Institute, 10117 Berlin, Germany; Translational Gastroenterology Unit, Experimental Medicine Division Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, OX3 9DU Oxford, UK","institution_ids":["https://openalex.org/I2802742124","https://openalex.org/I40120149","https://openalex.org/I4210095248","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Experimental Immunology, Department of Rheumatology and Clinical Immunology, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, Charit\u00e9platz 1, 10117 Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"German Rheumatism Research Center (DRFZ), a Leibniz Institute, 10117 Berlin, Germany","institution_ids":["https://openalex.org/I4210095248"]},{"raw_affiliation_string":"Translational Gastroenterology Unit, Experimental Medicine Division Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, OX3 9DU Oxford, UK","institution_ids":["https://openalex.org/I2802742124","https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061384595","display_name":"Nikolaus Deigendesch","orcid":"https://orcid.org/0000-0002-6036-3327","observed_orcids":["https://orcid.org/0000-0002-6036-3327"]},"institutions":[{"id":"https://openalex.org/I4210087223","display_name":"Max Planck Institute for Infection Biology","ror":"https://ror.org/0046gcs23","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210087223"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nikolaus Deigendesch","raw_affiliation_strings":["Max Planck Institute for Infection Biology, Charit\u00e9platz 1, 10117 Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max Planck Institute for Infection Biology, Charit\u00e9platz 1, 10117 Berlin, Germany","institution_ids":["https://openalex.org/I4210087223"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042808371","display_name":"Lindsay Kosack","orcid":"https://orcid.org/0000-0001-7266-0006","observed_orcids":["https://orcid.org/0000-0001-7266-0006"]},"institutions":[{"id":"https://openalex.org/I138211613","display_name":"Austrian Academy of Sciences","ror":"https://ror.org/03anc3s24","country_code":"AT","type":"government","lineage":["https://openalex.org/I138211613"]},{"id":"https://openalex.org/I4210127611","display_name":"CeMM Research Center for Molecular Medicine","ror":"https://ror.org/02z2dfb58","country_code":"AT","type":"facility","lineage":["https://openalex.org/I138211613","https://openalex.org/I4210127611"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Lindsay Kosack","raw_affiliation_strings":["CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14 AKH BT25.3, 1090 Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14 AKH BT25.3, 1090 Vienna, Austria","institution_ids":["https://openalex.org/I138211613","https://openalex.org/I4210127611"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064900991","display_name":"Jovana Cupovic","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799884508","display_name":"Kantonsspital St. Gallen","ror":"https://ror.org/00gpmb873","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2799884508"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Jovana Cupovic","raw_affiliation_strings":["Institute of Immunobiology, Cantonal Hospital St. Gallen, Rorschacherstrasse 95, 9007 St. Gallen, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Immunobiology, Cantonal Hospital St. Gallen, Rorschacherstrasse 95, 9007 St. Gallen, Switzerland","institution_ids":["https://openalex.org/I2799884508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083127295","display_name":"Richard K. Kandasamy","orcid":"https://orcid.org/0000-0002-0894-1222","observed_orcids":["https://orcid.org/0000-0002-0894-1222"]},"institutions":[{"id":"https://openalex.org/I138211613","display_name":"Austrian Academy of Sciences","ror":"https://ror.org/03anc3s24","country_code":"AT","type":"government","lineage":["https://openalex.org/I138211613"]},{"id":"https://openalex.org/I4210127611","display_name":"CeMM Research Center for Molecular Medicine","ror":"https://ror.org/02z2dfb58","country_code":"AT","type":"facility","lineage":["https://openalex.org/I138211613","https://openalex.org/I4210127611"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Richard\u00a0K. Kandasamy","raw_affiliation_strings":["CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14 AKH BT25.3, 1090 Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14 AKH BT25.3, 1090 Vienna, Austria","institution_ids":["https://openalex.org/I138211613","https://openalex.org/I4210127611"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Andrea Hildebrandt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138211613","display_name":"Austrian Academy of Sciences","ror":"https://ror.org/03anc3s24","country_code":"AT","type":"government","lineage":["https://openalex.org/I138211613"]},{"id":"https://openalex.org/I4210127611","display_name":"CeMM Research Center for Molecular Medicine","ror":"https://ror.org/02z2dfb58","country_code":"AT","type":"facility","lineage":["https://openalex.org/I138211613","https://openalex.org/I4210127611"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Andrea