{"id":"https://openalex.org/W2178762865","doi":"https://doi.org/10.1186/s13287-015-0220-0","title":"Porcine lung mesenchymal stromal cells possess differentiation and immunoregulatory properties","display_name":"Porcine lung mesenchymal stromal cells possess differentiation and immunoregulatory properties","publication_year":2015,"publication_date":"2015-11-11","ids":{"openalex":"https://openalex.org/W2178762865","doi":"https://doi.org/10.1186/s13287-015-0220-0","mag":"2178762865","pmid":"https://pubmed.ncbi.nlm.nih.gov/26560714","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4642738"},"language":"en","primary_location":{"id":"doi:10.1186/s13287-015-0220-0","doi":"https://doi.org/10.1186/s13287-015-0220-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13287-015-0220-0","pdf_url":"https://stemcellres.biomedcentral.com/track/pdf/10.1186/s13287-015-0220-0","source":{"id":"https://openalex.org/S2061155","display_name":"Stem Cell Research & Therapy","issn_l":"1757-6512","issn":["1757-6512"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Research & Therapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://stemcellres.biomedcentral.com/track/pdf/10.1186/s13287-015-0220-0","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014599903","display_name":"Mahesh Khatri","orcid":"https://orcid.org/0000-0002-0419-1815","observed_orcids":["https://orcid.org/0000-0002-0419-1815"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mahesh Khatri","raw_affiliation_strings":["Department of Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Avenue, Wooster, OH, 44691, USA. khatri.14@osu.edu","Department of Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Avenue, Wooster, OH, 44691, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Avenue, Wooster, OH, 44691, USA. khatri.14@osu.edu","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"Department of Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Avenue, Wooster, OH, 44691, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114377333","display_name":"Timothy D. O\u2019Brien","orcid":"https://orcid.org/0000-0001-9742-0930","observed_orcids":["https://orcid.org/0000-0001-9742-0930"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy D. O\u2019Brien","raw_affiliation_strings":["Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, St. Paul, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, St. Paul, MN, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091910210","display_name":"Kuldeep S. Chattha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kuldeep S. Chattha","raw_affiliation_strings":["Department of Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Avenue, Wooster, OH, 44691, USA. kschattha@gmail.com","Department of Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Avenue, Wooster, OH, 44691, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Avenue, Wooster, OH, 44691, USA. kschattha@gmail.com","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"Department of Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Avenue, Wooster, OH, 44691, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064559752","display_name":"Linda J. Saif","orcid":"https://orcid.org/0000-0002-3224-9009","observed_orcids":["https://orcid.org/0000-0002-3224-9009"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linda J. Saif","raw_affiliation_strings":["Department of Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Avenue, Wooster, OH, 44691, USA. saif.2@osu.edu","Department of Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Avenue, Wooster, OH, 44691, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Avenue, Wooster, OH, 44691, USA. saif.2@osu.edu","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"Department of Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Avenue, Wooster, OH, 44691, USA","institution_ids":["https://openalex.org/I52357470"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5014599903"],"corresponding_institution_ids":["https://openalex.org/I52357470"],"apc_list":{"value":3190,"currency":"USD","value_usd":3190},"apc_paid":{"value":3190,"currency":"USD","value_usd":3190},"fwci":0.9323,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.75274792,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"6","issue":"1","first_page":"222","last_page":"222"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/porcine-lung","display_name":"porcine lung","score":0.8610000014305115},{"id":"https://openalex.org/keywords/immune-regulation","display_name":"immune regulation","score":0.8679999709129333},{"id":"https://openalex.org/keywords/multipotent-differentiation","display_name":"multipotent differentiation","score":0.753000020980835},{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":0.8370000123977661},{"id":"https://openalex.org/keywords/th2-cytokines","display_name":"Th2 cytokines","score":0.8579999804496765},{"id":"https://openalex.org/keywords/t-cell-proliferation-inhibition","display_name":"T cell proliferation inhibition","score":0.6079999804496765},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.8659999966621399},{"id":"https://openalex.org/keywords/lung-disease","display_name":"lung