{"id":"https://openalex.org/W2178486764","doi":"https://doi.org/10.1146/annurev.nu.08.070188.001005","title":"Consequences Of Phosphate Imbalance","display_name":"Consequences Of Phosphate Imbalance","publication_year":1988,"publication_date":"1988-01-01","ids":{"openalex":"https://openalex.org/W2178486764","doi":"https://doi.org/10.1146/annurev.nu.08.070188.001005","mag":"2178486764","pmid":"https://pubmed.ncbi.nlm.nih.gov/3060161"},"language":"en","primary_location":{"id":"doi:10.1146/annurev.nu.08.070188.001005","doi":"https://doi.org/10.1146/annurev.nu.08.070188.001005","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev.nu.08.070188.001005","pdf_url":null,"source":{"id":"https://openalex.org/S160110530","display_name":"Annual Review of Nutrition","issn_l":"0199-9885","issn":["0199-9885","1545-4312"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Nutrition","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113675936","display_name":"Yitshal Berner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y N Berner","raw_affiliation_strings":["Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York 10021"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York 10021","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015081535","display_name":"Moshe Shike","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Shike","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.6639,"has_fulltext":false,"cited_by_count":121,"citation_normalized_percentile":{"value":0.84418336,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"8","issue":"1","first_page":"121","last_page":"148"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12840","display_name":"Renal function and acid-base balance","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phosphate-homeostasis","display_name":"phosphate homeostasis","score":0.8519999980926514},{"id":"https://openalex.org/keywords/hypophosphatemia","display_name":"hypophosphatemia","score":0.9940000176429749},{"id":"https://openalex.org/keywords/hyperphosphatemia","display_name":"hyperphosphatemia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/phosphate-metabolism","display_name":"phosphate metabolism","score":0.6859999895095825},{"id":"https://openalex.org/keywords/phosphate-binders","display_name":"phosphate binders","score":0.6470000147819519},{"id":"https://openalex.org/keywords/renal-phosphate-reabsorption","display_name":"renal phosphate reabsorption","score":0.6819999814033508},{"id":"https://openalex.org/keywords/2-3-bisphosphoglycerate","display_name":"2,3-diphosphoglycerate","score":0.7300000190734863},{"id":"https://openalex.org/keywords/atp-depletion","display_name":"ATP depletion","score":0.8410000205039978},{"id":"https://openalex.org/keywords/kidney-failure","display_name":"renal failure","score":0.6499999761581421},{"id":"https://openalex.org/keywords/tumor-lysis-syndrome","display_name":"tumor lysis syndrome","score":0.9340000152587891},{"id":"https://openalex.org/keywords/hemolysis","display_name":"hemolysis","score":0.7760000228881836},{"id":"https://openalex.org/keywords/rhabdomyolysis","display_name":"rhabdomyolysis","score":0.9890000224113464},{"id":"https://openalex.org/keywords/phosphate-supplementation","display_name":"phosphorus supplementation","score":0.37700000405311584},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.4779999852180481}],"concepts":[{"id":"https://openalex.org/C2778573388","wikidata":"https://www.wikidata.org/wiki/Q1641384","display_name":"Hypophosphatemia","level":2,"score":0.7118749022483826},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7106110453605652},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6787494421005249},{"id":"https://openalex.org/C2777132085","wikidata":"https://www.wikidata.org/wiki/Q46220103","display_name":"Phosphate","level":2,"score":0.6037230491638184},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5614801645278931},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5250125527381897},{"id":"https://openalex.org/C56906281","wikidata":"https://www.wikidata.org/wiki/Q4391435","display_name":"Reabsorption","level":3,"score":0.48206931352615356},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.