Hildebrandt","raw_affiliation_strings":["CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14 AKH BT25.3, 1090 Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14 AKH BT25.3, 1090 Vienna, Austria","institution_ids":["https://openalex.org/I138211613","https://openalex.org/I4210127611"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074794983","display_name":"Doron Merkler","orcid":"https://orcid.org/0000-0002-0247-2007","observed_orcids":["https://orcid.org/0000-0002-0247-2007"]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]},{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]},{"id":"https://openalex.org/I74656192","display_name":"University of G\u00f6ttingen","ror":"https://ror.org/01y9bpm73","country_code":"DE","type":"education","lineage":["https://openalex.org/I74656192"]}],"countries":["CH","DE"],"is_corresponding":false,"raw_author_name":"Doron Merkler","raw_affiliation_strings":["Department of Pathology and Immunology, University of Geneva, Centre M\u00e9dical Universitaire, 1 rue Michel Servet, 1211 Geneva, Switzerland; Department of Neuropathology, University Medicine G\u00f6ttingen, Robert-Koch Strasse 40, 37099 Goettingen, Germany","Department of Neuropathology, University Medicine G\u00f6ttingen, Robert-Koch Strasse 40, 37099 Goettingen, Germany","Department of Pathology and Immunology, University of Geneva, Centre M\u00e9dical Universitaire, 1 rue Michel Servet, 1211 Geneva, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Immunology, University of Geneva, Centre M\u00e9dical Universitaire, 1 rue Michel Servet, 1211 Geneva, Switzerland; Department of Neuropathology, University Medicine G\u00f6ttingen, Robert-Koch Strasse 40, 37099 Goettingen, Germany","institution_ids":["https://openalex.org/I114457229","https://openalex.org/I4210116730","https://openalex.org/I74656192"]},{"raw_affiliation_string":"Department of Neuropathology, University Medicine G\u00f6ttingen, Robert-Koch Strasse 40, 37099 Goettingen, Germany","institution_ids":["https://openalex.org/I4210116730"]},{"raw_affiliation_string":"Department of Pathology and Immunology, University of Geneva, Centre M\u00e9dical Universitaire, 1 rue Michel Servet, 1211 Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029305848","display_name":"Anja Andrea K\u00fchl","orcid":"https://orcid.org/0000-0003-2293-5387","observed_orcids":["https://orcid.org/0000-0003-2293-5387"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anja\u00a0A. K\u00fchl","raw_affiliation_strings":["Department of Medicine I for Gastroenterology, Infectious Disease and Rheumatology, Campus Benjamin Franklin, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Hindenburgdamm 30, 12200 Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine I for Gastroenterology, Infectious Disease and Rheumatology, Campus Benjamin Franklin, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Hindenburgdamm 30, 12200 Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090711849","display_name":"Bojan Vilagos","orcid":"https://orcid.org/0000-0002-8506-637X","observed_orcids":["https://orcid.org/0000-0002-8506-637X"]},"institutions":[{"id":"https://openalex.org/I138211613","display_name":"Austrian Academy of Sciences","ror":"https://ror.org/03anc3s24","country_code":"AT","type":"government","lineage":["https://openalex.org/I138211613"]},{"id":"https://openalex.org/I4210127611","display_name":"CeMM Research Center for Molecular Medicine","ror":"https://ror.org/02z2dfb58","country_code":"AT","type":"facility","lineage":["https://openalex.org/I138211613","https://openalex.org/I4210127611"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Bojan Vilagos","raw_affiliation_strings":["CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14 AKH BT25.3, 1090 Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14 AKH BT25.3, 1090 Vienna, Austria","institution_ids":["https://openalex.org/I138211613","https://openalex.org/I4210127611"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083561712","display_name":"Christopher Schliehe","orcid":"https://orcid.org/0000-0002-1923-8620","observed_orcids":["https://orcid.org/0000-0002-1923-8620"]},"institutions":[{"id":"https://openalex.org/I138211613","display_name":"Austrian Academy of Sciences","ror":"https://ror.org/03anc3s24","country_code":"AT","type":"government","lineage":["https://openalex.org/I138211613"]},{"id":"https://openalex.org/I4210127611","display_name":"CeMM Research Center for Molecular Medicine","ror":"https://ror.org/02z2dfb58","country_code":"AT","type":"facility","lineage":["https://openalex.org/I138211613","https://openalex.org/I4210127611"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Christopher Schliehe","raw_affiliation_strings":["CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14 AKH BT25.3, 1090 Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14 AKH BT25.3, 1090 Vienna, Austria","institution_ids":["https://openalex.org/I138211613","https://openalex.org/I4210127611"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108817874","display_name":"Isabel