{"id":"https://openalex.org/W21790820","doi":null,"title":"[Paraneoplastic syndrome hematologic abnormalities].","display_name":"[Paraneoplastic syndrome hematologic abnormalities].","publication_year":1991,"publication_date":"1991-03-01","ids":{"openalex":"https://openalex.org/W21790820","mag":"21790820","pmid":"https://pubmed.ncbi.nlm.nih.gov/2003736"},"language":"ja","primary_location":{"id":"pmid:2003736","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2003736","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gan to kagaku ryoho. Cancer & chemotherapy","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050087202","display_name":"Hidehiko Saito","orcid":"https://orcid.org/0000-0002-1714-0005","observed_orcids":["https://orcid.org/0000-0002-1714-0005"]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"H Saito","raw_affiliation_strings":["First Dept. of Medicine, Nagoya University School of Medicine, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Dept. of Medicine, Nagoya University School of Medicine, Japan","institution_ids":["https://openalex.org/I60134161"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5050087202"],"corresponding_institution_ids":["https://openalex.org/I60134161"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.00212673,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":92},"biblio":{"volume":"18","issue":"3","first_page":"337","last_page":"42"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":0.36649999022483826,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":0.36649999022483826,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.19709999859333038,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.14110000431537628,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/paraneoplastic-syndrome","display_name":"paraneoplastic syndrome","score":0.9419999718666077},{"id":"https://openalex.org/keywords/hematologic-abnormalities","display_name":"hematological abnormalities","score":0.9909999966621399},{"id":"https://openalex.org/keywords/erythrocytosis","display_name":"erythrocytosis","score":0.972000002861023},{"id":"https://openalex.org/keywords/anemia","display_name":"anemia","score":0.9559999704360962},{"id":"https://openalex.org/keywords/neutrophilia","display_name":"neutrophilia","score":0.9750000238418579},{"id":"https://openalex.org/keywords/neutropenia","display_name":"neutropenia","score":0.9810000061988831},{"id":"https://openalex.org/keywords/eosinophilia","display_name":"eosinophilia","score":0.9959999918937683},{"id":"https://openalex.org/keywords/thrombocytosis","display_name":"thrombocytosis","score":0.996999979019165},{"id":"https://openalex.org/keywords/thrombocytopenia","display_name":"thrombocytopenia","score":1.0},{"id":"https://openalex.org/keywords/venous-thromboembolism","display_name":"venous thromboembolism","score":0.9990000128746033},{"id":"https://openalex.org/keywords/disseminated-intravascular-coagulation","display_name":"disseminated intravascular coagulation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tumor-growth-factors","display_name":"tumor growth factors","score":0.7889999747276306},{"id":"https://openalex.org/keywords/granulocyte-colony-stimulating-factor","display_name":"granulocyte colony-stimulating factor","score":0.8050000071525574},{"id":"https://openalex.org/keywords/platelet-aggregation","display_name":"platelet aggregation","score":0.9430000185966492},{"id":"https://openalex.org/keywords/glycoprotein-iib-iiia","display_name":"integrin \u03b1IIb\u03b23","score":0.9449999928474426},{"id":"https://openalex.org/keywords/tissue-factor","display_name":"tissue factor","score":0.7950000166893005},{"id":"https://openalex.org/keywords/factor-x-activation","display_name":"factor X