{"id":"https://openalex.org/W2178476123","doi":null,"title":"[Cholesterol overload in hepatocytes affects nicotinamide adenine dinucleotide phosphate oxidase (NADPH) activity abrogating hepatocyte growth factor (HGF) induced cellular protection].","display_name":"[Cholesterol overload in hepatocytes affects nicotinamide adenine dinucleotide phosphate oxidase (NADPH) activity abrogating hepatocyte growth factor (HGF) induced cellular protection].","publication_year":2015,"publication_date":"2015-07-01","ids":{"openalex":"https://openalex.org/W2178476123","mag":"2178476123","pmid":"https://pubmed.ncbi.nlm.nih.gov/26290021"},"language":"es","primary_location":{"id":"pmid:26290021","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26290021","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gaceta medica de Mexico","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030980297","display_name":"Alberto Gabriel L\u00f3pez-Reyes","orcid":"https://orcid.org/0000-0002-2575-2589","observed_orcids":["https://orcid.org/0000-0002-2575-2589"]},"institutions":[{"id":"https://openalex.org/I200362191","display_name":"Universidad Aut\u00f3noma Metropolitana","ror":"https://ror.org/02kta5139","country_code":"MX","type":"education","lineage":["https://openalex.org/I200362191"]},{"id":"https://openalex.org/I4210124243","display_name":"Instituto Nacional de Rehabilitaci\u00f3n","ror":"https://ror.org/03734cd59","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210124243"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Alberto G L\u00f3pez-Reyes","raw_affiliation_strings":["Doctorado en Biolog\u00eda Experimental, DCBS, Universidad Aut\u00f3noma Metropolitana Iztapalapa, M\u00e9xico, D.F., M\u00e9xico","Laboratorio de Sinovioan\u00e1lisis, Instituto Nacional de Rehabilitaci\u00f3n, M\u00e9xico, D.F., M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Doctorado en Biolog\u00eda Experimental, DCBS, Universidad Aut\u00f3noma Metropolitana Iztapalapa, M\u00e9xico, D.F., M\u00e9xico","institution_ids":["https://openalex.org/I200362191"]},{"raw_affiliation_string":"Laboratorio de Sinovioan\u00e1lisis, Instituto Nacional de Rehabilitaci\u00f3n, M\u00e9xico, D.F., M\u00e9xico","institution_ids":["https://openalex.org/I4210124243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052542079","display_name":"Karina Mart\u00ednez\u2010Flores","orcid":"https://orcid.org/0000-0003-0675-0227","observed_orcids":["https://orcid.org/0000-0003-0675-0227"]},"institutions":[{"id":"https://openalex.org/I4210124243","display_name":"Instituto Nacional de Rehabilitaci\u00f3n","ror":"https://ror.org/03734cd59","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210124243"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Karina Mart\u00ednez-Flores","raw_affiliation_strings":["Laboratorio de Sinovioan\u00e1lisis, Instituto Nacional de Rehabilitaci\u00f3n, M\u00e9xico, D.F., M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio de Sinovioan\u00e1lisis, Instituto Nacional de Rehabilitaci\u00f3n, M\u00e9xico, D.F., M\u00e9xico","institution_ids":["https://openalex.org/I4210124243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089971687","display_name":"Denise Clavijo\u2010Cornejo","orcid":"https://orcid.org/0000-0002-6399-9865","observed_orcids":["https://orcid.org/0000-0002-6399-9865"]},"institutions":[{"id":"https://openalex.org/I4210124243","display_name":"Instituto Nacional de Rehabilitaci\u00f3n","ror":"https://ror.org/03734cd59","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210124243"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Denise Clavijo-Cornejo","raw_affiliation_strings":["Laboratorio de Sinovioan\u00e1lisis, Instituto Nacional de Rehabilitaci\u00f3n, M\u00e9xico, D.F., M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio de Sinovioan\u00e1lisis, Instituto