Panse","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210095248","display_name":"German Rheumatism Research Centre","ror":"https://ror.org/00shv0x82","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210095248"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Isabel Panse","raw_affiliation_strings":["Experimental Immunology, Department of Rheumatology and Clinical Immunology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Charit\u00e9platz 1, 10117 Berlin, Germany; German Rheumatism Research Center (DRFZ), a Leibniz Institute, 10117 Berlin, Germany","Experimental Immunology, Department of Rheumatology and Clinical Immunology, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, Charit\u00e9platz 1, 10117 Berlin, Germany","German Rheumatism Research Center (DRFZ), a Leibniz Institute, 10117 Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental Immunology, Department of Rheumatology and Clinical Immunology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Charit\u00e9platz 1, 10117 Berlin, Germany; German Rheumatism Research Center (DRFZ), a Leibniz Institute, 10117 Berlin, Germany","institution_ids":["https://openalex.org/I4210095248","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Experimental Immunology, Department of Rheumatology and Clinical Immunology, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, Charit\u00e9platz 1, 10117 Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"German Rheumatism Research Center (DRFZ), a Leibniz Institute, 10117 Berlin, Germany","institution_ids":["https://openalex.org/I4210095248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002448970","display_name":"Kseniya Khamina","orcid":"https://orcid.org/0000-0002-7363-7905","observed_orcids":["https://orcid.org/0000-0002-7363-7905"]},"institutions":[{"id":"https://openalex.org/I138211613","display_name":"Austrian Academy of Sciences","ror":"https://ror.org/03anc3s24","country_code":"AT","type":"government","lineage":["https://openalex.org/I138211613"]},{"id":"https://openalex.org/I4210127611","display_name":"CeMM Research Center for Molecular Medicine","ror":"https://ror.org/02z2dfb58","country_code":"AT","type":"facility","lineage":["https://openalex.org/I138211613","https://openalex.org/I4210127611"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Kseniya Khamina","raw_affiliation_strings":["CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14 AKH BT25.3, 1090 Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14 AKH BT25.3, 1090 Vienna, Austria","institution_ids":["https://openalex.org/I138211613","https://openalex.org/I4210127611"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000795297","display_name":"Hatoon Baazim","orcid":"https://orcid.org/0000-0003-4243-4950","observed_orcids":["https://orcid.org/0000-0003-4243-4950"]},"institutions":[{"id":"https://openalex.org/I138211613","display_name":"Austrian Academy of Sciences","ror":"https://ror.org/03anc3s24","country_code":"AT","type":"government","lineage":["https://openalex.org/I138211613"]},{"id":"https://openalex.org/I4210127611","display_name":"CeMM Research Center for Molecular Medicine","ror":"https://ror.org/02z2dfb58","country_code":"AT","type":"facility","lineage":["https://openalex.org/I138211613","https://openalex.org/I4210127611"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Hatoon Baazim","raw_affiliation_strings":["CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14 AKH BT25.3, 1090 Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14 AKH BT25.3, 1090 Vienna, Austria","institution_ids":["https://openalex.org/I138211613","https://openalex.org/I4210127611"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078331369","display_name":"Isabelle Catherine Arnold","orcid":"https://orcid.org/0000-0001-8679-9666","observed_orcids":["https://orcid.org/0000-0001-8679-9666"]},"institutions":[{"id":"https://openalex.org/I2802742124","display_name":"John Radcliffe Hospital","ror":"https://ror.org/0080acb59","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802742124","https://openalex.org/I4210127145","https://openalex.org/I4210147381"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Isabelle Arnold","raw_affiliation_strings":["Translational Gastroenterology Unit, Experimental Medicine Division Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, OX3 9DU Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Gastroenterology Unit, Experimental Medicine Division Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, OX3 9DU Oxford, UK","institution_ids":["https://openalex.org/I2802742124","https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087984672","display_name":"Lukas Flatz","orcid":"https://orcid.org/0000-0001-9683-8390","observed_orcids":["https://orcid.org/0000-0001-9683-8390"]},"institutions":[{"id":"https://openalex.org/I2799884508","display_name":"Kantonsspital St. Gallen","ror":"https://ror.org/00gpmb873","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2799884508"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Lukas