{"id":"https://openalex.org/W2178614686","doi":null,"title":"siRNA ET microRNA : BIOGENESE, MECANISME ET FONCTIONS","display_name":"siRNA ET microRNA : BIOGENESE, MECANISME ET FONCTIONS","publication_year":2007,"publication_date":"2007-12-01","ids":{"openalex":"https://openalex.org/W2178614686","mag":"2178614686"},"language":"fr","primary_location":{"id":"pmh:oai:doaj.org/article:60398904850b4c3ba1fbfac4a48d2f9f","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/60398904850b4c3ba1fbfac4a48d2f9f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Analele \u015etiin\u0163ifice Ale Universit\u0103\u0163ii Alexandru Ioan Cuza din Ia\u0219i,Sectiunea II A : Genetica si Biologie Moleculara, Vol 8, Iss 2 (2007)","raw_type":"article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doaj.org/article/60398904850b4c3ba1fbfac4a48d2f9f","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003374394","display_name":"Mariana Varna","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mariana Varna","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5061814437","display_name":"Vlad Artenie","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vlad Artenie","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10184","display_name":"Plant Molecular Biology Research","score":0.45559999346733093,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10184","display_name":"Plant Molecular Biology Research","score":0.45559999346733093,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.34549999237060547,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.147599995136261,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sirna","display_name":"siRNA","score":0.843999981880188},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.9890000224113464},{"id":"https://openalex.org/keywords/rna-interference","display_name":"RNA interference","score":0.9919999837875366},{"id":"https://openalex.org/keywords/gene-silencing","display_name":"gene silencing","score":0.8379999995231628},{"id":"https://openalex.org/keywords/post-transcriptional-regulation","display_name":"post-transcriptional regulation","score":0.8899999856948853},{"id":"https://openalex.org/keywords/sirna-biogenesis","display_name":"siRNA biogenesis","score":0.8069999814033508},{"id":"https://openalex.org/keywords/antiviral-defense","display_name":"antiviral defense","score":0.9380000233650208},{"id":"https://openalex.org/keywords/endogenous-micrornas","display_name":"endogenous microRNAs","score":0.6779999732971191},{"id":"https://openalex.org/keywords/double-stranded-rna","display_name":"double-stranded RNA","score":0.6460000276565552}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43367600440979004},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33035579323768616}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:doaj.org/article:60398904850b4c3ba1fbfac4a48d2f9f","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/60398904850b4c3ba1fbfac4a48d2f9f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Analele \u015etiin\u0163ifice Ale Universit\u0103\u0163ii Alexandru Ioan Cuza din Ia\u0219i,Sectiunea II A : Genetica si Biologie Moleculara, Vol 8, Iss 2 (2007)","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:doaj.org/article:60398904850b4c3ba1fbfac4a48d2f9f","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/60398904850b4c3ba1fbfac4a48d2f9f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Analele \u015etiin\u0163ifice Ale Universit\u0103\u0163ii Alexandru Ioan Cuza din Ia\u0219i,Sectiunea II A : Genetica si Biologie Moleculara, Vol 8, Iss 2 (2007)","raw_type":"article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":65,"referenced_works":["https://openalex.org/W144423133","https://openalex.org/W1605264168","https://openalex.org/W1611419331","https://openalex.org/W1643938048","https://openalex.org/W1647075334","https://openalex.org/W1920303762","https://openalex.org/W1963743411","https://openalex.org/W1966116761","https://openalex.org/W1972937465","https://openalex.org/W1976027235","https://openalex.org/W1980269624","https://openalex.org/W1990645475","https://openalex.org/W1994873854","https://openalex.org/W1996163490","https://openalex.org/W1997424007","https://openalex