{"id":"https://openalex.org/W2178496109","doi":null,"title":"The Association between Polymorphismsin Insulin and Obesity Related Genesand Risk of Colorectal Cancer.","display_name":"The Association between Polymorphismsin Insulin and Obesity Related Genesand Risk of Colorectal Cancer.","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2178496109","mag":"2178496109","pmid":"https://pubmed.ncbi.nlm.nih.gov/25250132","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4142938"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:3142502","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4142938","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4142938","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091836453","display_name":"Mostafa Rezaei\u2013Tavirani","orcid":"https://orcid.org/0000-0003-1767-7475","observed_orcids":["https://orcid.org/0000-0003-1767-7475","https://orcid.org/0000-0002-5284-3179"]},"institutions":[{"id":"https://openalex.org/I48379061","display_name":"Shahid Beheshti University","ror":"https://ror.org/0091vmj44","country_code":"IR","type":"education","lineage":["https://openalex.org/I48379061"]},{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mostafa Rezaei-Tavirani","raw_affiliation_strings":["Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I48379061","https://openalex.org/I58048189"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Akram Safaei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I48379061","display_name":"Shahid Beheshti University","ror":"https://ror.org/0091vmj44","country_code":"IR","type":"education","lineage":["https://openalex.org/I48379061"]},{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Akram Safaei","raw_affiliation_strings":["Gastroentrology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastroentrology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I48379061","https://openalex.org/I58048189"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004425214","display_name":"Mohammad Reza Zali","orcid":"https://orcid.org/0000-0002-9027-4560","observed_orcids":["https://orcid.org/0000-0002-9027-4560"]},"institutions":[{"id":"https://openalex.org/I48379061","display_name":"Shahid Beheshti University","ror":"https://ror.org/0091vmj44","country_code":"IR","type":"education","lineage":["https://openalex.org/I48379061"]},{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mohammad Reza Zali","raw_affiliation_strings":["Gastroentrology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastroentrology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I48379061","https://openalex.org/I58048189"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3614,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.83299006,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"6","issue":"4","first_page":"179","last_page":"85"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.5317000150680542,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.5317000150680542,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.2741999924182892,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.07029999792575836,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9980000257492065},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.8880000114440918},{"id":"https://openalex.org/keywords/obesity-genes","display_name":"obesity-related genes","score":0.8360000252723694},{"id":"https://openalex.org/keywords/insulin-like-growth-factor","display_name":"insulin-like growth factor","score":0.8159999847412109},{"id":"https://openalex.org/keywords/insulin-receptor","display_name":"insulin receptor","score":0.9760000109672546},{"id":"https://openalex.org/keywords/adiponectin","display_name":"adiponectin","score":0.902999997138977},{"id":"https://openalex.org/keywords/leptin","display_name":"leptin","score":0.8240000009536743},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.6039999723434448},{"id":"https://openalex.org/keywords/cancer-risk","display_name":"cancer risk","score":0.6940000057220459}],"concepts":[{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.8868392705917358},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8512401580810547},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.7384753823280334},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6600703001022339},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5397603511810303},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.48980045318603516},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4478694200515747},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3713400959968567},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11187750101089478}],"mesh":[],"locations_count":5,"locations":[{"id":"pmh:oai:europepmc.org:3142502","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4142938","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4142938","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4142938","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iran