Flatz","raw_affiliation_strings":["Institute of Immunobiology, Cantonal Hospital St. Gallen, Rorschacherstrasse 95, 9007 St. Gallen, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Immunobiology, Cantonal Hospital St. Gallen, Rorschacherstrasse 95, 9007 St. Gallen, Switzerland","institution_ids":["https://openalex.org/I2799884508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066535943","display_name":"Haifeng C. Xu","orcid":"https://orcid.org/0000-0002-7999-0814","observed_orcids":["https://orcid.org/0000-0002-7999-0814"]},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Haifeng\u00a0C. Xu","raw_affiliation_strings":["Department of Gastroenterology, Heinrich-Heine-University, Moorenstrasse 5, 40225 D\u00fcsseldorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Heinrich-Heine-University, Moorenstrasse 5, 40225 D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002342983","display_name":"Philipp Alexander Lang","orcid":"https://orcid.org/0000-0001-5341-0407","observed_orcids":["https://orcid.org/0000-0001-5341-0407"]},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Philipp\u00a0A. Lang","raw_affiliation_strings":["Department of Gastroenterology, Heinrich-Heine-University, Moorenstrasse 5, 40225 D\u00fcsseldorf, Germany; Department of Molecular Medicine II, Heinrich Heine University, Universit\u00e4tsstrasse 1, 40225 D\u00fcsseldorf, Germany","Department of Gastroenterology, Heinrich-Heine-University, Moorenstrasse 5, 40225 D\u00fcsseldorf, Germany","Department of Molecular Medicine II, Heinrich Heine University, Universit\u00e4tsstrasse 1, 40225 D\u00fcsseldorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Heinrich-Heine-University, Moorenstrasse 5, 40225 D\u00fcsseldorf, Germany; Department of Molecular Medicine II, Heinrich Heine University, Universit\u00e4tsstrasse 1, 40225 D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]},{"raw_affiliation_string":"Department of Gastroenterology, Heinrich-Heine-University, Moorenstrasse 5, 40225 D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]},{"raw_affiliation_string":"Department of Molecular Medicine II, Heinrich Heine University, Universit\u00e4tsstrasse 1, 40225 D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063227404","display_name":"Alan A. Aderem","orcid":"https://orcid.org/0000-0003-4031-5499","observed_orcids":["https://orcid.org/0000-0003-4031-5499"]},"institutions":[{"id":"https://openalex.org/I1294824412","display_name":"Center for Infectious Disease Research","ror":"https://ror.org/04jkbnw46","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1294824412"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan Aderem","raw_affiliation_strings":["Seattle Biomedical Research Institute, 307 Westlake Avenue North, Suite 500, Seattle, WA 98109-5219, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seattle Biomedical Research Institute, 307 Westlake Avenue North, Suite 500, Seattle, WA 98109-5219, USA","institution_ids":["https://openalex.org/I1294824412"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073909800","display_name":"Akinori Takaoka","orcid":"https://orcid.org/0000-0002-6036-3757","observed_orcids":["https://orcid.org/0000-0002-6036-3757"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]},{"id":"https://openalex.org/I4405286760","display_name":"Institute for Genetic Medicine, Hokkaido University","ror":"https://ror.org/0319h6x77","country_code":"JP","type":"facility","lineage":["https://openalex.org/I205349734","https://openalex.org/I4405286760"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akinori Takaoka","raw_affiliation_strings":["Division of Signaling in Cancer and Immunology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Hokkaido 060-0815, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Signaling in Cancer and Immunology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Hokkaido 060-0815, Japan","institution_ids":["https://openalex.org/I205349734","https://openalex.org/I4405286760"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069216326","display_name":"Giulio Superti\u2010Furga","orcid":"https://orcid.org/0000-0002-0570-1768","observed_orcids":["https://orcid.org/0000-0002-0570-1768"]},"institutions":[{"id":"https://openalex.org/I138211613","display_name":"Austrian Academy of Sciences","ror":"https://ror.org/03anc3s24","country_code":"AT","type":"government","lineage":["https://openalex.org/I138211613"]},{"id":"https://openalex.org/I4210127611","display_name":"CeMM Research Center for Molecular Medicine","ror":"https://ror.org/02z2dfb58","country_code":"AT","type":"facility","lineage":["https://openalex.org/I138211613","https://openalex.org/I4210127611"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Giulio Superti-Furga","raw_affiliation_strings":["CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14 AKH BT25.3, 1090 Vienna, Austria; Center for Physiology and Pharmacology, Medical University of Vienna, Lazarettgasse 