Nacional de Rehabilitaci\u00f3n, M\u00e9xico, D.F., M\u00e9xico","institution_ids":["https://openalex.org/I4210124243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058340473","display_name":"Natalia Nu\u00f1o\u2010L\u00e1mbarri","orcid":"https://orcid.org/0000-0001-7616-2661","observed_orcids":["https://orcid.org/0000-0001-7616-2661"]},"institutions":[{"id":"https://openalex.org/I200362191","display_name":"Universidad Aut\u00f3noma Metropolitana","ror":"https://ror.org/02kta5139","country_code":"MX","type":"education","lineage":["https://openalex.org/I200362191"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Natalia Nu\u00f1o-L\u00e1mbarri","raw_affiliation_strings":["Departamento de Ciencias de la Salud, Universidad Aut\u00f3noma Metropolitana Iztapalapa, M\u00e9xico, D.F., M\u00e9xico","Departamento de Ciencias de la Salud, Universidad Aut\u00f3noma Metropolitana-Iztapalapa, M\u00e9xico D.F, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Ciencias de la Salud, Universidad Aut\u00f3noma Metropolitana Iztapalapa, M\u00e9xico, D.F., M\u00e9xico","institution_ids":["https://openalex.org/I200362191"]},{"raw_affiliation_string":"Departamento de Ciencias de la Salud, Universidad Aut\u00f3noma Metropolitana-Iztapalapa, M\u00e9xico D.F, Mexico","institution_ids":["https://openalex.org/I200362191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005028263","display_name":"Mayrel Palestino Dom\u00ednguez","orcid":"https://orcid.org/0000-0002-1442-9719","observed_orcids":["https://orcid.org/0000-0002-1442-9719"]},"institutions":[{"id":"https://openalex.org/I200362191","display_name":"Universidad Aut\u00f3noma Metropolitana","ror":"https://ror.org/02kta5139","country_code":"MX","type":"education","lineage":["https://openalex.org/I200362191"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Mayrel Palestino-Dom\u00ednguez","raw_affiliation_strings":["Departamento de Ciencias de la Salud, Universidad Aut\u00f3noma Metropolitana Iztapalapa, M\u00e9xico, D.F., M\u00e9xico","Departamento de Ciencias de la Salud, Universidad Aut\u00f3noma Metropolitana-Iztapalapa, M\u00e9xico D.F, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Ciencias de la Salud, Universidad Aut\u00f3noma Metropolitana Iztapalapa, M\u00e9xico, D.F., M\u00e9xico","institution_ids":["https://openalex.org/I200362191"]},{"raw_affiliation_string":"Departamento de Ciencias de la Salud, Universidad Aut\u00f3noma Metropolitana-Iztapalapa, M\u00e9xico D.F, Mexico","institution_ids":["https://openalex.org/I200362191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112348635","display_name":"Ver\u00f3nica Souza","orcid":"https://orcid.org/0000-0002-3923-6278","observed_orcids":["https://orcid.org/0000-0002-3923-6278"]},"institutions":[{"id":"https://openalex.org/I1302736544","display_name":"Secretariat of Public Education","ror":"https://ror.org/02e1c4h55","country_code":"MX","type":"government","lineage":["https://openalex.org/I1302736544"]},{"id":"https://openalex.org/I200362191","display_name":"Universidad Aut\u00f3noma Metropolitana","ror":"https://ror.org/02kta5139","country_code":"MX","type":"education","lineage":["https://openalex.org/I200362191"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Ver\u00f3nica Souza","raw_affiliation_strings":["Departamento de Ciencias de la Salud, Universidad Aut\u00f3noma Metropolitana Iztapalapa, M\u00e9xico, D.F., M\u00e9xico","Red Fisiopatolog\u00eda de las Enfermedades Hep\u00e1ticas, PROMEP-SEP, M\u00e9xico D.F., M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Ciencias de la Salud, Universidad Aut\u00f3noma Metropolitana Iztapalapa, M\u00e9xico, D.F., M\u00e9xico","institution_ids":["https://openalex.org/I200362191"]},{"raw_affiliation_string":"Red Fisiopatolog\u00eda de las Enfermedades Hep\u00e1ticas, PROMEP-SEP, M\u00e9xico