33697062730789185},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26807379722595215},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15213626623153687}],"mesh":[{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010710","descriptor_name":"Phosphates","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010710","descriptor_name":"Phosphates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010710","descriptor_name":"Phosphates","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1146/annurev.nu.08.070188.001005","doi":"https://doi.org/10.1146/annurev.nu.08.070188.001005","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev.nu.08.070188.001005","pdf_url":null,"source":{"id":"https://openalex.org/S160110530","display_name":"Annual Review of Nutrition","issn_l":"0199-9885","issn":["0199-9885","1545-4312"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Nutrition","raw_type":"journal-article"},{"id":"doi:10.1146/annurev.nutr.8.1.121","doi":"https://doi.org/10.1146/annurev.nutr.8.1.121","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev.nutr.8.1.121","pdf_url":null,"source":{"id":"https://openalex.org/S160110530","display_name":"Annual Review of Nutrition","issn_l":"0199-9885","issn":["0199-9885","1545-4312"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Nutrition","raw_type":"journal-article"},{"id":"pmid:3060161","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3060161","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual review of nutrition","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9074000120162964,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W10867494","https://openalex.org/W87552923","https://openalex.org/W159916367","https://openalex.org/W285607327","https://openalex.org/W1556300555","https://openalex.org/W1867983657","https://openalex.org/W1911508886","https://openalex.org/W1925555331","https://openalex.org/W1969710190","https://openalex.org/W1980432366","https://openalex.org/W1982972915","https://openalex.org/W1984187097","https://openalex.org/W1987477127","https://openalex.org/W1987520232","https://openalex.org/W1988908530","https://openalex.org/W2007904438","https://openalex.org/W2010383411","https://openalex.org/W2011390377","https://openalex.org/W2018096397","https://openalex.org/W2022850165","https://openalex.org/W2033973493","https://openalex.org/W2036204726","https://openalex.org/W2041331016","https://openalex.org/W2047246334","https://openalex.org/W2051598838","https://openalex.org/W2051922120","https://openalex.org/W2052050469","https://openalex.org/W2057971464","https://openalex.org/W2062962962","https://openalex.org/W2067726621","https://openalex.org/W2068767812","https://openalex.org/W2074218345","https://openalex.org/W2074892655","https://openalex.org/W2075305134","https://openalex.org/W2078191848","https://openalex.org/W2090790017","https://openalex.org/W2093864252","https://openalex.org/W2095389393","https://openalex.org/W2110631456","https://openalex.org/W2117987354","https://openalex.org/W2122016427","https://openalex.org/W2124099652","https://openalex.org/W2168938911","https://openalex.org/W2261711143","https://openalex.org/W2270042474","https://openalex.org/W2289652535","https://openalex.org/W2293264624","https://openalex.org/W2301591846","https://openalex.org/W2317745660","https://openalex.org/W2337554440","https://openalex.org/W2338497360","https://openalex.org/W2338614070","https://openalex.org/W2342215062","https://openalex.org/W2345784276","https://openalex.org/W2397031455","https://openalex.org/W2400131153","https://openalex.org/W2408554903","https://openalex.org/W2417717378","https://openalex.org/W2424849478","https://openalex.org/W4248429963"],"related_works":["https://openalex.org/W4233686822","https://openalex.org/W3185472714","https://openalex.org/W4239718207","https://openalex.org/W2153910126","https://openalex.org/W2971045141","https://openalex.org/W4391126688","https://openalex.org/W2548484757","https://openalex.org/W3203934154","https://openalex.org/W4290052404","https://openalex.org/W2095410603"],"abstract_inverted_index":{"Phosphorus":[0],"is":[1,32,44,80,87,94,122,257,263,322,382],"the":[2,8,22,35,38,46,50,67,74,82,97,103,114,118,123,130