14, 1090 Vienna, Austria","CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14 AKH BT25.3, 1090 Vienna, Austria","Center for Physiology and Pharmacology, Medical University of Vienna, Lazarettgasse 14, 1090 Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14 AKH BT25.3, 1090 Vienna, Austria; Center for Physiology and Pharmacology, Medical University of Vienna, Lazarettgasse 14, 1090 Vienna, Austria","institution_ids":["https://openalex.org/I138211613","https://openalex.org/I4210127611","https://openalex.org/I76134821"]},{"raw_affiliation_string":"CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14 AKH BT25.3, 1090 Vienna, Austria","institution_ids":["https://openalex.org/I138211613","https://openalex.org/I4210127611"]},{"raw_affiliation_string":"Center for Physiology and Pharmacology, Medical University of Vienna, Lazarettgasse 14, 1090 Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029758467","display_name":"Jacques Colinge","orcid":"https://orcid.org/0000-0003-2466-4824","observed_orcids":["https://orcid.org/0000-0003-2466-4824"]},"institutions":[{"id":"https://openalex.org/I138211613","display_name":"Austrian Academy of Sciences","ror":"https://ror.org/03anc3s24","country_code":"AT","type":"government","lineage":["https://openalex.org/I138211613"]},{"id":"https://openalex.org/I4210127611","display_name":"CeMM Research Center for Molecular Medicine","ror":"https://ror.org/02z2dfb58","country_code":"AT","type":"facility","lineage":["https://openalex.org/I138211613","https://openalex.org/I4210127611"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Jacques Colinge","raw_affiliation_strings":["CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14 AKH BT25.3, 1090 Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14 AKH BT25.3, 1090 Vienna, Austria","institution_ids":["https://openalex.org/I138211613","https://openalex.org/I4210127611"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031118170","display_name":"Burkhard Ludewig","orcid":"https://orcid.org/0000-0002-7685-573X","observed_orcids":["https://orcid.org/0000-0002-7685-573X"]},"institutions":[{"id":"https://openalex.org/I2799884508","display_name":"Kantonsspital St. Gallen","ror":"https://ror.org/00gpmb873","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2799884508"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Burkhard Ludewig","raw_affiliation_strings":["Institute of Immunobiology, Cantonal Hospital St. Gallen, Rorschacherstrasse 95, 9007 St. Gallen, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Immunobiology, Cantonal Hospital St. Gallen, Rorschacherstrasse 95, 9007 St. Gallen, Switzerland","institution_ids":["https://openalex.org/I2799884508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009054700","display_name":"Max L\u00f6hning","orcid":"https://orcid.org/0000-0001-6382-7281","observed_orcids":["https://orcid.org/0000-0001-6382-7281"]},"institutions":[{"id":"https://openalex.org/I4210095248","display_name":"German Rheumatism Research Centre","ror":"https://ror.org/00shv0x82","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210095248"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Max L\u00f6hning","raw_affiliation_strings":["Experimental Immunology, Department of Rheumatology and Clinical Immunology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Charit\u00e9platz 1, 10117 Berlin, Germany; German Rheumatism Research Center (DRFZ), a Leibniz Institute, 10117 Berlin, Germany","Experimental Immunology, Department of Rheumatology and Clinical Immunology, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, Charit\u00e9platz 1, 10117 Berlin, Germany","German Rheumatism Research Center (DRFZ), a Leibniz Institute, 10117 Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental Immunology, Department of Rheumatology and Clinical Immunology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Charit\u00e9platz 1, 10117 Berlin, Germany; German Rheumatism Research Center (DRFZ), a Leibniz Institute, 10117 Berlin, Germany","institution_ids":["https://openalex.org/I4210095248","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Experimental Immunology, Department of Rheumatology and Clinical Immunology, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, Charit\u00e9platz 1, 10117 Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"German Rheumatism Research Center (DRFZ), a Leibniz Institute, 10117 Berlin, Germany","institution_ids":["https://openalex.org/I4210095248"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068285493","display_name":"Andreas Bergthaler","orcid":"https://orcid.org/0000-0003-0597-1976","observed_orcids":["https://orcid.org/0000-0003-0597-1976"]},"institutions":[{"id":"https://openalex.org/I138211613","display_name":"Austrian Academy of Sciences","ror":"https://ror.org/03anc3s24","country_code":"AT","type":"government","lineage":["https://openalex.org/I138211613"]},{"id":"https://openalex.org/I4210127611","display_name":"CeMM Research Center for Molecular