{"id":"https://openalex.org/W2178393107","doi":"https://doi.org/10.1016/s1474-4422(15)00323-3","title":"Transition rates between amyloid and neurodegeneration biomarker states and to dementia: a population-based, longitudinal cohort study","display_name":"Transition rates between amyloid and neurodegeneration biomarker states and to dementia: a population-based, longitudinal cohort study","publication_year":2015,"publication_date":"2015-11-17","ids":{"openalex":"https://openalex.org/W2178393107","doi":"https://doi.org/10.1016/s1474-4422(15)00323-3","mag":"2178393107","pmid":"https://pubmed.ncbi.nlm.nih.gov/26597325","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4784263"},"language":"en","primary_location":{"id":"doi:10.1016/s1474-4422(15)00323-3","doi":"https://doi.org/10.1016/s1474-4422(15)00323-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s1474-4422(15)00323-3","pdf_url":null,"source":{"id":"https://openalex.org/S70053155","display_name":"The Lancet Neurology","issn_l":"1474-4422","issn":["1474-4422","1474-4465"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Lancet Neurology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4784263","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005099850","display_name":"Clifford R. Jack","orcid":"https://orcid.org/0000-0001-7916-622X","observed_orcids":["https://orcid.org/0000-0001-7916-622X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Clifford R Jack","raw_affiliation_strings":["Department of Radiology, Mayo Clinic and Foundation, Rochester, MN, USA. Electronic address: jack.clifford@mayo.edu","Department of Radiology, Mayo Clinic and Foundation, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Mayo Clinic and Foundation, Rochester, MN, USA. Electronic address: jack.clifford@mayo.edu","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Radiology, Mayo Clinic and Foundation, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014433885","display_name":"Terry M. Therneau","orcid":"https://orcid.org/0000-0003-1490-6711","observed_orcids":["https://orcid.org/0000-0003-1490-6711"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Terry M Therneau","raw_affiliation_strings":["Department of Health Sciences Research, Mayo Clinic and Foundation, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Sciences Research, Mayo Clinic and Foundation, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112476693","display_name":"Heather J. Wiste","orcid":"https://orcid.org/0009-0002-8833-2693","observed_orcids":["https://orcid.org/0009-0002-8833-2693"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heather J Wiste","raw_affiliation_strings":["Department of Health Sciences Research, Mayo Clinic and Foundation, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Sciences Research, Mayo Clinic and Foundation, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022452703","display_name":"Stephen D. Weigand","orcid":"https://orcid.org/0000-0002-4541-9011","observed_orcids":["https://orcid.org/0000-0002-4541-9011"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen D Weigand","raw_affiliation_strings":["Department of Health Sciences Research, Mayo Clinic and Foundation, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Sciences Research, Mayo Clinic and Foundation, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059027860","display_name":"David S. Knopman","orcid":"https://orcid.org/0000-0002-6544-066X","observed_orcids":["https://orcid.org/0000-0002-6544-066X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David S Knopman","raw_affiliation_strings":["Department of Neurology, Mayo Clinic and Foundation, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Mayo Clinic and Foundation, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001313680","display_name":"Val J. Lowe","orcid":"https://orcid.org/0000-0002-5612-1667","observed_orcids":["https://orcid.org/0000-0002-5612-1667"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Val J Lowe","raw_affiliation_strings":["Department of Radiology, Mayo Clinic and Foundation, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Mayo Clinic and Foundation, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090710393","display_name":"Michelle M. Mielke","orcid":"https://orcid.org/0000-0001-7177-1185","observed_orcids":["https://orcid.org/0000-0001-7177-1185"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle M Mielke","raw_affiliation_strings":["Department of Health Sciences Research, Mayo Clinic and Foundation, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Sciences Research, Mayo Clinic and Foundation, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043921358","display_name":"Prashanthi Vemuri","orcid":"https://orcid.org/0000-0003-4286-0589","observed_orcids":["https://orcid.org/0000-0003-4286-0589"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Prashanthi Vemuri","raw_affiliation_strings":["Department of Radiology, Mayo Clinic and Foundation, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Mayo Clinic and Foundation, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112116344","display_name":"Rosebud O. Roberts","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rosebud O Roberts","raw_affiliation_strings":["Department of Health Sciences Research, Mayo Clinic and Foundation, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Sciences Research, Mayo Clinic and Foundation, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032297807","display_name":"Mary M. Machulda","orcid":"https://orcid.org/0000-0003-4834-5967","observed_orcids":["https://orcid.org/0000-0003-4834-5967"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary M Machulda","raw_affiliation_strings":["Department of Psychiatry and Psychology, Mayo Clinic and Foundation, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Psychology, Mayo Clinic and Foundation, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050718938","display_name":"Matthew L. Senjem","orcid":"https://orcid.org/0000-0001-9308-9275","observed_orcids":["https://orcid.org/0000-0001-9308-9275"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew L Senjem","raw_affiliation_strings":["Department