disease","score":0.6150000095367432},{"id":"https://openalex.org/keywords/tissue-repair","display_name":"tissue repair","score":0.699999988079071},{"id":"https://openalex.org/keywords/germ-free-pigs","display_name":"germ-free pigs","score":0.5740000009536743}],"concepts":[{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.889855146408081},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.5836738348007202},{"id":"https://openalex.org/C116716535","wikidata":"https://www.wikidata.org/wiki/Q5009851","display_name":"CD90","level":4,"score":0.5774292945861816},{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.5573529005050659},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5331598520278931},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5042139291763306},{"id":"https://openalex.org/C13685319","wikidata":"https://www.wikidata.org/wiki/Q7607302","display_name":"Stem cell transplantation for articular cartilage repair","level":5,"score":0.4984414577484131},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.47438839077949524},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.4523998498916626},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4450252056121826},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.438524067401886},{"id":"https://openalex.org/C10882517","wikidata":"https://www.wikidata.org/wiki/Q15268054","display_name":"Cell therapy","level":3,"score":0.4233923554420471},{"id":"https://openalex.org/C2780932548","wikidata":"https://www.wikidata.org/wiki/Q1056532","display_name":"CD44","level":3,"score":0.4214630126953125},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38371777534484863},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.3597438633441925},{"id":"https://openalex.org/C20875687","wikidata":"https://www.wikidata.org/wiki/Q2642600","display_name":"Adult stem cell","level":4,"score":0.2738627791404724},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.1804344356060028},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000943","descriptor_name":"Antigens, Differentiation","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002469","descriptor_name":"Cell Separation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015232","descriptor_name":"Dinoprostone","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D039904","descriptor_name":"Pluripotent Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056747","descriptor_name":"Immunomodulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s13287-015-0220-0","doi":"https://doi.org/10.1186/s13287-015-0220-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13287-015-0220-0","pdf_url":"https://stemcellres.biomedcentral.com/track/pdf/10.1186/s13287-015-0220-0","source":{"id":"https://openalex.org/S2061155","display_name":"Stem Cell Research & Therapy","issn_l":"1757-6512","issn":["1757-6512"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Research & Therapy","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3615259","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4642738","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4642738","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4642738","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Res Ther","raw_type":"Text"},{"id":"pmid:26560714","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26560714","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem cell research & therapy","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1186/s13287-015-0220-0","doi":"https://doi.org/10.1186/s13287-015-0220-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13287-015-0220-0","pdf_url":"https://stemcellres.biomedcentral.com/track/pdf/10.1186/s13287-015-0220-0","source":{"id":"https://openalex.org/S2061155","display_name":"Stem Cell Research & Therapy","issn_l":"1757-6512","issn":["1757-6512"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Research & Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.6700000166893005,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1015898916","display_name":"MSCs therapy for acute lung injury and its effect on antiviral immunity","funder_award_id":"R21HL125191","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2736901605","display_name":null,"funder_award_id":"HL125191","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320310462","display_name":"National Pork Board","ror":"https://ror.org/00safct20"},{"id":"https://openalex.org/F4320313885","display_name":"Zoetis","ror":null},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2178762865.pdf","grobid_xml":"https://content.openalex.org/works/W2178762865.