Medicine","ror":"https://ror.org/02z2dfb58","country_code":"AT","type":"facility","lineage":["https://openalex.org/I138211613","https://openalex.org/I4210127611"]}],"countries":["AT"],"is_corresponding":true,"raw_author_name":"Andreas Bergthaler","raw_affiliation_strings":["CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14 AKH BT25.3, 1090 Vienna, Austria. Electronic address: abergthaler@cemm.oeaw.ac.at","CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14 AKH BT25.3, 1090 Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14 AKH BT25.3, 1090 Vienna, Austria. Electronic address: abergthaler@cemm.oeaw.ac.at","institution_ids":["https://openalex.org/I138211613","https://openalex.org/I4210127611"]},{"raw_affiliation_string":"CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14 AKH BT25.3, 1090 Vienna, Austria","institution_ids":["https://openalex.org/I138211613","https://openalex.org/I4210127611"]}]}],"institutions":[],"countries_distinct_count":6,"institutions_distinct_count":16,"corresponding_author_ids":["https://openalex.org/A5068285493"],"corresponding_institution_ids":["https://openalex.org/I138211613","https://openalex.org/I4210127611"],"apc_list":{"value":10400,"currency":"USD","value_usd":10400},"apc_paid":{"value":4462,"currency":"EUR","value_usd":4812},"fwci":3.7744,"has_fulltext":true,"cited_by_count":61,"citation_normalized_percentile":{"value":0.93957115,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"43","issue":"5","first_page":"974","last_page":"986"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.8647000193595886,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.8647000193595886,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.02889999933540821,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.020899999886751175,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/superoxide-dismutase-1","display_name":"superoxide dismutase 1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/type-i-interferon","display_name":"type I interferon","score":0.8899999856948853},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8539999723434448},{"id":"https://openalex.org/keywords/viral-hepatitis","display_name":"viral hepatitis","score":0.8029999732971191},{"id":"https://openalex.org/keywords/hepatocyte-injury","display_name":"hepatocyte injury","score":0.7580000162124634},{"id":"https://openalex.org/keywords/sod1-knockout-mice","display_name":"Sod1 knockout mice","score":0.7390000224113464},{"id":"https://openalex.org/keywords/antioxidant-therapy","display_name":"antioxidant therapy","score":0.5130000114440918},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.718999981880188},{"id":"https://openalex.org/keywords/liver-inflammation","display_name":"liver inflammation","score":0.7239999771118164},{"id":"https://openalex.org/keywords/redox-pathways","display_name":"redox pathways","score":0.6800000071525574},{"id":"https://openalex.org/keywords/interferon-signaling","display_name":"interferon signaling","score":0.765999972820282}],"concepts":[{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.8521174192428589},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.695410966873169},{"id":"https://openalex.org/C3020296196","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative damage","level":3,"score":0.6668394804000854},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.5584135055541992},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.5274099111557007},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4005993604660034},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.38122832775115967},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23539388179779053}],"mesh":[{"descriptor_ui":"D000072105","descriptor_name":"Superoxide Dismutase-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006524","descriptor_name":"Hepatitis, Viral, Animal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007370","descriptor_name":"Interferon Type I","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":10,"locations":[{"id":"doi:10.1016/j.immuni.2015.10.013","doi":"https://doi.org/10.1016/j.immuni.2015.10.013","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.immuni.2015.10.013","pdf_url":"http://www.cell.com/article/S1074761315004380/pdf","source":{"id":"https://openalex.org/S199671312","display_name":"Immunity","issn_l":"1074-7613","issn":["1074-7613","1097-4180"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunity","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4658338","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4658338","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunity","raw_type":"Text"},{"id":"pmid:26588782","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26588782","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunity","raw_type":"Journal Article"},{"id":"pmh:oai:unige.ch:aou:unige:79114","doi":null,"is_oa":false,"landing_page_url":"https://archive-ouverte.unige.ch/unige:79114","pdf_url":null,"source":{"id":"https://openalex.org/S4306402259","display_name":"Archive ouverte UNIGE (University of