J Cancer Prev","raw_type":"Text"},{"id":"pmid:25250132","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25250132","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iranian journal of cancer prevention","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.773.8249","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.773.8249","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/7e/c3/IJCP-06-179.PMC4142938.pdf","raw_type":"text"},{"id":"mag:2178496109","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25250132","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3142502","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4142938","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":81,"referenced_works":["https://openalex.org/W1512335967","https://openalex.org/W1517245545","https://openalex.org/W1525361117","https://openalex.org/W1555554287","https://openalex.org/W1751894264","https://openalex.org/W1902678347","https://openalex.org/W1968805253","https://openalex.org/W1971452427","https://openalex.org/W1978281808","https://openalex.org/W1978641258","https://openalex.org/W1988560784","https://openalex.org/W1992092910","https://openalex.org/W1993415234","https://openalex.org/W1994256100","https://openalex.org/W1995174093","https://openalex.org/W1997978122","https://openalex.org/W1998122962","https://openalex.org/W2022474551","https://openalex.org/W2022595644","https://openalex.org/W2027586254","https://openalex.org/W2029904263","https://openalex.org/W2030159961","https://openalex.org/W2032455797","https://openalex.org/W2034773448","https://openalex.org/W2042580075","https://openalex.org/W2044251727","https://openalex.org/W2044643325","https://openalex.org/W2051051060","https://openalex.org/W2053401836","https://openalex.org/W2056352776","https://openalex.org/W2056854271","https://openalex.org/W2057418848","https://openalex.org/W2057828033","https://openalex.org/W2058595652","https://openalex.org/W2059751368","https://openalex.org/W2061320466","https://openalex.org/W2063849708","https://openalex.org/W2068961038","https://openalex.org/W2070001214","https://openalex.org/W2073533462","https://openalex.org/W2077296319","https://openalex.org/W2080191453","https://openalex.org/W2089171551","https://openalex.org/W2089415609","https://openalex.org/W2093716255","https://openalex.org/W2096371251","https://openalex.org/W2104559155","https://openalex.org/W2110441026","https://openalex.org/W2111843196","https://openalex.org/W2112556479","https://openalex.org/W2113664327","https://openalex.org/W2117530385","https://openalex.org/W2119550028","https://openalex.org/W2128412799","https://openalex.org/W2128986538","https://openalex.org/W2134359224","https://openalex.org/W2135771868","https://openalex.org/W2136522433","https://openalex.org/W2138750223","https://openalex.org/W2141163594","https://openalex.org/W2143145174","https://openalex.org/W2143551572","https://openalex.org/W2144224364","https://openalex.org/W2144601959","https://openalex.org/W2144833292","https://openalex.org/W2146562835","https://openalex.org/W2146934602","https://openalex.org/W2148910409","https://openalex.org/W2150081825","https://openalex.org/W2150262444","https://openalex.org/W2157109399","https://openalex.org/W2160573743","https://openalex.org/W2160835537","https://openalex.org/W2162750087","https://openalex.org/W2165139442","https://openalex.org/W2167596697","https://openalex.org/W2169000886","https://openalex.org/W2172462801","https://openalex.org/W2201110441","https://openalex.org/W2222409048","https://openalex.org/W4244922393"],"related_works":["https://openalex.org/W7100069278","https://openalex.org/W4389619131","https://openalex.org/W1751894264","https://openalex.org/W2122473859","https://openalex.org/W2164875559","https://openalex.org/W4300336440","https://openalex.org/W1953239028","https://openalex.org/W1981642992","https://openalex.org/W4377293247","https://openalex.org/W1882512877"],"abstract_inverted_index":{"Colon":[0,20],"cancer":[1,4,21,27],"is":[2,11,22,37],"the":[3,6,14,23,31,71],"of":[5,17,47,61,73,75,91],"large":[7],"intestine":[8],"(colon),":[9],"which":[10],"located":[12],"in":[13,28,33,43,65,89],"lower":[15],"part":[16],"digestive":[18],"system.":[19],"third":[24],"most":[25],"common":[26],"men":[29],"and":[30,59,77,87],"second":[32],"women":[34],"worldwide.Genetic":[35],"background":[36],"thought":[38],"to":[39],"play":[40],"a":[41],"role":[42,72],"modulating":[44],"individual":[45],"risks":[46],"this":[48],"cancer.Many":[49],"studies":[50],"support":[51],"an":[52],"association":[53],"between":[54],"insulin":[55,76],"pathway":[56,79],"gene":[57],"polymorphisms":[58,74],"regulation":[60],"tumor":[62],"cell":[63],"biology":[64],"colorectal":[66,92],"cancer.":[67,93],"This":[68],"review":[69],"examines":[70],"obesity":[78],"genes":[80],"(IGFs,":[81],"INS,":[82],"INSR,":[83],"ADIPOQ,":[84],"ADIPOQR,":[85],"LEP":[86],"LEPR)":[88],"development":[90]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}