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W74387004","https://openalex.org/W1631250427","https://openalex.org/W1718946616","https://openalex.org/W1971533405","https://openalex.org/W1982022033","https://openalex.org/W1982975148","https://openalex.org/W1987767450","https://openalex.org/W1997082970","https://openalex.org/W2015050458","https://openalex.org/W2016707632","https://openalex.org/W2020460921","https://openalex.org/W2021474483","https://openalex.org/W2025371271","https://openalex.org/W2026315775","https://openalex.org/W2026431947","https://openalex.org/W2034452944","https://openalex.org/W2035521125","https://openalex.org/W2040997766","https://openalex.org/W2044695442","https://openalex.org/W2049955797","https://openalex.org/W2061647372","https://openalex.org/W2062915300","https://openalex.org/W2067088705","https://openalex.org/W2068043688","https://openalex.org/W2072425808","https://openalex.org/W2080266587","https://openalex.org/W2082359168","https://openalex.org/W2084481314","https://openalex.org/W2086381423","https://openalex.org/W2087326716","https://openalex.org/W2095543724","https://openalex.org/W2095666785","https://openalex.org/W2104581392","https://openalex.org/W2116355510","https://openalex.org/W2117274549","https://openalex.org/W2125635123","https://openalex.org/W2130083775","https://openalex.org/W2130486201","https://openalex.org/W2132241785","https://openalex.org/W2135437517","https://openalex.org/W2148562877","https://openalex.org/W2152976668","https://openalex.org/W2155044423","https://openalex.org/W2155842880","https://openalex.org/W2159358845","https://openalex.org/W2160519869","https://openalex.org/W2161905225","https://openalex.org/W2168457616","https://openalex.org/W2169547726"],"related_works":["https://openalex.org/W7100685568","https://openalex.org/W2095543724","https://openalex.org/W2771615296","https://openalex.org/W63429999","https://openalex.org/W2146106904","https://openalex.org/W2356898755","https://openalex.org/W2045833440","https://openalex.org/W6983393947","https://openalex.org/W4409439722","https://openalex.org/W8674852"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Mesenchymal":[1],"stem":[2],"(stromal)":[3],"cells":[4,168,191,201,278,301],"(MSCs)":[5],"possess":[6,268],"self-renewal,":[7,116],"differentiation":[8,119,272],"and":[9,12,22,25,79,82,118,142,155,157,165,171,176,186,192,194,202,206,216,233,259,273,302],"immunoregulatory":[10,184],"properties,":[11],"therefore":[13],"are":[14,34,72],"being":[15],"evaluated":[16],"as":[17,60,65,86,281],"cellular":[18,96],"therapy":[19,61,97],"for":[20,26,62,98],"inflammatory":[21],"autoimmune":[23],"diseases,":[24],"tissue":[27,303],"repair.":[28],"MSCs":[29,40,55,104,134,252,291],"isolated":[30,103,135,255],"from":[31,105,136,256],"bone":[32,38,68],"marrow":[33],"extensively":[35],"studied.":[36],"Besides":[37],"marrow,":[39],"have":[41],"been":[42],"identified":[43],"in":[44,76,145,229,269,292,305],"almost":[45],"all":[46],"organs":[47],"of":[48,109,121,128,161,189,210,225,235,245,289,309],"the":[49,52,106,115,126,159,208,223,241,287,294],"body":[50],"including":[51],"lungs.":[53],"Lung-derived":[54],"may":[56,84,279],"be":[57,254],"more":[58],"effective":[59],"lung":[63,258,266,290,311],"diseases":[64],"compared":[66],"to":[67,74,93,264,285],"marrow-derived":[69],"MSCs.":[70],"Pigs":[71],"similar":[73,263],"humans":[75],"anatomy,":[77],"physiology":[78],"immunological":[80],"responses,":[81],"thus":[83],"serve":[85,280],"a":[87,282,306],"useful":[88],"large":[89],"animal":[90],"preclinical":[91],"model":[92,283,308],"study":[94],"potential":[95,120],"human":[99,180,265,310],"diseases.":[100,312],"METHODS:":[101],"We":[102,113,123],"lungs":[107,138],"(L-MSCs)":[108],"4-6-week-old":[110],"germ-free":[111],"pigs.":[112],"determined":[114],"proliferation":[117,188],"L-MSCs.":[122,132,246],"also":[124],"examined":[125],"mechanisms":[127],"immunoregulation":[129],"by":[130,199,218],"porcine":[131,137,257],"RESULTS:":[133],"showed":[139],"spindle-shaped":[140],"morphology":[141],"proliferated":[143],"actively":[144],"culture.":[146],"Porcine":[147],"L-MSCs":[148,182,221],"expressed":[149],"mesenchymal":[150],"markers":[151,163],"CD29,":[152],"CD44,":[153],"CD90":[154],"CD105":[156],"lacked":[158],"expression":[160],"hematopoietic":[162],"CD34":[164],"CD45.":[166],"These":[167],"were":[169],"multipotent":[170],"differentiated":[172],"into":[173],"adipocytes,":[174],"osteocytes":[175],"epithelial":[177,300],"cells.":[178,220],"Like":[179],"MSCs,":[181,267],"possessed":[183],"properties":[185],"inhibited":[187],"T":[190,200,219],"interferon-\u03b3":[193],"tumor":[195],"necrosis":[196],"factor-\u03b1":[197],"production":[198,209,224],"dendritic":[203],"cells,":[204,262],"respectively,":[205],"increased":[207],"T-helper":[211],"2":[212],"cytokines":[213],"interleukin":[214],"(IL)-4":[215],"IL-13":[217],"induced":[222],"prostaglandin":[226],"E2":[227],"(PGE2)":[228],"MSC-T":[230],"cell":[231],"co-cultures":[232],"inhibition":[234],"PGE2":[236],"significantly":[237],"restored":[238],"(not":[239],"completely)":[240],"immune":[242,295],"modulatory":[243],"effects":[244],"CONCLUSIONS:":[247],"Here,":[248],"we":[249],"demonstrate":[250],"that":[251,260],"can":[253],"these":[261,277],"vitro":[270],"proliferation,":[271],"immunomodulatory":[274],"functions.":[275],"Thus,":[276],"system":[284],"evaluate":[286],"contribution":[288],"modulating":[293],"response,":[296],"interactions":[297],"with":[298],"resident":[299],"repair":[304],"pig":[307]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}