Geneva)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114457229","host_organization_name":"University of Geneva","host_organization_lineage":["https://openalex.org/I114457229"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunity, vol. 43, no. 5 (2015) p. 974-986","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.818.3758","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.818.3758","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/36/b4/emss-66224.PMC4658338.pdf","raw_type":"text"},{"id":"pmh:oai:HAL:hal-02336008v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.umontpellier.fr/hal-02336008","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Immunity, 2015, 43 (5), pp.974-986. &#x27E8;10.1016/j.immuni.2015.10.013&#x27E9;","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:goescholar:1/12708","doi":null,"is_oa":true,"landing_page_url":"http://resolver.sub.uni-goettingen.de/purl?gs-1/12708","pdf_url":null,"source":{"id":"https://openalex.org/S4306401634","display_name":"GoeScholar  The Publication Server of the Georg-August-Universit\u00e4t G\u00f6ttingen (Georg-August-Universit\u00e4t G\u00f6ttingen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210122495","host_organization_name":"Asklepios Klinik St. Georg","host_organization_lineage":["https://openalex.org/I4210122495"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"journalArticle"},{"id":"pmh:oai:publications.goettingen-research-online.de:2/35389","doi":null,"is_oa":true,"landing_page_url":"https://resolver.sub.uni-goettingen.de/purl?gro-2/35389","pdf_url":null,"source":{"id":"https://openalex.org/S7407055187","display_name":"GRO","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.mpg.de:item_2243340","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11858/00-001M-0000-0029-6589-1","pdf_url":null,"source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Immunity","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:unige.ch:unige:79114","doi":null,"is_oa":true,"landing_page_url":"https://archive-ouverte.unige.ch/unige:79114","pdf_url":null,"source":{"id":"https://openalex.org/S4306402259","display_name":"Archive ouverte UNIGE (University of Geneva)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114457229","host_organization_name":"University of Geneva","host_organization_lineage":["https://openalex.org/I114457229"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1074-7613","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1016/j.immuni.2015.10.013","doi":"https://doi.org/10.1016/j.immuni.2015.10.013","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.immuni.2015.10.013","pdf_url":"http://www.cell.com/article/S1074761315004380/pdf","source":{"id":"https://openalex.org/S199671312","display_name":"Immunity","issn_l":"1074-7613","issn":["1074-7613","1097-4180"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunity","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1263991214","display_name":null,"funder_award_id":"LA2558/5\u20101","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G1650684859","display_name":null,"funder_award_id":"SFB650","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G2303867986","display_name":"Viral triggers and gray matter involvement in multiple sclerosis","funder_award_id":"152928","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G4662980202","display_name":null,"funder_award_id":"SFB618","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G5033043955","display_name":null,"funder_award_id":"LO 1542/3-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G614235862","display_name":null,"funder_award_id":"SKA 2010","funder_id":"https://openalex.org/F4320308269","funder_display_name":"Alexander von Humboldt-Stiftung"},{"id":"https://openalex.org/G8170427123","display_name":"Regulation of Pathogenic CD4 T Cell Responses in Inflammatory Bowel Disease","funder_award_id":"330621","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G840949211","display_name":null,"funder_award_id":"SFB 650","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G853243261","display_name":null,"funder_award_id":"SFB 974","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G859356930","display_name":"The novel post-transcriptional regulation mechanism of antiviral host defense","funder_award_id":"25253030","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320308269","display_name":"Alexander von Humboldt-Stiftung","ror":"https://ror.org/012kf4317"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320875","display_name":"Deutscher Akademischer Austauschdienst","ror":"https://ror.org/039djdh30"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320320882","display_name":"Volkswagen Foundation","ror":"https://ror.org/03bsmfz84"},{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"},{"id":"https://openalex.org/F4320321004","display_name":"\u00d6sterreichischen Akademie der Wissenschaften","ror":"https://ror.org/03anc3s24"},{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"},{"id":"https://openalex.org/F4320321181","display_name":"Austrian Science Fund","ror":"https://ror.org/013tf3c58"},{"id":"https://openalex.org/F4320321691","display_name":"Universit\u00e4t Wien","ror":"https://ror.org/03prydq77"},{"id":"https://openalex.org/F4320323437","display_name":"Medizinische Universit\u00e4t Wien","ror":"https://ror.org/05n3x4p02"},{"id":"https://openalex.org/F4320325611","display_name":"Veterin\u00e4rmedizinische Universit\u00e4t Wien","ror":"https://ror.org/01w6qp003"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2179216099.pdf","grobid_xml":"https://content.openalex.org/works/W2179216099.