D.F., M\u00e9xico","institution_ids":["https://openalex.org/I1302736544"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053733929","display_name":"Leticia Bucio","orcid":"https://orcid.org/0000-0002-6963-2642","observed_orcids":["https://orcid.org/0000-0002-6963-2642"]},"institutions":[{"id":"https://openalex.org/I1302736544","display_name":"Secretariat of Public Education","ror":"https://ror.org/02e1c4h55","country_code":"MX","type":"government","lineage":["https://openalex.org/I1302736544"]},{"id":"https://openalex.org/I200362191","display_name":"Universidad Aut\u00f3noma Metropolitana","ror":"https://ror.org/02kta5139","country_code":"MX","type":"education","lineage":["https://openalex.org/I200362191"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Leticia Bucio","raw_affiliation_strings":["Departamento de Ciencias de la Salud, Universidad Aut\u00f3noma Metropolitana Iztapalapa, M\u00e9xico, D.F., M\u00e9xico","Red Fisiopatolog\u00eda de las Enfermedades Hep\u00e1ticas, PROMEP-SEP, M\u00e9xico D.F., M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Ciencias de la Salud, Universidad Aut\u00f3noma Metropolitana Iztapalapa, M\u00e9xico, D.F., M\u00e9xico","institution_ids":["https://openalex.org/I200362191"]},{"raw_affiliation_string":"Red Fisiopatolog\u00eda de las Enfermedades Hep\u00e1ticas, PROMEP-SEP, M\u00e9xico D.F., M\u00e9xico","institution_ids":["https://openalex.org/I1302736544"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053218626","display_name":"Arturo Panduro","orcid":"https://orcid.org/0000-0003-4784-748X","observed_orcids":["https://orcid.org/0000-0003-4784-748X"]},"institutions":[{"id":"https://openalex.org/I1302736544","display_name":"Secretariat of Public Education","ror":"https://ror.org/02e1c4h55","country_code":"MX","type":"government","lineage":["https://openalex.org/I1302736544"]},{"id":"https://openalex.org/I193181351","display_name":"Universidad de Guadalajara","ror":"https://ror.org/043xj7k26","country_code":"MX","type":"education","lineage":["https://openalex.org/I193181351"]},{"id":"https://openalex.org/I4210120508","display_name":"Hospital Civil de Guadalajara","ror":"https://ror.org/02epdjj68","country_code":"MX","type":"healthcare","lineage":["https://openalex.org/I4210120508"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Arturo Panduro","raw_affiliation_strings":["Red Fisiopatolog\u00eda de las Enfermedades Hep\u00e1ticas, PROMEP-SEP, M\u00e9xico D.F., M\u00e9xico","Departamento de Biolog\u00eda Molecular en Medicina, Hospital Civil de Guadalajara Fray Antonio Alcalde, Universidad de Guadalajara, Guadalajara, Jal., M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Red Fisiopatolog\u00eda de las Enfermedades Hep\u00e1ticas, PROMEP-SEP, M\u00e9xico D.F., M\u00e9xico","institution_ids":["https://openalex.org/I1302736544"]},{"raw_affiliation_string":"Departamento de Biolog\u00eda Molecular en Medicina, Hospital Civil de Guadalajara Fray Antonio Alcalde, Universidad de Guadalajara, Guadalajara, Jal., M\u00e9xico","institution_ids":["https://openalex.org/I193181351","https://openalex.org/I4210120508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023811509","display_name":"Roxana U. Miranda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1302736544","display_name":"Secretariat of Public Education","ror":"https://ror.org/02e1c4h55","country_code":"MX","type":"government","lineage":["https://openalex.org/I1302736544"]},{"id":"https://openalex.org/I200362191","display_name":"Universidad Aut\u00f3noma Metropolitana","ror":"https://ror.org/02kta5139","country_code":"MX","type":"education","lineage":["https://openalex.org/I200362191"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Roxana U Miranda","raw_affiliation_strings":["Departamento de Ciencias de la Salud, Universidad Aut\u00f3noma Metropolitana