of Radiology, Mayo Clinic and Foundation, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Mayo Clinic and Foundation, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013894575","display_name":"Jeffrey L. Gunter","orcid":"https://orcid.org/0000-0001-7813-9078","observed_orcids":["https://orcid.org/0000-0001-7813-9078"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey L Gunter","raw_affiliation_strings":["Department of Radiology, Mayo Clinic and Foundation, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Mayo Clinic and Foundation, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030579684","display_name":"Walter A. Rocca","orcid":"https://orcid.org/0000-0002-1832-7664","observed_orcids":["https://orcid.org/0000-0002-1832-7664"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Walter A Rocca","raw_affiliation_strings":["Department of Health Sciences Research, Mayo Clinic and Foundation, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Sciences Research, Mayo Clinic and Foundation, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110342810","display_name":"Ronald Carl Petersen","orcid":"https://orcid.org/0000-0002-8178-6601","observed_orcids":["https://orcid.org/0000-0002-8178-6601"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald C Petersen","raw_affiliation_strings":["Department of Health Sciences Research, Mayo Clinic and Foundation, Rochester, MN, USA; Department of Neurology, Mayo Clinic and Foundation, Rochester, MN, USA","Department of Health Sciences Research, Mayo Clinic and Foundation, Rochester, MN, USA","Department of Neurology, Mayo Clinic and Foundation, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Sciences Research, Mayo Clinic and Foundation, Rochester, MN, USA; Department of Neurology, Mayo Clinic and Foundation, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Health Sciences Research, Mayo Clinic and Foundation, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Neurology, Mayo Clinic and Foundation, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5005099850"],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":{"value":7280,"currency":"USD","value_usd":7280},"apc_paid":null,"fwci":15.1187,"has_fulltext":false,"cited_by_count":127,"citation_normalized_percentile":{"value":0.99541531,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"15","issue":"1","first_page":"56","last_page":"64"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13077","display_name":"Cancer-related cognitive impairment studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amyloid-pet","display_name":"amyloid PET","score":0.7990000247955322},{"id":"https://openalex.org/keywords/neurodegeneration-markers","display_name":"neurodegeneration biomarkers","score":0.9539999961853027},{"id":"https://openalex.org/keywords/dementia-risk","display_name":"dementia risk","score":0.3880000114440918},{"id":"https://openalex.org/keywords/multi-state-markov-model","display_name":"multi-state Markov model","score":0.8230000138282776},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.5830000042915344},{"id":"https://openalex.org/keywords/mild-cognitive-impairment","display_name":"mild cognitive impairment","score":0.7519999742507935},{"id":"https://openalex.org/keywords/11c-pittsburgh-compound-b","display_name":"11C-Pittsburgh compound B","score":0.7730000019073486},{"id":"https://openalex.org/keywords/18f-fdg-pet","display_name":"18F-FDG PET","score":0.9269999861717224},{"id":"https://openalex.org/keywords/brain-mri","display_name":"brain MRI","score":0.4350000023841858},{"id":"https://openalex.org/keywords/mayo-clinic-study-of-aging","display_name":"Mayo Clinic Study of Aging","score":0.8939999938011169},{"id":"https://openalex.org/keywords/preclinical-alzheimer-s-disease","display_name":"preclinical Alzheimer's disease","score":0.5759999752044678}],"concepts":[{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.8639867901802063},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.8267080783843994},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.6159359812736511},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.610492467880249},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5499630570411682},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5103604197502136},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.4751072824001312},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4514715075492859},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.43189701437950134},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.40881186723709106},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3456445336341858},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.32513856887817383},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.29242122173309326},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09942030906677246},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011159","descriptor_name":"Population Surveillance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D058225","descriptor_name":"Plaque, Amyloid","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D058225","descriptor_name":"Plaque, Amyloid","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/s1474-4422(15)00323-3","doi":"https://doi.org/10.1016/s1474-4422(15)00323-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s1474-4422(15)00323-3","pdf_url":null,"source":{"id":"https://openalex.org/S70053155","display_name":"The Lancet Neurology","issn_l":"1474-4422","issn":["1474-4422","1474-4465"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Lancet Neurology","raw_type":"journal-article"},{"id":"pmid:26597325","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26597325","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Lancet. Neurology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:4103632","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4784263","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4784263","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4784263","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Lancet