{"id":"https://openalex.org/W2178468356","doi":"https://doi.org/10.1016/j.ijbiomac.2015.11.049","title":"Separation, characterization and anticancer activities of a sulfated polysaccharide from Undaria pinnatifida","display_name":"Separation, characterization and anticancer activities of a sulfated polysaccharide from Undaria pinnatifida","publication_year":2015,"publication_date":"2015-11-23","ids":{"openalex":"https://openalex.org/W2178468356","doi":"https://doi.org/10.1016/j.ijbiomac.2015.11.049","mag":"2178468356","pmid":"https://pubmed.ncbi.nlm.nih.gov/26616455"},"language":"en","primary_location":{"id":"doi:10.1016/j.ijbiomac.2015.11.049","doi":"https://doi.org/10.1016/j.ijbiomac.2015.11.049","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ijbiomac.2015.11.049","pdf_url":null,"source":{"id":"https://openalex.org/S83853393","display_name":"International Journal of Biological Macromolecules","issn_l":"0141-8130","issn":["0141-8130","1879-0003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Biological Macromolecules","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009776070","display_name":"Yun Hee Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I134841294","display_name":"Binzhou Medical University","ror":"https://ror.org/008w1vb37","country_code":"CN","type":"education","lineage":["https://openalex.org/I134841294"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yun Han","raw_affiliation_strings":["School of Integrated Chinese and Western Medicine, Binzhou Medical University, Yantai 264003, Shangdong, PR China. Electronic address: hykh888@163.com","School of Integrated Chinese and Western Medicine, Binzhou Medical University, Yantai 264003, Shangdong, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Integrated Chinese and Western Medicine, Binzhou Medical University, Yantai 264003, Shangdong, PR China. Electronic address: hykh888@163.com","institution_ids":["https://openalex.org/I134841294"]},{"raw_affiliation_string":"School of Integrated Chinese and Western Medicine, Binzhou Medical University, Yantai 264003, Shangdong, PR China","institution_ids":["https://openalex.org/I134841294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101996711","display_name":"Jun Wu","orcid":"https://orcid.org/0000-0002-6785-6976","observed_orcids":["https://orcid.org/0000-0002-6785-6976"]},"institutions":[{"id":"https://openalex.org/I4405282212","display_name":"Shandong College of Traditional Chinese Medicine","ror":"https://ror.org/05g0h7f55","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405282212"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Wu","raw_affiliation_strings":["School of Chinese Medicine, Shandong College of Traditional Chinese Medicine, Yantai 264199, Shangdong, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chinese Medicine, Shandong College of Traditional Chinese Medicine, Yantai 264199, Shangdong, PR China","institution_ids":["https://openalex.org/I4405282212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100442013","display_name":"Tingting Liu","orcid":"https://orcid.org/0000-0002-2636-9899","observed_orcids":["https://orcid.org/0000-0002-2636-9899","https://orcid.org/0000-0002-7743-8903"]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tingting Liu","raw_affiliation_strings":["Affiliated Huaian Hospital of Xuzhou Medical College, Huaian 223002, Jiangsu, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affiliated Huaian Hospital of Xuzhou Medical College, Huaian 223002, Jiangsu, PR China","institution_ids":["https://openalex.org/I177388780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068086294","display_name":"Youdong Hu","orcid":"https://orcid.org/0000-0003-3584-0651","observed_orcids":["https://orcid.org/0000-0003-3584-0651","https://orcid.org/0000-0001-6192-7721","https://orcid.org/0000-0001-9948-7602"]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Youdong Hu","raw_affiliation_strings":["Affiliated Huaian Hospital of Xuzhou Medical College, Huaian 223002, Jiangsu, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affiliated Huaian Hospital of Xuzhou Medical College, Huaian 223002, Jiangsu, PR China","institution_ids":["https://openalex.org/I177388780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100750519","display_name":"Qiusheng Zheng","orcid":"https://orcid.org/0000-0001-6413-9878","observed_orcids":["https://orcid.org/0000-0001-6413-9878"]},"institutions":[{"id":"https://openalex.org/I134841294","display_name":"Binzhou Medical University","ror":"https://ror.org/008w1vb37","country_code":"CN","type":"education","lineage":["https://openalex.org/I134841294"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiusheng Zheng","raw_affiliation_strings":["School of Integrated Chinese and Western Medicine, Binzhou Medical University, Yantai 264003, Shangdong, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Integrated Chinese and Western Medicine, Binzhou Medical University, Yantai 264003, Shangdong, PR China","institution_ids":["https://openalex.org/I134841294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068580768","display_name":"Binsheng Wang","orcid":"https://orcid.org/0000-0002-1206-5843","observed_orcids":["https://orcid.org/0000-0002-1206-5843"]},"institutions":[{"id":"https://openalex.org/I134841294","display_name":"Binzhou