Iztapalapa, M\u00e9xico, D.F., M\u00e9xico","Red Fisiopatolog\u00eda de las Enfermedades Hep\u00e1ticas, PROMEP-SEP, M\u00e9xico D.F., M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Ciencias de la Salud, Universidad Aut\u00f3noma Metropolitana Iztapalapa, M\u00e9xico, D.F., M\u00e9xico","institution_ids":["https://openalex.org/I200362191"]},{"raw_affiliation_string":"Red Fisiopatolog\u00eda de las Enfermedades Hep\u00e1ticas, PROMEP-SEP, M\u00e9xico D.F., M\u00e9xico","institution_ids":["https://openalex.org/I1302736544"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056670813","display_name":"Luis Enrique G\u00f3mez-Quiroz","orcid":"https://orcid.org/0000-0002-5704-5985","observed_orcids":["https://orcid.org/0000-0002-5704-5985"]},"institutions":[{"id":"https://openalex.org/I1302736544","display_name":"Secretariat of Public Education","ror":"https://ror.org/02e1c4h55","country_code":"MX","type":"government","lineage":["https://openalex.org/I1302736544"]},{"id":"https://openalex.org/I200362191","display_name":"Universidad Aut\u00f3noma Metropolitana","ror":"https://ror.org/02kta5139","country_code":"MX","type":"education","lineage":["https://openalex.org/I200362191"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Luis Enrique G\u00f3mez-Quiroz","raw_affiliation_strings":["Departamento de Ciencias de la Salud, Universidad Aut\u00f3noma Metropolitana Iztapalapa, M\u00e9xico, D.F., M\u00e9xico","Red Fisiopatolog\u00eda de las Enfermedades Hep\u00e1ticas, PROMEP-SEP, M\u00e9xico D.F., M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Ciencias de la Salud, Universidad Aut\u00f3noma Metropolitana Iztapalapa, M\u00e9xico, D.F., M\u00e9xico","institution_ids":["https://openalex.org/I200362191"]},{"raw_affiliation_string":"Red Fisiopatolog\u00eda de las Enfermedades Hep\u00e1ticas, PROMEP-SEP, M\u00e9xico D.F., M\u00e9xico","institution_ids":["https://openalex.org/I1302736544"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083205788","display_name":"Mar\u00eda Concepci\u00f3n Guti\u00e9rrez\u2010Ru\u00edz","orcid":"https://orcid.org/0000-0003-0501-7226","observed_orcids":["https://orcid.org/0000-0003-0501-7226"]},"institutions":[{"id":"https://openalex.org/I1302736544","display_name":"Secretariat of Public Education","ror":"https://ror.org/02e1c4h55","country_code":"MX","type":"government","lineage":["https://openalex.org/I1302736544"]},{"id":"https://openalex.org/I200362191","display_name":"Universidad Aut\u00f3noma Metropolitana","ror":"https://ror.org/02kta5139","country_code":"MX","type":"education","lineage":["https://openalex.org/I200362191"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Mar\u00eda Concepci\u00f3n Guti\u00e9rrez-Ruiz","raw_affiliation_strings":["Departamento de Ciencias de la Salud, Universidad Aut\u00f3noma Metropolitana Iztapalapa, M\u00e9xico, D.F., M\u00e9xico","Red Fisiopatolog\u00eda de las Enfermedades Hep\u00e1ticas, PROMEP-SEP, M\u00e9xico D.F., M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Ciencias de la Salud, Universidad Aut\u00f3noma Metropolitana Iztapalapa, M\u00e9xico, D.F., M\u00e9xico","institution_ids":["https://openalex.org/I200362191"]},{"raw_affiliation_string":"Red Fisiopatolog\u00eda de las Enfermedades Hep\u00e1ticas, PROMEP-SEP, M\u00e9xico D.F., M\u00e9xico","institution_ids":["https://openalex.org/I1302736544"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0184,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.75006932,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"151","issue":"4","first_page":"456","last_page":"64"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.6499000191688538,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.6499000191688538,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.2831999957561493,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.04670000076293945,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocytes","display_name":"hepatocytes","score":0.9279999732971191},{"id":"https://openalex.org/keywords/nadph-oxidase","display_name":"NADPH