{"id":"https://openalex.org/W2178648698","doi":"https://doi.org/10.1146/annurev.ph.41.030179.003451","title":"The Crossbridge Theory","display_name":"The Crossbridge Theory","publication_year":1979,"publication_date":"1979-10-01","ids":{"openalex":"https://openalex.org/W2178648698","doi":"https://doi.org/10.1146/annurev.ph.41.030179.003451","mag":"2178648698","pmid":"https://pubmed.ncbi.nlm.nih.gov/373607"},"language":"en","primary_location":{"id":"doi:10.1146/annurev.ph.41.030179.003451","doi":"https://doi.org/10.1146/annurev.ph.41.030179.003451","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev.ph.41.030179.003451","pdf_url":null,"source":{"id":"https://openalex.org/S196366644","display_name":"Annual Review of Physiology","issn_l":"0066-4278","issn":["0066-4278","1545-1585"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110112919","display_name":"Richard T. Tregear","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R T Tregear","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5090645838","display_name":"Steven Baxter Marston","orcid":"https://orcid.org/0000-0001-6054-6070","observed_orcids":["https://orcid.org/0000-0001-6054-6070","https://orcid.org/0000-0002-1162-4447"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S B Marston","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.1504,"has_fulltext":false,"cited_by_count":52,"citation_normalized_percentile":{"value":0.87927412,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"41","issue":"1","first_page":"723","last_page":"736"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.9189000129699707,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.9189000129699707,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.023000000044703484,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/macrophage-polarization","display_name":"macrophage polarization","score":0.9210000038146973},{"id":"https://openalex.org/keywords/macrophage-activation","display_name":"macrophage activation","score":0.8889999985694885},{"id":"https://openalex.org/keywords/macrophage-plasticity","display_name":"macrophage plasticity","score":0.9549999833106995},{"id":"https://openalex.org/keywords/tissue-damage-signals","display_name":"tissue damage signals","score":0.4749999940395355},{"id":"https://openalex.org/keywords/microbial-signals","display_name":"microbial signals","score":0.6129999756813049}],"concepts":[{"id":"https://openalex.org/C2776329151","wikidata":"https://www.wikidata.org/wiki/Q4683968","display_name":"CrossBridge","level":3,"score":0.922958493232727},{"id":"https://openalex.org/C2776682551","wikidata":"https://www.wikidata.org/wiki/Q21072584","display_name":"Macrophage polarization","level":4,"score":0.602440357208252},{"id":"https://openalex.org/C205049153","wikidata":"https://www.wikidata.org/wiki/Q2698605","display_name":"Polarization (electrochemistry)","level":2,"score":0.5109578967094421},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.4263143539428711},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3719382882118225},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3564460277557373},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32101625204086304},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28608840703964233},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10747358202934265},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.08984425663948059},{"id":"https://openalex.org/C6997183","wikidata":"https://www.wikidata.org/wiki/Q271727","display_name":"Myosin","level":2,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000244","descriptor_name":"Adenosine Diphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009218","descriptor_name":"Myosins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009218","descriptor_name":"Myosins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1146/annurev.ph.41.030179.003451","doi":"https://doi.org/10.1146/annurev.ph.41.030179.003451","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev.ph.41.030179.003451","pdf_url":null,"source":{"id":"https://openalex.org/S196366644","display_name":"Annual Review of Physiology","issn_l":"0066-4278","issn":["0066-4278","1545-1585"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Physiology","raw_type":"journal-article"},{"id":"pmid:373607","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/373607","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual review of physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W124285527","https://openalex.org/W637077988","https://openalex.org/W789458867","https://openalex.org/W1533173993","https://openalex.org/W1563356369","https://openalex.org/W1965337436","https://openalex.org/W1968639904","https://openalex.org/W1968778374","https://openalex.org/W1969301033","https://openalex.org/W1970305288","https://openalex.org/W1971819609","https://openalex.org/W1972506441","https://openalex.org/W1973038113","https://openalex.org/W1974927543","https://openalex.org/W1975714515","https://openalex.org/W1977701526","https://openalex.org/W1980685237","https://openalex.org/W1984850967","https://openalex.org/W1987034229","https://openalex.org/W1987589427","https://openalex.org/W1990901750","https://openalex.org/W1993815496","https://openalex.org/W1997246410","https://openalex.org/W1999796721","https://openalex.org/W2002093894","https://openalex.org/W2002922777","https://openalex.org/W2006998430","https://openalex.org/W2009467733","https://openalex.org/W2017651513","https://openalex.org/W2020436698","https://openalex.org/W2023542738","https://openalex.org/W2026145805","https://openalex.org/W2033028307","https://openalex.org/W2035304834","https://openalex.org/W2042868213","https://openalex.org/W2045012506","https://openalex.org/W2046091868","https://openalex.org/W2050394193","https://openalex.org/W2051774176","https://openalex.org/W2053788196","https://openalex.org/W2055223288","https://openalex.org/W2058628872","https://openalex.org/W2067190245","https://openalex.org/W2070122055","https://openalex.org/W2075804785","https://openalex.org/W2078288389","https://openalex.org/W2086214093","https://openalex.org/W2087574343","https://openalex.org/W2089114409","https://openalex.org/W2090509500","https://openalex.org/W2091275330","https://openalex.org/W2102582198","https://openalex.org/W2127917887","https://openalex.org/W2128621894","https://openalex.org/W2137884062","https://openalex.org/W2139485132","https://openalex.org/W2140994672","https://openalex.org/W2142600764","https://openalex.org/W2145953691","https://openalex.org/W2169400659","https://openalex.org/W2172329772","https://openalex.org/W2178239314","https://openalex.org/W2242855238","https://openalex.org/W2330764451"],"related_works":["https://openalex.org/W4239597882","https://openalex.org/W4249461399","https://openalex.org/W4247495352","https://openalex.org/W4245825632","https://openalex.org/W2407555235","https://openalex.org/W2113671769","https://openalex.org/W4250065240","https://openalex.org/W4235626244","https://openalex.org/W4245608625","https://openalex.org/W4245431668"],"abstract_inverted_index":{"Macrophage":[0],"polarization":[1],"refers":[2],"to":[3,26],"how":[4],"macrophages":[5,22],"have":[6],"been":[7],"activated":[8],"at":[9],"a":[10],"given":[11],"point":[12],"in":[13],"space":[14],"and":[15,37],"time.":[16],"Polarization":[17],"is":[18],"not":[19],"fixed,":[20],"as":[21,31],"are":[23],"sufficiently":[24],"plastic":[25],"integrate":[27],"multiple":[28],"signals,":[29],"such":[30],"those":[32],"from":[33],"microbes,":[34],"damaged":[35],"tissues,":[36],"...Read":[38],"More":[39]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}