Neurol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:4103632","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4784263","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G104586243","display_name":null,"funder_award_id":"U01-AG-024904","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G1062948755","display_name":"Multimorbidity and Aging: Rochester Epidemiology Project","funder_award_id":"R01AG034676","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G142564060","display_name":"Sex-specific Risk for Vascular Dysfunction and Cognitive Decline","funder_award_id":"P50AG044170","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G1703452710","display_name":"Aerobic Exercise in Alzheimer's Disease Cognition and Hippocampal Volume Effects","funder_award_id":"R01AG043392","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G1907494464","display_name":"Multi-morbidity in Heart Failure","funder_award_id":"R21AG045228","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2470713673","display_name":"Synergizing genome sequencing with advances in patient reprted outcomes (PRO)","funder_award_id":"R01NR015259","funder_id":"https://openalex.org/F4320337353","funder_display_name":"National Institute of Nursing Research"},{"id":"https://openalex.org/G3152329173","display_name":"COllaborative Care to Preserve PErformance in Cancer (COPE) Trial","funder_award_id":"R01CA163803","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3210008823","display_name":"'Heart Failure in the Community: Multimorbidity and Outcomes'","funder_award_id":"R01HL120859","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G388381678","display_name":"Alzheimers Disease Patient Registry","funder_award_id":"U01AG006786","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4189569330","display_name":null,"funder_award_id":"U01AG24904","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G517245306","display_name":"Evaluating and Extending Our Hypothetical Model of Alzheimer's Biomarkers","funder_award_id":"R01AG011378","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5295743969","display_name":"Photon-Counting Spectral CT to Reduce Dose and Detect Early Vascular Disease","funder_award_id":"R01EB016966","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G5437636530","display_name":"Role of Endothelial Progenitor Cells in vascular Aging and Calcification","funder_award_id":"R01AG031750","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5707695498","display_name":"Alzheimer's Disease Neuroimaging Initiative","funder_award_id":"5u01ag024904-10","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6779489907","display_name":"ARIC Neurocognitive Study (ARIC-NCS) Renewal 2 of 5","funder_award_id":"U01HL096917","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7391181871","display_name":"Epidemiology of Age-Related Bone Loss and Fractures","funder_award_id":"R01AR027065","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G7640049654","display_name":"Prevalence and Progression of Monoclonal Gammopathies","funder_award_id":"R01CA107476","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7815058649","display_name":"Stroke and Cognitive Impairment in Aging Chronic Kidney Disease Patients","funder_award_id":"R01AG037551","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8251536870","display_name":"Brain Aging and Alzheimer's Biomarker Classification Using Amyloid PET, tau PET, and Neurodegeneration on MRI: Developing the ATN system","funder_award_id":"R01AG041851","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G89179543","display_name":"Beyond Heart Disease in Rheumatoid Arthritis: Multimorbidity","funder_award_id":"R01AR046849","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G8960160257","display_name":"Onset and biomarkers for progression of monoclonal gammopathies","funder_award_id":"R01CA168762","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000866180","display_name":"Mayo Clinic Comprehensive Cancer Center Support Grant","funder_award_id":"P30CA015083","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G95754455","display_name":"Mayo Alzheimer's Disease Research Center","funder_award_id":"P50AG016574","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320306143","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337353","display_name":"National Institute of Nursing Research","ror":"https://ror.org/01y3zfr79"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1548995643","https://openalex.org/W1562754477","https://openalex.org/W1919480245","https://openalex.org/W1948376220","https://openalex.org/W1971032265","https://openalex.org/W1975216966","https://openalex.org/W1987064062","https://openalex.org/W1996347667","https://openalex.org/W2003428745","https://openalex.org/W2004249343","https://openalex.org/W2017022537","https://openalex.org/W2020780341","https://openalex.org/W2024311012","https://openalex.org/W2030651223","https://openalex.org/W2044429455","https://openalex.org/W2063136428","https://openalex.org/W2074274706","https://openalex.org/W2090523774","https://openalex.org/W2104287008","https://openalex.org/W2104384019","https://openalex.org/W2112882050","https://openalex.org/W2115017507","https://openalex.org/W2116709840","https://openalex.org/W2116886795","https://openalex.org/W2122280897","https://openalex.org/W2129497119","https://openalex.org/W2133719476","https://openalex.org/W2134711807","https://openalex.org/W2148457471","https://openalex.org/W2149862198","https://openalex.org/W2167720733","https://openalex.org/W2168357345","https://openalex.org/W2170937822","https://openalex.org/W2187760945","https://openalex.org/W2290692729","https://openalex.org/W2582524520"],"related_works":["https://openalex.org/W2112882050","https://openalex.org/W2608642452","https://openalex.org/W3193477054","https://openalex.org/W2337835162","https://openalex.org/W3017173131","https://openalex.org/W2187760945","https://openalex.org/W2070396063","https://openalex.org/W2951707943","https://openalex.org/W2101241299","https://openalex.org/W4242134214"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":23},{"year":2017,"cited_by_count":21},{"year":2016,"cited_by_count":16},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