Medical University","ror":"https://ror.org/008w1vb37","country_code":"CN","type":"education","lineage":["https://openalex.org/I134841294"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Binsheng Wang","raw_affiliation_strings":["School of Integrated Chinese and Western Medicine, Binzhou Medical University, Yantai 264003, Shangdong, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Integrated Chinese and Western Medicine, Binzhou Medical University, Yantai 264003, Shangdong, PR China","institution_ids":["https://openalex.org/I134841294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101413173","display_name":"Haiyan Lin","orcid":"https://orcid.org/0000-0002-5771-3947","observed_orcids":["https://orcid.org/0000-0002-5771-3947"]},"institutions":[{"id":"https://openalex.org/I134841294","display_name":"Binzhou Medical University","ror":"https://ror.org/008w1vb37","country_code":"CN","type":"education","lineage":["https://openalex.org/I134841294"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haiyan Lin","raw_affiliation_strings":["School of Integrated Chinese and Western Medicine, Binzhou Medical University, Yantai 264003, Shangdong, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Integrated Chinese and Western Medicine, Binzhou Medical University, Yantai 264003, Shangdong, PR China","institution_ids":["https://openalex.org/I134841294"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101901444","display_name":"Xia Li","orcid":"https://orcid.org/0000-0002-2668-5728","observed_orcids":["https://orcid.org/0000-0002-2668-5728"]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xia Li","raw_affiliation_strings":["Affiliated Huaian Hospital of Xuzhou Medical College, Huaian 223002, Jiangsu, PR China. Electronic address: xial_li@qq.com","Affiliated Huaian Hospital of Xuzhou Medical College, Huaian 223002, Jiangsu, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affiliated Huaian Hospital of Xuzhou Medical College, Huaian 223002, Jiangsu, PR China. Electronic address: xial_li@qq.com","institution_ids":["https://openalex.org/I177388780"]},{"raw_affiliation_string":"Affiliated Huaian Hospital of Xuzhou Medical College, Huaian 223002, Jiangsu, PR China","institution_ids":["https://openalex.org/I177388780"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5009776070","https://openalex.org/A5101901444"],"corresponding_institution_ids":["https://openalex.org/I134841294","https://openalex.org/I177388780"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":5.8333,"has_fulltext":false,"cited_by_count":54,"citation_normalized_percentile":{"value":0.95808989,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"83","issue":null,"first_page":"42","last_page":"49"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11390","display_name":"Seaweed-derived Bioactive Compounds","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1104","display_name":"Aquatic Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11390","display_name":"Seaweed-derived Bioactive Compounds","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1104","display_name":"Aquatic Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12192","display_name":"Polysaccharides Composition and Applications","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11085","display_name":"Fungal Biology and Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/undaria-pinnatifida","display_name":"Undaria pinnatifida","score":0.9259999990463257},{"id":"https://openalex.org/keywords/sulfated-polysaccharides","display_name":"sulfated polysaccharides","score":0.9940000176429749},{"id":"https://openalex.org/keywords/brown-seaweed-polysaccharides","display_name":"brown seaweed polysaccharides","score":0.800000011920929},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.8619999885559082},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9890000224113464},{"id":"https://openalex.org/keywords/dmba-induced-mammary-tumors","display_name":"DMBA-induced mammary tumors","score":0.9190000295639038},{"id":"https://openalex.org/keywords/polysaccharide-purification","display_name":"polysaccharide purification","score":0.6610000133514404},{"id":"https://openalex.org/keywords/uronic-acid","display_name":"uronic acid","score":0.6830000281333923},{"id":"https://openalex.org/keywords/fucose","display_name":"fucose","score":0.8420000076293945},{"id":"https://openalex.org/keywords/galactose","display_name":"galactose","score":0.7179999947547913},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.8050000071525574},{"id":"https://openalex.org/keywords/sex-hormone-regulation","display_name":"sex hormone regulation","score":0.8140000104904175}],"concepts":[{"id":"https://openalex.org/C100817775","wikidata":"https://www.wikidata.org/wiki/Q134219","display_name":"Polysaccharide","level":2,"score":0.777224063873291},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7696940898895264},{"id":"https://openalex.org/C2778284416","wikidata":"https://www.wikidata.org/wiki/Q412056","display_name":"Uronic