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W112798770","https://openalex.org/W1488854843","https://openalex.org/W1759342672","https://openalex.org/W1802861244","https://openalex.org/W1841796848","https://openalex.org/W1966478716","https://openalex.org/W1966590237","https://openalex.org/W1973413639","https://openalex.org/W1976269285","https://openalex.org/W1976599392","https://openalex.org/W1977728069","https://openalex.org/W1986696487","https://openalex.org/W1987160791","https://openalex.org/W1989978580","https://openalex.org/W1996822762","https://openalex.org/W1996833241","https://openalex.org/W2004829503","https://openalex.org/W2005132438","https://openalex.org/W2005853038","https://openalex.org/W2011678998","https://openalex.org/W2013866322","https://openalex.org/W2024556668","https://openalex.org/W2028368003","https://openalex.org/W2037434205","https://openalex.org/W2038576929","https://openalex.org/W2043931994","https://openalex.org/W2047681783","https://openalex.org/W2047742947","https://openalex.org/W2047882003","https://openalex.org/W2049868800","https://openalex.org/W2050287929","https://openalex.org/W2050792354","https://openalex.org/W2054828149","https://openalex.org/W2055104815","https://openalex.org/W2058821788","https://openalex.org/W2064706357","https://openalex.org/W2072158757","https://openalex.org/W2078646756","https://openalex.org/W2079357798","https://openalex.org/W2079954571","https://openalex.org/W2081796577","https://openalex.org/W2087459059","https://openalex.org/W2090530862","https://openalex.org/W2091129202","https://openalex.org/W2091172564","https://openalex.org/W2092632463","https://openalex.org/W2094908805","https://openalex.org/W2099441245","https://openalex.org/W2102047778","https://openalex.org/W2103946207","https://openalex.org/W2108462008","https://openalex.org/W2108934654","https://openalex.org/W2119371081","https://openalex.org/W2120775018","https://openalex.org/W2124728669","https://openalex.org/W2131605289","https://openalex.org/W2137850511","https://openalex.org/W2138392157","https://openalex.org/W2145221987","https://openalex.org/W2149472519","https://openalex.org/W2153747150","https://openalex.org/W2158279512","https://openalex.org/W2164289775","https://openalex.org/W2168312698","https://openalex.org/W2170880806","https://openalex.org/W2171729436","https://openalex.org/W2314120200"],"related_works":["https://openalex.org/W1975658673","https://openalex.org/W7098200017","https://openalex.org/W2023840341","https://openalex.org/W1990206563","https://openalex.org/W4391642422","https://openalex.org/W4385767561","https://openalex.org/W1561448351","https://openalex.org/W2105533975","https://openalex.org/W1970810460","https://openalex.org/W7144922634"],"abstract_inverted_index":{"Tissue":[0],"damage":[1,50,83,117],"caused":[2,80],"by":[3,66],"viral":[4,20,52],"hepatitis":[5],"is":[6],"a":[7,16,75,111,120],"major":[8],"cause":[9],"of":[10,19,37,57,77,93,114,122],"morbidity":[11],"and":[12,47,59,62,79,86,90,118,132],"mortality":[13],"worldwide.":[14],"Using":[15],"mouse":[17],"model":[18],"hepatitis,":[21],"we":[22],"identified":[23],"virus-induced":[24,100,115],"early":[25],"transcriptional":[26],"changes":[27],"in":[28,32,84],"the":[29,33,94],"redox":[30],"pathways":[31],"liver,":[34],"including":[35],"downregulation":[36,76],"superoxide":[38],"dismutase":[39],"1":[40],"(Sod1).":[41],"Sod1(-/-)":[42,85],"mice":[43],"exhibited":[44],"increased":[45],"inflammation":[46],"aggravated":[48],"liver":[49,82,101,116],"upon":[51],"infection,":[53],"which":[54],"was":[55],"independent":[56],"T":[58],"NK":[60],"cells":[61],"could":[63],"be":[64],"ameliorated":[65],"antioxidant":[67,129],"treatment.":[68],"Type":[69],"I":[70],"interferon":[71],"(IFN-I)":[72],"led":[73],"to":[74],"Sod1":[78],"oxidative":[81,108],"wild-type":[87],"mice.":[88],"Genetic":[89],"pharmacological":[91],"ablation":[92],"IFN-I":[95,106,126],"signaling":[96,127],"pathway":[97],"protected":[98],"against":[99],"damage.":[102,135],"These":[103],"results":[104],"delineate":[105],"mediated":[107],"stress":[109],"as":[110],"key":[112],"mediator":[113],"describe":[119],"mechanism":[121],"innate-immunity-driven":[123],"pathology,":[124],"linking":[125],"with":[128],"host":[130],"defense":[131],"infection-associated":[133],"tissue":[134],"VIDEO":[136],"ABSTRACT.":[137]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":9}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