,137,143,147,153,157,173,179,183,187,192,217,267,280,315,325,330,355,373],"sixth":[3],"most":[4,119],"abundant":[5],"element":[6],"in":[7,34,37,45,49,61,66,73,81,116,136,156,210,259,269,294,329,336],"body":[9,24,174],"after":[10],"oxygen,":[11],"hydrogen,":[12],"carbon,":[13],"nitrogen,":[14],"and":[15,63,71,133,171,195,204,243,262,274,343,368],"calcium.":[16],"It":[17],"comprises":[18],"about":[19],"1%":[20,79],"of":[21,26,30,40,52,99,102,106,129,141,169,175,212,216,220,237,254,272,277,289,299,302,312,319,347,351,357,378],"total":[23],"weight":[25],"humans.":[27],"Eighty-five":[28],"percent":[29],"it":[31,135],"stored":[33],"bone":[36],"form":[39,51],"hydroxyapatite":[41],"crystal;":[42],"14%":[43],"soft":[47],"tissues":[48],"energy-storing":[53],"bonds":[54],"with":[55,314],"nucleotides":[56],"(ATP,":[57],"GTP),":[58],"nucleic":[59],"acids":[60],"chromosomes":[62],"ribosomes,":[64],"2,3-DPG":[65,284],"red":[68],"blood":[69],"cells,":[70],"phospholipids":[72],"cells'":[75],"membranes.":[76],"Less":[77],"than":[78],"extracellular":[83],"fluids.":[84],"Phosphate":[85],"balance":[86,189],"maintained":[88],"by":[89,190,384],"multiple":[90],"systems.":[91],"The":[92,125,162,251,286,297,345,376],"gut":[93],"responsible":[95],"for":[96],"absorption":[98],"two":[100],"thirds":[101],"4-30":[104],"mg/kg/day":[105],"phosphate":[107,132,170,176,188,213,221,238,255,290,307,320,363,374,380],"intake.":[108],"Absorption":[109],"sites":[110],"are":[111,292],"all":[112],"along":[113],"gut;":[115],"humans":[117],"active":[120],"site":[121],"jejunum.":[124],"kidney":[126,144,164,358],"filters":[127],"90%":[128],"plasma":[131],"reabsorbs":[134],"tubuli.":[138],"In":[139,360],"states":[140],"hypophosphatemia":[142,300],"can":[145,165,334,371],"reabsorb":[146],"filtered":[148],"phosphates":[149],"very":[150],"efficiently,":[151],"reducing":[152],"amount":[154],"excreted":[155],"urine":[158],"virtually":[159],"to":[160,228,248,266,279,283,323],"zero.":[161],"healthy":[163],"excrete":[166],"high":[167],"loads":[168],"rid":[172],"overload.":[177],"Through":[178],"vitamin":[180],"D-PTH":[181],"axis":[182],"endocrine":[184],"system":[185],"regulates":[186],"influencing":[191],"kidney,":[193],"gut,":[194],"bone.":[196],"Other":[197],"hormones,":[198],"including":[199],"thyroid,":[200],"insulin,":[201],"glucagon,":[202],"glucocorticosteroid,":[203],"thyrocalcitonin,":[205],"play":[206],"a":[207],"lesser":[208],"role":[209],"regulation":[211],"metabolism.":[214],"Because":[215],"complex":[218],"control":[219],"homeostasis,":[222],"various":[223,287],"clinical":[224,252],"conditions":[225],"may":[226],"lead":[227],"hypophosphatemia.":[229],"These":[230],"include":[231],"nutritional":[232],"repletion,":[233],"gastrointestinal":[234],"malabsorption,":[235],"use":[236,377],"binders,":[239],"starvation,":[240],"diabetes":[241],"mellitus,":[242],"increased":[244],"urinary":[245],"losses":[246],"due":[247,264],"tubular":[249],"dysfunction.":[250],"picture":[253],"depletion":[256,291,321,326],"manifested":[258],"different":[260],"organs":[261],"mainly":[265],"fall":[268],"intracellular":[270],"levels":[271],"ATP":[273],"decreased":[275],"availability":[276],"oxygen":[278],"tissues,":[281],"secondary":[282],"depletion.":[285],"manifestations":[288],"listed":[293],"Table":[295],"2.":[296],"treatment":[298,346],"consists":[301,350],"administering":[303],"enteral":[304],"or":[305],"parenteral":[306],"salts.":[308],"An":[309],"important":[310],"aspect":[311],"dealing":[313],"potentially":[316],"serious":[317],"effects":[318],"prevent":[324],"from":[327],"happening":[328],"first":[331],"place.":[332],"Hyperphosphatemia":[333],"occur":[335],"renal":[337],"failure,":[338],"hemolysis,":[339],"tumor":[340],"lysis":[341],"syndrome,":[342],"rhabdomyolysis.":[344],"hyperphosphatemia":[348],"usually":[349],"fluid":[352],"administration":[353],"(in":[354],"absence":[356],"failure).":[359],"chronic":[361],"hyperphosphatemia,":[362],"binders":[364,381],"such":[365],"as":[366],"aluminum":[367],"magnesium":[369],"salts":[370],"reduce":[372],"load.":[375],"these":[379],"limited":[383],"their":[385],"potential":[386],"side":[387],"effects.":[388]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