oxidase","score":0.9950000047683716},{"id":"https://openalex.org/keywords/hepatocyte-growth-factor","display_name":"hepatocyte growth factor","score":0.996999979019165},{"id":"https://openalex.org/keywords/cytoprotection","display_name":"cytoprotection","score":0.6909999847412109},{"id":"https://openalex.org/keywords/high-cholesterol-diet","display_name":"high-cholesterol diet","score":0.8939999938011169},{"id":"https://openalex.org/keywords/hepatic-steatosis","display_name":"hepatic steatosis","score":0.7519999742507935},{"id":"https://openalex.org/keywords/liver-injury","display_name":"liver injury","score":0.5509999990463257},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.5789999961853027},{"id":"https://openalex.org/keywords/hepatocyte-viability","display_name":"hepatocyte viability","score":0.6129999756813049},{"id":"https://openalex.org/keywords/obesity-related-liver-disease","display_name":"obesity-related liver disease","score":0.6570000052452087}],"concepts":[{"id":"https://openalex.org/C2777989768","wikidata":"https://www.wikidata.org/wiki/Q28747","display_name":"Nicotinamide adenine dinucleotide phosphate","level":4,"score":0.9198427200317383},{"id":"https://openalex.org/C2776996007","wikidata":"https://www.wikidata.org/wiki/Q2399112","display_name":"Hepatocyte growth factor","level":3,"score":0.7636297941207886},{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.7119162082672119},{"id":"https://openalex.org/C2779719074","wikidata":"https://www.wikidata.org/wiki/Q2038057","display_name":"NADPH oxidase","level":3,"score":0.6536718010902405},{"id":"https://openalex.org/C2776175330","wikidata":"https://www.wikidata.org/wiki/Q1365091","display_name":"Steatosis","level":2,"score":0.5989063382148743},{"id":"https://openalex.org/C38485361","wikidata":"https://www.wikidata.org/wiki/Q576379","display_name":"Oxidase test","level":3,"score":0.5305175185203552},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4972441494464874},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.47583484649658203},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45644763112068176},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4332699179649353},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37052053213119507},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3138274848461151},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2135944366455078},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2107393443584442},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.20296630263328552},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07348248362541199},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017228","descriptor_name":"Hepatocyte Growth Factor","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019255","descriptor_name":"NADPH Oxidases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:26290021","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26290021","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gaceta medica de Mexico","raw_type":"Journal Article"},{"id":"mag:2178476123","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26290021","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null},{"id":"mag:2993853067","doi":null,"is_oa":false,"landing_page_url":"https://conacyt.demo.elsevierpure.com/en/publications/cholesterol-accumulation-in-hepatocytes-overactivates-nicotinamid-2","pdf_url":null,"source":{"id":"https://openalex.org/S55067821","display_name":"Gaceta M\u00e9dica de M\u00e9xico","issn_l":"0016-3813","issn":["0016-3813","2696-1288"],"is_oa":false,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","dongbi-c","jufo-1","medline","norway-1","oarl","poland-20","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310319614","host_organization_name":"Academia