acid","level":3,"score":0.6810891032218933},{"id":"https://openalex.org/C2776841590","wikidata":"https://www.wikidata.org/wiki/Q66589589","display_name":"Fucose","level":3,"score":0.6646444797515869},{"id":"https://openalex.org/C2778173381","wikidata":"https://www.wikidata.org/wiki/Q66589593","display_name":"Galactose","level":2,"score":0.6023521423339844},{"id":"https://openalex.org/C193363816","wikidata":"https://www.wikidata.org/wiki/Q1617865","display_name":"Size-exclusion chromatography","level":3,"score":0.5660096406936646},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.5612279772758484},{"id":"https://openalex.org/C51724486","wikidata":"https://www.wikidata.org/wiki/Q908955","display_name":"Column chromatography","level":2,"score":0.5224517583847046},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.5202780365943909},{"id":"https://openalex.org/C2780294150","wikidata":"https://www.wikidata.org/wiki/Q66589603","display_name":"Xylose","level":3,"score":0.496142715215683},{"id":"https://openalex.org/C2777108408","wikidata":"https://www.wikidata.org/wiki/Q11002","display_name":"Sugar","level":2,"score":0.4610947370529175},{"id":"https://openalex.org/C175528265","wikidata":"https://www.wikidata.org/wiki/Q500256","display_name":"Chemical structure","level":2,"score":0.4496970772743225},{"id":"https://openalex.org/C2775887612","wikidata":"https://www.wikidata.org/wiki/Q10809118","display_name":"Mannose","level":2,"score":0.432259738445282},{"id":"https://openalex.org/C155138218","wikidata":"https://www.wikidata.org/wiki/Q994559","display_name":"Sulfation","level":2,"score":0.4281262159347534},{"id":"https://openalex.org/C134121241","wikidata":"https://www.wikidata.org/wiki/Q899301","display_name":"Yield (engineering)","level":2,"score":0.4200728237628937},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30730342864990234},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.12806501984596252},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0},{"id":"https://openalex.org/C100544194","wikidata":"https://www.wikidata.org/wiki/Q41760","display_name":"Fermentation","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002850","descriptor_name":"Chromatography, Gel","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005643","descriptor_name":"Fucose","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005690","descriptor_name":"Galactose","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011134","descriptor_name":"Polysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011134","descriptor_name":"Polysaccharides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013431","descriptor_name":"Sulfates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044648","descriptor_name":"Undaria","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ijbiomac.2015.11.049","doi":"https://doi.org/10.1016/j.ijbiomac.2015.11.049","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ijbiomac.2015.11.049","pdf_url":null,"source":{"id":"https://openalex.org/S83853393","display_name":"International Journal of Biological Macromolecules","issn_l":"0141-8130","issn":["0141-8130","1879-0003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Biological Macromolecules","raw_type":"journal-article"},{"id":"pmid:26616455","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26616455","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of biological macromolecules","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W960509236","https://openalex.org/W1106420127","https://openalex.org/W1544812408","https://openalex.org/W1545121368","https://openalex.org/W1551632868","https://openalex.org/W1973432283","https://openalex.org/W1981867717","https://openalex.org/W1982323023","https://openalex.org/W1991044308","https://openalex.org/W1992262527","https://openalex.org/W2009925755","https://openalex.org/W2010001103","https://openalex.org/W2010973187","https://openalex.org/W2016891344","https://openalex.org/W2018433640","https://openalex.org/W2018502785","https://openalex.org/W2019028405","https://openalex.org/W2027171894","https://openalex.org/W2029751462","https://openalex.org/W2031618397","https://openalex.org/W2040903325","https://openalex.org/W2044714523","https://openalex.org/W2047556994","https://openalex.org/W2054795728","https://openalex.org/W2056249332","https://openalex.org/W2058645022","https://openalex.org/W2060249816","https://openalex.org/W2066719859","https://openalex.org/W2068498799","https://openalex.org/W2069851464","https://openalex.org/W2072029917","https://openalex.org/W2073292219","https://openalex.org/W2078124668","https://openalex.org/W2088010807","https://openalex.org/W2088235679","https://openalex.org/W2090506723","https://openalex.org/W2092041087","https://openalex.org/W2093495910","https://openalex.org/W2096787650","https://openalex.org/W2103456203","https://openalex.org/W2113709403","https://openalex.org/W2118278569","https://openalex.org/W2142155304","https://openalex.org/W2164790671","https://openalex.org/W2168439058","https://openalex.org/W2419655347","https://openalex.org/W3190782283"],"related_works":["https://openalex.org/W3023509442","https://openalex.org/W2897905862","https://openalex.org/W2355534049","https://openalex.org/W2018502785","https://openalex.org/W2182210371","https://openalex.org/W2081587998","https://openalex.org/W4214697474","https://openalex.org/W2782978334","https://openalex.org/W2386546188","https://openalex.org/W4210900992"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}