activation","score":0.6129999756813049}],"concepts":[{"id":"https://openalex.org/C2777802486","wikidata":"https://www.wikidata.org/wiki/Q491741","display_name":"Neutrophilia","level":2,"score":0.8779758810997009},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.777422308921814},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.64336758852005},{"id":"https://openalex.org/C2779788118","wikidata":"https://www.wikidata.org/wiki/Q1542410","display_name":"Thrombocytosis","level":3,"score":0.5988014340400696},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.517869234085083},{"id":"https://openalex.org/C2778734968","wikidata":"https://www.wikidata.org/wiki/Q823027","display_name":"Disseminated intravascular coagulation","level":2,"score":0.49295711517333984},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.478963166475296},{"id":"https://openalex.org/C194409129","wikidata":"https://www.wikidata.org/wiki/Q103824","display_name":"Hematology","level":2,"score":0.4538094997406006},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4229794144630432},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3978278636932373},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3391057252883911}],"mesh":[{"descriptor_ui":"D000740","descriptor_name":"Anemia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D001791","descriptor_name":"Blood Platelet Disorders","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D004211","descriptor_name":"Disseminated Intravascular Coagulation","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D004802","descriptor_name":"Eosinophilia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009503","descriptor_name":"Neutropenia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D010257","descriptor_name":"Paraneoplastic Syndromes","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D010257","descriptor_name":"Paraneoplastic Syndromes","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D011086","descriptor_name":"Polycythemia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2003736","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2003736","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gan to kagaku ryoho. Cancer & chemotherapy","raw_type":"English Abstract"},{"id":"mag:21790820","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2003736","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":89,"referenced_works":["https://openalex.org/W1503264286","https://openalex.org/W1517403057","https://openalex.org/W1608595414","https://openalex.org/W1834547006","https://openalex.org/W1839139427","https://openalex.org/W1894609058","https://openalex.org/W1963762049","https://openalex.org/W1967318355","https://openalex.org/W1970154583","https://openalex.org/W1972404789","https://openalex.org/W1979878567","https://openalex.org/W1980454123","https://openalex.org/W1986824272","https://openalex.org/W1990337934","https://openalex.org/W1994250687","https://openalex.org/W1997476591","https://openalex.org/W2002861881","https://openalex.org/W2011451809","https://openalex.org/W2015310037","https://openalex.org/W2017721083","https://openalex.org/W2017828975","https://openalex.org/W2021098202","https://openalex.org/W2032060693","https://openalex.org/W2033260912","https://openalex.org/W2036330326","https://openalex.org/W2039213946","https://openalex.org/W2039521136","https://openalex.org/W2041688307","https://openalex.org/W2042830518","https://openalex.org/W2046062863","https://openalex.org/W2049633694","https://openalex.org/W2050808207","https://openalex.org/W2059051061","https://openalex.org/W2062584673","https://openalex.org/W2077989318","https://openalex.org/W2079347509","https://openalex.org/W2087154862","https://openalex.org/W2092613863","https://openalex.org/W2093723452","https://openalex.org/W2094020982","https://openalex.org/W2096176820","https://openalex.org/W2098165869","https://openalex.org/W2098787755","https://openalex.org/W2103571367","https://openalex.org/W2106055540","https://openalex.org/W2106781564","https://openalex.org/W2109326794","https://openalex.org/W2111791193","https://openalex.org/W2112263661","https://openalex.org/W2112799266","https://openalex.org/W2114709340","https://openalex.org/W2116524028","https://openalex.org/W2116811579","https://openalex.org/W2119659661","https://openalex.org/W2119872481","https://openalex.org/W2121786023","https