Nacional de Medicina de M\u00e9xico","host_organization_lineage":["https://openalex.org/P4310319614"],"host_organization_lineage_names":["Academia Nacional de Medicina de M\u00e9xico"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Gaceta M\u00e9dica de M\u00e9xico","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W202362494","https://openalex.org/W1480604482","https://openalex.org/W1964995369","https://openalex.org/W2002721855","https://openalex.org/W2005547992","https://openalex.org/W2010101404","https://openalex.org/W2016118319","https://openalex.org/W2017978418","https://openalex.org/W2019654086","https://openalex.org/W2020914780","https://openalex.org/W2024940131","https://openalex.org/W2042571415","https://openalex.org/W2069421644","https://openalex.org/W2070053386","https://openalex.org/W2082011949","https://openalex.org/W2082272174","https://openalex.org/W2085128107","https://openalex.org/W2093342196","https://openalex.org/W2109767417","https://openalex.org/W2111045432","https://openalex.org/W2111934534","https://openalex.org/W2120080994","https://openalex.org/W2120445700","https://openalex.org/W2125837657","https://openalex.org/W2151106792"],"related_works":["https://openalex.org/W2993853067","https://openalex.org/W2319218769","https://openalex.org/W2117712921","https://openalex.org/W7223415342","https://openalex.org/W2133545678","https://openalex.org/W7168247535","https://openalex.org/W2894504469","https://openalex.org/W2507121494","https://openalex.org/W2127011184","https://openalex.org/W2999851464"],"abstract_inverted_index":{"The":[0,121,156],"increment":[1],"in":[2,8,15,43,48,100,119,130,153,180],"the":[3,13,33,39,44,49,52,60,63,77,87,95,101,148,177,183],"prevalence":[4],"of":[5,35,41,55,138,140,159,166],"obesity":[6],"incidence":[7],"Mexico":[9],"is":[10,23,30,82],"leading":[11],"to":[12,32,92],"increase":[14,129],"many":[16],"chronic":[17],"maladies,":[18],"including":[19],"liver":[20,28,50,57,115],"diseases.":[21],"It":[22],"well":[24],"known":[25],"that":[26,110],"lipid-induced":[27],"sensitization":[29],"related":[31],"kind":[34],"lipid":[36],"rather":[37],"than":[38],"amount":[40],"them":[42],"organ.":[45],"Cholesterol":[46],"overload":[47,179],"aggravates":[51],"toxic":[53],"effects":[54],"canonical":[56],"insults.":[58],"However,":[59],"status":[61],"on":[62,147],"repair":[64],"and":[65,76,117],"survival":[66,173],"response":[67],"elicited":[68],"by":[69,171],"nicotinamide":[70],"adenine":[71],"dinucleotide":[72],"phosphate":[73],"(NADPH)":[74],"oxidase":[75,133,149],"hepatocyte":[78,102],"growth":[79],"factor":[80],"(HGF)":[81],"not":[83],"completely":[84],"understood.":[85],"In":[86,175],"present,":[88],"work":[89],"we":[90],"aimed":[91],"figure":[93],"out":[94],"HGF/NADPH":[96,184],"oxidase-induced":[97,185],"cellular":[98,168,186],"protection":[99],"with":[103],"a":[104,111,164,172],"cholesterol":[105,167,178],"overload.":[106],"Our":[107],"results":[108],"show":[109],"hypercholesterolemic":[112],"diet":[113],"induced":[114],"damage":[116],"steatosis":[118],"mice.":[120],"hepatocytes":[122,181],"isolated":[123],"from":[124],"these":[125],"animals":[126],"exhibited":[127],"an":[128],"basal":[131],"NADPH":[132],"activity,":[134],"although":[135],"transcriptional":[136],"levels":[137],"some":[139],"its":[141],"components":[142],"were":[143],"decreased.":[144],"No":[145],"effect":[146,158],"activity":[150],"was":[151,161],"observed":[152],"HGF":[154,160],"treatments.":[155],"protective":[157],"abrogated":[162],"as":[163],"result":[165],"overload,":[169],"calculated":[170],"assay.":[174],"conclusion,":[176],"impairs":[182],"protection.":[187]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}