.org/W2000093333","https://openalex.org/W2002212941","https://openalex.org/W2004812096","https://openalex.org/W2015926921","https://openalex.org/W2017991840","https://openalex.org/W2018403717","https://openalex.org/W2027862889","https://openalex.org/W2030489111","https://openalex.org/W2042673698","https://openalex.org/W2044543540","https://openalex.org/W2045812968","https://openalex.org/W2047147668","https://openalex.org/W2050298867","https://openalex.org/W2060711522","https://openalex.org/W2063729111","https://openalex.org/W2063732648","https://openalex.org/W2067928188","https://openalex.org/W2072543946","https://openalex.org/W2072697431","https://openalex.org/W2080407932","https://openalex.org/W2082213106","https://openalex.org/W2086439640","https://openalex.org/W2096501973","https://openalex.org/W2097595476","https://openalex.org/W2103211592","https://openalex.org/W2103809350","https://openalex.org/W2117991391","https://openalex.org/W2124248783","https://openalex.org/W2126426563","https://openalex.org/W2126630077","https://openalex.org/W2127022091","https://openalex.org/W2127497651","https://openalex.org/W2134074192","https://openalex.org/W2135135539","https://openalex.org/W2135314242","https://openalex.org/W2138664009","https://openalex.org/W2139818451","https://openalex.org/W2140415861","https://openalex.org/W2140716778","https://openalex.org/W2143978130","https://openalex.org/W2150809319","https://openalex.org/W2155612281","https://openalex.org/W2160467221","https://openalex.org/W2163199119","https://openalex.org/W2164194749","https://openalex.org/W2165430941","https://openalex.org/W2171269761","https://openalex.org/W2292621739","https://openalex.org/W2413851143","https://openalex.org/W7033783247"],"related_works":["https://openalex.org/W7015115264","https://openalex.org/W2914679193","https://openalex.org/W620771892","https://openalex.org/W2095952224","https://openalex.org/W2997811184","https://openalex.org/W6992367470","https://openalex.org/W6903405372","https://openalex.org/W2113282396","https://openalex.org/W6922051179","https://openalex.org/W2105136608"],"abstract_inverted_index":{"L\u2019ARN":[0],"interf\u00e9rence":[1],"est":[2],"un":[3,21,59],"m\u00e9canisme":[4,54],"hautement":[5],"conserv\u00e9":[6],"entre":[7],"esp\u00e8ces":[8],"et":[9,48,90,136,142],"permet":[10],"d\u2019\u00e9teindre":[11],"l\u2019expression":[12,133],"\\nd\u2019un":[13],"g\u00e8ne":[14],"de":[15,132,145],"mani\u00e8re":[16],"s\u00e9quence":[17,84],"sp\u00e9cifique":[18,85],"en":[19],"utilisant":[20],"ARN":[22,31],"double":[23,101],"brin.":[24],"Le":[25],"r\u00f4le":[26],"naturel":[27],"du":[28,53],"silencing":[29],"par":[30,56,121],"semble":[32],"\\n\u00eatre":[33],"la":[34,42,63,130,140],"r\u00e9gulation":[35,131],"fine":[36],"des":[37,65,73,82,114,117,134,150],"g\u00e8nes":[38,66,135],"mais":[39],"aussi":[40],"dans":[41,62,68,154],"d\u00e9fense":[43],"contre":[44],"les":[45,49,88,91,155,158],"\u00e9l\u00e9ments":[46],"transposables":[47],"virus.":[50],"\\nLa":[51],"d\u00e9couverte":[52],"d\u2019interf\u00e9rence":[55],"l\u2019ARN":[57],"repr\u00e9sente":[58],"saut":[60],"majeur":[61],"recherche":[64],"cibles":[67],"\\ndiff\u00e9rentes":[69],"maladies.":[70],"\\nDeux":[71],"classes":[72],"petites":[74],"mol\u00e9cules":[75,152],"d\u2019ARN":[76,103],"ont":[77],"\u00e9t\u00e9":[78],"trouv\u00e9es":[79],"comme":[80],"\u00e9tant":[81],"r\u00e9gulateurs":[83],"posttranscriptionnelle":[86],":":[87],"siRNA":[89,95],"microRNA":[92],"(miRNA).":[93],"Les":[94,147],"sont":[96,127,149],"produits":[97],"\u00e0":[98,112,139],"partir":[99,113],"d\u2019un":[100],"brin":[102],"qui":[104],"\\nest":[105],"synth\u00e9tis\u00e9":[106],"in":[107,110],"vitro":[108],"ou":[109,116],"vivo":[111],"virus":[115],"s\u00e9quences":[118],"r\u00e9p\u00e9titives":[119],"introduites":[120],"ing\u00e9nierie":[122],"g\u00e9n\u00e9tique.":[123],"\\nPlusieurs":[124],"miRNA":[125,148],"endog\u00e8nes":[126],"programm\u00e9s":[128],"pour":[129],"ainsi":[137],"participent":[138],"\\ncroissance":[141],"le":[143],"d\u00e9veloppement":[144],"l\u2019organisme.":[146],"importantes":[151],"r\u00e9gulatrices":[153],"plantes":[156],"\\net":[157],"animaux":[159]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