://openalex.org/W2122242997","https://openalex.org/W2123498662","https://openalex.org/W2123600031","https://openalex.org/W2128850039","https://openalex.org/W2131700426","https://openalex.org/W2134870644","https://openalex.org/W2136168956","https://openalex.org/W2136231401","https://openalex.org/W2140042713","https://openalex.org/W2140403952","https://openalex.org/W2142644281","https://openalex.org/W2142924932","https://openalex.org/W2144241251","https://openalex.org/W2147351854","https://openalex.org/W2148183464","https://openalex.org/W2148544598","https://openalex.org/W2150931281","https://openalex.org/W2153345179","https://openalex.org/W2154131760","https://openalex.org/W2156664710","https://openalex.org/W2156734874","https://openalex.org/W2158364367","https://openalex.org/W2161818428","https://openalex.org/W2162534431","https://openalex.org/W2170126301","https://openalex.org/W2170665985","https://openalex.org/W2172086791","https://openalex.org/W2179448457","https://openalex.org/W2253414912","https://openalex.org/W2322741287","https://openalex.org/W2764468073","https://openalex.org/W4241659171","https://openalex.org/W4299498251"],"related_works":["https://openalex.org/W61113018","https://openalex.org/W2473219909","https://openalex.org/W2031376273","https://openalex.org/W2768077268","https://openalex.org/W2023902889","https://openalex.org/W2253646158","https://openalex.org/W1971903259","https://openalex.org/W2198346478","https://openalex.org/W112640041","https://openalex.org/W2073409988"],"abstract_inverted_index":{"The":[0,110,145],"paraneoplastic":[1],"syndrome":[2],"(PNS)":[3],"is":[4,96,199],"an":[5],"association":[6],"of":[7,20,56,73,86,105,147,189,196,204],"symptoms":[8],"and":[9,41,50,130,139],"signs":[10],"not":[11],"directly":[12,170],"related":[13],"to":[14,53,99,181,185],"the":[15,54,68,83,103,108,153,205],"site":[16],"or":[17,24,62],"local":[18],"manifestations":[19],"a":[21,163,186],"malignant":[22],"tumor":[23,114,143],"its":[25],"metastases.":[26],"Hematologic":[27],"abnormalities":[28,47],"as":[29,63],"PNS":[30,88,198],"include":[31],"erythrocytosis,":[32],"anemia,":[33],"neutrophilia,":[34],"neutropenia,":[35],"eosinophilia,":[36],"thrombocytosis,":[37],"thrombocytopenia,":[38],"venous":[39],"thromboembolism":[40,116,190],"disseminated":[42],"intravascular":[43],"coagulation":[44],"(DIC).":[45],"These":[46],"are,":[48],"by":[49,67,102,107,112],"large,":[51],"due":[52],"production":[55,104],"biologically":[57],"active":[58],"growth":[59,74],"factors,":[60],"hormones":[61],"yet":[64],"unidentified":[65],"\"humors\"":[66],"tumor.":[69,109],"As":[70],"our":[71],"understanding":[72,195],"factors":[75],"controlling":[76],"hematopoiesis":[77],"has":[78,136,156],"increased":[79],"in":[80,128,131,152,191],"recent":[81],"years,":[82],"biologic":[84],"basis":[85],"hematologic":[87,197],"are":[89],"better":[90],"understood.":[91],"For":[92],"instance,":[93],"tumor-associated":[94],"neutrophilia":[95],"now":[97],"known":[98],"be":[100],"caused":[101],"G-CSF":[106],"mechanism":[111],"which":[113],"causes":[115],"have":[117,182],"also":[118,157],"been":[119,137,158,183],"extensively":[120],"investigated.":[121],"Cancer":[122],"cells":[123,161],"induce":[124],"platelet":[125,148],"aggregation":[126],"both":[127],"vitro":[129],"vivo.":[132],"Platelet":[133],"aggregating":[134],"material":[135],"isolated":[138],"partially":[140],"characterized":[141],"from":[142],"cells.":[144],"involvement":[146],"glycoprotein":[149],"II":[150],"b/IIIa":[151],"tumor-platelet":[154],"interaction":[155],"shown.":[159],"Malignant":[160],"contain":[162],"unique":[164],"procoagulant,":[165],"cancer":[166,192],"procoagulant":[167,179],"A,":[168],"that":[169],"activates":[171],"factor":[172],"X.":[173],"Together":[174],"with":[175,207],"tissue":[176],"factor,":[177],"this":[178],"appears":[180],"contribute":[184],"high":[187],"incidence":[188],"patients.":[193],"Better":[194],"important":[200],"for":[201],"clinical":[202],"care":[203],"patients":[206],"cancer.":[208]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
