{"id":"https://openalex.org/W2178678422","doi":"https://doi.org/10.1097/mop.0000000000000296","title":"Genetic discoveries and treatment advances in neuroblastoma","display_name":"Genetic discoveries and treatment advances in neuroblastoma","publication_year":2015,"publication_date":"2015-12-02","ids":{"openalex":"https://openalex.org/W2178678422","doi":"https://doi.org/10.1097/mop.0000000000000296","mag":"2178678422","pmid":"https://pubmed.ncbi.nlm.nih.gov/26576010","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4731097"},"language":"en","primary_location":{"id":"doi:10.1097/mop.0000000000000296","doi":"https://doi.org/10.1097/mop.0000000000000296","is_oa":false,"landing_page_url":"https://doi.org/10.1097/mop.0000000000000296","pdf_url":null,"source":{"id":"https://openalex.org/S204673346","display_name":"Current Opinion in Pediatrics","issn_l":"1040-8703","issn":["1040-8703","1080-8116","1531-698X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Pediatrics","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4731097","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036062620","display_name":"Rochelle Bagatell","orcid":"https://orcid.org/0000-0002-5729-8819","observed_orcids":["https://orcid.org/0000-0002-5729-8819"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I4210136340","display_name":"Comer Children's Hospital","ror":"https://ror.org/02y96rp12","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210136340"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rochelle Bagatell","raw_affiliation_strings":["aDivision of Oncology, The Children's Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania bDepartment of Pediatrics, Comer Children's Hospital, University of Chicago, Chicago, Illinois, USA","Division of Oncology, The Children's Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"aDivision of Oncology, The Children's Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania bDepartment of Pediatrics, Comer Children's Hospital, University of Chicago, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I40347166","https://openalex.org/I4210136340","https://openalex.org/I79576946"]},{"raw_affiliation_string":"Division of Oncology, The Children's Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035030496","display_name":"Susan Lerner Cohn","orcid":"https://orcid.org/0000-0001-5749-7650","observed_orcids":["https://orcid.org/0000-0001-5749-7650"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I4210136340","display_name":"Comer Children's Hospital","ror":"https://ror.org/02y96rp12","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210136340"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Susan L. Cohn","raw_affiliation_strings":["Department of Pediatrics, Comer Children's Hospital, University of Chicago, Chicago, Illinois, USA","to Susan L. Cohn, MD, Department of Pediatrics, University of Chicago 900 East, 57th Street KCBD Rm 5100, Chicago, IL 60637, USA. Tel: +1 773 702 2571; e-mail: [email\u00a0protected]","e-mail: [email\u00a0protected]","to Susan L. Cohn, MD, Department of Pediatrics, University of Chicago 900 East, 57th Street KCBD Rm 5100, Chicago, IL 60637, USA. Tel: +1 773 702 2571"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Comer Children's Hospital, University of Chicago, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I40347166","https://openalex.org/I4210136340"]},{"raw_affiliation_string":"to Susan L. Cohn, MD, Department of Pediatrics, University of Chicago 900 East, 57th Street KCBD Rm 5100, Chicago, IL 60637, USA. Tel: +1 773 702 2571; e-mail: [email\u00a0protected]","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"e-mail: [email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"to Susan L. Cohn, MD, Department of Pediatrics, University of Chicago 900 East, 57th Street KCBD Rm 5100, Chicago, IL 60637, USA. Tel: +1 773 702 2571","institution_ids":["https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5035030496"],"corresponding_institution_ids":["https://openalex.org/I40347166","https://openalex.org/I4210136340"],"apc_list":null,"apc_paid":null,"fwci":0.7051,"has_fulltext":false,"cited_by_count":56,"citation_normalized_percentile":{"value":0.57649667,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"28","issue":"1","first_page":"19","last_page":"25"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroblastoma","display_name":"neuroblastoma","score":1.0},{"id":"https://openalex.org/keywords/somatic-alterations","display_name":"somatic alterations","score":0.6489999890327454},{"id":"https://openalex.org/keywords/cancer-genetics","display_name":"cancer genetics","score":0.48500001430511475},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.875},{"id":"https://openalex.org/keywords/dna-copy-number-alterations","display_name":"DNA copy number alterations","score":0.7879999876022339},{"id":"https://openalex.org/keywords/molecular-classification","display_name":"molecular classification","score":0.6230000257492065},{"id":"https://openalex.org/keywords/prognosis-prediction","display_name":"outcome prediction","score":0.8999999761581421},{"id":"https://openalex.org/keywords/relapsed-neuroblastoma","display_name":"relapsed neuroblastoma","score":0.8579999804496765},{"id":"https://openalex.org/keywords/actionable-mutations","display_name":"actionable mutations","score":0.9660000205039978},{"id":"https://openalex.org/keywords/systemic-radiotherapy","display_name":"systemic radiotherapy","score":0.7400000095367432},{"id":"https://openalex.org/keywords/small-molecule-inhibitors","display_name":"small molecule inhibitors","score":0.5339999794960022}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7042423486709595},{"id":"https://openalex.org/C2776715637","wikidata":"https://www.wikidata.org/wiki/Q938205","display_name":"Neuroblastoma","level":3,"score":0.6764665246009827},{"id":"https://openalex.org/C3020404979","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk stratification","level":2,"score":0.604877233505249},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.587289571762085},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5028511881828308},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.4657578766345978},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.42715612053871155},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4200328588485718},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.41126465797424316},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31818222999572754},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2562830448150635},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20541304349899292},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16669192910194397},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1459667682647705},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1097/mop.0000000000000296","doi":"https://doi.org/10.1097/mop.0000000000000296","is_oa":false,"landing_page_url":"https://doi.org/10.1097/mop.0000000000000296","pdf_url":null,"source":{"id":"https://openalex.org/S204673346","display_name":"Current Opinion in Pediatrics","issn_l":"1040-8703","issn":["1040-8703","1080-8116","1531-698X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Pediatrics","raw_type":"journal-article"},{"id":"pmid:26576010","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26576010","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in pediatrics","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:4143159","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4731097","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4731097","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4731097","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Curr Opin Pediatr","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:4143159","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4731097","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3733707689","display_name":"Re-Engineering Translational Research at the University of Chicago","funder_award_id":"UL1TR000430","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5094520579","display_name":"COG NCTN Network Group Operations Center","funder_award_id":"U10CA180886","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G77358762","display_name":"Children's Oncology Group Chair's Grant","funder_award_id":"U10CA098543","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W31569885","https://openalex.org/W1607569714","https://openalex.org/W1859714693","https://openalex.org/W1966935624","https://openalex.org/W1967139222","https://openalex.org/W1968530152","https://openalex.org/W1973422796","https://openalex.org/W1999080932","https://openalex.org/W2013276712","https://openalex.org/W2015155629","https://openalex.org/W2017277108","https://openalex.org/W2024963052","https://openalex.org/W2028935623","https://openalex.org/W2033285652","https://openalex.org/W2033632794","https://openalex.org/W2070595468","https://openalex.org/W2075180535","https://openalex.org/W2079957854","https://openalex.org/W2086000896","https://openalex.org/W2095695060","https://openalex.org/W2097120541","https://openalex.org/W2108541596","https://openalex.org/W2110788947","https://openalex.org/W2112612051","https://openalex.org/W2116365316","https://openalex.org/W2118071133","https://openalex.org/W2122250312","https://openalex.org/W2126352399","https://openalex.org/W2129688634","https://openalex.org/W2130465135","https://openalex.org/W2131776400","https://openalex.org/W2132546867","https://openalex.org/W2136574608","https://openalex.org/W2138805078","https://openalex.org/W2138983295","https://openalex.org/W2140360759","https://openalex.org/W2145836134","https://openalex.org/W2147800896","https://openalex.org/W2149034978","https://openalex.org/W2150148604","https://openalex.org/W2151322893","https://openalex.org/W2152420890","https://openalex.org/W2161798205","https://openalex.org/W2163651972","https://openalex.org/W2164349814","https://openalex.org/W2168064716","https://openalex.org/W2170379053","https://openalex.org/W2213548494","https://openalex.org/W2219761119","https://openalex.org/W2323539794"],"related_works":["https://openalex.org/W2901513667","https://openalex.org/W2139558183","https://openalex.org/W2097120541","https://openalex.org/W2002695625","https://openalex.org/W2164143957","https://openalex.org/W2069356699","https://openalex.org/W2909088478","https://openalex.org/W2101953505","https://openalex.org/W2037017061","https://openalex.org/W4211031423"],"abstract_inverted_index":{"PURPOSE":[0],"OF":[1],"REVIEW:":[2],"Major":[3],"advances":[4],"in":[5,20,28,66,139,146,180],"our":[6],"understanding":[7],"of":[8,12,54,69,97,155,162,177],"the":[9,15,34,50,60,67,153,174,183],"genetic":[10],"basis":[11],"neuroblastoma,":[13],"and":[14,31,48,52,102,115,129,142],"role":[16],"somatic":[17],"alterations":[18],"play":[19],"driving":[21],"tumor":[22,148],"growth,":[23],"have":[24,32,150],"led":[25,151],"to":[26,152,185],"improvements":[27],"risk-stratified":[29],"therapy":[30,130],"provided":[33],"rationale":[35],"for":[36,81,93],"targeted":[37,123,131],"therapies.":[38],"In":[39],"this":[40,94],"review,":[41],"we":[42],"highlight":[43],"current":[44],"risk-based":[45,75],"treatment":[46,68,76,117,164],"approaches":[47],"discuss":[49],"opportunities":[51],"challenges":[53],"translating":[55],"recent":[56,143],"genomic":[57,144],"discoveries":[58,145],"into":[59,106],"clinic.":[61],"RECENT":[62],"FINDINGS:":[63],"Significant":[64],"progress":[65],"neuroblastoma":[70,107,181],"has":[71,79,182],"been":[72],"realized":[73],"using":[74],"strategies.":[77],"Outcome":[78],"improved":[80],"all":[82],"patients,":[83],"including":[84],"those":[85],"classified":[86],"as":[87],"high-risk,":[88],"although":[89],"survival":[90],"remains":[91],"poor":[92],"cohort.":[95],"Integration":[96],"whole-genome":[98,168],"DNA":[99],"copy":[100],"number":[101],"comprehensive":[103],"molecular":[104,175],"profiles":[105,169],"classification":[108],"systems":[109],"will":[110],"allow":[111],"more":[112],"precise":[113],"prognostication":[114],"refined":[116,163],"assignment.":[118],"Promising":[119],"treatments":[120],"that":[121,172],"include":[122],"systemic":[124],"radiotherapy,":[125],"pathway-targeted":[126],"small":[127],"molecules,":[128],"at":[132],"cell":[133],"surface":[134],"molecules":[135],"are":[136],"being":[137],"evaluated":[138],"clinical":[140],"trials,":[141],"relapsed":[147],"samples":[149],"identification":[154],"new":[156],"actionable":[157],"mutations.":[158],"SUMMARY:":[159],"The":[160],"integration":[161],"stratification":[165],"based":[166],"on":[167],"with":[170,189],"therapeutics":[171],"target":[173],"drivers":[176],"malignant":[178],"behavior":[179],"potential":[184],"dramatically":[186],"improve":[187],"survival,":[188],"decreased":[190],"toxicity.":[191]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":6}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}